The epigenetic landscape related to reactive oxygen species formation in the cardiovascular system
Open accessAbstract
Cardiovascular diseases are among the leading causes of death worldwide. Reactive oxygen species (ROS) can act as damaging molecules but also represent central hubs in cellular signalling networks. Increasing evidence indicates that ROS play an important role in the pathogenesis of cardiovascular diseases, although the underlying mechanisms and consequences of pathophysiologically elevated ROS in the cardiovascular system are still not completely resolved. More recently, alterations of the epigenetic landscape, which can affect DNA methylation, post‐translational histone modifications, ATP‐dependent alterations to chromatin and non‐coding RNA transcripts, have been considered to be of increasing importance in the pathogenesis of cardiovascular diseases. While it has long been accepted that epigenetic changes are imprinted during development or even inherited and are not changed after reaching the lineage‐specific expression profile, it becomes more and more clear that epigenetic modifications are highly dynamic. Thus, they might provide an important link between the actions of ROS and cardiovascular diseases. This review will provide an overview of the role of ROS in modulating the epigenetic landscape in the context of the cardiovascular system. Linked Articles: This article is part of a themed section on Redox Biology and Oxidative Stress in Health and Disease. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v174.12/issuetoc
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Other proteins related to direct or indirect production of ROS in the cardiovascular system include peroxidases, cyclooxygenases (COX), lipoxygenases, monoamine oxidase, heme oxygenase (HO), glucose oxidase, cytochrome b5 reductase, and CYPOR.
“Other proteins have been related to the direct or indirect production of ROS in the cardiovascular system, including, but not limited to, peroxidases, cyclooxygenases (COX), lipoxygenases, monoamine oxidase, heme oxygenase (HO), glucose oxidase, cytochrome b5 reductase, and CYPOR (209, 505, 790, 908).”
From Sources of Vascular Nitric Oxide and Reactive Oxygen Species and Their Regulation (2019) · cites this paper as [505]
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- BJP T Kietzmann et al. 1548 British Journal of Pharmacology (2017) 174 1533-1554 14765381, 2017, 12, · DOI
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Sources of Vascular Nitric Oxide and Reactive Oxygen Species and Their Regulation
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Griñán-Ferré, C., Bellver-Sanchis, A., Izquierdo, V., Corpas, R., Roig-Soriano, J., Chillón, M., Andres-Lacueva, C., Somogyvári, M., Sőti, C., Sanfeliu, C., et al. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101271 · Cited by 208 · see citing works
Fiorito, G., Caini, S., Palli, D., Bendinelli, B., Saieva, C., Ermini, I., Valentini, V., Assedi, M., Rizzolo, P., Ambrogetti, D., et al. (2021) · Aging Cell · doi:10.1111/acel.13439 · Cited by 202 · see citing works
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Mitochondrial epigenetics regulating inflammation in cancer and aging
Chatterjee, D., Das, P., & Chakrabarti, O. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.929708 · Cited by 33 · see citing works
- Authors
- Kietzmann, T., Petry, A., Shvetsova, A., Gerhold, J. M., & Görlach, A.
- Affiliations
- University of Oulu (FI)
- German Centre for Cardiovascular Research (DE)
- University of Tartu (EE)
- Corresponding author
- Görlach, Agnes
- Venue
- British Journal of Pharmacology
- Publisher
- Wiley
- Published
- 2017-05-10
- Volume
- 174
- Issue
- 12
- Pages
- 1533-1554
- ISSN
- 0007-1188 (ISSN-L)
- 1476-5381
- PMC
- PMC5446579
- OpenAlex
- W2602526631
- Cited by
- 253
- References
- 238
- Citations by year
- 2026: 26 · 2025: 22 · 2024: 39 · 2023: 23 · 2022: 40 · 2021: 39 · 2020: 34 · 2019: 15 · 2018: 12 · 2017: 3
- FWCI
- 1.64
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- British Journal of Pharmacology (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Suomen Akatemia
- Bundesministerium für Bildung und Forschung (Epiros)
- Eesti Teadusagentuur (PUT610)
- Deutsche Forschungsgemeinschaft (GO709/4‐5)
- Jane ja Aatos Erkon Säätiö
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Keywords
- reactive oxygen species, epigenetics, cardiovascular disease, DNA methylation, histone modifications, chromatin, non-coding RNA, oxidative stress, redox biology
- MeSH terms
- Animals, Cardiovascular Diseases, Cardiovascular System, Humans, Reactive Oxygen Species, Epigenesis, Genetic
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