A cytokine-mediated link between innate immunity, inflammation, and cancer

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Pathogen Recognition and Innate Immunity

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Smad-dependent and Smad-independent pathways in TGF-β family signalling

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Toll-like receptors and innate immunity

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IL-23 drives a pathogenic T cell population that induces autoimmune inflammation

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Hepatogastroenterology

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Inflammatory Bowel Disease

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NF-κB: linking inflammation and immunity to cancer development and progression

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IKKβ Links Inflammation and Tumorigenesis in a Mouse Model of Colitis-Associated Cancer

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NF-κB functions as a tumour promoter in inflammation-associated cancer

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TGF-β Signaling in Tumor Suppression and Cancer Progression

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Inactivation of the Type II TGF-β Receptor in Colon Cancer Cells with Microsatellite Instability

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Paradoxical roles of the immune system during cancer development

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Smoldering and polarized inflammation in the initiation and promotion of malignant disease

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Radical causes of cancer

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Divergent Pro- and Antiinflammatory Roles for IL-23 and IL-12 in Joint Autoimmune Inflammation

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Resident Enteric Bacteria Are Necessary for Development of Spontaneous Colitis and Immune System Activation in Interleukin-10-Deficient Mice

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Immune cell migration in inflammation: present and future therapeutic targets

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Enterocolitis and colon cancer in interleukin-10-deficient mice are associated with aberrant cytokine production and CD4(+) TH1-like responses.

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Cytokine Signaling in 2002

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I nterleukin -10 and R elated C ytokines and R eceptors

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IL-23 promotes tumour incidence and growth

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The role of IL-6 and STAT3 in inflammation and cancer.

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Interleukin-17 family and IL-17 receptors

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Targeted disruption of SMAD3 results in impaired mucosal immunity and diminished T cell responsiveness to TGF‐β

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Nod-like proteins in immunity, inflammation and disease

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IKK/NF- B signaling: balancing life and death - a new approach to cancer therapy

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Apo2L/TRAIL and its death and decoy receptors

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Mice deficient in tumor necrosis factor-α are resistant to skin carcinogenesis

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Interleukin-17 promotes angiogenesis and tumor growth

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IL-6 in autoimmune disease and chronic inflammatory proliferative disease

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Regulatory T cells suppress tumor-specific CD8 T cell cytotoxicity through TGF-β signals <i>in vivo</i>

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Tumor cells convert immature myeloid dendritic cells into TGF-β–secreting cells inducing CD4 + CD25 + regulatory T cell proliferation

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Inflammation, atrophy, and gastric cancer

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CD4+CD25+ TR Cells Suppress Innate Immune Pathology Through Cytokine-dependent Mechanisms

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Microsatellite instability and mutations of the transforming growth factor beta type II receptor gene in colorectal cancer.

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TGF-β Suppresses Tumor Progression in Colon Cancer by Inhibition of IL-6 trans-Signaling

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Interleukin-6 biology is coordinated by membrane-bound and soluble receptors: role in inflammation and cancer

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Chronic inflammation and cancer.

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Inhibition of NF-κB in cancer cells converts inflammation- induced tumor growth mediated by TNFα to TRAIL-mediated tumor regression

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The involvement of IL-1 in tumorigenesis, tumor invasiveness, metastasis and tumor-host interactions

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The TREM receptor family and signal integration

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Chronic Inflammation and Cancer

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Multiple myeloma cell adhesion-induced interleukin-6 expression in bone marrow stromal cells involves activation of NF-kappa B

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Interleukin-10 Signaling Blocks Inhibitor of κB Kinase Activity and Nuclear Factor κB DNA Binding

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Myeloid C-type lectins in innate immunity

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Critical Role for Tumor Necrosis Factor–related Apoptosis-inducing Ligand in Immune Surveillance Against Tumor Development

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Tumor-Driven Evolution of Immunosuppressive Networks during Malignant Progression

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Cytokines in cancer immunity and immunotherapy

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IL-17 Enhances the Net Angiogenic Activity and In Vivo Growth of Human Non-Small Cell Lung Cancer in SCID Mice through Promoting CXCR-2-Dependent Angiogenesis

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Interleukin-10 and the immune response against cancer: a counterpoint

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Functional Cooperation between Interleukin-17 and Tumor Necrosis Factor-α Is Mediated by CCAAT/Enhancer-binding Protein Family Members

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Interleukin-17 inhibits tumor cell growth by means of a T-cell–dependent mechanism

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Inflammation-associated immune suppression in cancer: The roles played by cytokines, chemokines and additional mediators

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TNF-α Inhibits Asbestos-Induced Cytotoxicity via a NF-ΚB-Dependent Pathway, a Possible Mechanism for Asbestos-Induced Oncogenesis

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Limiting inflammatory responses during activation of innate immunity

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Tumor necrosis factor, cancer and anticancer therapy

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STAT3 and NF-κB Signal Pathway Is Required for IL-23-Mediated IL-17 Production in Spontaneous Arthritis Animal Model IL-1 Receptor Antagonist-Deficient Mice

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Hyperactivation of Stat3 in gp130 mutant mice promotes gastric hyperproliferation and desensitizes TGF-β signaling

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CD4+ CD25+ Regulatory T Lymphocytes Inhibit Microbially Induced Colon Cancer in Rag2-Deficient Mice

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NF‐κB and cancer: Mechanisms and targets

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Impaired Preneoplastic Changes and Liver Tumor Formation in Tumor Necrosis Factor Receptor Type 1 Knockout Mice

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Interleukin 17, a T-cell-derived cytokine, promotes tumorigenicity of human cervical tumors in nude mice.

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Untitled work

(2001) · PubMed · Cited by 279 · see citing works

IL-12, but not IFN-gamma, plays a major role in sustaining the chronic phase of colitis in IL-10-deficient mice.

Davidson, N. J., Hudak, S. A., Lesley, R., Menon, S., Leach, M. W., & Rennick, D. M. (1998) · PubMed · Cited by 250 · see citing works

Lipopolysaccharide‐induced metastatic growth is associated with increased angiogenesis, vascular permeability and tumor cell invasion

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Interleukin-17: a mediator of inflammatory responses

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Tumor-derived CD4+CD25+ regulatory T cell suppression of dendritic cell function involves TGF-β and IL-10

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CD4+CD25+ Regulatory Lymphocytes Induce Regression of Intestinal Tumors in <i>ApcMin/+</i> Mice

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CD4(+)CD25(+) regulatory lymphocytes require interleukin 10 to interrupt colon carcinogenesis in mice.

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TGF-β: the missing link in CD4+CD25+ regulatory T cell-mediated immunosuppression

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Helicobacter Infection Is Required for Inflammation and Colon Cancer in Smad3-Deficient Mice

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Expression of both TNF-α receptor subtypes is essential for optimal skin tumour development

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IL-12, But Not IFN-γ, Plays a Major Role in Sustaining the Chronic Phase of Colitis in IL-10-Deficient Mice

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Elimination of colon cancer in germ-free transforming growth factor beta 1-deficient mice.

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Molecular mechanisms of inactivation of TGF-β receptors during carcinogenesis

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NOD2 and Crohn’s Disease: Loss or Gain of Function?

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The role of tumor stroma in the interaction between tumor and immune system

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Antitumor and Antimetastatic Activity of IL-23

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