XIAP Restricts TNF- and RIP3-Dependent Cell Death and Inflammasome Activation
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X-linked inhibitor of apoptosis protein (XIAP) has been identified as a potent regulator of innate immune responses, and loss-of-function mutations in XIAP cause the development of the X-linked lymphoproliferative syndrome type 2 (XLP-2) in humans. Using gene-targeted mice, we show that loss of XIAP or deletion of its RING domain lead to excessive cell death and IL-1β secretion from dendritic cells triggered by diverse Toll-like receptor stimuli. Aberrant IL-1β secretion is TNF dependent and requires RIP3 but is independent of cIAP1/cIAP2. The observed cell death also requires TNF and RIP3 but proceeds independently of caspase-1/caspase-11 or caspase-8 function. Loss of XIAP results in aberrantly elevated ubiquitylation of RIP1 outside of TNFR complex I. Virally infected Xiap(-/-) mice present with symptoms reminiscent of XLP-2. Our data show that XIAP controls RIP3-dependent cell death and IL-1β secretion in response to TNF, which might contribute to hyperinflammation in patients with XLP-2.
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Necroptosis is tonically inhibited by c-IAPs, owing to their ability to ubiquitinate RIPK1.
“Necroptosis is also tonically inhibited by c-IAPs, owing to their ability to ubiquitinate RIPK1 [490–493].”
From Molecular mechanisms of cell death: recommendations of the nomenclature committee on cell death 2018. (2018) · cites this paper as [493]
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- Authors
- Yabal, M., Müller, N., Adler, H., Knies, N., Groß, C. J., Damgaard, R. B., Kanegane, H., Ringelhan, M., Kaufmann, T., Heikenwälder, M., Strasser, A., Groß, O., Ruland, J., Peschel, C., Gyrd-Hansen, M., & Jost, P. J.
- Affiliations
- TUM Klinikum (DE)
- Helmholtz Munich (DE)
- University of Copenhagen (DK)
- University of Toyama (JP)
- University of Bern (CH)
- The University of Melbourne (AU)
- Corresponding author
- Jost, Philipp J.
- ORCID
- Venue
- Cell Reports
- Publisher
- Elsevier BV
- Published
- 2014-06
- Volume
- 7
- Issue
- 6
- Pages
- 1796-1808
- ISSN
- 2211-1247 (ISSN-L)
- OpenAlex
- W2081745303
- Cited by
- 255
- References
- 49
- Citations by year
- 2026: 7 · 2025: 14 · 2024: 13 · 2023: 12 · 2022: 24 · 2021: 20 · 2020: 32 · 2019: 23 · 2018: 32 · 2017: 20 · 2016: 25 · 2015: 22 · 2014: 8 · 2012: 1
- FWCI
- 10.24
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Cell Reports (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Bern Open Repository and Information System (University of Bern) (submittedVersion, cc-by-nc-nd)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- mediaTUM (Technical University of Munich) (submittedVersion)
- Site cant be reached (submittedVersion, cc-by-nc-nd)
- Research at the University of Copenhagen (University of Copenhagen) (submittedVersion)
- Open Access CRIS of the University of Bern
- Funders
- Novo Nordisk Fonden
- Natural Sciences and Engineering Research Council of Canada
- Human Frontier Science Program (0073/2012)
- Bundesministerium für Bildung und Forschung (PIM-01GS0802-3)
- Lundbeckfonden
- Deutsche Krebshilfe (109310)
- Wilhelm Sander-Stiftung (2009.046.1+2)
- Natur og Univers, Det Frie Forskningsråd
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Inflammasome and immune disorders
- Keywords
- XIAP, RIPK3, IL-1β secretion, inflammasome activation, dendritic cells, Toll-like receptor signaling, RING domain, innate immunity, viral infection, hyperinflammation
- MeSH terms
- Animals, Dendritic Cells, Female, Lipopolysaccharides, Male, Mice, Transgenic, Tumor Necrosis Factor-alpha, Cell Death, Apoptosis, Mice, X-Linked Inhibitor of Apoptosis Protein, Receptor-Interacting Protein Serine-Threonine Kinases, Interleukin-1beta, Inflammasomes
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