The DOI matches its Crossref record; 64 of the 64 references it cites were found in a registry or an index.
Fatty Acid Uptake and Lipid Storage Induced by HIF-1α Contribute to Cell Growth and Survival after Hypoxia-Reoxygenation
Open accessAbstract
An in vivo model of antiangiogenic therapy allowed us to identify genes upregulated by bevacizumab treatment, including Fatty Acid Binding Protein 3 (FABP3) and FABP7, both of which are involved in fatty acid uptake. In vitro, both were induced by hypoxia in a hypoxia-inducible factor-1α (HIF-1α)-dependent manner. There was a significant lipid droplet (LD) accumulation in hypoxia that was time and O2 concentration dependent. Knockdown of endogenous expression of FABP3, FABP7, or Adipophilin (an essential LD structural component) significantly impaired LD formation under hypoxia. We showed that LD accumulation is due to FABP3/7-dependent fatty acid uptake while de novo fatty acid synthesis is repressed in hypoxia. We also showed that ATP production occurs via β-oxidation or glycogen degradation in a cell-type-dependent manner in hypoxia-reoxygenation. Finally, inhibition of lipid storage reduced protection against reactive oxygen species toxicity, decreased the survival of cells subjected to hypoxia-reoxygenation in vitro, and strongly impaired tumorigenesis in vivo.
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Citations
Cites
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BackgroundTriglyceride accumulation protects against fatty acid-induced lipotoxicity
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Cited by
Microenvironmental regulation of tumour angiogenesis
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The multifaceted roles of fatty acid synthesis in cancer
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Self-citationReprogramming of fatty acid metabolism in cancer
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Hypoxia-Inducible Factors: Master Regulators of Cancer Progression
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Metadata
- Authors
- Bensaad, K., Favaro, E., Lewis, C. A., Peck, B., Lord, S., Collins, J. M., Pinnick, K. E., Wigfield, S., Buffa, F. M., Li, J.-L., Zhang, Q., Wakelam, M. J. O., Karpe, F., Schulze, A., & Harris, A. L.
- Venue
- Cell Reports
- Publisher
- Elsevier BV
- Published
- 2014-10
- Volume
- 9
- Issue
- 1
- Pages
- 349-365
- ISSN
- 2211-1247 (ISSN-L)
- OpenAlex
- W2057001750
- Cited by
- 665
- References
- 64
- FWCI
- 7.19
- Type
- journal article
- Language
- en
- Open access
- gold
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- CoChat. (2026). Citation check: Fatty Acid Uptake and Lipid Storage Induced by HIF-1α Contribute to Cell Growth and Survival after Hypoxia-Reoxygenation. https://app.cochat.ai/papers/10.1016/j.celrep.2014.08.056
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- Bensaad, K., Favaro, E., Lewis, C. A., Peck, B., Lord, S., Collins, J. M., Pinnick, K. E., Wigfield, S., Buffa, F. M., Li, J.-L., Zhang, Q., Wakelam, M. J. O., Karpe, F., Schulze, A., & Harris, A. L. (2014). Fatty Acid Uptake and Lipid Storage Induced by HIF-1α Contribute to Cell Growth and Survival after Hypoxia-Reoxygenation. Cell Reports. https://doi.org/10.1016/j.celrep.2014.08.056
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
