The DOI matches its Crossref record; 14 of the 14 references it cites were found in a registry or an index.
TET1-Mediated Hydroxymethylation Facilitates Hypoxic Gene Induction in Neuroblastoma
Open accessAbstract
The ten-eleven-translocation 5-methylcytosine dioxygenase (TET) family of enzymes catalyzes the conversion of 5-methylcytosine (5-mC) to 5-hydroxymethylcytosine (5-hmC), a modified cytosine base that facilitates gene expression. Cells respond to hypoxia by inducing a transcriptional program regulated in part by oxygen-dependent dioxygenases that require Fe(II) and α-ketoglutarate. Given that the TET enzymes also require these cofactors, we hypothesized that the TETs regulate the hypoxia-induced transcriptional program. Here, we demonstrate that hypoxia increases global 5-hmC levels, with accumulation of 5-hmC density at canonical hypoxia response genes. A subset of 5-hmC gains colocalize with hypoxia response elements facilitating DNA demethylation and HIF binding. Hypoxia results in transcriptional activation of TET1, and full induction of hypoxia-responsive genes and global 5-hmC increases require TET1. Finally, we show that 5-hmC increases and TET1 upregulation in hypoxia are HIF-1 dependent. These findings establish TET1-mediated 5-hmC changes as an important epigenetic component of the hypoxic response.
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Cites
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Cited by
TET-mediated active DNA demethylation: mechanism, function and beyond
Wu, X., & Zhang, Y. (2017) · Nature Reviews Genetics · doi:10.1038/nrg.2017.33 · Cited by 1,661
Tumour hypoxia causes DNA hypermethylation by reducing TET activity
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Histone demethylase KDM6A directly senses oxygen to control chromatin and cell fate
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Fumarate and Succinate Regulate Expression of Hypoxia-inducible Genes via TET Enzymes
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Self-citationThe epigenetic landscape related to reactive oxygen species formation in the cardiovascular system
Kietzmann, T., Petry, A., Shvetsova, A., Gerhold, J. M., & Görlach, A. (2017) · British Journal of Pharmacology · doi:10.1111/bph.13792 · Cited by 253
Metadata
- Authors
- Mariani, C. J., Vasanthakumar, A., Madzo, J., Yesilkanal, A., Bhagat, T., Yu, Y., Bhattacharyya, S., Wenger, R. H., Cohn, S. L., Nanduri, J., Verma, A., Prabhakar, N. R., & Godley, L. A.
- Venue
- Cell Reports
- Publisher
- Elsevier BV
- Published
- 2014-06
- Volume
- 7
- Issue
- 5
- Pages
- 1343-1352
- ISSN
- 2211-1247 (ISSN-L)
- OpenAlex
- W1998886399
- Cited by
- 169
- References
- 14
- FWCI
- 7.06
- Type
- journal article
- Language
- en
- Open access
- gold
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