Cited by 1,243Cancer, Hypoxia, and MetabolismMetabolism, Diabetes, and CancerCancer and biochemical research

The Control of the Metabolic Switch in Cancers by Oncogenes and Tumor Suppressor Genes

Levine, Arnold J., Puzio-Kuter, Anna M.·2010·Science

Abstract

Cells from some tumors use an altered metabolic pattern compared with that of normal differentiated adult cells in the body. Tumor cells take up much more glucose and mainly process it through aerobic glycolysis, producing large quantities of secreted lactate with a lower use of oxidative phosphorylation that would generate more adenosine triphosphate (ATP), water, and carbon dioxide. This is the Warburg effect, which provides substrates for cell growth and division and free energy (ATP) from enhanced glucose use. This metabolic switch places the emphasis on producing intermediates for cell growth and division, and it is regulated by both oncogenes and tumor suppressor genes in a number of key cancer-producing pathways. Blocking these metabolic pathways or restoring these altered pathways could lead to a new approach in cancer treatments.

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Crossref · 10.1126/science.1193494

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38 of 38 references verified0 citation errors · 0 not checkable

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  • Oncogenes including RAS can promote aerobic glycolysis and activate anabolic pathways.

    “The recognition that oncogenes, including RAS, can promote aerobic glycolysis, commonly known as the Warburg effect, and activate anabolic pathways 22,23, has increased efforts to understand the molecular underpinnings of altered metabolism in cancer24.”

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Authors
Levine, A. J., & Puzio-Kuter, A. M.
Affiliations
  • Institute for Advanced Study (US)
  • Cancer Institute of New Jersey, New Brunswick, NJ 08903, USA.
Corresponding author
Levine, Arnold J.
Venue
Science
Published
2010-12-03
Volume
330
Issue
6009
Pages
1340-1344
ISSN
  • 0036-8075 (ISSN-L)
  • 1095-9203
OpenAlex
W1975854213
Cited by
1,243
References
38
Citations by year
2026: 15 · 2025: 55 · 2024: 56 · 2023: 61 · 2022: 87 · 2021: 90 · 2020: 68 · 2019: 87 · 2018: 74 · 2017: 74 · 2016: 96 · 2015: 82 · 2014: 109 · 2013: 106 · 2012: 120
FWCI
7.71
Type
journal article
Language
en
Open access
closed
Locations
  • Science (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cancer and biochemical research
Keywords
Warburg effect, aerobic glycolysis, cancer metabolism, metabolic switch, oncogenes, tumor suppressor, glucose uptake, lactic acid production, oxidative phosphorylation, cancer therapy
MeSH terms
Adenosine Triphosphate, Cell Division, Citric Acid Cycle, Glucose, Glutamine, Glycolysis, Humans, NADP, Neoplasms, Oncogenes, Pentose Phosphate Pathway, Signal Transduction, Gene Expression Regulation, Neoplastic, Genes, Tumor Suppressor

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