The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
Heterogeneous Tumor Subpopulations Cooperate to Drive Invasion
Open accessAbstract
Clonal selection and transcriptional reprogramming (e.g., epithelial-mesenchymal transition or phenotype switching) are the predominant theories thought to underlie tumor progression. However, a "division of labor" leading to cooperation among tumor-cell subpopulations could be an additional catalyst of progression. Using a zebrafish-melanoma xenograft model, we found that in a heterogeneous setting, inherently invasive cells, which possess protease activity and deposit extracellular matrix (ECM), co-invade with subpopulations of poorly invasive cells, a phenomenon we term "cooperative invasion". Whereas the poorly invasive cells benefit from heterogeneity, the invasive cells switch from protease-independent to an MT1-MMP-dependent mode of invasion. We did not observe changes in expression of the melanoma phenotype determinant MITF during cooperative invasion, thus ruling out the necessity for phenotype switching for invasion. Altogether, our data suggest that cooperation can drive melanoma progression without the need for clonal selection or phenotype switching and can account for the preservation of heterogeneity seen throughout tumor progression.
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“Such behavior has been described for tumor-associated fibroblasts, which contribute to the matrix metalloproteinase (MMP)-mediated degradation of the extracellularmembrane (ECM), thereby enabling epithelial cancer cells to invade (Gaggioli et al., 2007).”
BackgroundIn vivo Switching of Human Melanoma Cells between Proliferative and Invasive States
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Mitf regulation of Dia1 controls melanoma proliferation and invasiveness
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Interaction between RasV12 and scribbled clones induces tumour growth and invasion
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Senescent cells develop a parp-1 and nuclear factor-κB-associated secretome (PNAS).
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Cited by
Biological and therapeutic impact of intratumor heterogeneity in cancer evolution
McGranahan, N., & Swanton, C. (2015) · Cancer Cell · doi:10.1016/j.ccell.2014.12.001 · Cited by 1,077
Lee, S. Y., Jeong, E. K., Ju, M. K., Jeon, H. M., Kim, M. Y., Kim, C. H., Park, H. G., Han, S. I., & Kang, H. S. (2017) · Molecular Cancer · doi:10.1186/s12943-016-0577-4 · Cited by 578
Tumorigenesis: it takes a village
Tabassum, D. P., & Polyak, K. (2015) · Nature Reviews Cancer · doi:10.1038/nrc3971 · Cited by 564
Classifying the evolutionary and ecological features of neoplasms
Maley, C. C., Aktipis, A., Graham, T. A., Sottoriva, A., Boddy, A. M., Janiszewska, M., Silva, A. S., Gerlinger, M., Yuan, Y., Pienta, K. J., et al. (2017) · Nature Reviews Cancer · doi:10.1038/nrc.2017.69 · Cited by 423
Phenotype plasticity as enabler of melanoma progression and therapy resistance
Arozarena, I., & Wellbrock, C. (2019) · Nature Reviews Cancer · doi:10.1038/s41568-019-0154-4 · Cited by 381
Self-citation
Metadata
- Authors
- Chapman, A., Fernandez del Ama, L., Ferguson, J., Kamarashev, J., Wellbrock, C., & Hurlstone, A.
- Venue
- Cell Reports
- Publisher
- Elsevier BV
- Published
- 2014-08
- Volume
- 8
- Issue
- 3
- Pages
- 688-695
- ISSN
- 2211-1247 (ISSN-L)
- OpenAlex
- W1966245674
- Cited by
- 203
- References
- 7
- FWCI
- 9.62
- Type
- journal article
- Language
- en
- Open access
- gold
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- Chapman, A., Fernandez del Ama, L., Ferguson, J., Kamarashev, J., Wellbrock, C., & Hurlstone, A. (2014). Heterogeneous Tumor Subpopulations Cooperate to Drive Invasion. Cell Reports. https://doi.org/10.1016/j.celrep.2014.06.045
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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