How steroids steer T cells
Open accessAbstract
Recent papers from Mahata et al. and Bereshchenko et al. reveal how steroids steer immune responses by tipping T helper (Th) subset balances and activities. Pregnenolone produced by Th2 cells mediates immunosuppressive responses, and glucocorticoids stimulate regulatory T cell development via the induction of GILZ expression.
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CS promote M2 macrophage polarization, induce T regulatory cell recruitment and expansion, Th1 to Th2 phenotype skewing, and apoptosis in lymphocytes, thereby blunting a proliferative burst of CD8-positive T cells needed in cancer response to PD-1/PD-L1 blockade.
“CS, the most widely used immunosuppressants, promote M2 macrophage polarization, 36 induce T regulatory cells recruitment and expansions, 37 Th1 to Th2 phenotype skewing, 38 and apoptosis in lymphocytes, 39 thereby blunting a proliferative burst of CD8-positive T cells needed in cancer response to PD-1/PD-L-1 blockade.40”
From Autoimmune diseases and immune-checkpoint inhibitors for cancer therapy: Review of the literature and personalized risk-based prevention strategy (2020) · cites this paper as [38]
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- Authors
- Libert, C., & Dejager, L.
- Affiliations
- Vlaams Instituut voor Biotechnologie (BE)
- Ghent University (BE)
- ORCID
- Libert, Claude
- Venue
- Cell Reports
- Publisher
- Elsevier BV
- Published
- 2014-05
- Volume
- 7
- Issue
- 4
- Pages
- 938-939
- ISSN
- 2211-1247 (ISSN-L)
- OpenAlex
- W1970594782
- Cited by
- 69
- References
- 10
- Citations by year
- 2026: 4 · 2025: 5 · 2024: 9 · 2023: 7 · 2022: 5 · 2021: 9 · 2020: 14 · 2019: 9 · 2018: 1 · 2017: 3 · 2016: 1 · 2015: 2
- FWCI
- 0.91
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Cell Reports (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Ghent University Academic Bibliography (Ghent University) (submittedVersion, other-oa)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
- Keywords
- steroids, T cells, T helper cell subsets, Th2 cells, pregnenolone, glucocorticoids, regulatory T cells, GILZ, immunosuppression, immune regulation
- MeSH terms
- Animals, Glucocorticoids, Humans, Pregnenolone, RNA, Transcription Factors, Transforming Growth Factor beta, Th1 Cells, Th2 Cells, T-Lymphocytes, Regulatory
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