The multifaceted roles of fatty acid synthesis in cancer

Hallmarks of Cancer: The Next Generation

Hanahan, D., & Weinberg, R. A. (2011) · Cell · doi:10.1016/j.cell.2011.02.013 · Cited by 66,590 · see citing works

On the origin of cancer cells

Warburg, O. (1956) · Science · doi:10.1126/science.123.3191.309 · Cited by 13,425 · see citing works

Why Do Cancers Have High Aerobic Glycolysis?

Gatenby, R. A., & Gillies, R. J. (2004) · Nature reviews. Cancer · doi:10.1038/nrc1478 · Cited by 4,784 · see citing works

SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver

Horton, J. D., Goldstein, J. L., & Brown, M. S. (2002) · Journal of Clinical Investigation · doi:10.1172/jci15593 · Cited by 4,285 · see citing works

SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver

Horton, J. D., Goldstein, J. L., & Brown, M. S. (2002) · Journal of Clinical Investigation · doi:10.1172/jci0215593 · Cited by 4,092 · see citing works

The SREBP pathway: regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor

Brown, M. S., & Goldstein, J. L. (1997) · Cell · doi:10.1016/s0092-8674(00)80213-5 · Cited by 3,834 · see citing works

MYC on the Path to Cancer

Dang, C. V. (2012) · Cell · doi:10.1016/j.cell.2012.03.003 · Cited by 3,390 · see citing works

Metabolic Competition in the Tumor Microenvironment Is a Driver of Cancer Progression

Chang, C.-H., Qiu, J., O’Sullivan, D., Buck, M. D., Noguchi, T., Curtis, J. D., Chen, Q., Gindin, M., Gubin, M. M., van der Windt, G. J. W., et al. (2015) · Cell · doi:10.1016/j.cell.2015.08.016 · Cited by 3,331 · see citing works

Fatty acid synthase and the lipogenic phenotype in cancer pathogenesis

Menendez, J. A., & Lupu, R. (2007) · Nature Reviews Cancer · doi:10.1038/nrc2222 · Cited by 2,941 · see citing works

Role of angiogenesis in tumor growth and metastasis

Folkman, J. (2002) · Seminars in Oncology · doi:10.1016/s0093-7754(02)70065-1 · Cited by 2,862 · see citing works

EMT, cancer stem cells and drug resistance: an emerging axis of evil in the war on cancer

Singh, A., & Settleman, J. (2010) · Oncogene · doi:10.1038/onc.2010.215 · Cited by 2,545 · see citing works

Regulatory networks defining EMT during cancer initiation and progression

Craene, B. D., & Berx, G. (2013) · Nature Reviews Cancer · doi:10.1038/nrc3447 · Cited by 2,487 · see citing works

Role of angiogenesis in tumor growth and metastasis

Folkman, J. (2002) · Seminars in Oncology · doi:10.1053/sonc.2002.37263 · Cited by 2,424 · see citing works

Mitochondria and cancer

Wallace, D. C. (2012) · Nature Reviews Cancer · doi:10.1038/nrc3365 · Cited by 2,404 · see citing works

ATP-citrate lyase links cellular metabolism to histone acetylation

Wellen, K. E., Hatzivassiliou, G., Sachdeva, U. M., Bui, T. V., Cross, J. R., & Thompson, C. B. (2009) · Science · doi:10.1126/science.1164097 · Cited by 2,298 · see citing works

Adipocytes promote ovarian cancer metastasis and provide energy for rapid tumor growth

Nieman, K. M., Kenny, H. A., Penicka, C. V., Ladanyi, A., Buell-Gutbrod, R., Zillhardt, M. R., Romero, I. L., Carey, M. S., Mills, G. B., Hotamisligil, G. S., et al. (2011) · Nature Medicine · doi:10.1038/nm.2492 · Cited by 2,279 · see citing works

HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption

Papandreou, I., Cairns, R. A., Fontana, L., Lim, A. L., & Denko, N. C. (2006) · Cell Metabolism · doi:10.1016/j.cmet.2006.01.012 · Cited by 2,267 · see citing works

Cellular Fatty Acid Metabolism and Cancer

Currie, E., Schulze, A., Zechner, R., Walther, T. C., & Farese, R. V. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.05.017 · Cited by 2,123 · see citing works

Activation of a metabolic gene regulatory network downstream of mTOR complex 1

Düvel, K., Yecies, J. L., Menon, S., Raman, P., Lipovsky, A. I., Souza, A. L., Triantafellow, E., Ma, Q., Gorski, R., Cleaver, S., et al. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.06.022 · Cited by 2,020 · see citing works

WNT signalling pathways as therapeutic targets in cancer

Anastas, J. N., & Moon, R. T. (2012) · Nature reviews. Cancer · doi:10.1038/nrc3419 · Cited by 1,902 · see citing works

Eicosanoids and cancer

Wang, D., & DuBois, R. N. (2010) · Nature reviews. Cancer · doi:10.1038/nrc2809 · Cited by 1,794 · see citing works

Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia

Metallo, C. M., Gameiro, P. A., Bell, E. L., Mattaini, K. R., Yang, J., Hiller, K., Jewell, C. M., Johnson, Z. R., Irvine, D. J., Guarente, L., et al. (2012) · Nature · doi:10.1038/nature10602 · Cited by 1,791 · see citing works

Phthalimide conjugation as a strategy for in vivo target protein degradation

Winter, G. E., Buckley, D. L., Paulk, J., Roberts, J. M., Souza, A., Dhe-Paganon, S., & Bradner, J. E. (2015) · Science · doi:10.1126/science.aab1433 · Cited by 1,760 · see citing works

Targeting lactate-fueled respiration selectively kills hypoxic tumor cells in mice

Sonveaux, P., Végran, F., Schroeder, T., Wergin, M., Verrax, J., Rabbani, Z. N., Saedeleer, C. J. D., Kennedy, K. M., Diepart, C., Jordan, B. F., et al. (2008) · Journal of Clinical Investigation · doi:10.1172/jci36843 · Cited by 1,633 · see citing works

Cancer cachexia: understanding the molecular basis

Argilés, J. M. A., Busquets, S., Stemmler, B., & López-Soriano, F. J. (2014) · Nature reviews. Cancer · doi:10.1038/nrc3829 · Cited by 1,518 · see citing works

Regulation of Immune Responses by Prostaglandin E2

Kaliński, P. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1101029 · Cited by 1,477 · see citing works

SREBP activity is regulated by mTORC1 and contributes to Akt-dependent cell growth

Porstmann, T., Santos, C. R., Griffiths, B., Cully, M., Wu, M., Leevers, S., Griffiths, J. R., Chung, Y.-L., & Schulze, A. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2008.07.007 · Cited by 1,413 · see citing works

Lipid metabolism in cancer

Santos, C. R., & Schulze, A. (2012) · FEBS Journal · doi:10.1111/j.1742-4658.2012.08644.x · Cited by 1,344 · see citing works

Cancer metabolism: fatty acid oxidation in the limelight

Carracedo, A., Cantley, L. C., & Pandolfi, P. P. (2013) · Nature reviews. Cancer · doi:10.1038/nrc3483 · Cited by 1,316 · see citing works

Lipid signalling in disease

Wymann, M. P., & Schneiter, R. (2008) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2335 · Cited by 1,285 · see citing works

mTOR Complex 1 Regulates Lipin 1 Localization to Control the SREBP Pathway

Peterson, T. R., Sengupta, S., Harris, T. E., Carmack, A. E., Kang, S. A. W., Balderas, E., Guertin, D. A., Madden, K. L., Carpenter, A. E., Finck, B. N., et al. (2011) · Cell · doi:10.1016/j.cell.2011.06.034 · Cited by 1,233 · see citing works

AMPK regulates NADPH homeostasis to promote tumour cell survival during energy stress

Jeon, S.-M., Chandel, N. S., & Hay, N. (2012) · Nature · doi:10.1038/nature11066 · Cited by 1,132 · see citing works

Cyclooxygenase-Dependent Tumor Growth through Evasion of Immunity

Zelenay, S., van der Veen, A. G., Böttcher, J. P., Snelgrove, K. J., Rogers, N. C., Acton, S. E., Chakravarty, P., Girotti, M. R., Marais, R., Quezada, S. A., et al. (2015) · Cell · doi:10.1016/j.cell.2015.08.015 · Cited by 1,123 · see citing works

ATP citrate lyase inhibition can suppress tumor cell growth

Hatzivassiliou, G., Zhao, F., Bauer, D. E., Andreadis, C., Shaw, A. N., Dhanak, D., Hingorani, S. R., Tuveson, D. A., & Thompson, C. B. (2005) · Cancer Cell · doi:10.1016/j.ccr.2005.09.008 · Cited by 1,086 · see citing works

FBW7 ubiquitin ligase: a tumour suppressor at the crossroads of cell division, growth and differentiation

Welcker, M., & Clurman, B. E. (2008) · Nature Reviews Cancer · doi:10.1038/nrc2290 · Cited by 1,084 · see citing works

Reduced Food Intake and Body Weight in Mice Treated with Fatty Acid Synthase Inhibitors

Loftus, T. M., Jaworsky, D. E., Frehywot, G. L., Townsend, C. A., Ronnett, G. V., Lane, M. D., & Kuhajda, F. P. (2000) · Science · doi:10.1126/science.288.5475.2379 · Cited by 1,004 · see citing works

PI3K signalling: the path to discovery and understanding

Vanhaesebroeck, B., Stephens, L., & Hawkins, P. T. (2012) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3290 · Cited by 991 · see citing works

Protein kinase C and other diacylglycerol effectors in cancer

Griner, E. M., & Kazanietz, M. G. (2007) · Nature Reviews Cancer · doi:10.1038/nrc2110 · Cited by 978 · see citing works

Hypoxia promotes isocitrate dehydrogenase-dependent carboxylation of α-ketoglutarate to citrate to support cell growth and viability

Wise, D. R., Ward, P. S., Shay, J. E. S., Cross, J. R., Gruber, J. J., Sachdeva, U. M., Platt, J. M., DeMatteo, R. G., Simon, M. C., & Thompson, C. B. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1117773108 · Cited by 975 · see citing works

SREBP-1, a basic-helix-loop-helix-leucine zipper protein that controls transcription of the low density lipoprotein receptor gene

Yokoyama, C., Wang, X., Briggs, M. R., Admon, A., Wu, J., Hua, X., Goldstein, J. L., & Brown, M. S. (1993) · Cell · doi:10.1016/s0092-8674(05)80095-9 · Cited by 968 · see citing works

Fatty acid elongases in mammals: their regulation and roles in metabolism

JAKOBSSON, A., WESTERBERG, R., & JACOBSSON, A. (2006) · Progress in Lipid Research · doi:10.1016/j.plipres.2006.01.004 · Cited by 936 · see citing works

Cholesteryl Ester Accumulation Induced by PTEN Loss and PI3K/AKT Activation Underlies Human Prostate Cancer Aggressiveness

Yue, S., Li, J., Lee, S. Y., Lee, H. J., Shao, T., Song, B., Liang Cheng, C., Masterson, T. A., Liu, X., Ratliff, T. L., et al. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2014.01.019 · Cited by 931 · see citing works

Prostaglandin E 2 Promotes Colon Cancer Cell Growth Through a G s -Axin-ß-Catenin Signaling Axis

Castellone, M. D., Teramoto, H., Williams, B. O., Druey, K. M., & Gutkind, J. S. (2005) · Science · doi:10.1126/science.1116221 · Cited by 884 · see citing works

Sphingosine 1-phosphate and cancer

Pyne, N. J., & Pyne, S. (2010) · Nature reviews. Cancer · doi:10.1038/nrc2875 · Cited by 856 · see citing works

LXR Regulates Cholesterol Uptake Through Idol-Dependent Ubiquitination of the LDL Receptor

Zelcer, N., Hong, C., Boyadjian, R., & Tontonoz, P. (2009) · Science · doi:10.1126/science.1168974 · Cited by 848 · see citing works

LPA Receptors: Subtypes and Biological Actions

Choi, J. W., Herr, D. R., Noguchi, K., Yung, Y. C., Lee, C., Mutoh, T., Lin, M., Teo, S. T., Park, K. E., Austin, A. M., et al. (2010) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.010909.105753 · Cited by 840 · see citing works

Targeting Wnt-driven cancer through the inhibition of Porcupine by LGK974

Liu, J., Pan, S., Hsieh, M. H., Ng, N., Sun, F., Wang, T., Kasibhatla, S., Schuller, A. G., Li, A. G., Cheng, D., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1314239110 · Cited by 836 · see citing works

Lipidomics: coming to grips with lipid diversity

Shevchenko, A., & Simons, K. (2010) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2934 · Cited by 828 · see citing works

Acetyl-CoA synthetase 2 promotes acetate utilization and maintains cancer cell growth under metabolic stress

Schug, Z. T., Peck, B., Jones, D. T., Zhang, Q., Grosskurth, S., Alam, I. S., Goodwin, L. M., Smethurst, E., Mason, S., Blyth, K., et al. (2015) · Cancer Cell · doi:10.1016/j.ccell.2014.12.002 · Cited by 820 · see citing works

NAFLD causes selective CD4+ T lymphocyte loss and promotes hepatocarcinogenesis

Ma, C., Kesarwala, A. H., Eggert, T., Medina-Echeverz, J., Kleiner, D. E., Jin, P., Stroncek, D. F., Terabe, M., Kapoor, V., ElGindi, M., et al. (2016) · Nature · doi:10.1038/nature16969 · Cited by 766 · see citing works

Acetate is a bioenergetic substrate for human glioblastoma and brain metastases

Mashimo, T., Pichumani, K., Vemireddy, V., Hatanpaa, K. J., Singh, D. K., Sirasanagandla, S., Nannepaga, S., Piccirillo, S. G., Kovacs, Z., Foong, C., et al. (2014) · Cell · doi:10.1016/j.cell.2014.11.025 · Cited by 760 · see citing works

Hypoxic and Ras-transformed cells support growth by scavenging unsaturated fatty acids from lysophospholipids

Kamphorst, J. J., Cross, J. R., Fan, J., de Stanchina, E., Mathew, R., White, E. P., Thompson, C. B., & Rabinowitz, J. D. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1307237110 · Cited by 726 · see citing works

De novo Lipogenesis Protects Cancer Cells from Free Radicals and Chemotherapeutics by Promoting Membrane Lipid Saturation

Rysman, E., Brusselmans, K., Scheys, K., Timmermans, L., Derua, R., Munck, S., Veldhoven, P. P. V., Waltregny, D., Daniëls, V. W., Machiels, J., et al. (2010) · Cancer Research · doi:10.1158/0008-5472.can-09-3871 · Cited by 723 · see citing works

Pharmacologic inhibition of fatty acid oxidation sensitizes human leukemia cells to apoptosis induction

Samudio, I. J., Harmancey, R., Fiegl, M., Kantarjian, H. M., Konopleva, M. Y., Korchin, B., Kaluarachchi, K. K., Bornmann, W. G., Duvvuri, S. R., Taegtmeyer, H., et al. (2009) · Journal of Clinical Investigation · doi:10.1172/jci38942 · Cited by 710 · see citing works

Fatty acid synthesis: a potential selective target for antineoplastic therapy

Kuhajda, F. P., Jenner, K., Wood, F. D., Hennigar, R. A., Jacobs, L. B., Dick, J. D., & Pasternack, G. R. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.14.6379 · Cited by 705 · see citing works

The interplay between cell signalling and the mevalonate pathway in cancer

Mullen, P., Yu, R., Longo, J., Archer, M. C., & Penn, L. Z. (2016) · Nature reviews. Cancer · doi:10.1038/nrc.2016.76 · Cited by 697 · see citing works

Sterol Regulatory Element-binding Protein-1 as a Key Transcription Factor for Nutritional Induction of Lipogenic Enzyme Genes

Shimano, H., Yahagi, N., Amemiya-Kudo, M., Hasty, A. H., Osuga, J.-I., Tamura, Y., Shionoiri, F., Iizuka, Y., Ohashi, K., Harada, K., et al. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.50.35832 · Cited by 691 · see citing works

Antiangiogenic therapy: impact on invasion, disease progression, and metastasis

Ebos, J. M. L., & Kerbel, R. S. (2011) · Nature Reviews Clinical Oncology · doi:10.1038/nrclinonc.2011.21 · Cited by 685 · see citing works

Acetate dependence of tumors

Comerford, S. A., Huang, Z., Du, X., Wang, Y., Cai, L., Witkiewicz, A. K., Walters, H., Tantawy, M. N., Fu, A., Manning, H. C., et al. (2014) · Cell · doi:10.1016/j.cell.2014.11.020 · Cited by 681 · see citing works

Fatty Acid Uptake and Lipid Storage Induced by HIF-1α Contribute to Cell Growth and Survival after Hypoxia-Reoxygenation

Bensaad, K., Favaro, E., Lewis, C. A., Peck, B., Lord, S., Collins, J. M., Pinnick, K. E., Wigfield, S., Buffa, F. M., Li, J., et al. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.08.056 · Cited by 667 · see citing works

Fatty acid carbon is essential for dNTP synthesis in endothelial cells

Schoors, S., Bruning, U., Missiaen, R., Queiroz, K. C. S., Borgers, G., Elia, I., Zecchin, A., Cantelmo, A. R., Christen, S., Goveia, J., et al. (2015) · Nature · doi:10.1038/nature14362 · Cited by 646 · see citing works

Role of cardiolipin alterations in mitochondrial dysfunction and disease

Chicco, A. J., & Sparagna, G. C. (2006) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00243.2006 · Cited by 641 · see citing works

�ber den Stoffwechsel der Carcinomzelle

Warburg, O. (1924) · Die Naturwissenschaften · doi:10.1007/bf01504608 · Cited by 631 · see citing works

SREBP-2, a second basic-helix-loop-helix-leucine zipper protein that stimulates transcription by binding to a sterol regulatory element.

Hua, X., Yokoyama, C., Wu, J. I., Briggs, M. R., Brown, M. S., Goldstein, J. L., & Wang, X. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.24.11603 · Cited by 626 · see citing works

Orlistat Is a Novel Inhibitor of Fatty Acid Synthase with Antitumor Activity

Kridel, S. J., Axelrod, F. T., Rozenkrantz, N., & Smith, J. W. (2004) · Cancer Research · doi:10.1158/0008-5472.can-03-3645 · Cited by 610 · see citing works

ADD1: a Novel Helix-Loop-Helix Transcription Factor Associated with Adipocyte Determination and Differentiation

Tontonoz, P., Kim, J. B., Graves, R. A., & Spiegelman, B. M. (1993) · Molecular and Cellular Biology · doi:10.1128/mcb.13.8.4753-4759.1993 · Cited by 599 · see citing works

Regulation of Sterol Synthesis in Eukaryotes

Espenshade, P. J., & Hughes, A. L. (2007) · Annual Review of Genetics · doi:10.1146/annurev.genet.41.110306.130315 · Cited by 593 · see citing works

Acceleration of intestinal polyposis through prostaglandin receptor EP2 in ApcΔ716 knockout mice

Sonoshita, M., Takaku, K., Sasaki, N., Sugimoto, Y., Ushikubi, F., Narumiya, S., Oshima, M., & Taketo, M. M. (2001) · Nature Medicine · doi:10.1038/nm0901-1048 · Cited by 587 · see citing works

Lipin 1 is an inducible amplifier of the hepatic PGC-1α/PPARα regulatory pathway

Finck, B. N., Gropler, M. C., Chen, Z., Leone, T. C., Croce, M. A., Harris, T. E., Lawrence, J. C., & Kelly, D. P. (2006) · Cell Metabolism · doi:10.1016/j.cmet.2006.08.005 · Cited by 555 · see citing works

ATP-Citrate Lyase: A Key Player in Cancer Metabolism

Zaidi, N., Swinnen, J. V., & Smans, K. A. (2012) · Cancer Research · doi:10.1158/0008-5472.can-11-4112 · Cited by 549 · see citing works

ATP citrate lyase is an important component of cell growth and transformation

Bauer, D. E., Hatzivassiliou, G., Zhao, F., Andreadis, C., & Thompson, C. B. (2005) · Oncogene · doi:10.1038/sj.onc.1208773 · Cited by 537 · see citing works

Novel Theranostic Opportunities Offered by Characterization of Altered Membrane Lipid Metabolism in Breast Cancer Progression

Hilvo, M., Denkert, C., Lehtinen, L., Müller, B. M., Brockmöller, S. F., Seppänen‐Laakso, T., Budczies, J., Bucher, E., Yetukuri, L., Castillo, S., et al. (2011) · Cancer Research · doi:10.1158/0008-5472.can-10-3894 · Cited by 532 · see citing works

Leukemic stem cells evade chemotherapy by metabolic adaptation to an adipose tissue niche

Ye, H., Adane, B., Khan, N., Sullivan, T., Minhajuddin, M., Gasparetto, M., Stevens, B. M., Pei, S.-S., Balys, M., Ashton, J., et al. (2016) · Cell Stem Cell · doi:10.1016/j.stem.2016.06.001 · Cited by 509 · see citing works

The Crystal Structure of a Mammalian Fatty Acid Synthase

Maier, T., Leibundgut, M., & Ban, N. (2008) · Science · doi:10.1126/science.1161269 · Cited by 507 · see citing works

A CD36-dependent signaling cascade is necessary for macrophage foam cell formation

Rahaman, S. O., Lennon, D. J., Febbraio, M., Podrez, E. A., Hazen, S. L., & Silverstein, R. L. (2006) · Cell Metabolism · doi:10.1016/j.cmet.2006.06.007 · Cited by 506 · see citing works

Metabolic control of adult neural stem cell activity by Fasn-dependent lipogenesis

Knobloch, M., Braun, S., Zurkirchen, L., Schoultz, C., Zamboni, N., Araúzo-Bravo, M., Kovacs, W. J., Karalay, Ö., Suter, U., Machado, R. A. C., et al. (2012) · Nature · doi:10.1038/nature11689 · Cited by 503 · see citing works

Carnitine palmitoyltransferase 1C promotes cell survival and tumor growth under conditions of metabolic stressPreprint

Zaugg, K., Yao, Y., Reilly, P. T., Kannan, K., Kiarash, R., Mason, J. M., Huang, P., Sawyer, S. K., Fuerth, B. J., Faubert, B., et al. (2011) · Genes & Development · doi:10.1101/gad.1987211 · Cited by 493 · see citing works

PKB/Akt induces transcription of enzymes involved in cholesterol and fatty acid biosynthesis via activation of SREBP

Porstmann, T., Griffiths, B., Chung, Y.-L., Delpuech, O., Griffiths, J., Downward, J., & Schulze, A. (2005) · Oncogene · doi:10.1038/sj.onc.1208802 · Cited by 479 · see citing works

A Conserved SREBP-1/Phosphatidylcholine Feedback Circuit Regulates Lipogenesis in Metazoans

Walker, A. K., Jacobs, R. L., Watts, J. L., Rottiers, V., Jiang, K., Finnegan, D. M., Shioda, T., Hansen, M., Yang, F., Niebergall, L. J., et al. (2011) · Cell · doi:10.1016/j.cell.2011.09.045 · Cited by 466 · see citing works

Metabolic checkpoints in activated T cells

Wang, R., & Green, D. R. (2012) · Nature Immunology · doi:10.1038/ni.2386 · Cited by 457 · see citing works

An LXR Agonist Promotes Glioblastoma Cell Death through Inhibition of an EGFR/AKT/SREBP-1/LDLR–Dependent Pathway

Guo, D., Reinitz, F., Youssef, M., Hong, C., Nathanson, D., Akhavan, D., Kuga, D., Amzajerdi, A. N., Soto, H., Zhu, S., et al. (2011) · Cancer Discovery · doi:10.1158/2159-8290.cd-11-0102 · Cited by 452 · see citing works

Control of lipid metabolism by phosphorylation-dependent degradation of the SREBP family of transcription factors by SCFFbw7

Sundqvist, A., Bengoechea-Alonso, M. T., Ye, X., Lukiyanchuk, V., Jin, J., Harper, J. W., & Ericsson, J. (2005) · Cell Metabolism · doi:10.1016/j.cmet.2005.04.010 · Cited by 444 · see citing works

Regulation of acetyl-CoA carboxylase

Brownsey, R. W., Boone, A. N., Elliott, J. E., Kulpa, J. E., & Lee, W. M. (2006) · Biochemical Society Transactions · doi:10.1042/bst20060223 · Cited by 432 · see citing works

Greasing Their Way: Lipid Modifications Determine Protein Association with Membrane Rafts

Levental, I., Grzybek, M., & Simons, K. (2010) · Biochemistry · doi:10.1021/bi100882y · Cited by 421 · see citing works

Purification and characterization of the AMP‐activated protein kinase

Carling, D., Clarke, P. R., Zammit, V. A., & Hardie, D. G. (1989) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1989.tb15186.x · Cited by 418 · see citing works

Inhibition of SREBP by a Small Molecule, Betulin, Improves Hyperlipidemia and Insulin Resistance and Reduces Atherosclerotic Plaques

Tang, J.-J., Li, J., Qi, W., Qiu, W., Li, P., Li, B.-L., & Song, B. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2010.12.004 · Cited by 409 · see citing works

Metabolism of neoplastic tissue. IV. A study of lipid synthesis in neoplastic tissue slices in vitro.

Medes, G., Thomas, A. J., & Weinhouse, S. (1953) · PubMed · Cited by 405 · see citing works

Transcriptional activities of nuclear SREBP-1a, -1c, and -2 to different target promoters of lipogenic and cholesterogenic genes

Amemiya-Kudo, M., Shimano, H., Hasty, A. H., Yahagi, N., Yoshikawa, T., Matsuzaka, T., Okazaki, H., Tamura, Y., Iizuka, Y., Ohashi, K., et al. (2002) · Journal of Lipid Research · doi:10.1194/jlr.m100417-jlr200 · Cited by 398 · see citing works

Pharmacological Inhibition of the Wnt Acyltransferase PORCN Prevents Growth of WNT-Driven Mammary Cancer

Proffitt, K. D., Madan, B., Ke, Z., Pendharkar, V. V., Ding, L., Lee, M. A., Hannoush, R. N., & Virshup, D. M. (2012) · Cancer Research · doi:10.1158/0008-5472.can-12-2258 · Cited by 383 · see citing works

Malonyl-coenzyme-A is a potential mediator of cytotoxicity induced by fatty-acid synthase inhibition in human breast cancer cells and xenografts.

Pizer, E. S., Thupari, J. N., Han, W. F., Pinn, M. L., Chrest, F. J., Frehywot, G. L., Townsend, C. A., & Kuhajda, F. P. (2000) · PubMed · Cited by 366 · see citing works

Sterol regulatory element-binding proteins: transcriptional activators of lipid synthesis

Horton, J. D. (2002) · Biochemical Society Transactions · doi:10.1042/bst0301091 · Cited by 353 · see citing works

EGFR signaling through an Akt-SREBP-1-dependent, rapamycin-resistant pathway sensitizes glioblastomas to antilipogenic therapy

Guo, D., Prins, R. M., Dang, J., Kuga, D., Iwanami, A., Soto, H., Lin, K. Y., Huang, T. T., Akhavan, D., Hock, M. B., et al. (2009) · Science Signaling · doi:10.1126/scisignal.2000446 · Cited by 351 · see citing works

Acetyl-CoA Carboxylase α Is Essential to Breast Cancer Cell Survival

Chajès, V., Cambot, M., Moreau, K., Lenoir, G. M., & Joulin, V. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-1489 · Cited by 347 · see citing works

SREBP cleavage-activating protein (SCAP) is required for increased lipid synthesis in liver induced by cholesterol deprivation and insulin elevationPreprint

Matsuda, M., Korn, B. S., Hammer, R. E., Moon, Y.-A., Komuro, R., Horton, J. D., Goldstein, J. L., Brown, M. S., & Shimomura, I. (2001) · Genes & Development · doi:10.1101/gad.891301 · Cited by 338 · see citing works

From mice to humans: developments in cancer immunoediting

Teng, M. W. L., Galon, J., Fridman, W.-H., & Smyth, M. J. (2015) · Journal of Clinical Investigation · doi:10.1172/jci80004 · Cited by 337 · see citing works

Sterol Regulation of Fatty Acid Synthase Promoter

Bennett, M. K., López, J. M., Sanchez, H. B., & Osborne, T. F. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.43.25578 · Cited by 336 · see citing works

Elevated free fatty acid uptake via CD36 promotes epithelial-mesenchymal transition in hepatocellular carcinoma

Nath, A., Li, I., Roberts, L. R., & Chan, C. (2015) · Scientific Reports · doi:10.1038/srep14752 · Cited by 336 · see citing works

The metabolic fate of acetate in cancer

Schug, Z. T., Vande Voorde, J., & Gottlieb, E. (2016) · Nature reviews. Cancer · doi:10.1038/nrc.2016.87 · Cited by 331 · see citing works

Inhibition of fatty acid synthase (FAS) suppresses HER2/neu ( erb B-2) oncogene overexpression in cancer cells

Menéndez, J. A., Vellón, L., Mehmi, I., Oza, B. P., Ropero, S., Colomer, R., & Lupu, R. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0403390101 · Cited by 326 · see citing works

Stearoyl-CoA desaturase-1: a novel key player in the mechanisms of cell proliferation, programmed cell death and transformation to cancer

Igal, R. A. (2010) · Carcinogenesis · doi:10.1093/carcin/bgq131 · Cited by 322 · see citing works

Glucose-Mediated N-glycosylation of SCAP Is Essential for SREBP-1 Activation and Tumor Growth

Cheng, C., Ru, P., Geng, F., Liu, J., Yoo, J. Y., Wu, X., Cheng, X., Euthine, V., Hu, P., Guo, J. Y., et al. (2015) · Cancer Cell · doi:10.1016/j.ccell.2015.09.021 · Cited by 321 · see citing works

Fatty Acid Oxidation-Driven Src Links Mitochondrial Energy Reprogramming and Oncogenic Properties in Triple-Negative Breast Cancer

Park, J. H., Vithayathil, S. A., Kumar, S., Sung, P., Dobrolecki, L. E., Putluri, V., Bhat, V. B., Bhowmik, S. K., Gupta, V. K., Arora, K., et al. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.02.004 · Cited by 316 · see citing works

Chemical Inhibition of Acetyl-CoA Carboxylase Induces Growth Arrest and Cytotoxicity Selectively in Cancer Cells

Beckers, A., Organe, S., Timmermans, L., Scheys, K., Peeters, A., Brusselmans, K., Verhoeven, G., & Swinnen, J. V. (2007) · Cancer Research · doi:10.1158/0008-5472.can-07-0389 · Cited by 315 · see citing works

The CREB coactivator CRTC2 controls hepatic lipid metabolism by regulating SREBP1

Han, J., Li, E., Chen, L., Zhang, Y., Wei, F., Liu, J., Deng, H., & Wang, Y. (2015) · Nature · doi:10.1038/nature14557 · Cited by 312 · see citing works

Sphingosine 1-phosphate signalling

Mendelson, K., Evans, T., & Hla, T. (2013) · Development · doi:10.1242/dev.094805 · Cited by 310 · see citing works

Inhibition of de novo palmitate synthesis by fatty acid synthase induces apoptosis in tumor cells by remodeling cell membranes, inhibiting signaling pathways, and reprogramming gene expression

Ventura, R., Mordec, K., Waszczuk, J., Wang, Z., Lai, J., Fridlib, M., Buckley, D., Kemble, G., & Heuer, T. S. (2015) · EBioMedicine · doi:10.1016/j.ebiom.2015.06.020 · Cited by 301 · see citing works

Cardiolipin and electron transport chain abnormalities in mouse brain tumor mitochondria: lipidomic evidence supporting the Warburg theory of cancer

Kiebish, M. A., Han, X., Cheng, H., Chuang, J. H., & Seyfried, T. N. (2008) · Journal of Lipid Research · doi:10.1194/jlr.m800319-jlr200 · Cited by 294 · see citing works

Inhibition of fatty acid synthesis induces programmed cell death in human breast cancer cells.

Pizer, E. S., Jackisch, C., Wood, F. D., Pasternack, G. R., Davidson, N. E., & Kuhajda, F. P. (1996) · PubMed · Cited by 291 · see citing works

A Small Molecule That Blocks Fat Synthesis By Inhibiting the Activation of SREBP

Kamisuki, S., Mao, Q., Abu-Elheiga, L. A., Gu, Z., Kugimiya, A., Kwon, Y., Shinohara, T., Kawazoe, Y., Sato, S., Asakura, K., et al. (2009) · Chemistry & Biology · doi:10.1016/j.chembiol.2009.07.007 · Cited by 282 · see citing works

CREB pathway links PGE2 signaling with macrophage polarization

Luan, B., Yoon, Y., Lay, J. E. L., Kaestner, K. H., Hedrick, S. A., & Montminy, M. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1519644112 · Cited by 278 · see citing works

Inhibition of fatty acid synthesis delays disease progression in a xenograft model of ovarian cancer.

Pizer, E. S., Wood, F. D., Heine, H. S., Romantsev, F. E., Pasternack, G. R., & Kuhajda, F. P. (1996) · PubMed · Cited by 277 · see citing works

RNA Interference–Mediated Silencing of the <i>Acetyl-CoA-Carboxylase-α</i> Gene Induces Growth Inhibition and Apoptosis of Prostate Cancer Cells

Brusselmans, K., De Schrijver, E., Verhoeven, G., & Swinnen, J. V. (2005) · Cancer Research · doi:10.1158/0008-5472.can-05-0571 · Cited by 277 · see citing works

Phospholipase signalling networks in cancer

Park, J. B., Lee, C. S., Jang, J.-H., Ghim, J., Kim, Y.-J., You, S., Hwang, D., Suh, P.-G., & Ryu, S. H. (2012) · Nature Reviews Cancer · doi:10.1038/nrc3379 · Cited by 276 · see citing works

Stearoyl-CoA Desaturase 1 Is a Novel Molecular Therapeutic Target for Clear Cell Renal Cell Carcinoma

Roemeling, C. A. V., Marlow, L. A., Wei, J. J., Cooper, S. J., Caulfield, T. R., Wu, K. J., Tan, W. W., Tun, H. W., & Copland, J. A. (2013) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-12-3249 · Cited by 273 · see citing works

Abrogation of De novo Lipogenesis by Stearoyl-CoA Desaturase 1 Inhibition Interferes with Oncogenic Signaling and Blocks Prostate Cancer Progression in Mice

Fritz, V., Benfodda, Z., Rodier, G., Henriquet, C., Iborra, F., Avancès, C., Allory, Y., TAILLE, A. D. L., Culine, S., Blancou, H., et al. (2010) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-09-1064 · Cited by 270 · see citing works

Cancer Cell Dependence on Unsaturated Fatty Acids Implicates Stearoyl-CoA Desaturase as a Target for Cancer Therapy

Roongta, U. V., Pabalan, J. G., Wang, X., Ryseck, R.-P., Fargnoli, J., Henley, B. J., Yang, W.-P., Zhu, J., Madireddi, M. T., Lawrence, R. M., et al. (2011) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-11-0126 · Cited by 266 · see citing works

Sterol regulatory element binding protein-dependent regulation of lipid synthesis supports cell survival and tumor growth

Griffiths, B. L., Lewis, C. A., Bensaad, K., R�os, S., Zhang, Q., Ferber, E. C., Konisti, S., Peck, B., Miess, H., East, P., et al. (2013) · Cancer & Metabolism · doi:10.1186/2049-3002-1-3 · Cited by 266 · see citing works

Lysophosphatidic acid (LPA) receptors of the EDG family are differentially activated by LPA species

Bandoh, K., Aoki, J., Taira, A., Tsujimoto, M., Arai, H., & Inoue, K. (2000) · FEBS Letters · doi:10.1016/s0014-5793(00)01827-5 · Cited by 264 · see citing works

Cardiolipin acts as a mitochondrial signalling platform to launch apoptosis

Schug, Z. T., & Gottlieb, E. (2009) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2009.05.004 · Cited by 259 · see citing works

Inhibition of fatty acid desaturation is detrimental to cancer cell survival in metabolically compromised environments

Peck, B., Schug, Z. T., Zhang, Q., Dankworth, B., Jones, D. T., Smethurst, E. A., Patel, R., Mason, S. M., Jiang, M., Saunders, R. E., et al. (2016) · Cancer & Metabolism · doi:10.1186/s40170-016-0146-8 · Cited by 254 · see citing works

Pharmacological inhibitors of mammalian fatty acid synthase suppress DNA replication and induce apoptosis in tumor cell lines.

Pizer, E. S., Chrest, F. J., DiGiuseppe, J. A., & Han, W. F. (1998) · PubMed · Cited by 250 · see citing works

Cycling hypoxia: A key feature of the tumor microenvironment

Michiels, C., Tellier, C., & Féron, O. (2016) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2016.06.004 · Cited by 239 · see citing works

Integrated Metabolite and Gene Expression Profiles Identify Lipid Biomarkers Associated With Progression of Hepatocellular Carcinoma and Patient Outcomes

Budhu, A., Roessler, S. K., Zhao, X., Yu, Z., Forgues, M., Ji, J., Karoly, E. D., Qin, L., Ye, Q., Jia, H., et al. (2013) · Gastroenterology · doi:10.1053/j.gastro.2013.01.054 · Cited by 238 · see citing works

SREBP maintains lipid biosynthesis and viability of cancer cells under lipid- and oxygen-deprived conditions and defines a gene signature associated with poor survival in glioblastoma multiforme

Lewis, C. A., Brault, C., Peck, B., Bensaad, K., Griffiths, B. L., Mitter, R., Chakravarty, P., East, P., Dankworth, B., Alibhai, D., et al. (2015) · Oncogene · doi:10.1038/onc.2014.439 · Cited by 235 · see citing works

Quantitative analysis of acetyl-CoA production in hypoxic cancer cells reveals substantial contribution from acetate

Kamphorst, J. J., Chung, M. K., Fan, J., & Rabinowitz, J. D. (2014) · Cancer &amp; Metabolism · doi:10.1186/2049-3002-2-23 · Cited by 227 · see citing works

Androgens stimulate fatty acid synthase in the human prostate cancer cell line LNCaP.

Swinnen, J. V., Esquenet, M., Goossens, K., Heyns, W., & Verhoeven, G. (1997) · PubMed · Cited by 225 · see citing works

Metabolic reprogramming during TGFβ1-induced epithelial-to-mesenchymal transition

Jiang, L., Xiao, L., Sugiura, H., Huang, X., Ali, A., Kuro‐o, M., DeBerardinis, R. J., & Boothman, D. A. (2014) · Oncogene · doi:10.1038/onc.2014.321 · Cited by 221 · see citing works

Comprehensive Review on Betulin as a Potent Anticancer Agent

Król, S. K., Kiełbus, M., Rivero‐Müller, A., & Stepulak, A. (2015) · BioMed Research International · doi:10.1155/2015/584189 · Cited by 221 · see citing works

A new mechanism of drug resistance in breast cancer cells: fatty acid synthase overexpression-mediated palmitate overproduction

Liu, H., Liu, Y., & Zhang, J. (2008) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-07-0445 · Cited by 217 · see citing works

Fatty acid synthase inhibition triggers apoptosis during S phase in human cancer cells.

Zhou, W., Simpson, P. J., McFadden, J. M., Townsend, C. A., Medghalchi, S. M., Vadlamudi, A., Pinn, M. L., Ronnett, G. V., & Kuhajda, F. P. (2003) · PubMed · Cited by 216 · see citing works

Dysregulated mTORC1 renders cells critically dependent on desaturated lipids for survival under tumor-like stressPreprint

Young, R. M., Ackerman, D., Quinn, Z. L., Mancuso, A., Gruber, M., Liu, L., Giannoukos, D. N., Bobrovnikova-Marjon, E. V., Diehl, J. A., Keith, B., et al. (2013) · Genes & Development · doi:10.1101/gad.198630.112 · Cited by 214 · see citing works

Broad Anti-tumor Activity of a Small Molecule that Selectively Targets the Warburg Effect and Lipogenesis

Flaveny, C. A., Griffett, K., Elgendy, B., Kazantzis, M., Sengupta, M., Amelio, A. L., Chatterjee, A., Walker, J. K., Solt, L. A., Kamenecka, T. M., et al. (2015) · Cancer Cell · doi:10.1016/j.ccell.2015.05.007 · Cited by 209 · see citing works

Uncoupling Nuclear Receptor LXR and Cholesterol Metabolism in Cancer

Bovenga, F., Sabbà, C., & Moschetta, A. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2015.03.002 · Cited by 208 · see citing works

Deregulated Myc Requires MondoA/Mlx for Metabolic Reprogramming and Tumorigenesis

Carroll, P. A., Diolaiti, D., McFerrin, L. G., Gu, H., Djukovic, D., Du, J., Cheng, P. F., Anderson, S., Ulrich, M. L., Hurley, J. B., et al. (2015) · Cancer Cell · doi:10.1016/j.ccell.2014.11.024 · Cited by 202 · see citing works

Liver and adipose tissue contributions to newly formed fatty acids in an ascites tumor

Ookhtens, M., Kannan, R., Lyon, I., & Baker, N. (1984) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1984.247.1.r146 · Cited by 199 · see citing works

Inhibition of StearoylCoA Desaturase-1 Inactivates Acetyl-CoA Carboxylase and Impairs Proliferation in Cancer Cells: Role of AMPK

Scaglia, N., Chisholm, J. W., & Igal, R. A. (2009) · PLoS ONE · doi:10.1371/journal.pone.0006812 · Cited by 199 · see citing works

An Essential Requirement for the SCAP/SREBP Signaling Axis to Protect Cancer Cells from Lipotoxicity

Williams, K. J., Argus, J. P., Zhu, Y., Wilks, M. Q., Marbois, B. N., York, A. G., Kidani, Y., Pourzia, A. L., Akhavan, D., Lisiero, D. N., et al. (2013) · Cancer Research · doi:10.1158/0008-5472.can-13-0382-t · Cited by 197 · see citing works

The Critical Role of the Tumor Microenvironment in Shaping Natural Killer Cell-Mediated Anti-Tumor Immunity

Bagińska, J., Viry, E., Paggetti, J., Medves, S., Berchem, G., Moussay, E., & Janji, B. (2013) · Frontiers in Immunology · doi:10.3389/fimmu.2013.00490 · Cited by 196 · see citing works

Regulation of sterol regulatory-element binding protein 1 gene expression in liver: role of insulin and protein kinase B/cAkt

Fleischmann, M. M., & Iynedjian, P. B. (2000) · Biochemical Journal · doi:10.1042/0264-6021:3490013 · Cited by 195 · see citing works

Inhibition of StearoylCoA Desaturase Activity Blocks Cell Cycle Progression and Induces Programmed Cell Death in Lung Cancer Cells

Hess, D., Chisholm, J. W., & Igal, R. A. (2010) · PLoS ONE · doi:10.1371/journal.pone.0011394 · Cited by 195 · see citing works

Activation of Fatty Acid Synthesis during Neoplastic Transformation: Role of Mitogen-Activated Protein Kinase and Phosphatidylinositol 3-Kinase

Yang, Y. (2002) · Experimental Cell Research · doi:10.1006/excr.2002.5600 · Cited by 193 · see citing works

Prostaglandin E2 Enhances Intestinal Adenoma Growth via Activation of the Ras-Mitogen-Activated Protein Kinase Cascade

Wang, D., Buchanan, F. G., Wang, H., Dey, S. K., & DuBois, R. N. (2005) · Cancer Research · doi:10.1158/0008-5472.can-04-3671 · Cited by 193 · see citing works

TGF-β Effects on Prostate Cancer Cell Migration and Invasion Are Mediated by PGE2 through Activation of PI3K/AKT/mTOR Pathway

Vo, B. T., Morton, D. J., Komaragiri, S. K., Millena, A. C., Leath, C., & Khan, S. A. (2013) · Endocrinology · doi:10.1210/en.2012-2074 · Cited by 192 · see citing works

Loss of Chromosome 8p Governs Tumor Progression and Drug Response by Altering Lipid Metabolism

Cai, Y., Crowther, J., Pastor, T., Asbagh, L. A., Baietti, M. F., Troyer, M. D., Vázquez, I., Talebi, A., Renzi, F., Dehairs, J., et al. (2016) · Cancer Cell · doi:10.1016/j.ccell.2016.04.003 · Cited by 191 · see citing works

Effect of a fatty acid synthase inhibitor on food intake and expression of hypothalamic neuropeptides

Shimokawa, T., Kumar, M. V., & Lane, M. D. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.012606199 · Cited by 187 · see citing works

Fatostatin Displays High Antitumor Activity in Prostate Cancer by Blocking SREBP-Regulated Metabolic Pathways and Androgen Receptor Signaling

Li, X., Chen, Y., Hu, P., & Huang, W. (2014) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-13-0797 · Cited by 185 · see citing works

Green Tea Epigallocatechin Gallate: A Natural Inhibitor of Fatty-Acid Synthase

Wang, X., & Tian, W. (2001) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2001.5923 · Cited by 183 · see citing works

Metabolic alterations and targeted therapies in prostate cancer

Flavin, R., Zadra, G., & Loda, M. F. (2010) · The Journal of Pathology · doi:10.1002/path.2809 · Cited by 177 · see citing works

Coordination of Lipid Metabolism in Membrane Biogenesis

Nohturfft, A., & Zhang, S. C. (2009) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.24.110707.175344 · Cited by 175 · see citing works

Delta-5 and Delta-6 Desaturases: Crucial Enzymes in Polyunsaturated Fatty Acid-Related Pathways with Pleiotropic Influences in Health and Disease

Tosi, F., Sartori, F., Guarini, P., Olivieri, O., & Martinelli, N. (2014) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-07320-0_7 · Cited by 173 · see citing works

SCD1 Inhibition Causes Cancer Cell Death by Depleting Mono-Unsaturated Fatty Acids

Mason, P., Liang, B., Li, L., Fremgen, T., Murphy, E., Quinn, A., Madden, S. L., Biemann, H.-P., Wang, B., Cohen, A., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0033823 · Cited by 173 · see citing works

Candidate Antimetastasis Drugs Suppress the Metastatic Capacity of Breast Cancer Cells by Reducing Membrane Fluidity

Zhao, W., Prijic, S., Urban, B. C., Tisza, M. J., Zuo, Y., Li, L., Tan, Z., Chen, X., Mani, S. A., & Chang, J. T. (2016) · Cancer Research · doi:10.1158/0008-5472.can-15-1970 · Cited by 172 · see citing works

Fatty acid synthase inhibition with Orlistat promotes apoptosis and reduces cell growth and lymph node metastasis in a mouse melanoma model

Carvalho, M. A., Zecchin, K. G., Seguin, F., Bastos, D. C., Agostini, M., Rangel, A. L. C. A., Veiga, S. S., Raposo, H. F., Oliveira, H. C. F., Loda, M. F., et al. (2008) · International Journal of Cancer · doi:10.1002/ijc.23835 · Cited by 171 · see citing works

Blocking Lipid Synthesis Overcomes Tumor Regrowth and Metastasis after Antiangiogenic Therapy Withdrawal

Sounni, N. E., Cimino, J., Blacher, S., Primac, I., Truong, A., Mazzucchelli, G., Paye, A., Calligaris, D., Debois, D., Tullio, P. D., et al. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2014.05.022 · Cited by 169 · see citing works

Fatty acid synthase inhibitors are chemopreventive for mammary cancer in neu-N transgenic mice

Alli, P. M., Pinn, M. L., Jaffee, E. M., McFadden, J. M., & Kuhajda, F. P. (2004) · Oncogene · doi:10.1038/sj.onc.1208174 · Cited by 167 · see citing works

Pharmacological inhibition of fatty acid synthase activity produces both cytostatic and cytotoxic effects modulated by p53.

Li, J. N., Gorospe, M., Chrest, F. J., Kumaravel, T. S., Evans, M. K., Han, W. F., & Pizer, E. S. (2001) · PubMed · Cited by 166 · see citing works

HER2/neu-Induced Mammary Tumorigenesis and Angiogenesis Are Reduced in Cyclooxygenase-2 Knockout Mice

Howe, L. R., Chang, S.-H., Tolle, K. C., et al. (2005) · Cancer Research · doi:10.1158/0008-5472.can-05-1524 · Cited by 165 · see citing works

Stearoyl CoA Desaturase Is Required to Produce Active, Lipid-Modified Wnt Proteins

Rios-Esteves, J., & Resh, M. D. (2013) · Cell Reports · doi:10.1016/j.celrep.2013.08.027 · Cited by 157 · see citing works

Fatty Acid Synthase Is Expressed Mainly in Adult Hormone-sensitive Cells or Cells with High Lipid Metabolism and in Proliferating Fetal Cells 1

Kusakabe, T., Maeda, M., Hoshi, N., Sugino, T., Watanabe, K., Fukuda, T., & Suzuki, T. (2000) · Journal of Histochemistry & Cytochemistry · doi:10.1177/002215540004800505 · Cited by 157 · see citing works

Fatty Acid Synthase Inhibition Activates AMP-Activated Protein Kinase in SKOV3 Human Ovarian Cancer Cells

Zhou, W., Han, W. F., Landree, L. E., Thupari, J. N., Pinn, M. L., Bililign, T., Kim, E. K., Vadlamudi, A., Medghalchi, S. M., Meskini, R. E., et al. (2007) · Cancer Research · doi:10.1158/0008-5472.can-06-3439 · Cited by 157 · see citing works

Altered metabolic responses to intermittent hypoxia in mice with partial deficiency of hypoxia-inducible factor-1α

Li, J., Bosch‐Marcé, M., Nanayakkara, A., Savransky, V., Fried, S. K., Semenza, G. L., & Polotsky, V. Y. (2006) · Physiological Genomics · doi:10.1152/physiolgenomics.00293.2005 · Cited by 157 · see citing works

The glucose-responsive transcription factor ChREBP contributes to glucose-dependent anabolic synthesis and cell proliferation

Tong, X., Zhao, F., Mancuso, A., Gruber, J. J., & Thompson, C. B. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0911316106 · Cited by 155 · see citing works

Cancer cells incorporate and remodel exogenous palmitate into structural and oncogenic signaling lipids

Louie, S. M., Roberts, L. S., Mulvihill, M. M., Luo, K., & Nomura, D. K. (2013) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2013.07.008 · Cited by 154 · see citing works

Melanoma Cells Break Down LPA to Establish Local Gradients That Drive Chemotactic Dispersal

Muinonen‐Martin, A., Susanto, O., Zhang, Q., Smethurst, E. A., Faller, W. J., Veltman, D. M., Kalna, G., Lindsay, C. R., Bennett, D. C., Sansom, O. J., et al. (2014) · PLoS Biology · doi:10.1371/journal.pbio.1001966 · Cited by 152 · see citing works

Inactivation of fatty acid synthase impairs hepatocarcinogenesis driven by AKT in mice and humans

Li, L., Pilo, G., Li, X., Cigliano, A., Latte, G., Che, L., Joseph, C., Mela, M., Wang, C., Jiang, L., et al. (2015) · Journal of Hepatology · doi:10.1016/j.jhep.2015.10.004 · Cited by 145 · see citing works

The fatty acid synthase inhibitor triclosan: repurposing an anti-microbial agent for targeting prostate cancer

Sadowski, M. C., Pouwer, R. H., Gunter, J. H., Lubik, A. A., Quinn, R. J., & Nelson, C. C. (2014) · Oncotarget · doi:10.18632/oncotarget.2433 · Cited by 144 · see citing works

A Phosphorylation Cascade Controls the Degradation of Active SREBP1*

Bengoechea-Alonso, M., & Ericsson, J. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m807906200 · Cited by 144 · see citing works

Inhibition of Stearoyl-CoA Desaturase 1 expression in human lung adenocarcinoma cells impairs tumorigenesis

Iga (1992) · International Journal of Oncology · doi:10.3892/ijo_00000072 · Cited by 136 · see citing works

Wnt Signaling, Stem Cells, and Cancer of the Gastrointestinal TractPreprint

Schepers, A. G., & Clevers, H. C. (2012) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a007989 · Cited by 135 · see citing works

Regulation of sterol regulatory-element binding protein 1 gene expression in liver: role of insulin and protein kinase B/cAkt

Fleischmann, M. M., & Iynedjian, P. B. (2000) · Biochemical Journal · doi:10.1042/bj3490013 · Cited by 133 · see citing works

Low-Field Magnetic Resonance Imaging to Visualize Chronic and Cycling Hypoxia in Tumor-Bearing Mice

Yasui, H., Matsumoto, S., Devasahayam, N., Munasinghe, J., Choudhuri, R., Saito, K., Subramanian, S., Mitchell, J. B., & Krishna, M. C. (2010) · Cancer Research · doi:10.1158/0008-5472.can-10-1350 · Cited by 127 · see citing works

Selective Inhibition of Fatty Acid Synthase for Lung Cancer Treatment

Orita, H., Coulter, J. B., Lemmon, C., Tully, E., Vadlamudi, A., Medghalchi, S. M., Kuhajda, F. P., & Gabrielson, E. (2007) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-07-1186 · Cited by 126 · see citing works

Acetyl-CoA carboxylase-α inhibitor TOFA induces human cancer cell apoptosis

Wang, C., Xu, C., Sun, M., Luo, D., Liao, D., & Cao, D. (2009) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2009.05.045 · Cited by 116 · see citing works

ATP Citrate Lyase Knockdown Induces Growth Arrest and Apoptosis through Different Cell- and Environment-Dependent Mechanisms

Zaidi, N., Royaux, I. E., Swinnen, J. V., & Smans, K. A. (2012) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-12-0095 · Cited by 116 · see citing works

p53-Defective Tumors With a Functional Apoptosome-Mediated Pathway: A New Therapeutic Target

Mashima, T., Oh‐hara, T., Sato, S., Mochizuki, M., Sugimoto, Y., Yamazaki, K., Hamada, J.-I., Tada, M., Moriuchi, T., Ishikawa, Y., et al. (2005) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/dji133 · Cited by 114 · see citing works

Inhibition of Fatty Acid Metabolism Reduces Human Myeloma Cells Proliferation

Tirado-Vélez, J. M., Joumady, I., Sáez-Benito, A., Cózar‐Castellano, I., & Perdomo, G. (2012) · PLoS ONE · doi:10.1371/journal.pone.0046484 · Cited by 113 · see citing works

Pharmacological and small interference RNA‐mediated inhibition of breast cancer‐associated fatty acid synthase (oncogenic antigen‐519) synergistically enhances Taxol (paclitaxel)‐induced cytotoxicity

Menéndez, J. A., Vellón, L., Colomer, R., & Lupu, R. (2005) · International Journal of Cancer · doi:10.1002/ijc.20754 · Cited by 110 · see citing works

Increased fatty acid synthase is a therapeutic target in mesothelioma.

Gabrielson, E. W., Pinn, M. L., Testa, J. R., & Kuhajda, F. P. (2001) · PubMed · Cited by 110 · see citing works

Progression of Breast Cancer Cells Was Enhanced by Endocrine-Disrupting Chemicals, Triclosan and Octylphenol, via an Estrogen Receptor-Dependent Signaling Pathway in Cellular and Mouse Xenograft Models

Lee, H.-R., Hwang, K., Nam, K., Kim, H.-C., & Choi, K. (2014) · Chemical Research in Toxicology · doi:10.1021/tx5000156 · Cited by 109 · see citing works

Cytosolic acetyl‐CoA synthetase affected tumor cell survival under hypoxia: the possible function in tumor acetyl‐CoA/acetate metabolism

Yoshii, Y., Furukawa, T., Yoshii, H., Mori, T., Kiyono, Y., Waki, A., Kobayashi, M., Tsujikawa, T., Kudo, T., Okazawa, H., et al. (2009) · Cancer Science · doi:10.1111/j.1349-7006.2009.01099.x · Cited by 108 · see citing works

Effect of Obesity on Ambient Plasma Glucose, Free Fatty Acid, Insulin, Growth Hormone, and Glucagon Concentrations*

Golay, A., Swislocki, A., Chen, Y. I., Jaspan, J., & Reaven, G. M. (1986) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-63-2-481 · Cited by 107 · see citing works

Lipogenetic and glycolytic enzyme activities in carcinoma and nonmalignant diseases of the human breast

Szutowicz, A., Kwiatkowski, J., & Angielski, S. (1979) · British Journal of Cancer · doi:10.1038/bjc.1979.120 · Cited by 103 · see citing works

Different fatty acid metabolism effects of (−)-Epigallocatechin-3-Gallate and C75 in Adenocarcinoma lung cancer

Relat, J., Blancafort, A., Oliveras, G., et al. (2012) · BMC Cancer · doi:10.1186/1471-2407-12-280 · Cited by 102 · see citing works

IDH1 gene transcription is sterol regulated and activated by SREBP-1a and SREBP-2 in human hepatoma HepG2 cells

Shechter, I., Dai, P., Huo, L., & Guan, G. (2003) · Journal of Lipid Research · doi:10.1194/jlr.m300285-jlr200 · Cited by 101 · see citing works

Inhibition of hypothalamic fatty acid synthase triggers rapid activation of fatty acid oxidation in skeletal muscle

Cha, S. H., Hu, Z., Chohnan, S., & Lane, M. D. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0507300102 · Cited by 100 · see citing works

Fatty acid activated PPARγ promotes tumorigenicity of prostate cancer cells by up regulating VEGF via PPAR responsive elements of the promoter

Forootan, F. S., Forootan, S. S., Gou, X., Yang, J. K., Liu, B., Chen, D., Fayi, M. S. A., Al-Jameel, W. H., Rudland, P. S., Hussain, S. A., et al. (2016) · Oncotarget · doi:10.18632/oncotarget.6975 · Cited by 98 · see citing works

Fatty acylation of Wnt proteins.

Nile, A. H., & Hannoush, R. (2016) · Nature Chemical Biology · doi:10.1038/nchembio.2005 · Cited by 93 · see citing works

Molecular Pathways: Trafficking of Metabolic Resources in the Tumor Microenvironment

Romero, I. L., Mukherjee, A., Kenny, H. A., Litchfield, L. M., & Lengyel, E. R. (2015) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-14-2198 · Cited by 91 · see citing works

Elimination of chronic lymphocytic leukemia cells in stromal microenvironment by targeting CPT with an antiangina drug perhexiline

Liu, P.-P., Liu, J., Jiang, W.-Q., Carew, J. S., Ogasawara, M. A., Pelicano, H., Croce, C. M., Estrov, Z., Xu, R., Keating, M., et al. (2016) · Oncogene · doi:10.1038/onc.2016.103 · Cited by 89 · see citing works

Intra‐tumour heterogeneity – going beyond genetics

Caiado, F., Silva‐Santos, B., & Norell, H. (2016) · FEBS Journal · doi:10.1111/febs.13705 · Cited by 87 · see citing works

Inhibition of Tumor-associated Fatty Acid Synthase Hyperactivity Induces Synergistic Chemosensitization of HER-2/neu-Overexpressing Human Breast Cancer Cells to Docetaxel (taxotere)

Menéndez, J. A., Lupu, R., & Colomer, R. (2004) · Breast Cancer Research and Treatment · doi:10.1023/b:brea.0000018409.59448.60 · Cited by 82 · see citing works

Free fatty acid release from human breast cancer tissue inhibits cytotoxic T-lymphocyte-mediated killing

Kleinfeld, A. M., & Okada, C. (2005) · Journal of Lipid Research · doi:10.1194/jlr.m500151-jlr200 · Cited by 79 · see citing works

Pharmacological Inhibitor of Fatty Acid Synthase Suppresses Growth and Invasiveness of Renal Cancer Cells

Horiguchi, A., Asano, T., Asano, T., et al. (2008) · The Journal of Urology · doi:10.1016/j.juro.2008.03.186 · Cited by 75 · see citing works

Anti-cancer efficacy of SREBP inhibitor, alone or in combination with docetaxel, in prostate cancer harboring p53 mutations

Li, X., Wu, B. J., Chung, L. W. K., & Huang, W. (2015) · Oncotarget · doi:10.18632/oncotarget.5879 · Cited by 73 · see citing works

The Expression Profile of Phosphatidylinositol in High Spatial Resolution Imaging Mass Spectrometry as a Potential Biomarker for Prostate Cancer

Goto, T., Terada, N., Inoue, T., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0090242 · Cited by 72 · see citing works

LPA3 receptor mediates chemotaxis of immature murine dendritic cells to unsaturated lysophosphatidic acid (LPA)

Chan, L. C., Peters, W., Xu, Y., et al. (2007) · Journal of Leukocyte Biology · doi:10.1189/jlb.0407221 · Cited by 72 · see citing works

Betulinic acid induces a novel cell death pathway that depends on cardiolipin modification

Potze, L., Franco, S. D., Grandela, C., Pras‐Raves, M. L., Picavet, D. I., van Veen, H. A., van LENTHE, H., Mullauer, F. B., van der Wel, N. N., Luyf, A. C. M., et al. (2015) · Oncogene · doi:10.1038/onc.2015.102 · Cited by 69 · see citing works

Inhibition of Fatty Acid Synthase (FASN) synergistically enhances the efficacy of 5-fluorouracil in breast carcinoma cells

Vazquez-Martin, A., Ropero, S., Brunet, J., Colomer, R., & Menéndez, J. A. (2007) · Oncology Reports · doi:10.3892/or.18.4.973 · Cited by 67 · see citing works

Phospholipid profiling identifies acyl chain elongation as a ubiquitous trait and potential target for the treatment of lung squamous cell carcinoma

Marien, E., Meister, M. A., Muley, T., del Pulgar, T. G., Derua, R., Spraggins, J. M., de Plas, R. V., Vanderhoydonc, F., Machiels, J., Binda, M. M., et al. (2016) · Oncotarget · doi:10.18632/oncotarget.7179 · Cited by 67 · see citing works

Unsaturated Fatty Acids Stimulate Tumor Growth through Stabilization of β-Catenin

Kim, H., Rodríguez‐Navas, C., Kollipara, R. K., Kapur, P., Pedrosa, I., Brugarolas, J., Kittler, R., & Ye, J. (2015) · Cell Reports · doi:10.1016/j.celrep.2015.09.010 · Cited by 65 · see citing works

The multifaceted contributions of mitochondria to cellular metabolism

Spinelli, J. B., & Haigis, M. C. (2018) · Nature Cell Biology · doi:10.1038/s41556-018-0124-1 · Cited by 1,935 · see citing works

Targeting Metabolism for Cancer Therapy

Luengo, A., Gui, D. Y., & Vander Heiden, M. G. (2017) · Cell Chemical Biology · doi:10.1016/j.chembiol.2017.08.028 · Cited by 971 · see citing works

Lactate modulation of immune responses in inflammatory versus tumour microenvironments

Certo, M., Tsai, C.-H., Pucino, V., Ho, P.-C., & Mauro, C. (2021) · Nature Reviews Immunology · doi:10.1038/s41577-020-0406-2 · Cited by 924 · see citing works

Functional screening in human cardiac organoids reveals a metabolic mechanism for cardiomyocyte cell cycle arrest

Mills, R. J., Titmarsh, D. M., Koenig, X., Parker, B. L., Ryall, J. G., Quaife-Ryan, G. A., Voges, H. K., Hodson, M. P., Ferguson, C., Drowley, L., et al. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1707316114 · Cited by 478 · see citing works

HIFs, angiogenesis, and metabolism: Elusive enemies in breast cancer

de Heer, E. C., Jalving, M., & Harris, A. L. (2020) · Journal of Clinical Investigation · doi:10.1172/jci137552 · Cited by 372 · see citing works

The molecular biology of pancreatic adenocarcinoma: Translational challenges and clinical perspectives

Wang, S., Zheng, Y., Yang, F., Zhu, L., Zhu, X.-Q., Wang, Z.-F., Wu, X.-L., Zhou, C.-H., Yan, J.-Y., Hu, B.-Y., et al. (2021) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-021-00659-4 · Cited by 369 · see citing works

The gluconeogenic enzyme PCK1 phosphorylates INSIG1/2 for lipogenesis

Xu, D., Wang, Z., Xia, Y., Shao, F., Xia, W., Wei, Y., Li, X., Qian, X., Lee, J.-H., Du, L., et al. (2020) · Nature · doi:10.1038/s41586-020-2183-2 · Cited by 360 · see citing works

Acetyl-CoA metabolism in cancer

Guertin, D. A., & Wellen, K. E. (2023) · Nature Reviews Cancer · doi:10.1038/s41568-022-00543-5 · Cited by 303 · see citing works

The Influence of Metabolism on Drug Response in Cancer

Zaal, E. A., & Berkers, C. R. (2018) · Frontiers in Oncology · doi:10.3389/fonc.2018.00500 · Cited by 272 · see citing works

Metabolic reprogramming in triple-negative breast cancer

Sun, X., Wang, M., Wang, M., Yu, X., Guo, J., Sun, T., Li, X., Yao, L., Dong, H., & Xu, Y. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2020.00428 · Cited by 243 · see citing works

Serine, glycine and one‑carbon metabolism in cancer (Review)

Pan, S., Fan, M., Liu, Z., Li, X., & Wang, H. (2020) · International Journal of Oncology · doi:10.3892/ijo.2020.5158 · Cited by 227 · see citing works

Resistance to tyrosine kinase inhibitors in chronic myeloid leukemia-from molecular mechanisms to clinical relevance

Alves, R., Gonçalves, A. C., Rutella, S., Almeida, A. M., De Las Rivas, J., Trougakos, I. P., & Sarmento Ribeiro, A. B. (2021) · Cancers · doi:10.3390/cancers13194820 · Cited by 204 · see citing works

Metabolic adaptation of cancer and immune cells mediated by hypoxia-inducible factors

Samanta, D., & Semenza, G. L. (2018) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2018.07.002 · Cited by 190 · see citing works

Raman-guided subcellular pharmaco-metabolomics for metastatic melanoma cells

Du, J., Su, Y., Qian, C., Yuan, D., Miao, K., Lee, D., Ng, A. H. C., Wijker, R. S., Ribas, A., Levine, R. D., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-18376-x · Cited by 171 · see citing works

Sustained SREBP-1-dependent lipogenesis as a key mediator of resistance to BRAF-targeted therapy

Talebi, A., Dehairs, J., Rambow, F., Rogiers, A., Nittner, D., Derua, R., Vanderhoydonc, F., Duarte, J. A. G., Bosisio, F., Van den Eynde, K., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-04664-0 · Cited by 155 · see citing works

Regulatory T Cells in Cancer

Plitas, G., & Rudensky, A. Y. (2020) · Annual Review of Cancer Biology · doi:10.1146/annurev-cancerbio-030419-033428 · Cited by 148 · see citing works

Ketolysis drives CD8+ T cell effector function through effects on histone acetylation

Luda, K. M., Longo, J., Kitchen-Goosen, S. M., Duimstra, L. R., Ma, E. H., Watson, M. J., Oswald, B. M., Fu, Z., Madaj, Z., Kupai, A., et al. (2023) · Immunity · doi:10.1016/j.immuni.2023.07.002 · Cited by 140 · see citing works

Preclinical evaluation of novel fatty acid synthase inhibitors in primary colorectal cancer cells and a patient-derived xenograft model of colorectal cancer

Zaytseva, Y. Y., Rychahou, P. G., Le, A.-T., Scott, T. L., Flight, R. M., Kim, J. T., Harris, J., Liu, J., Wang, C., Morris, A. J., et al. (2018) · Oncotarget · doi:10.18632/oncotarget.25361 · Cited by 123 · see citing works

Cancer cells depend on environmental lipids for proliferation when electron acceptors are limited

Li, Z., Ji, B. W., Dixit, P. D., Tchourine, K., Lien, E. C., Hosios, A. M., Abbott, K. L., Rutter, J. C., Westermark, A. M., Gorodetsky, E. F., et al. (2022) · Nature Metabolism · doi:10.1038/s42255-022-00588-8 · Cited by 81 · see citing works

Regulation of Metabolic Activity by p53

Flöter, J., Kaymak, I., & Schulze, A. (2017) · Metabolites · doi:10.3390/metabo7020021 · Cited by 81 · see citing works

Acetyl-CoA metabolism as a therapeutic target for cancer

Chen, G., Bao, B., Cheng, Y., Tian, M., Song, J., Zheng, L., & Tong, Q. (2023) · Biomedicine &amp; Pharmacotherapy · doi:10.1016/j.biopha.2023.115741 · Cited by 54 · see citing works

HDACs and the epigenetic plasticity of cancer cells: target the complexity

Brancolini, C., Gagliano, T., & Minisini, M. (2022) · Pharmacology &amp; Therapeutics · doi:10.1016/j.pharmthera.2022.108190 · Cited by 55 · see citing works

Multimodal Metabolic Imaging Reveals Pigment Reduction and Lipid Accumulation in Metastatic Melanoma

Lee, H. J., Chen, Z., Collard, M., Chen, F., Chen, J. G., Wu, M., Alani, R. M., & Cheng, J.-X. (2021) · BME Frontiers · doi:10.34133/2021/9860123 · Cited by 38 · see citing works

Glucose-sensitive acetylation of Seryl tRNA synthetase regulates lipid synthesis in breast cancer

Zhao, J., Bai, H., Li, X., Yan, J., Zou, G., Wang, L., Li, X., Liu, Z., Xiang, R., Yang, X.-L., et al. (2021) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-021-00714-0 · Cited by 27 · see citing works

Reactive cholangiocyte-derived ORM2 drives a pathogenic modulation of the injured biliary niche through macrophage reprogramming

Liu, H., Yin, G., Franco Leonardi, B., Lan, T., Ait Ahmed, Y., Berger, H., Kohlhepp, M. S., Amiridze, N., Martagón Calderón, N., Frau, C., et al. (2025) · Gut · doi:10.1136/gutjnl-2024-334425 · Cited by 23 · see citing works

Prognostic Implication of Plasma Metabolites in Gastric Cancer

Cao, K., Lyu, Y., Chen, J., He, C., Lyu, X., Zhang, Y., Chen, L., Jiang, Y., Xiang, J., Liu, B., et al. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241612774 · Cited by 16 · see citing works

A system-wide approach to monitor responses to synergistic BRAF and EGFR inhibition in colorectal cancer cells

Ressa, A., Bosdriesz, E., de Ligt, J., Mainardi, S., Maddalo, G., Prahallad, A., Jager, M., de la Fonteijne, L., Fitzpatrick, M., Groten, S., et al. (2018) · Molecular &amp; Cellular Proteomics · doi:10.1074/mcp.ra117.000486 · Cited by 17 · see citing works

Fatty acid synthesis in mouse brown adipose tissue the influence of environmental temperature on the proportion of whole-body fatty acid synthesis in brown adipose tissue and the liver

Trayhurn, P. (1981) · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · doi:10.1016/0005-2760(81)90132-6 · Cited by 98 · see citing works

Relative contribution of the main tissues and organs to body fatty acid synthesis in the rat

Gandemer, G., Durand, G., & Pascal, G. (1983) · Lipids · doi:10.1007/bf02534552 · Cited by 42 · see citing works

Effects of 2[5(4-chlorphenyl)pentyl]oxirane-2- carboxylate on fatty acid synthesis and fatty acid oxidation in isolated rat hepatocytes

Agius, L., Pillay, D., George, K., et al. (1985) · Biochemical Pharmacology · doi:10.1016/0006-2952(85)90562-3 · Cited by 15 · see citing works

Fatty Acid Metabolism as a Tumor Marker

Winarno, G. N. A. (2022) · Biochemistry · doi:10.5772/intechopen.106072 · Cited by 1 · see citing works

Short-term regulation of fatty acid synthesis in cultured glial and neuronal cells

Volpe, J. J., & Marasa, J. C. (1977) · Brain Research · doi:10.1016/0006-8993(77)90972-6 · Cited by 14 · see citing works