The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
An Active Role for the Ribosome in Determining the Fate of Oxidized mRNA
Open accessAbstract
Chemical damage to RNA affects its functional properties and thus may pose a significant hurdle to the translational apparatus; however, the effects of damaged mRNA on the speed and accuracy of the decoding process and their interplay with quality-control processes are not known. Here, we systematically explore the effects of oxidative damage on the decoding process using a well-defined bacterial in vitro translation system. We find that the oxidative lesion 8-oxoguanosine (8-oxoG) reduces the rate of peptide-bond formation by more than three orders of magnitude independent of its position within the codon. Interestingly, 8-oxoG had little effect on the fidelity of the selection process, suggesting that the modification stalls the translational machinery. Consistent with these findings, 8-oxoG mRNAs were observed to accumulate and associate with polyribosomes in yeast strains in which no-go decay is compromised. Our data provide compelling evidence that mRNA-surveillance mechanisms have evolved to cope with damaged mRNA.
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Cites
NMD: a multifaceted response to premature translational termination
Kervestin, S., & Jacobson, A. (2012) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3454 · Cited by 572
Quantification of oxidized RNAs in Alzheimer's disease
Shan, X., & Lin, C.-L. G. (2006) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2005.03.022 · Cited by 125
Cited by
Clinical Relevance of Biomarkers of Oxidative Stress
Frijhoff, J., Winyard, P. G., Zarkovic, N., Davies, S. S., Stocker, R., Cheng, D., Knight, A. R., Taylor, E. L., Oettrich, J., Ruskovska, T., et al. (2015) · Antioxidants & Redox Signaling · doi:10.1089/ars.2015.6317 · Cited by 909
Dynamics of Translation of Single mRNA Molecules In Vivo
Yan, X., Hoek, T. A., Vale, R. D., & Tanenbaum, M. E. (2016) · Cell · doi:10.1016/j.cell.2016.04.034 · Cited by 490
Ribosome Collision Is Critical for Quality Control during No-Go Decay
Simms, C. L., Yan, L. L., & Zaher, H. S. (2017) · Molecular Cell · doi:10.1016/j.molcel.2017.08.019 · Cited by 319
Self-citationOxidation and alkylation stresses activate ribosome-quality control
Yan, L. L., Simms, C. L., McLoughlin, F., Vierstra, R. D., & Zaher, H. S. (2019) · Nature Communications · doi:10.1038/s41467-019-13579-3 · Cited by 123
Self-citationA cellular handbook for collided ribosomes: Surveillance pathways and collision types
Meydan, S., & Guydosh, N. R. (2021) · Current Genetics · doi:10.1007/s00294-020-01111-w · Cited by 87
Metadata
- Authors
- Simms, C. L., Hudson, B. H., Mosior, J. W., Rangwala, A. S., & Zaher, H. S.
- Venue
- Cell Reports
- Publisher
- Elsevier BV
- Published
- 2014-11
- Volume
- 9
- Issue
- 4
- Pages
- 1256-1264
- ISSN
- 2211-1247 (ISSN-L)
- OpenAlex
- W2088155226
- Cited by
- 213
- References
- 2
- FWCI
- 4.75
- Type
- journal article
- Language
- en
- Open access
- gold
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