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The DOI matches its Crossref record; 202 of the 202 references it cites were found in a registry or an index.

Clinical Relevance of Biomarkers of Oxidative Stress

Open access
Frijhoff, Jeroen, Winyard, Paul G., Zarkovic, Neven, Davies, Sean S., Stocker, Roland, Cheng, David, Knight, Annie R., Taylor, Emma Louise, Oettrich, Jeannette, Ruskovska, Tatjana, Gasparovic, Ana Cipak, Cuadrado, Antonio, Weber, Daniela, Poulsen, Henrik Enghusen, Grune, Tilman, Schmidt, Harald H.H.W., Ghezzi, Pietro·2015·Antioxidants & Redox Signaling
DOI 10.1089/ars.2015.6317
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Abstract

SIGNIFICANCE: Oxidative stress is considered to be an important component of various diseases. A vast number of methods have been developed and used in virtually all diseases to measure the extent and nature of oxidative stress, ranging from oxidation of DNA to proteins, lipids, and free amino acids. RECENT ADVANCES: An increased understanding of the biology behind diseases and redox biology has led to more specific and sensitive tools to measure oxidative stress markers, which are very diverse and sometimes very low in abundance. CRITICAL ISSUES: The literature is very heterogeneous. It is often difficult to draw general conclusions on the significance of oxidative stress biomarkers, as only in a limited proportion of diseases have a range of different biomarkers been used, and different biomarkers have been used to study different diseases. In addition, biomarkers are often measured using nonspecific methods, while specific methodologies are often too sophisticated or laborious for routine clinical use. FUTURE DIRECTIONS: Several markers of oxidative stress still represent a viable biomarker opportunity for clinical use. However, positive findings with currently used biomarkers still need to be validated in larger sample sizes and compared with current clinical standards to establish them as clinical diagnostics. It is important to realize that oxidative stress is a nuanced phenomenon that is difficult to characterize, and one biomarker is not necessarily better than others. The vast diversity in oxidative stress between diseases and conditions has to be taken into account when selecting the most appropriate biomarker.

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Metadata

Authors
Frijhoff, J., Winyard, P. G., Zarkovic, N., Davies, S. S., Stocker, R., Cheng, D., Knight, A. R., Taylor, E. L., Oettrich, J., Ruskovska, T., Gasparovic, A. C., Cuadrado, A., Weber, D., Poulsen, H. E., Grune, T., Schmidt, H. H. H. W., & Ghezzi, P.
Venue
Antioxidants & Redox Signaling
Publisher
SAGE Publications
Published
2015-11-10
Volume
23
Issue
14
Pages
1144-1170
ISSN
  • 1523-0864 (ISSN-L)
  • 1557-7716
DOI
10.1089/ars.2015.6317
OpenAlex
W2139131794
Cited by
909
References
202
FWCI
24.78
Type
journal article
Language
en
Open access
hybrid

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CoChat. (2026). Citation check: Clinical Relevance of Biomarkers of Oxidative Stress. https://app.cochat.ai/papers/10.1089/ars.2015.6317
The paper
Frijhoff, J., Winyard, P. G., Zarkovic, N., Davies, S. S., Stocker, R., Cheng, D., Knight, A. R., Taylor, E. L., Oettrich, J., Ruskovska, T., Gasparovic, A. C., Cuadrado, A., Weber, D., Poulsen, H. E., Grune, T., Schmidt, H. H. H. W., & Ghezzi, P. (2015). Clinical Relevance of Biomarkers of Oxidative Stress. Antioxidants & Redox Signaling. https://doi.org/10.1089/ars.2015.6317

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.