XIAP Restricts TNF- and RIP3-Dependent Cell Death and Inflammasome Activation

Yabal, Monica, Müller, Nicole, Adler, Heiko, Knies, Nathalie, Groß, Christina J., Damgaard, Rune Busk, Kanegane, Hirokazu, Ringelhan, Marc, Kaufmann, Thomas, Heikenwälder, Mathias, Strasser, Andreas, Groß, Olaf, Ruland, Jürgen, Peschel, Christian, Gyrd-Hansen, Mads, Jost, Philipp J.·2014·Cell Reports
DOI 10.1016/j.celrep.2014.05.008

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  2. Unique BIR domain sets determine inhibitor of apoptosis protein–driven cell death and NOD2 complex signal specificity
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  3. Comprehensive analysis of necroptosis-related genes in renal ischemia-reperfusion injury
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  12. XIAP promotes the expansion and limits the contraction of CD8 T cell response through cell extrinsic and intrinsic mechanisms respectively
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  13. Genetics and Pathogenesis of Hemophagocytic Lymphohistiocytosis
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  15. The anti-apoptosis ubiquitin E3 ligase XIAP promotes autophagosome-lysosome fusion during autophagy
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  16. Necroptosis
    Ben A. Croker, James A. Rickard, Inbar Shlomovitz, Arshed Al‐Obeidi, Akshay A. D’Cruz, Motti Gerlic · 2018 · Wiley eBooks
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  18. Seminars in Cell & Developmental Biology
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  19. Metabolic function of bladder-drained pancreas transplants: relationship between exocrine and endocrine function.
    Philippe Morel, Kenneth L. Brayman, C Chau, B Stevens, M. Balakumar, Frederick C. Goetz, David E.R. Sutherland · 1991 · PubMed
  20. Autoinflammatory Contributors to Cytokine Storm
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  22. The Intersections of Autoinflammation and Cytokine Storm
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  24. Murine Models of Familial Cytokine Storm Syndromes
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  26. Implications of neonatal absence of innate immune mediated NFκB/AP1 signaling in the murine liver
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    Thomas Hachenberg, Jörg Meyer, Andreas Wilhelm Sielenkämper, W Kraft, B Vogt, Guenter Breithardt, Peter Lawin · 1993 · PubMed
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