Yan, Zhen

The stressed synapse: the impact of stress and glucocorticoids on glutamate transmission

Popoli, M., Yan, Z., McEwen, B. S., & Sanacora, G. (2012) · Nature Reviews Neuroscience

Stress Responses and CortisolNeuroscience and Neuropharmacology Research

Cited by 1,393

Repeated Stress Causes Cognitive Impairment by Suppressing Glutamate Receptor Expression and Function in Prefrontal Cortex

Yuen, E. Y., Wei, J., Liu, W., Zhong, P., Li, X., & Yan, Z. (2012) · Neuron

Neuroscience and Neuropharmacology ResearchStress Responses and Cortisol

Cited by 558

Acute stress enhances glutamatergic transmission in prefrontal cortex and facilitates working memory

Yuen, E. Y., Liu, W., Karatsoreos, I. N., Feng, J., McEwen, B. S., & Yan, Z. (2009) · Proceedings of the National Academy of Sciences

Neuroscience and Neuropharmacology ResearchStress Responses and Cortisol

Cited by 481

Disrupted-in-Schizophrenia 1 (DISC1) regulates spines of the glutamate synapse via Rac1

Hayashi-Takagi, A., Takaki, M., Graziane, N., Seshadri, S., Murdoch, H., Dunlop, A. J., Makino, Y., Seshadri, A. J., Ishizuka, K., Srivastava, D. P., et al. (2010) · Nature Neuroscience

Neuroscience and Neuropharmacology ResearchSchizophrenia research and treatment

Cited by 399

Mechanisms for acute stress-induced enhancement of glutamatergic transmission and working memory

Yuen, E. Y., Liu, W., Karatsoreos, I. N., Ren, Y., Feng, J., McEwen, B. S., & Yan, Z. (2011) · Molecular Psychiatry

Neuroscience and Neuropharmacology ResearchStress Responses and Cortisol

Cited by 324

Mechanisms of synaptic transmission dysregulation in the prefrontal cortex: pathophysiological implications

Yan, Z., & Rein, B. (2022) · Molecular Psychiatry

Neuroscience and Neuropharmacology ResearchNeurotransmitter Receptor Influence on Behavior

Cited by 300

Autism-like Deficits in Shank3-Deficient Mice Are Rescued by Targeting Actin Regulators

Duffney, L. J., Zhong, P., Wei, J., Matas, E., Cheng, J., Qin, L., Ma, K., Dietz, D. M., Kajiwara, Y., Buxbaum, J. D., et al. (2015) · Cell Reports

Genetics and Neurodevelopmental DisordersAutism Spectrum Disorder Research

Cited by 281

Parkin controls dopamine utilization in human midbrain dopaminergic neurons derived from induced pluripotent stem cells

Jiang, H., Ren, Y., Yuen, E. Y., Zhong, P., Ghaedi, M., Hu, Z., Azabdaftari, G., Nakaso, K., Yan, Z., & Feng, J. (2012) · Nature Communications

Parkinson's Disease Mechanisms and TreatmentsPluripotent Stem Cells Research

Cited by 254

Social deficits in Shank3-deficient mouse models of autism are rescued by histone deacetylase (HDAC) inhibition

Qin, L., Ma, K., Wang, Z.-J., Hu, Z., Matas, E., Wei, J., & Yan, Z. (2018) · Nature Neuroscience

Genetics and Neurodevelopmental DisordersAutism Spectrum Disorder Research

Cited by 240

Cellular and molecular basis for stress-induced depression

Seo, J.-S., Wei, J., Qin, L., Kim, Y., Yan, Z., & Greengard, P. (2017) · Molecular Psychiatry

Treatment of Major DepressionNeurotransmitter Receptor Influence on Behavior

Cited by 235

Serotonin Receptors Modulate GABAAReceptor Channels through Activation of Anchored Protein Kinase C in Prefrontal Cortical Neurons

Feng, J., Cai, X., Zhao, J., & Yan, Z. (2001) · The Journal of Neuroscience

Neuroscience and Neuropharmacology ResearchNeurotransmitter Receptor Influence on Behavior

Cited by 212

The stressed synapse 2.0: pathophysiological mechanisms in stress-related neuropsychiatric disorders

Sanacora, G., Yan, Z., & Popoli, M. (2022) · Nature Reviews Neuroscience

Stress Responses and CortisolNeuroscience and Neuropharmacology Research

Cited by 197

Inhibition of EHMT1/2 rescues synaptic and cognitive functions for Alzheimer’s disease

Zheng, Y., Liu, A., Wang, Z.-J., Cao, Q., Wang, W., Lin, L., Ma, K., Zhang, F., Wei, J., Matas, E., et al. (2019) · Brain

Alzheimer's disease research and treatmentsEpigenetics and DNA Methylation

Cited by 168

16p11.2 Copy Number Variations and Neurodevelopmental Disorders

Rein, B., & Yan, Z. (2020) · Trends in Neurosciences

Genomic variations and chromosomal abnormalitiesGenetics and Neurodevelopmental Disorders

Cited by 160

Regulation of NMDA Receptors by Dopamine D4Signaling in Prefrontal Cortex

Wang, X., Zhong, P., Gu, Z., & Yan, Z. (2003) · The Journal of Neuroscience

Neuroscience and Neuropharmacology ResearchNeurotransmitter Receptor Influence on Behavior

Cited by 159

Dopamine D4Receptors Modulate GABAergic Signaling in Pyramidal Neurons of Prefrontal Cortex

Wang, X., Zhong, P., & Yan, Z. (2002) · The Journal of Neuroscience

Neuroscience and Neuropharmacology ResearchNeurotransmitter Receptor Influence on Behavior

Cited by 155

Activation of 5-HT2A/C Receptors Counteracts 5-HT1A Regulation of N-Methyl-D-aspartate Receptor Channels in Pyramidal Neurons of Prefrontal Cortex

Yuen, E. Y., Jiang, Q., Chen, P., Feng, J., & Yan, Z. (2008) · Journal of Biological Chemistry

Neuroscience and Neuropharmacology ResearchNeurotransmitter Receptor Influence on Behavior

Cited by 125

Synaptic Actin Dysregulation, a Convergent Mechanism of Mental Disorders?

Yan, Z., Kim, E., Datta, D., Lewis, D. A., & Soderling, S. H. (2016) · The Journal of Neuroscience

Neuroscience and Neuropharmacology ResearchGenetics and Neurodevelopmental Disorders

Cited by 120

Shank3 Deficiency Induces NMDA Receptor Hypofunction via an Actin-Dependent Mechanism

Duffney, L. J., Wei, J., Cheng, J., Liu, W., Smith, K. R., Kittler, J. T., & Yan, Z. (2013) · The Journal of Neuroscience

Neuroscience and Neuropharmacology ResearchGenetics and Neurodevelopmental Disorders

Cited by 115

Corticotropin-Releasing Factor and Acute Stress Prolongs Serotonergic Regulation of GABA Transmission in Prefrontal Cortical Pyramidal Neurons

Tan, H., Zhong, P., & Yan, Z. (2004) · The Journal of Neuroscience

Stress Responses and CortisolNeuroscience and Neuropharmacology Research

Cited by 112

Targeting histone K4 trimethylation for treatment of cognitive and synaptic deficits in mouse models of Alzheimer’s disease

Cao, Q., Wang, W., Williams, J. B., Yang, F., Wang, Z.-J., & Yan, Z. (2020) · Science Advances

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 108

PAKs inhibitors ameliorate schizophrenia-associated dendritic spine deterioration in vitro and in vivo during late adolescence

Hayashi-Takagi, A., Araki, Y., Nakamura, M., Vollrath, B., Duron, S. G., Yan, Z., Kasai, H., Huganir, R. L., Campbell, D. A., & Sawa, A. (2014) · Proceedings of the National Academy of Sciences

Schizophrenia research and treatmentNeuroscience and Neuropharmacology Research

Cited by 101

Regulation of GABAergic Inhibition by Serotonin Signaling in Prefrontal Cortex: Molecular Mechanisms and Functional Implications

Yan, Z. (2002) · Molecular Neurobiology

Neuroscience and Neuropharmacology ResearchNeurotransmitter Receptor Influence on Behavior

Cited by 100

Activity‐dependent bidirectional regulation of GABAA receptor channels by the 5‐HT4 receptor‐mediated signalling in rat prefrontal cortical pyramidal neurons

Cai, X., Flores‐Hernandez, J., Feng, J., & Yan, Z. (2002) · The Journal of Physiology

Neuroscience and Neuropharmacology ResearchReceptor Mechanisms and Signaling

Cited by 97