Association between antipsychotic medication use and diabetes
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PURPOSE OF REVIEW: The prevalence of diabetes is 2-3-fold higher in people with severe mental illness than the general population. There are concerns that antipsychotics increase the risk of diabetes. This review will examine the latest epidemiological studies linking antipsychotics and diabetes, as well as the mechanisms underlying the association and the clinical implications to minimise the impact of antipsychotics on metabolic health. RECENT FINDINGS: Although there is an increased risk of diabetes in people with first-episode psychosis, the prevalence increases rapidly after antipsychotics are started. Antipsychotics likely increase the risk of diabetes through weight gain and directly by adversely affecting insulin sensitivity and secretion. It is important to implement measures to prevent diabetes, to screen for diabetes to ensure prompt diagnosis and to provide effective diabetes care. Further research is needed to understand how antipsychotics cause diabetes and to improve the clinical management of diabetes in people with severe mental illness.
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Taking second-generation (atypical) antipsychotics, such as olanzapine, is associated with an increase in risk of type 2 diabetes.
“In addition, those taking second-generation (atypical) antipsychotics, such as olanzapine, require greater monitoring because of an increase in risk of type 2 diabetes associated with this medication (418-420).”
From 5. Facilitating Positive Health Behaviors and Well-being to Improve Health Outcomes:<i>Standards of Care in Diabetes—2023</i> (2023) · cites this paper as [420]
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- Authors
- Holt, R. I. G.
- Affiliations
- Southampton General Hospital (GB)
- Corresponding author
- Holt, Richard I. G.
- ORCID
- Holt, Richard I. G.
- Venue
- Current Diabetes Reports
- Published
- 2019-09-02
- Volume
- 19
- Issue
- 10
- Pages
- 96-96
- ISSN
- 1534-4827 (ISSN-L)
- 1539-0829
- PMC
- PMC6718373
- OpenAlex
- W2970171902
- Cited by
- 162
- References
- 74
- Citations by year
- 2026: 20 · 2025: 26 · 2024: 22 · 2023: 32 · 2022: 25 · 2021: 22 · 2020: 12 · 2019: 3
- FWCI
- 2.61
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- Current Diabetes Reports (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- ePrints Soton (University of Southampton) (acceptedVersion)
- ePrints Soton (University of Southampton) (submittedVersion)
- Funders
- University of Southampton
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Keywords
- antipsychotic drugs, diabetes risk, severe mental illness, first-episode psychosis, weight gain, insulin resistance, insulin secretion, metabolic side effects, diabetes screening, diabetes prevention, diabetes management
- MeSH terms
- Diabetes Mellitus, Humans, Insulin Resistance, Psychotic Disorders, Antipsychotic Agents, Weight Gain
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