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A novel insulin receptor-signaling platform and its link to insulin resistance and type 2 diabetes
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Desialylation of the insulin receptor (IR) induces its activation and insulin signal transduction.
“Notably, desialylation of the insulin receptor (IR) induces its activation and insulin signal transduction (41, 42).”
From Hypomorphic ASGR1 modulates lipid homeostasis via INSIG1-mediated SREBP signaling suppression (2021) · cites this paper as [41]
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Metadata
- Authors
- Alghamdi, F., Guo, M., Abdulkhalek, S., Crawford, N., Amith, S. R., & Szewczuk, M. R.
- Venue
- Cellular Signalling
- Publisher
- Elsevier BV
- Published
- 2014-06
- Volume
- 26
- Issue
- 6
- Pages
- 1355-1368
- ISSN
- 0898-6568
- Cited by
- 87
- References
- 0
- Language
- en
- Funders
- Natural Sciences and Engineering Research Council of Canada (NSERC)
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