Cytokines and abnormal glucose and lipid metabolism

Positional cloning of the mouse obese gene and its human homologue

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Adipose Expression of Tumor Necrosis Factor-α: Direct Role in Obesity-Linked Insulin Resistance

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Adipose Tissue as an Endocrine Organ

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Leptin and the regulation of body weight in mammals

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A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis

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The hormone resistin links obesity to diabetes

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Sox9 Modulates Proliferation and Expression of Osteogenic Markers of Adipose-Derived Stem Cells (ASC)

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C-Reactive Protein, Interleukin 6, and Risk of Developing Type 2 Diabetes Mellitus

Pradhan, A. D. (2001) · JAMA · doi:10.1001/jama.286.3.327 · Cited by 4,433 · see citing works

Mutation of the mouse klotho gene leads to a syndrome resembling ageing

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Inflammatory Mechanisms in Obesity

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Type 2 diabetes as an inflammatory disease

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Immunological and inflammatory functions of the interleukin-1 family

Dinarello, C. A. (2009) · Annual Review of Immunology · doi:10.1146/annurev.immunol.021908.132612 · Cited by 3,466 · see citing works

Cloning of adiponectin receptors that mediate antidiabetic metabolic effects

Yamauchi, T., Kamon, J., Ito, Y., Tsuchida, A., Yokomizo, T., Kita, S., Sugiyama, T., Miyagishi, M., Hara, K., Tsunoda, M., et al. (2003) · Nature · doi:10.1038/nature01705 · Cited by 3,176 · cited 1× · see citing works

Muscles, exercise and obesity: skeletal muscle as a secretory organ

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Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome

Kadowaki, T. (2006) · Journal of Clinical Investigation · doi:10.1172/jci29126 · Cited by 2,824 · see citing works

MCP-1 contributes to macrophage infiltration into adipose tissue, insulin resistance, and hepatic steatosis in obesity

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Endocrine regulation of energy metabolism by the skeleton

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Protection from obesity-induced insulin resistance in mice lacking TNF-α function

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FGF-21 as a novel metabolic regulator

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Leptin stimulates fatty-acid oxidation by activating AMP-activated protein kinase

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Lipocalin 2 mediates an innate immune response to bacterial infection by sequestrating iron

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Klotho converts canonical FGF receptor into a specific receptor for FGF23

Urakawa, I., Yamazaki, Y., Shimada, T., Iijima, K., Hasegawa, H., Okawa, K., Fujita, T., Fukumoto, S., & Yamashita, T. (2006) · Nature · doi:10.1038/nature05315 · Cited by 1,846 · see citing works

Interleukin-1-receptor antagonist in type 2 diabetes mellitus

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Cloning of a T Cell Growth Factor that Interacts with the β Chain of the Interleukin-2 Receptor

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Beneficial effects of leptin on obesity, T cell hyporesponsiveness, and neuroendocrine/metabolic dysfunction of human congenital leptin deficiency

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Macrophage-mediated inflammation in metabolic disease

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Leptin-Replacement Therapy for Lipodystrophy

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Prdm16 determines the thermogenic program of subcutaneous white adipose tissue in mice

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Insulin signaling in osteoblasts integrates bone remodeling and energy metabolism

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Adiponectin and protection against type 2 diabetes mellitus

Spranger, J., Kroke, A., Möhlig, M., Bergmann, M. M., Ristow, M., Boeing, H., & Pfeiffer, A. F. H. (2003) · The Lancet · doi:10.1016/s0140-6736(03)12255-6 · Cited by 1,120 · see citing works

Glucose-induced β cell production of IL-1β contributes to glucotoxicity in human pancreatic islets

Maedler, K., Sergeev, P., Ris, F., Oberholzer, J., Joller‐Jemelka, H. I., Spinas, G. A., Kaiser, N., Halban, P. A., & Donath, M. Y. (2017) · Journal of Clinical Investigation · doi:10.1172/jci92172 · Cited by 1,114 · see citing works

Beneficial effects of leptin on obesity, T cell hyporesponsiveness, and neuroendocrine/metabolic dysfunction of human congenital leptin deficiency

Farooqi, I. S., Matarese, G., Lord, G. M., Keogh, J. M., Lawrence, E., Agwu, C., Sanna, V., Jebb, S. A., Perna, F., Fontana, S., et al. (2002) · Journal of Clinical Investigation · doi:10.1172/jci0215693 · Cited by 1,105 · see citing works

Mechanisms of leptin action and leptin resistance.

Myers, M. G., Cowley, M. A., & Münzberg, H. (2008) · Annual Review of Physiology · doi:10.1146/annurev.physiol.70.113006.100707 · Cited by 1,074 · see citing works

Interleukin-6 (IL-6) Induces Insulin Resistance in 3T3-L1 Adipocytes and Is, Like IL-8 and Tumor Necrosis Factor-α, Overexpressed in Human Fat Cells from Insulin-resistant Subjects

Rotter, V., Nagaev, I., & Smith, U. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m301977200 · Cited by 1,062 · see citing works

Adipokines in health and disease

Fasshauer, M., & Blüher, M. (2015) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2015.04.014 · Cited by 1,050 · see citing works

IL-6 Trans-Signaling via the Soluble IL-6 Receptor: Importance for the Pro-Inflammatory Activities of IL-6

Rose-John, S. (2012) · International Journal of Biological Sciences · doi:10.7150/ijbs.4989 · Cited by 1,040 · cited 1× · see citing works

NAFLD and diabetes mellitus

Tilg, H., Moschen, A. R., & Roden, M. (2017) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2016.147 · Cited by 1,002 · see citing works

Fetuin-A acts as an endogenous ligand of TLR4 to promote lipid-induced insulin resistance

Pal, D., Dasgupta, S., Kundu, R., Maitra, S., Das, G., Mukhopadhyay, S., Ray, S., Majumdar, S. S., & Bhattacharya, S. (2012) · Nature Medicine · doi:10.1038/nm.2851 · Cited by 922 · see citing works

Serum FGF21 levels are increased in obesity and are independently associated with the metabolic syndrome in humans

Zhang, X., Yeung, D. C. Y., Karpisek, M., Stejskal, D., Zhou, Z.-G., Liu, F., Wong, R. L. C., Chow, W.-S., Tso, A. W. K., Lam, K. S. L., et al. (2008) · Diabetes · doi:10.2337/db07-1476 · Cited by 908 · see citing works

The effects of LY2405319, an FGF21 analog, in obese human subjects with type 2 diabetes

Gaich, G., Chien, J. Y., Fu, H., Glass, L. C., Deeg, M. A., Holland, W. L., Kharitonenkov, A., Bumol, T., Schilske, H. K., & Moller, D. E. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.08.005 · Cited by 885 · see citing works

Identification of omentin as a novel depot-specific adipokine in human adipose tissue: possible role in modulating insulin action

Yang, R.-Z., Lee, M.-J., Hu, H., Pray, J., Wu, H.-B., Hansen, B. C., Shuldiner, A. R., Fried, S. K., McLenithan, J. C., & Gong, D.-W. (2006) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00572.2004 · Cited by 884 · see citing works

Chemerin Is a Novel Adipokine Associated with Obesity and Metabolic Syndrome

Bozaoglu, K., Bolton, K. A., McMillan, J. S., Zimmet, P., Jowett, J. B. M., Collier, G. R., Walder, K. R., & Segal, D. (2007) · Endocrinology · doi:10.1210/en.2007-0175 · Cited by 859 · see citing works

BDNF regulates eating behavior and locomotor activity in mice

Kernie, S. G., Liebl, D. J., & Parada, L. F. (2000) · The EMBO Journal · doi:10.1093/emboj/19.6.1290 · Cited by 806 · see citing works

Irisin is expressed and produced by human muscle and adipose tissue in association with obesity and insulin resistance

Moreno-Navarrete, J. M., Ortega, F., Serrano, M., Guerra, E., Pardo, G., Tinahones, F., Ricart, W., & Fernández-Real, J. M. (2013) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2012-2749 · Cited by 788 · see citing works

Inflammatory Markers and Risk of Developing Type 2 Diabetes in Women

Hu, F. B., Meigs, J. B., Li, T. Y., Rifai, N., & Manson, J. E. (2004) · Diabetes · doi:10.2337/diabetes.53.3.693 · Cited by 788 · see citing works

Insulin Receptor Signaling in Osteoblasts Regulates Postnatal Bone Acquisition and Body Composition

Fulzele, K. S., Riddle, R. C., DiGirolamo, D. J., Cao, X., Wan, C., Chen, D., Monier‐Faugere, M., Aja, S. M., Hussain, M. A., Brüning, J. C., et al. (2010) · Cell · doi:10.1016/j.cell.2010.06.002 · Cited by 768 · see citing works

Omentin Plasma Levels and Gene Expression Are Decreased in Obesity

Batista, C. M. D. S., Yang, R.-Z., Lee, M., Glynn, N. M., Yu, D.-Z., Pray, J., Ndubuizu, K., Patil, S. P., Schwartz, A. B., Kligman, M. D., et al. (2007) · Diabetes · doi:10.2337/db06-1506 · Cited by 760 · see citing works

Lack of Interleukin-1β Decreases the Severity of Atherosclerosis in ApoE-Deficient Mice

Kirii, H., Niwa, T., Yamada, Y., Wada, H., Saito, K., Iwakura, Y., Asano, M., Moriwaki, H., & Seishima, M. (2003) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000064374.15232.c3 · Cited by 748 · see citing works

Resistin / Fizz3 Expression in Relation to Obesity and Peroxisome Proliferator–Activated Receptor-γ Action in Humans

Savage, D. B., Sewter, C. P., Klenk, E. S., Segal, D. G., Vidal‐Puig, A., Considine, R. V., & O’Rahilly, S. (2001) · Diabetes · doi:10.2337/diabetes.50.10.2199 · Cited by 748 · see citing works

Toll-Like Receptor 9 Promotes Steatohepatitis by Induction of Interleukin-1β in Mice

Miura, K., Kodama, Y., Inokuchi, S., Schnabl, B., Aoyama, T., Ohnishi, H., Olefsky, J. M., Brenner, D. A., & Seki, E. (2010) · Gastroenterology · doi:10.1053/j.gastro.2010.03.052 · Cited by 741 · see citing works

Regulation of Fasted Blood Glucose by Resistin

Banerjee, R. R., Rangwala, S. M., Shapiro, J. S., Rich, A. S., Rhoades, B., Qi, Y., Wang, J., Rajala, M. W., Pocai, A., Scherer, P. E., et al. (2004) · Science · doi:10.1126/science.1092341 · Cited by 727 · see citing works

Brain-derived neurotrophic factor is produced by skeletal muscle cells in response to contraction and enhances fat oxidation via activation of AMP-activated protein kinase

Matthews, V. B., Åström, M.-B., Chan, M. H. S., Bruce, C. R., Krabbe, K. S., Prelovsek, O., Åkerström, T., Yfanti, C., Broholm, C., Mortensen, O. H., et al. (2009) · Diabetologia · doi:10.1007/s00125-009-1364-1 · Cited by 722 · see citing works

Potential Role of TNF-α in the Pathogenesis of Insulin Resistance and Type 2 Diabetes

Moller, D. E. (2000) · Trends in Endocrinology and Metabolism · doi:10.1016/s1043-2760(00)00272-1 · Cited by 718 · see citing works

Adipocytokines in Obesity and Metabolic Disease

Cao, H. (2014) · Journal of Endocrinology · doi:10.1530/joe-13-0339 · Cited by 705 · see citing works

Brain-derived neurotrophic factor (BDNF) and type 2 diabetes

Krabbe, K. S., Nielsen, A. R., Krogh‐Madsen, R., Plomgaard, P., Rasmussen, P., Erikstrup, C., Fischer, C. P., Lindegaard, B., Petersen, A. M. W., Taudorf, S., et al. (2006) · Diabetologia · doi:10.1007/s00125-006-0537-4 · Cited by 703 · see citing works

Research Resource: Comprehensive Expression Atlas of the Fibroblast Growth Factor System in Adult Mouse

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Interleukin-1β-Induced Insulin Resistance in Adipocytes through Down-Regulation of Insulin Receptor Substrate-1 Expression

Jager, J., Grémeaux, T., Cormont, M., MARCHAND‐BRUSTEL, Y. L., & Tanti, J. (2006) · Endocrinology · doi:10.1210/en.2006-0692 · Cited by 695 · see citing works

Adiponectin mediates the metabolic effects of FGF21 on glucose homeostasis and insulin sensitivity in mice

Lin, Z., Tian, H., Lam, K. S. L., Lin, S., Hoo, R. C. L., Konishi, M., Itoh, N., Wang, Y., Bornstein, S. R., Xu, A., et al. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.04.005 · Cited by 691 · see citing works

Targeting inflammation in the treatment of type 2 diabetes: time to start

Donath, M. Y. (2014) · Nature Reviews Drug Discovery · doi:10.1038/nrd4275 · Cited by 690 · see citing works

IL-6 signal transduction and its physiological roles: the signal orchestration model

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The diseasome of physical inactivity – and the role of myokines in muscle–fat cross talk

Pedersen, B. K. (2009) · The Journal of Physiology · doi:10.1113/jphysiol.2009.179515 · Cited by 631 · see citing works

Hepatokines: Linking nonalcoholic fatty liver disease and insulin resistance

Meex, R. C. R., & Watt, M. J. (2017) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2017.56 · Cited by 631 · see citing works

FNDC5/irisin is not only a myokine but also an adipokine

Roca-Rivada, A., Castelao, C., Senin, L. L., Landrove, M. O., Baltar, J., Crujeiras, A. B., Seoane, L. M., Casanueva, F. F., & Pardo, M. (2013) · PLoS ONE · doi:10.1371/journal.pone.0060563 · Cited by 612 · see citing works

Asprosin, a Fasting-Induced Glucogenic Protein Hormone

Romere, C., Duerrschmid, C., Bournat, J., Constable, P., Jain, M., Xia, F., Saha, P. K., Del Solar, M., Zhu, B., York, B., et al. (2016) · Cell · doi:10.1016/j.cell.2016.02.063 · Cited by 591 · see citing works

A liver-derived secretory protein, selenoprotein P, causes insulin resistance

Misu, H., Takamura, T., Takayama, H., Hayashi, H., Matsuzawa-Nagata, N., Kurita, S., Ishikura, K., Ando, H., Takeshita, Y., Ota, T., et al. (2010) · Cell Metabolism · doi:10.1016/j.cmet.2010.09.015 · Cited by 583 · see citing works

Lipocalin-2 Is an Inflammatory Marker Closely Associated with Obesity, Insulin Resistance, and Hyperglycemia in Humans

Wang, Y., Lam, K. S. L., Kraegen, E. W., Sweeney, G., Zhang, J., Tso, A. W., Chow, W.-S., Wat, N. M., Xu, J. Y., Hoo, R. L., et al. (2007) · Clinical Chemistry · doi:10.1373/clinchem.2006.075614 · Cited by 578 · see citing works

Insulin/Foxo1 Pathway Regulates Expression Levels of Adiponectin Receptors and Adiponectin Sensitivity

Tsuchida, A., Yamauchi, T., Ito, Y., Hada, Y., Maki, T., Takekawa, S., Kamon, J., Kobayashi, M., Suzuki, R., Hara, K., et al. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m402367200 · Cited by 550 · see citing works

Tumor necrosis factor impairs insulin action on peripheral glucose disposal and hepatic glucose output.

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Interleukin-6: Biology, signaling and strategies of blockade

Schaper, F., & Rose‐John, S. (2015) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2015.07.004 · Cited by 511 · see citing works

Phenotypic effects of leptin replacement on morbid obesity, diabetes mellitus, hypogonadism, and behavior in leptin-deficient adults

Licinio, J., Caglayan, S., Ozata, M., Yildiz, B. O., de Miranda, P. B., O'Kirwan, F., Whitby, R., Liang, L., Cohen, P., Bhasin, S., et al. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0308767101 · Cited by 505 · see citing works

The role of hepatokines in metabolism

Stefan, N., & Häring, H.-U. (2013) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2012.258 · Cited by 500 · see citing works

Fibroblast Growth Factor-21 Improves Pancreatic β-Cell Function and Survival by Activation of Extracellular Signal–Regulated Kinase 1/2 and Akt Signaling Pathways

Wente, W., Efanov, A. M., Brenner, M. B., Kharitonenkov, A., Koster, A. M., Sandusky, G. E., Sewing, S., Treinies, I., Zitzer, H., & Gromada, J. (2006) · Diabetes · doi:10.2337/db05-1435 · Cited by 497 · see citing works

The Adipokine Lipocalin 2 Is Regulated by Obesity and Promotes Insulin Resistance

Yan, Q.-W., Yang, Q., Mody, N., Graham, T. E., Hsu, C.-H., Xu, Z., Houstis, N. E., Kahn, B. B., & Rosen, E. D. (2007) · Diabetes · doi:10.2337/db07-0007 · Cited by 471 · see citing works

Adiponectin, TNF-α and Inflammatory Cytokines and Risk of Type 2 Diabetes: A Systematic Review and Meta-Analysis

Liu, C., Feng, X., Li, Q., Wang, Y., Li, Q., & Hua, M. (2016) · Cytokine · doi:10.1016/j.cyto.2016.06.028 · Cited by 470 · see citing works

The hypothalamic arcuate nucleus: A key site for mediating leptin’s effects on glucose homeostasis and locomotor activity

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MC4R-dependent suppression of appetite by bone-derived lipocalin 2

Mosialou, I., Shikhel, S., Liu, J., Maurizi, A., Luo, N., He, Z., Huang, Y., Zong, H., Friedman, R. A., Barasch, J. M., et al. (2017) · Nature · doi:10.1038/nature21697 · Cited by 457 · see citing works

Glucose Uptake and Runx2 Synergize to Orchestrate Osteoblast Differentiation and Bone Formation

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Regulation of fatty acid homeostasis in cells: Novel role of leptin

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Osteocalcin Signaling in Myofibers Is Necessary and Sufficient for Optimum Adaptation to Exercise

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The role of TNFα in adipocyte metabolism

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Resistin, central obesity, and type 2 diabetes

McTernan, C. L., McTernan, P. G., Harte, A. L., Levick, P., Barnett, A. H., & Kumar, S. (2002) · The Lancet · doi:10.1016/s0140-6736(02)07281-1 · Cited by 421 · see citing works

Adiponectin Receptor as a Key Player in Healthy Longevity and Obesity-Related Diseases

Yamauchi, T., & Kadowaki, T. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.01.001 · Cited by 415 · see citing works

Chronic interleukin-6 (IL-6) treatment increased IL-6 secretion and induced insulin resistance in adipocyte: prevention by rosiglitazone

Lagathu, C., Bastard, J.-P., Auclair, M., Maachi, M., Capeau, J., & Caron, M. (2003) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2003.10.013 · Cited by 385 · see citing works

Plasma fetuin-A levels and the risk of type 2 diabetes

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Chemerin Activation by Serine Proteases of the Coagulation, Fibrinolytic, and Inflammatory Cascades

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Metabolomic Biomarkers in Blood Samples Identify Cancers in a Mixed Population of Patients with Nonspecific Symptoms

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The Effect of Ketogenic Diet on Inflammatory Arthritis and Cardiovascular Health in Rheumatic Conditions: A Mini Review

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A Review of Metabolomic Profiling in Rheumatoid Arthritis: Bringing New Insights in Disease Pathogenesis, Treatment and Comorbidities

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Network Pharmacology Study to Interpret Signaling Pathways of Ilex cornuta Leaves against Obesity

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