The DOI matches its Crossref record; 63 of the 63 references it cites were found in a registry or an index.
Ribosome Collision Is Critical for Quality Control during No-Go Decay
Open accessAbstract
SUMMARY No-go decay (NGD) is a eukaryotic quality control mechanism that evolved to cope with translational arrests. The process is characterized by an endonucleolytic cleavage near the stall sequence, but the mechanistic details are unclear. Our analysis of cleavage sites indicates that cleavage requires multiple ribosomes on the mRNA. We also show that reporters harboring stall sequences near the initiation codon, which cannot accommodate multiple ribosomes, are not subject to NGD. Consistent with our model, we uncover an inverse correlation between ribosome density per mRNA and cleavage efficiency. Furthermore, promoting global ribosome collision in vivo resulted in ubiquitination of ribosomal proteins suggesting that collision is sensed by the cell to initiate downstream quality control processes. Collectively our data suggests that NGD and subsequent quality control are triggered by ribosome collision. This model provides insight into the regulation of quality control processes and the manner by which they reduce off target effects.
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Mechanisms and functions of ribosome-associated protein quality control
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Collided ribosomes form a unique structural interface to induce Hel2-driven quality control pathways
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Translation affects mRNA stability in a codon-dependent manner in human cells
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The ASC-1 complex disassembles collided ribosomes
Juszkiewicz, S., Speldewinde, S. H., Wan, L., Svejstrup, J. Q., & Hegde, R. S. (2020) · Molecular Cell · doi:10.1016/j.molcel.2020.06.006 · Cited by 206
Metadata
- Authors
- Simms, C. L., Yan, L. L., & Zaher, H. S.
- Venue
- Molecular Cell
- Publisher
- Elsevier BV
- Published
- 2017-10
- Volume
- 68
- Issue
- 2
- Pages
- 361-373.e5
- ISSN
- 1097-2765 (ISSN-L)
- OpenAlex
- W2758757342
- Cited by
- 319
- References
- 63
- FWCI
- 10.87
- Type
- journal article
- Language
- en
- Open access
- bronze
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