Cooperation between Noncanonical Ras Network Mutations
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(Cell Reports 10, 307–316; January 15, 2015) In the original published version of this paper, Paul C. Trampont was not marked as a co-first author. This error has been corrected, and the correct affiliations now appear with this paper online. Cell Reports apologizes for this error. Cooperation between Noncanonical Ras Network MutationsStites et al.Cell ReportsJanuary 15, 2015In BriefStites et al. use a mathematical model to investigate combinations of mutations in the Ras pathway. The model predicts synergy between specific combinations of mutations, and this prediction is supported by experiments. Mining human cancer genome databases finds increased co-occurrence of Ras pathway mutations, consistent with the model analysis. Full-Text PDF Open Access
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In some LUAD and LUSC, NF1 and RASA1 co-mutations create dependence on MEK-ERK signaling and greater sensitivity to MEK inhibitors.
“co-mutations in NF1 and RASA1, encoding two critical RAS pathway GTPase-activating proteins (GAPs), drive addiction to the MEK–ERK signaling axis and confer enhanced sensitivity to MEK inhibitors in a subset of both LUAD and LUSC171, 172.”
From Co-occurring genomic alterations in non-small-cell lung cancer biology and therapy (2019) · cites this paper as [171]
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Co-occurring genomic alterations in non-small-cell lung cancer biology and therapy
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Hayashi, T., Desmeules, P., Smith, R. S., Drilon, A., Somwar, R., & Ladanyi, M. (2018) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-17-2343 · Cited by 90 · see citing works
Advancement in research and therapy of NF1 mutant malignant tumors
Tao, J., Sun, D., Dong, L., Zhu, H., & Hou, H. (2020) · Cancer Cell International · doi:10.1186/s12935-020-01570-8 · Cited by 44 · see citing works
McFall, T. B., Schomburg, N. K., Rossman, K. L., & Stites, E. C. (2020) · Cell Communication and Signaling · doi:10.1186/s12964-020-00645-3 · Cited by 25 · see citing works
Self-citationZheng, L., Zhan, Y., Jia, L., et al. (2021) · Annals of Translational Medicine · doi:10.21037/atm-21-1010 · Cited by 9 · see citing works
Theoretical analysis reveals a role for RAF conformational autoinhibition in paradoxical activation
Mendiratta, G., & Stites, E. C. (2023) · eLife · doi:10.7554/elife.82739 · Cited by 8 · see citing works
Self-citation
- Authors
- Stites, E. C., Trampont, P. C., Haney, L. B., Walk, S. F., & Ravichandran, K. S.
- Corresponding author
- Stites, Edward C.
- Venue
- Cell Reports
- Publisher
- Elsevier BV
- Published
- 2015-02
- Volume
- 10
- Issue
- 5
- Pages
- 840
- ISSN
- 2211-1247 (ISSN-L)
- OpenAlex
- W4253000801
- Cited by
- 6
- References
- 0
- Citations by year
- 2023: 1 · 2021: 1 · 2020: 2 · 2019: 1 · 2017: 1
- FWCI
- 0.14
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Cell Reports (publishedVersion, cc-by-nc-nd)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer Genomics and Diagnostics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Tyrosine Phosphatases
- Keywords
- Ras signaling, mathematical model, co-occurring mutations, oncogenic signaling
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