Cited by 253Epigenetics and DNA MethylationNitric Oxide and Endothelin EffectsRedox biology and oxidative stress

The epigenetic landscape related to reactive oxygen species formation in the cardiovascular system

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Kietzmann, Thomas, Petry, Andreas, Shvetsova, Antonina, Gerhold, Joachim M, Görlach, Agnes·2017·British Journal of Pharmacology

Abstract

Cardiovascular diseases are among the leading causes of death worldwide. Reactive oxygen species (ROS) can act as damaging molecules but also represent central hubs in cellular signalling networks. Increasing evidence indicates that ROS play an important role in the pathogenesis of cardiovascular diseases, although the underlying mechanisms and consequences of pathophysiologically elevated ROS in the cardiovascular system are still not completely resolved. More recently, alterations of the epigenetic landscape, which can affect DNA methylation, post‐translational histone modifications, ATP‐dependent alterations to chromatin and non‐coding RNA transcripts, have been considered to be of increasing importance in the pathogenesis of cardiovascular diseases. While it has long been accepted that epigenetic changes are imprinted during development or even inherited and are not changed after reaching the lineage‐specific expression profile, it becomes more and more clear that epigenetic modifications are highly dynamic. Thus, they might provide an important link between the actions of ROS and cardiovascular diseases. This review will provide an overview of the role of ROS in modulating the epigenetic landscape in the context of the cardiovascular system. Linked Articles: This article is part of a themed section on Redox Biology and Oxidative Stress in Health and Disease. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v174.12/issuetoc

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  • Other proteins related to direct or indirect production of ROS in the cardiovascular system include peroxidases, cyclooxygenases (COX), lipoxygenases, monoamine oxidase, heme oxygenase (HO), glucose oxidase, cytochrome b5 reductase, and CYPOR.

    “Other proteins have been related to the direct or indirect production of ROS in the cardiovascular system, including, but not limited to, peroxidases, cyclooxygenases (COX), lipoxygenases, monoamine oxidase, heme oxygenase (HO), glucose oxidase, cytochrome b5 reductase, and CYPOR (209, 505, 790, 908).”

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  1. BJP T Kietzmann et al. 1548 British Journal of Pharmacology (2017) 174 1533-1554 14765381, 2017, 12, · DOI

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Authors
Kietzmann, T., Petry, A., Shvetsova, A., Gerhold, J. M., & Görlach, A.
Affiliations
  • University of Oulu (FI)
  • German Centre for Cardiovascular Research (DE)
  • University of Tartu (EE)
Corresponding author
Görlach, Agnes
Venue
British Journal of Pharmacology
Publisher
Wiley
Published
2017-05-10
Volume
174
Issue
12
Pages
1533-1554
ISSN
  • 0007-1188 (ISSN-L)
  • 1476-5381
OpenAlex
W2602526631
Cited by
253
References
238
Citations by year
2026: 26 · 2025: 22 · 2024: 39 · 2023: 23 · 2022: 40 · 2021: 39 · 2020: 34 · 2019: 15 · 2018: 12 · 2017: 3
FWCI
1.64
Type
journal article
Language
en
Open access
Locations
  • British Journal of Pharmacology (publishedVersion)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Suomen Akatemia
  • Bundesministerium für Bildung und Forschung (Epiros)
  • Eesti Teadusagentuur (PUT610)
  • Deutsche Forschungsgemeinschaft (GO709/4‐5)
  • Jane ja Aatos Erkon Säätiö
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
  • Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
Keywords
reactive oxygen species, epigenetics, cardiovascular disease, DNA methylation, histone modifications, chromatin, non-coding RNA, oxidative stress, redox biology
MeSH terms
Animals, Cardiovascular Diseases, Cardiovascular System, Humans, Reactive Oxygen Species, Epigenesis, Genetic

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