Autism-like Deficits in Shank3-Deficient Mice Are Rescued by Targeting Actin Regulators
Duffney, Lara J., Zhong, Ping, Wei, Jing, Matas, Emmanuel, Cheng, Jia, Qin, Luye, Ma, Kaijie, Dietz, David M., Kajiwara, Yuji, Buxbaum, Joseph D., Yan, Zhen·2015·Cell Reports
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- Altered sex differences related to food intake, hedonic preference, and FosB/deltaFosB expression within central neural circuit involved in homeostatic and hedonic food intake regulation in Shank3B mouse model of autism spectrum disorderZdeno Pirník, Ivan Szadvári, Veronika Borbélyová, Aleksandra Tomova · 2024 · Neurochemistry International
- Deficiency of the histone lysine demethylase KDM5B causes autism-like phenotypes via increased NMDAR signallingLeticia Pérez‐Sisqués, S. Bhatt, Angela Caruso, Mohi U. Ahmed, Talia E. Gileadi, Shoshana Spring, Eleanor Hendy, Joyce Taylor‐Papadimitriou, Diana Cash, Nicholas E. Clifton et al. · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
- Aberrant mRNA splicing and impaired hippocampal neurogenesis in Grin2b mutant miceZohreh Farsi, Ally A. Nicolella, Sean Simmons, Wangyong Shin, Muwon Kang, Gina Lee, Min Jee Kwon, Kira S. Brenner, Inès Picard, Nate Shepard et al. · 2026 · iScience
- miRNA-mediated inhibition of an actomyosin network in hippocampal pyramidal neurons restricts sociability in adult male miceRamanathan Narayanan, Brunno Rocha Levone, Jochen Winterer, Prakruti Nanda, Alexander Müller, Thomas Lobriglio, Roberto Fiore, Pierre‐Luc Germain, Marija Mihailovich, Giuseppe Testa et al. · 2024 · Cell Reports
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- Talin gets SHANKed in the fight for integrin activationPaul Atherton, Christoph Ballestrem · 2017 · Nature Cell Biology
- Comparing synaptic proteomes across seven mouse models for autism reveals molecular subtypes and deficits in Rho GTPase signalingAbigail U. Carbonell, Carmen Freire‐Cobo, Ilana V. Deyneko, Hediye Erdjument‐Bromage, Amy E. Clipperton‐Allen, Randall L. Rasmusson, Damon T. Page, Thomas A. Neubert, Bryen A. Jordan · 2021 · bioRxiv (Cold Spring Harbor Laboratory)
- Inhibiting proBDNF to mature BDNF conversion leads to autism-like phenotypes in vivoHe You, Toshiyuki Mizui, Kazuyuki Kiyosue, Keizo Takao, Tsuyoshi Miyakawa, Koichi Kato, Mitsuru Otsuka, Ting Bai, Kun Xia, Bai Lu et al. · 2020 · bioRxiv (Cold Spring Harbor Laboratory)
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- The Use of Nutraceutical and Pharmacological Strategies in Murine Models of Autism Spectrum DisorderMatteo Bonetti, Elisa Borsani, Francesca Bonomini · 2024 · Cells
- Comprehensive behavioral characterization and impaired hippocampal synaptic transmission in R1117X Shank3 mutant miceJingyao Gao, Shumin Wu, Jingxuan Yang, Tong Ye, Jie Yang, Wenhua Shen, Xingwang Chen, Li Huang, Ruiqi Pang, Ping Lin et al. · 2025 · Translational Psychiatry
- Kmt2c/Mll3 Haploinsufficiency Causes Autism-like Behavioral Deficits in MiceKaijie Ma, Maria Webb, Haniya Hayder, Luye Qin · 2025 · Biomolecules
- Early-life sleep disruption in Shank3-deficient rats: A preclinical model for autism-related sleep mechanisms and interventionsMei‐Hong Qiu, Zhi-Gang Zhong, Pei-wen Song, Gui‐Jin Tao, Jin-Tao Zhang, Yonghua Chen, Tian-Jia Song, Weimin Qu, Rong Zhang, Zhi‐Li Huang · 2026 · Translational Psychiatry
- ARP2/3 complex mediates the neuropathology of PTEN-deficient human neural cells downstream of mTORC1 and mTORC2 hyperactivationNavroop K. Dhaliwal, Octavia Yifang Weng, Ai Tian, Aditi Aggarwal, Mai Essam Ahmed, Guoria Sun, Afrin Bhattacharya, Wendy W. Y. Choi, Haruka Nishimura, Pragnya Chakraborty et al. · 2026 · Proceedings of the National Academy of Sciences
- Region-specific microglial alterations in the acoustic startle circuit in Shank3 miceXin Ren, Robbert Havekes, Martien J. Kas · 2026 · Biochemistry and Biophysics Reports
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- SynaptogenesisMargaret H. Hastings, James P. Gilbert, Yuda Huo, Heng‐Ye Man · 2023 · Springer eBooks
- NCBP2 modulates neurodevelopmental defects of the 3q29 deletion in Drosophila and X. laevis modelsMayanglambam Dhruba Singh, Matthew Jensen, Micaela C. Lasser, Emily Huber, Tanzeen Yusuff, Lucilla Pizzo, Brian Lifschutz, Inshya Desai, Alexis Kubina, Sneha Yennawar et al. · 2019 · bioRxiv (Cold Spring Harbor Laboratory)
- Conformational dynamics regulate SHANK3 actin and Rap1 bindingSiiri I. Salomaa, Mitro Miihkinen, Elena Kremneva, Ilkka Paatero, Johanna Lilja, Guillaume Jacquemet, Joni Vuorio, Lina Antenucci, Fatemeh Hassani Nia, Patrik Hollós et al. · 2020 · bioRxiv (Cold Spring Harbor Laboratory)
- Low-level Chlorpyrifos Exposure Affects Synaptic Plasticity in Hippocampal NeuronsWenjuan Zhou, Chen Zhang, Peipei Wang, Yuanying Deng, Hongmei Dai, XI Qiong, Jing Tian, Mengwen Zhao, Guojiao Wu, Lingling Zhao · 2021 · Research Square
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- Sensory abnormalities in autism spectrum disorder and their in vitro modelingTaeyeon Kim, Juwon Lee, Jiye Lee, Hannah Jo, Yohan Oh, Yong Jun Kim, Jinsoo Seo · 2025 · Translational Psychiatry
- Additional file 3 of Oxytocin ameliorates impaired social behavior in a Chd8 haploinsufficiency mouse model of autismЧерепанов Станислав Михайлович, Maria Gerasimenko, Teruko Yuhi, Kazumi Furuhara, Chiharu Tsuji, Yokoyama, Shigeru, Keiichi I. Nakayama, Masaaki Nishiyama, Haruhiro Higashida · 2021 · Figshare
- Additional file 2 of Oxytocin ameliorates impaired social behavior in a Chd8 haploinsufficiency mouse model of autismCherepanov, Stanislav M., Maria Gerasimenko, Teruko Yuhi, Kazumi Furuhara, Chiharu Tsuji, Yokoyama, Shigeru, Keiichi I. Nakayama, Masaaki Nishiyama, Haruhiro Higashida · 2021 · Figshare
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