Hepassocin activates the EGFR/ERK cascade and induces proliferation of L02 cells through the Src-dependent pathway
Abstract
Hepassocin (HPS) is a secreted protein with mitogenic activity on primary hepatocytes and protects hepatocytes from chemically-induced injury. Our previous studies showed that HPS stimulates proliferation of hepatocytes in an ERK pathway-dependent manner. However, the molecular mechanism of HPS-induced activation of the ERK pathway remains unclear. In this study, we found that HPS induced the phosphorylation of the epidermal growth factor receptor (EGFR) in the human L02 hepatocyte cell line, and this event was concomitant with the activation of the non-receptor tyrosine kinase Src. Specific inhibition of EGFR kinase activity by gefitinib or down-regulation of EGFR by specific EGFR siRNAs prevented HPS-induced activation of the ERK pathway and proliferation of L02 cells. Furthermore, inhibition of Src activity significantly blocked HPS-induced activation of the EGFR, which was suggestive of a ligand-independent transactivation mechanism of EGFR itself as well as ERK phosphorylation and proliferation of L02 cells. These results indicate that EGFR plays an important role in the mitogenic signaling induced by HPS in L02 cell lines and may further stimulate research on the role of HPS in hepatocytes within biological processes in human health and disease.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Hepassocin increases phosphorylation of ERK1/2, leading to hepatic lipogenesis and development of hepatic steatosis.
“Hepassocin increases the phosphorylation of ERK1/2, leading to hepatic lipogenesis and the development of hepatic steatosis [217,218].”
From Hepatokines and metabolism: Deciphering communication from the liver (2021) · cites this paper as [218]
Hepassocin has mitogenic activity on hepatocytes, serving as a regulator of hepatic growth and proliferation.
“Hepassocin has mitogenic activity on hepatocytes, serving as a regulator of hepatic growth and proliferation [218].”
From Hepatokines and metabolism: Deciphering communication from the liver (2021) · cites this paper as [218]
Cites
Prenzel, N., Zwick, E., Daub, H., Leserer, M., Abraham, R., Wallasch, C., & Ullrich, A. (1999) · Nature · doi:10.1038/47260 · Cited by 1,507 · see citing works
Genetic and cell biological analysis of integrin outside-in signalingPreprint
Legate, K. R., Wickström, S. A., & Fässler, R. (2009) · Genes & Development · doi:10.1101/gad.1758709 · Cited by 799 · see citing works
Biscardi, J. S., Maa, M.-C., Tice, D. A., Cox, M. E., Leu, T.-H., & Parsons, S. J. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.12.8335 · Cited by 649 · see citing works
Gschwind, A., Zwick, E., Prenzel, N., Leserer, M., & Ullrich, A. (2001) · Oncogene · doi:10.1038/sj.onc.1204192 · Cited by 462 · see citing works
β-Arrestin–mediated β1-adrenergic receptor transactivation of the EGFR confers cardioprotection
Noma, T., Lemaire, A., Prasad, S. V. N., Barki‐Harrington, L., Tilley, D. G., Chen, J., Corvoisier, P. L., Violin, J. D., Wei, H., Lefkowitz, R. J., et al. (2007) · Journal of Clinical Investigation · doi:10.1172/jci31901 · Cited by 450 · see citing works
EGFR signal transactivation in cancer cells
Fischer, O. M., Hart, S., Gschwind, A., & Ullrich, A. (2003) · Biochemical Society Transactions · doi:10.1042/bst0311203 · Cited by 412 · see citing works
ADAMs as mediators of EGF receptor transactivation by G protein-coupled receptors
Ohtsu, H., Dempsey, P. J., & Eguchi, S. (2006) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00620.2005 · Cited by 340 · see citing works
Toward an understanding of the protein interaction network of the human liver
Wang, J., Huo, K., Ma, L., Tang, L., Li, D., Huang, X., Yuan, Y., Li, C., Wang, W., Guan, W., et al. (2011) · Molecular Systems Biology · doi:10.1038/msb.2011.67 · Cited by 243 · see citing works
Self-citationNot so strange bedfellows: G-protein-coupled receptors and Src family kinases
Luttrell, D. K., & Luttrell, L. M. (2004) · Oncogene · doi:10.1038/sj.onc.1208162 · Cited by 221 · see citing works
Saito, Y., Haendeler, J., Hojo, Y., Yamamoto, K., & Berk, B. C. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.19.6387-6394.2001 · Cited by 180 · see citing works
Singh, R. K., & Lokeshwar, B. L. (2011) · Cancer Research · doi:10.1158/0008-5472.can-10-2769 · Cited by 178 · see citing works
Porcile, C., Bajetto, A., Barbieri, F., Barbero, S., Bonavia, R., Biglieri, M., Pirani, P., Florio, T., & Schettini, G. (2005) · Experimental Cell Research · doi:10.1016/j.yexcr.2005.04.024 · Cited by 160 · see citing works
EGF receptor activation by GPCRs: An universal pathway reveals different versions
Liebmann, C. (2010) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2010.04.008 · Cited by 143 · see citing works
HER1/EGFR Targeting: Refining the Strategy
Perez-Soler, R. (2004) · The Oncologist · doi:10.1634/theoncologist.9-1-58 · Cited by 116 · see citing works
Cellular Functions Regulated by Phosphorylation of EGFR on Tyr845
Sato, K. (2013) · International Journal of Molecular Sciences · doi:10.3390/ijms140610761 · Cited by 109 · see citing works
Zhougang, S., & Schnellmann, R. G. (2004) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00282.2003 · Cited by 96 · see citing works
Li, C. Y., Cao, C.-Z., Xu, W., Cao, M., Yang, F., Dong, L., Yu, M., Zhan, Y.-Q., Gao, Y.-B., Li, W., et al. (2009) · Gut · doi:10.1136/gut.2008.171124 · Cited by 85 · see citing works
Self-citationHara, H., Yoshimura, H., Uchida, S., Toyoda, Y., Aoki, M., Sakai, Y., Morimoto, S., & Shiokawa, K. (2001) · Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression · doi:10.1016/s0167-4781(01)00249-4 · Cited by 79 · see citing works
Functional implication of the interaction between EGF receptor and C-SRC
Leu, T. (2003) · Frontiers in bioscience · doi:10.2741/980 · Cited by 77 · see citing works
Li, Y., Li, M., Xing, G., Hu, Z., Wang, Q., Dong, C., Wei, H., Fan, G., Chen, J., Yang, X., et al. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m004373200 · Cited by 71 · see citing works
Self-citationYu, H., Yu, M., Li, C., Zhan, Y., Xu, W., Li, Y., Li, W., Wang, Z., Ge, C., & Yang, X. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m806393200 · Cited by 69 · see citing works
Self-citationHsieh, H., Sun, C., Wang, T.-S., & Yang, C. (2008) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2008.03.016 · Cited by 65 · see citing works
Hara, H., Uchida, S., Yoshimura, H., Aoki, M., Toyoda, Y., Sakai, Y., Morimoto, S., Fukamachi, H., Shiokawa, K., & Hanada, K. (2000) · Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression · doi:10.1016/s0167-4781(00)00056-7 · Cited by 63 · see citing works
Transactivation of EGFR by LPS Induces COX-2 Expression in Enterocytes
McElroy, S. J., Hobbs, S. S., Kallen, M. E., Tejera, N., Rosen, M. J., Grishin, A., Matta, P., Schneider, C. G., Upperman, J. S., Ford, H. R., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0038373 · Cited by 63 · see citing works
Drube, S., Stirnweiss, J., Valkova, C., & Liebmann, C. (2006) · Cellular Signalling · doi:10.1016/j.cellsig.2006.01.003 · Cited by 61 · see citing works
Zerrad-Saadi, A., Lambert-Blot, M., Mitchell, C., Bretes, H., de l’Hortet, A. C., Baud, V., Chéreau, F., Sotiropoulos, A., Kopchick, J. J., Liao, L., et al. (2011) · Endocrinology · doi:10.1210/en.2010-1193 · Cited by 60 · see citing works
Hsieh, H., Lin, C., Chan, H., Yang, C. M., & Yang, C. (2012) · Journal of Neuroinflammation · doi:10.1186/1742-2094-9-152 · Cited by 59 · see citing works
Site-Specific Association of c-SRC with Epidermal Growth Factor Receptor in A431 Cells
Sato, K., Sato, A., Aoto, M., & Fukami, Y. (1995) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1995.1735 · Cited by 51 · see citing works
ADAM‐mediated amphiregulin shedding and EGFR transactivation
Kasina, S., Scherle, P., Hall, C. L., & Macoska, J. A. (2009) · Cell Proliferation · doi:10.1111/j.1365-2184.2009.00645.x · Cited by 51 · see citing works
Sato, K., Kimoto, M., Kakumoto, M., Horiuchi, D., Iwasaki, T., Tokmakov, A. A., & Fukami, Y. (2000) · Genes to Cells · doi:10.1046/j.1365-2443.2000.00358.x · Cited by 47 · see citing works
Cao, M.-M., Xu, W., Li, C., Cao, C.-Z., Wang, Z., Yao, J., Yu, M., Zhan, Y., Wang, X., Tang, L., et al. (2011) · Journal of Cellular Biochemistry · doi:10.1002/jcb.23202 · Cited by 40 · see citing works
Self-citationYan, J., Ying, H., Gu, F., He, J., Yu Li, L. I., Liu, H. M., & Xu, Y. (2002) · Cell Research · doi:10.1038/sj.cr.7290137 · Cited by 37 · see citing works
Epidermal growth factor receptor signaling in liver cell proliferation and apoptosis
Reinehr, R., & Häussinger, D. (2009) · Biological Chemistry · doi:10.1515/bc.2009.106 · Cited by 33 · see citing works
Sarin, V., Gaffin, R. D., Meininger, G. A., & Muthuchamy, M. (2005) · The Journal of Physiology · doi:10.1113/jphysiol.2005.083238 · Cited by 33 · see citing works
Peng, L., Yu, A. C., Fung, K. Y., Prévot, V., & Hertz, L. (2003) · Brain Research · doi:10.1016/s0006-8993(03)02766-5 · Cited by 30 · see citing works
EGFR and the Complexity of Receptor Crosstalk in the Cardiovascular System
Sanchez-Guerrero, E., Jo, S.-I., Chong, B. H., & Khachigian, L. M. (2012) · Current Molecular Medicine · doi:10.2174/156652413804486313 · Cited by 14 · see citing works
EGFR and the Complexity of Receptor Crosstalk in the Cardiovascular System
Sanchez-Guerrero, E., Jo, S. R., Chong, B. H., & Khachigian, L. M. (2012) · Current Molecular Medicine · doi:10.2174/1566524011307010003 · Cited by 11 · see citing works
Flagged first, then by citations
1 of the 38 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
The Liver as an Endocrine Organ—Linking NAFLD and Insulin Resistance
Watt, M. J., Miotto, P. M., De Nardo, W., & Montgomery, M. K. (2019) · Endocrine Reviews · doi:10.1210/er.2019-00034 · Cited by 615 · see citing works
Cytokines and abnormal glucose and lipid metabolism
Shi, J., Fan, J., Su, Q., & Yang, Z. (2019) · Frontiers in Endocrinology · doi:10.3389/fendo.2019.00703 · Cited by 282 · see citing works
Hepatokines and metabolism: Deciphering communication from the liver
Jensen-Cody, S. O., & Potthoff, M. J. (2021) · Molecular Metabolism · doi:10.1016/j.molmet.2020.101138 · Cited by 252 · see citing works
Sun, C., Gao, W., Liu, J., Cheng, H., & Hao, J. (2020) · Respiratory Research · doi:10.1186/s12931-020-01477-y · Cited by 109 · see citing works
Mechanisms shaping the role of ERK1/2 in cellular sene scence (Review)
Zou, J., Lei, T., Guo, P., Yu, J., Xu, Q., Luo, Y., Ke, R., & Huang, D. (2018) · Molecular Medicine Reports · doi:10.3892/mmr.2018.9712 · Cited by 107 · see citing works
Wu, H.-T., Ou, H.-Y., Hung, H.-C., Su, Y.-C., Lu, F.-H., Wu, J.-S., Yang, Y.-C., Wu, C.-L., & Chang, C.-J. (2016) · Diabetologia · doi:10.1007/s00125-016-3991-7 · Cited by 96 · see citing works
Hyperlipidemia-induced hepassocin in the liver contributes to insulin resistance in skeletal muscle
Jung, T. W., Chung, Y. H., Kim, H., El‐Aty, A. M. A., & Jeong, J. H. (2017) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2017.10.014 · Cited by 64 · see citing works
The role of Fibrinogen-like proteins in Cancer
Yu, J., Li, J., Shen, J., Du, F., Wu, X., Li, M., Chen, Y., Cho, C. H., Li, X., Xiao, Z., et al. (2021) · International Journal of Biological Sciences · doi:10.7150/ijbs.56748 · Cited by 59 · see citing works
VEGFR2 activation mediates the pro-angiogenic activity of BMP4
Rezzola, S., Somma, M. D., Corsini, M., Leali, D., Ravelli, C., Polli, V. A. B., Grillo, E., Presta, M., & Mitola, S. M. F. (2019) · Angiogenesis · doi:10.1007/s10456-019-09676-y · Cited by 54 · see citing works
Plasma Fibrinogen-Like 1 as a Potential Biomarker for Radiation-Induced Liver Injury
Han, N., Jung, M. G., Jeong, Y. J., Son, Y., Han, S. C., Park, S. W., Lim, Y.-B., Lee, Y.-J., Kim, S., Park, S. C., et al. (2019) · Cells · doi:10.3390/cells8091042 · Cited by 46 · see citing works
Targeting fibrinogen‐like protein 1 is a novel therapeutic strategy to combat obesity
Wu, H., Chen, S., Fan, K., Kuo, C., Lin, S., Wang, S., Chang, C., & Li, H. (2019) · The FASEB Journal · doi:10.1096/fj.201901925r · Cited by 43 · see citing works
Identification of molecular signatures involved in radiation-induced lung fibrosis
Jin, H. K., Kang, G.-Y., Jeon, S., Kim, J.-M., Park, Y. N., Cho, J., & Lee, Y. (2018) · Journal of Molecular Medicine · doi:10.1007/s00109-018-1715-9 · Cited by 37 · see citing works
Liu, S., Guo, Y., Lu, L., Lu, J., Ke, M., Xu, T., Lu, Y., Chen, W., Wang, J., Kong, D., et al. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.579228 · Cited by 35 · see citing works
Gao, Q., Gu, Y., Jiang, Y., Fan, L., Wei, Z., Jin, H., Yang, X., Wang, L., Li, X., Tai, S., et al. (2018) · Cell Death and Disease · doi:10.1038/s41419-018-0595-9 · Cited by 33 · see citing works
Self-citationLiu, X.-H., Qi, L., Alolga, R. N., & Liu, Q. (2021) · International Journal of Biological Sciences · doi:10.7150/ijbs.66834 · Cited by 28 · see citing works
FGL1 as a Novel Mediator and Biomarker of Malignant Progression in Clear Cell Renal Cell Carcinoma
Lv, Z., Cui, B., Huang, X., Feng, H., Wang, T., Wang, H.-F., Xuan, Y., Li, H., Ma, X., Huang, Y., et al. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.756843 · Cited by 29 · see citing works
Role of placental fibrinogen-like protein 1 in gestational diabetes
Kang, L., Li, H., Ou, H., Wu, P., Wang, S., Chang, C., Lin, S., Wu, C., & Wu, H. (2020) · Translational research · doi:10.1016/j.trsl.2020.01.001 · Cited by 28 · see citing works
FGL1 and FGL2: emerging regulators of liver health and disease
Chen, J., Wu, L., & Li, Y. (2024) · Biomarker Research · doi:10.1186/s40364-024-00601-0 · Cited by 27 · see citing works
Discovery of a role of the novel hepatokine, hepassocin, in obesity
Huang, R., Li, C., Du, Y., Cheng, K., Lin, C., Hu, C., Wu, J. S., Chang, C., Wu, H., & Ou, H. (2020) · BioFactors · doi:10.1002/biof.1574 · Cited by 24 · see citing works
Self-citationLin, W.-W., Ho, K., Su, H.-H., Fang, T.-F., Tzou, S.-C., Chen, I., Lu, Y., Chang, M.-S., Tsai, Y.-C., Liu, E.-S., et al. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.767868 · Cited by 23 · see citing works
Hua, N., Chen, A., Yang, C., Dong, H., He, X., Ru, G., Tong, X., Zhou, F., & Wang, S. (2022) · Molecular Biology Reports · doi:10.1007/s11033-022-07624-6 · Cited by 21 · see citing works
Recombinant Human HPS Protects Mice and Nonhuman Primates from Acute Liver Injury
Yang, Y., Zhai, H., Wan, Y., Wang, X., Chen, H., Dong, L., Liu, T., Dou, G., Wu, C., & Yu, M. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222312886 · Cited by 18 · see citing works
Self-citationDai, H., Jia, G., Wang, H., Yang, J., Jiang, H., & Minghui, C. (2017) · Oncology Letters · doi:10.3892/ol.2017.6463 · Cited by 17 · see citing works
Liu, P., Lee, M., Choi, J., Choi, Y., & Nam, T. (2018) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2018.4025 · Cited by 17 · see citing works
Zhang, X., Zhu, H., Zheng, X., Jiao, Y., Ning, L., Zhou, E., & Yang, M. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.670626 · Cited by 15 · see citing works
Protective Role of Hepassocin against Hepatic Endoplasmic Reticulum Stress in Mice
Yang, Y., Chen, H., Wan, Y., Dong, D., Wang, X., Yao, S., Wang, P., Xiang, S., Yang, X., & Yu, M. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232113325 · Cited by 14 · see citing works
Self-citationYang, Y., Liu, X., Chen, H., Wang, P., Yao, S., Zhou, B., Yin, R., Li, C., Wu, C., Yang, X., et al. (2022) · FEBS Journal · doi:10.1111/febs.16430 · Cited by 14 · see citing works
Self-citationHepatokines: the missing link in the development of insulin resistance and hyperandrogenism in PCOS?
Stefanaki, K., Ilias, Ι., Paschou, S. Α., & Karagiannakis, D. S. (2023) · HORMONES · doi:10.1007/s42000-023-00487-x · Cited by 15 · see citing works
Sui, Y., Zhao, Z., Zhang, Y., Zhang, T., Li, G., Liu, L., Tan, H., Sun, B., & Li, L. (2022) · Medicina · doi:10.3390/medicina58121753 · Cited by 13 · see citing works
Zhang, Y., Zhang, W., Hou, J., Wang, X., Zheng, H., Xiong, W., & Yuan, J. (2017) · RSC Advances · doi:10.1039/c7ra11273d · Cited by 12 · see citing works
Self-citationTsai, I., Hung, W., Lu, Y., Wu, C., Lee, T., Hsuan, C., Yu, T., Wei, C., Chung, F., Lee, Y., et al. (2020) · International Journal of Medical Sciences · doi:10.7150/ijms.50646 · Cited by 11 · see citing works
Contribution of organokines in the development of NAFLD/NASH associated hepatocellular carcinoma
Vachher, M., Bansal, S., Kumar, B., Yadav, S., Arora, T. K., Wali, N. M., & Burman, A. (2022) · Journal of Cellular Biochemistry · doi:10.1002/jcb.30252 · Cited by 11 · see citing works
Novel sericin-based hepatocyte serum-free medium and sericin’s effect on hepatocyte transcriptome
Huang, Y., Peng, Q., Li, H., Jia, Z., Li, Y., & Gao, Y. (2018) · World Journal of Gastroenterology · doi:10.3748/wjg.v24.i30.3398 · Cited by 10 · see citing works
Ma, Y., Li, M.-M., Wu, Q., Xu, W., Lin, S., Chen, Z., Liu, L., Shi, L., Sheng, Q., Li, T., et al. (2018) · European Journal of Integrative Medicine · doi:10.1016/j.eujim.2018.11.007 · Cited by 8 · see citing works
Pan, Z., Hu, W., Huang, J., Zheng, Z., Lin, E., Wang, P., & Mao, L. (2023) · Biochemical Genetics · doi:10.1007/s10528-023-10545-z · Cited by 7 · see citing works
Mori, K., Suzuki, T., Miura, K., Dohmae, N., & Simizu, S. (2021) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2021.04.128 · Cited by 7 · see citing works
Role of Fibrinogen-like Protein 1 in Tumor Recurrence Following Hepatectomy
Shafieizadeh, Z., Shafieizadeh, Z., Davoudi, M., Afrisham, R., & Miao, X. (2024) · Journal of Clinical and Translational Hepatology · doi:10.14218/jcth.2023.00397 · Cited by 3 · see citing works
Stefaniuk, D., Misztal, T., Pięt, M., Zając, A., Kopycińska, M., Matuszewska, A., Ruminowicz-Stefaniuk, M., Matuszewski, Ł., Marcińczyk, N., Belcarz, A., et al. (2021) · Biomolecules · doi:10.3390/biom11091263 · Cited by 3 · see citing works
Pedersen, L., Eriksen, L. L., Brix, F. H., Vilstrup, H., Deleuran, B. W., Sandahl, T. D., & Støy, S. H. (2024) · Journal of Clinical and Experimental Hepatology · doi:10.1016/j.jceh.2024.102424 · Cited by 2 · see citing works
Fibrinogen superfamily proteins: Key regulators in hepatic disorders
Qu, R.-H., Rong, Y., Ni, W.-Z., Huang, X.-L., Chen, Y.-Z., & Li, H. (2025) · World Journal of Experimental Medicine · doi:10.5493/wjem.v15.i3.106677 · Cited by 2 · see citing works
Unraveling fibrinogen-like protein 1’s role in immune regulation
Xi, F., & Liu, R. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1753785 · Cited by 2 · see citing works
Compensatory Increase of Serum Hepassocin Protects Hyperthyroidism-Induced Hepatic Dysfunction
Wang, C., Lin, C., Chou, H., Wang, C., Liang, Y.-C., Wu, H., & Ou, H. (2023) · Biomedicines · doi:10.3390/biomedicines11071936 · Cited by 1 · see citing works
Tripathi, S., Maurya, S., & Singh, A. K. (2025) · Journal of Endocrinology · doi:10.1530/joe-25-0072 · Cited by 1 · see citing works
From Liver to Muscle: Crosstalk Mechanisms and Interventions in Sarcopenia
Wang, Q., Meng, Y., Wang, X., Lan, X., Fan, G., & Xiang, Y. (2025) · Health and Metabolism · doi:10.53941/hm.2025.100022 · Cited by 1 · see citing works
Self-citationWang, Q., Chen, S.-Z., & Zhang, H. (2021) · Research Square · doi:10.21203/rs.3.rs-147981/v1 · Cited by 1 · see citing works
Hua, N., Yang, C., Chen, A., Feng, Y., He, X., Ru, G., Tong, X., & Wang, S. (2021) · Research Square · doi:10.21203/rs.3.rs-1037866/v1 · Cited by 1 · see citing works
Hua, N., Chen, A., Chen, Y., Dong, H., He, X., Ru, G., Tong, X., Zhou, F., & Wang, S. (2021) · Research Square · doi:10.21203/rs.3.rs-1037866/v2
Çakmak, A., Kale, İ., & Muhçu, M. (2023) · Zeitschrift für Geburtshilfe und Neonatologie · doi:10.1055/a-2096-6339
Atypical Protein Glycosylation: C-Mannosylation and Glucosyl-Galactosyl-Hydroxylation
Mori, K., & Simizu, S. (2026) · Springer eBooks · doi:10.1007/978-981-95-5335-8_16
Le rôle de l'érythroferrone dans la régulation du métabolisme du fer
Sardo, U. (2020) · theses.fr (ABES) · doi:10.70675/d03e67aczc44bz4af9z8fa1zef080668f44f
Pyo, M. K., Park, H. S., Ko, J. H., Lim, D. S., Gwon, H. J., EL-Aty, A. M. A., Yağan, R., Song, J.-H., Shin, Y. K., Jeong, J. H., et al. (2026) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2026.110820
Yang, Y., Chen, H., 向慎思, Wei, Y., Zhang, L., Sun, A., Xiao, E., Wu, F., Luo, N., Liang, F., et al. (2026) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-026-02773-7
Self-citation
- Authors
- Gao, M., Zhan, Y.-Q., Yu, M., Ge, C.-H., Li, C.-Y., Zhang, J.-H., Wang, X.-H., Ge, Z.-Q., & Yang, X.-M.
- Affiliations
- Tianjin University (CN)
- State Key Laboratory of Proteomics (CN)
- Venue
- Cellular Signalling
- Publisher
- Elsevier BV
- Published
- 2014-10
- Volume
- 26
- Issue
- 10
- Pages
- 2161-2166
- ISSN
- 0898-6568 (ISSN-L)
- OpenAlex
- W2080832793
- Cited by
- 52
- References
- 38
- Citations by year
- 2026: 4 · 2025: 3 · 2024: 3 · 2023: 4 · 2022: 5 · 2021: 11 · 2020: 6 · 2019: 6 · 2018: 6 · 2017: 3 · 2016: 1
- FWCI
- 0.64
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Cellular Signalling (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Oncology › HER2/EGFR in Cancer Research
- Health Sciences › Medicine › Hepatology › Liver physiology and pathology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
- Keywords
- epidermal growth factor receptor, ERK signaling, Src kinase, hepatocyte proliferation, gefitinib, L02 hepatocytes, mitogenic signaling, hepatocyte growth factor
- MeSH terms
- Gefitinib, Cell Line, Epidermal Growth Factor, Fibrinogen, Humans, Neoplasm Proteins, Phosphorylation, Quinazolines, Recombinant Proteins, Signal Transduction, Transcriptional Activation, Down-Regulation, src-Family Kinases, RNA Interference, RNA, Small Interfering, Extracellular Signal-Regulated MAP Kinases, Cell Proliferation, ErbB Receptors
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
