Autism-like Deficits in Shank3-Deficient Mice Are Rescued by Targeting Actin Regulators
Open accessAbstract
Haploinsufficiency of the Shank3 gene, which encodes a scaffolding protein at glutamatergic synapses, is a highly prevalent and penetrant risk factor for autism. Using combined behavioral, electrophysiological, biochemical, imaging, and molecular approaches, we find that Shank3-deficient mice exhibit autism-like social deficits and repetitive behaviors, as well as the significantly diminished NMDA receptor (NMDAR) synaptic function and synaptic distribution in prefrontal cortex. Concomitantly, Shank3-deficient mice have a marked loss of cortical actin filaments, which is associated with the reduced Rac1/PAK activity and increased activity of cofilin, the major actin depolymerizing factor. The social deficits and NMDAR hypofunction are rescued by inhibiting cofilin or activating Rac1 in Shank3-deficient mice and are induced by inhibiting PAK or Rac1 in wild-type mice. These results indicate that the aberrant regulation of synaptic actin filaments and loss of synaptic NMDARs contribute to the manifestation of autism-like phenotypes. Thus, targeting actin regulators provides a strategy for autism treatment.
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Restoration of normal Rac1 activity or its downstream effectors corrects autism-like behaviors and synaptic abnormalities.
“Supporting this notion, restoration of normal activity of Rac1 or its downstream effectors was demonstrated as a successful approach for correcting autism-like behaviors and synaptic abnormalities 12–15.”
From Autism-like social deficit generated by Dock4 deficiency is rescued by restoration of Rac1 activity and NMDA receptor function. (2021) · cites this paper as [13]
Inhibiting cofilin or activating Rac1 rescues social deficits and NMDAR hypofunction in Shank3-deficient mice.
“Inhibiting cofilin or activating Rac1 rescues the social deficits and NMDAR hypofunction in Shank3-deficient mice 127”
From Mechanisms of synaptic transmission dysregulation in the prefrontal cortex: pathophysiological implications (2022) · cites this paper as [127]
The diminished NMDAR function in Shank3-deficient mice is caused by loss of actin filaments at glutamatergic synapses due to altered Rac1/PAK/cofilin signaling.
“In PFC pyramidal neurons of Shank3-deficient mice, NMDAR function and synaptic distribution are significantly diminished, which is caused by a marked loss of actin filaments at glutamatergic synapses due to the altered Rac1/PAK/cofilin signaling 127.”
From Mechanisms of synaptic transmission dysregulation in the prefrontal cortex: pathophysiological implications (2022) · cites this paper as [127]
In PFC pyramidal neurons of Shank3-deficient mice, NMDAR function and synaptic distribution are significantly diminished.
“In PFC pyramidal neurons of Shank3-deficient mice, NMDAR function and synaptic distribution are significantly diminished, which is caused by a marked loss of actin filaments at glutamatergic synapses due to the altered Rac1/PAK/cofilin signaling 127.”
From Mechanisms of synaptic transmission dysregulation in the prefrontal cortex: pathophysiological implications (2022) · cites this paper as [127]
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Cites
Rho GTPases and the Actin Cytoskeleton
Hall, A. (1998) · Science · doi:10.1126/science.279.5350.509 · Cited by 6,138 · see citing works
Strong association of de novo copy number mutations with autism
Sebat, J., Lakshmi, B., Malhotra, D., Troge, J., Lese-Martin, C., Walsh, T., Yamrom, B., Yoon, S., Krasnitz, A., Kendall, J., et al. (2007) · Science · doi:10.1126/science.1138659 · Cited by 2,795 · see citing works
Synaptic, transcriptional and chromatin genes disrupted in autism
Study, T. D., De Rubeis, S., Autism, H. M. C. F., UK10K Consortium, The Autism Sequencing Consortium, He, X., Goldberg, A. P., Poultney, C. S., Samocha, K., Ercument Cicek, A., et al. (2014) · Nature · doi:10.1038/nature13772 · Cited by 2,746 · see citing works
Self-citationTranscriptomic Analysis of Autistic Brain Reveals Convergent Molecular Pathology
Voineagu, I., Wang, X., Johnston, P., Lowe, J. K., Tian, Y., Horvath, S., Mill, J., Cantor, R. M., Blencowe, B. J., & Geschwind, D. H. (2011) · Nature · doi:10.1038/nature10110 · Cited by 1,874 · cited 6× · see citing works
“Juvenile male Shank3 +/ D C mice and age-matched wild-type mice were subject to the three-chamber social interaction assay (Wang et al., 2011; Won et al., 2012).”
InfluentialDe novo mutations in schizophrenia implicate synaptic networks
Fromer, M., Pocklington, A. J., Kavanagh, D. H., Williams, H. J., Dwyer, S., Gormley, P., Georgieva, L., Rees, E., Palta, P., Ruderfer, D. M., et al. (2014) · Nature · doi:10.1038/nature12929 · Cited by 1,617 · see citing works
Durand, C. M., Betancur, C., Boeckers, T. M., Bockmann, J., Chaste, P., Fauchereau, F., Nygren, G., Rastam, M., Gillberg, I. C., Anckarsäter, H., et al. (2007) · Nature Genetics · doi:10.1038/ng1933 · Cited by 1,602 · see citing works
Shank3 mutant mice display autistic-like behaviours and striatal dysfunction
Peça, J., Feliciano, C., Ting, J. T., Wang, W., Wells, M. F., Venkatraman, T. N., Lascola, C. D., Fu, Z., & Feng, G. (2011) · Nature · doi:10.1038/nature09965 · Cited by 1,570 · see citing works
Impairment of social and moral behavior related to early damage in human prefrontal cortex
Anderson, S. W., Bechara, A., Damasio, H., Tranel, D., & Damasio, A. R. (1999) · Nature Neuroscience · doi:10.1038/14833 · Cited by 1,539 · see citing works
Executive dysfunction in autism☆
Hill, E. L. (2004) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2003.11.003 · Cited by 1,468 · see citing works
Regulation of actin dynamics through phosphorylation of cofilin by LIM-kinase
Arber, S., Barbayannis, F. A., Hanser, H., Schneider, C., Stanyon, C. A., Bernard, O., & Caroni, P. (1998) · Nature · doi:10.1038/31729 · Cited by 1,426 · see citing works
Rho GTPases and actin dynamics in membrane protrusions and vesicle trafficking
Ridley, A. J. (2006) · Trends in Cell Biology · doi:10.1016/j.tcb.2006.08.006 · Cited by 1,180 · see citing works
Actin Binding Proteins: Regulation of Cytoskeletal Microfilaments
dos Remedios, C. G., Chhabra, D., Kekic, M., Dedova, I. V., Tsubakihara, M., Berry, D. A., & Nosworthy, N. J. (2003) · Physiological Reviews · doi:10.1152/physrev.00026.2002 · Cited by 1,058 · see citing works
Treatment of Ischemic Brain Damage by Perturbing NMDA Receptor- PSD-95 Protein Interactions
Aarts, M., Liu, Y., Liu, L.-D., Besshoh, S., Arundine, M., Gurd, J. W., Wang, Y.-T., Salter, M., & Tymianski, M. (2002) · Science · doi:10.1126/science.1072873 · Cited by 1,048 · see citing works
Proteins of the ADF/Cofilin Family: Essential Regulators of Actin Dynamics
Bamburg, J. R. (1999) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.15.1.185 · Cited by 1,015 · see citing works
Naisbitt, S., Kim, E., Tu, J. C., Xiao, B., Sala, C., Valtschanoff, J., Weinberg, R. J., Worley, P. F., & Sheng, M. (1999) · Neuron · doi:10.1016/s0896-6273(00)80809-0 · Cited by 1,009 · see citing works
Actin-based plasticity in dendritic spines
Matus, A. (2000) · Science · doi:10.1126/science.290.5492.754 · Cited by 815 · see citing works
Actin in dendritic spines: connecting dynamics to function
Hotulainen, P., & Hoogenraad, C. C. (2010) · Journal of Cell Biology · doi:10.1083/jcb.201003008 · Cited by 815 · see citing works
PAK Kinases Are Directly Coupled to the PIX Family of Nucleotide Exchange Factors
Manser, E. J., Loo, T.-H., Koh, C.-G., Zhao, Z.-S., Chen, X., Tan, L. H.-P., Tan, I., Leung, T., & Lim, L. (1998) · Molecular Cell · doi:10.1016/s1097-2765(00)80019-2 · Cited by 753 · see citing works
Patches of Disorganization in the Neocortex of Children with Autism
Stoner, R., Chow, M. L., Boyle, M. P., Sunkin, S. M., Mouton, P. R., Roy, S., Wynshaw-Boris, A., Colamarino, S. A., Lein, E. S., & Courchesne, E. (2014) · New England Journal of Medicine · doi:10.1056/nejmoa1307491 · Cited by 722 · see citing works
Regulation of Dendritic Spine Morphology and Synaptic Function by Shank and Homer
Sala, C., Piëch, V., Wilson, N. R., Passafaro, M., Liu, G., & Sheng, M. (2001) · Neuron · doi:10.1016/s0896-6273(01)00339-7 · Cited by 716 · see citing works
Gilman, S. R., Iossifov, I., Levy, D., Ronemus, M., Wigler, M., & Vitkup, D. (2011) · Neuron · doi:10.1016/j.neuron.2011.05.021 · Cited by 701 · see citing works
Autistic-like social behaviour in Shank2-mutant mice improved by restoring NMDA receptor function
Won, H., Lee, H.-R., Gee, H. Y., Mah, W., Kim, J.-I., Lee, J., Ha, S., Chung, C., Jung, E. S., Cho, Y. S., et al. (2012) · Nature · doi:10.1038/nature11208 · Cited by 695 · see citing works
Fukazawa, Y., Saitoh, Y., Ozawa, F., Ohta, Y., Mizuno, K., & Inokuchi, K. (2003) · Neuron · doi:10.1016/s0896-6273(03)00206-x · Cited by 695 · see citing works
Human p21-activated kinase (Pak1) regulates actin organization in mammalian cells
Sells, M. A., Knaus, U. G., Bagrodia, S., Ambrose, D., Bokoch, G., & Chernoff, J. (1997) · Current Biology · doi:10.1016/s0960-9822(97)70091-5 · Cited by 691 · see citing works
A peptide inhibitor of c-Jun N-terminal kinase protects against excitotoxicity and cerebral ischemia
Borsello, T., Clarke, P. G. H., Hirt, L., Vercelli, A., Repici, M., Schorderet, D. F., Bogousslavsky, J., & Bonny, C. (2003) · Nature Medicine · doi:10.1038/nm911 · Cited by 658 · see citing works
Competitive binding of α-actinin and calmodulin to the NMDA receptor
Wyszynski, M., Lin, J., Rao, A., Nigh, E., Beggs, A. H., Craig, A. M., & Sheng, M. (1997) · Nature · doi:10.1038/385439a0 · Cited by 596 · see citing works
Bozdagi, O., Sakurai, T., Papapetrou, D., Wang, X., Dickstein, D. L., Takahashi, N., Kajiwara, Y., Yang, M., Katz, A. M., Scattoni, M. L., et al. (2010) · Molecular Autism · doi:10.1186/2040-2392-1-15 · Cited by 584 · see citing works
Self-citationThe Shank family of scaffold proteins
Sheng, M., & Kim, E. (2000) · Journal of Cell Science · doi:10.1242/jcs.113.11.1851 · Cited by 578 · see citing works
Yuen, E. Y., Wei, J., Liu, W., Zhong, P., Li, X., & Yan, Z. (2012) · Neuron · doi:10.1016/j.neuron.2011.12.033 · Cited by 558 · see citing works
Self-citationAllison, D. W., Gelfand, V. I., Spector, I., & Craig, A. M. (1998) · The Journal of Neuroscience · doi:10.1523/jneurosci.18-07-02423.1998 · Cited by 556 · see citing works
Synaptic dysfunction and abnormal behaviors in mice lacking major isoforms of Shank3
Wang, X., McCoy, P. A., Rodriguiz, R. M., Pan, Y., Je, H. S., Roberts, A. C., Kim, C. J., Berrios, J., Colvin, J. S., Bousquet-Moore, D., et al. (2011) · Human Molecular Genetics · doi:10.1093/hmg/ddr212 · Cited by 537 · see citing works
Calcium-induced actin depolymerization reduces NMDA channel activity
Rosenmund, C., & Westbrook, G. L. (1993) · Neuron · doi:10.1016/0896-6273(93)90197-y · Cited by 503 · see citing works
Dendritic asymmetry cannot account for directional responses of neurons in visual cortex
Anderson, J. C., Binzegger, T., Kahana, O., Martin, K. A. C., & Segev, I. (1999) · Nature Neuroscience · doi:10.1038/12194 · Cited by 494 · see citing works
Regulation of Dendritic Growth and Remodeling by Rho, Rac, and Cdc42
Threadgill, R., Bobb, K., & Ghosh, A. (1997) · Neuron · doi:10.1016/s0896-6273(00)80376-1 · Cited by 492 · see citing works
Modeling Autism by SHANK Gene Mutations in Mice
Jiang, Y.-H., & Ehlers, M. D. (2013) · Neuron · doi:10.1016/j.neuron.2013.03.016 · Cited by 488 · see citing works
PAK3 mutation in nonsyndromic X-linked mental retardation
Allen, K. M., Gleeson, J. G., Bagrodia, S., Partington, M. W., MacMillan, J., Cerione, R. A., Mulley, J. C., & Walsh, C. A. (1998) · Nature Genetics · doi:10.1038/1675 · Cited by 470 · see citing works
Rho proteins, mental retardation and the cellular basis of cognition
Ramakers, G. J. A. (2002) · Trends in Neurosciences · doi:10.1016/s0166-2236(00)02118-4 · Cited by 374 · see citing works
The postsynaptic density proteins Homer and Shank form a polymeric network structure
Hayashi, M. K., Tang, C., Verpelli, C., Narayanan, R., Stearns, M. H., Xu, R.-M., Li, H., Sala, C., & Hayashi, Y. (2009) · Cell · doi:10.1016/j.cell.2009.01.050 · Cited by 356 · see citing works
SHANK3 overexpression causes manic-like behaviour with unique pharmacogenetic properties
Han, K., Holder, J. L., Schaaf, C. P., Lu, H., Chen, H., Kang, H., Tang, J., Wu, Z., Hao, S., Cheung, S. W., et al. (2013) · Nature · doi:10.1038/nature12630 · Cited by 351 · see citing works
Epigenetic regulation of RAC1 induces synaptic remodeling in stress disorders and depression
Golden, S. A., Christoffel, D. J., Heshmati, M., Hodes, G. E., Magida, J., Davis, K., Cahill, M. E., Dias, C., Ribeiro, E., Ables, J. L., et al. (2013) · Nature Medicine · doi:10.1038/nm.3090 · Cited by 322 · see citing works
Durand, C. M., Perroy, J., Loll, F., Perrais, D., Fagni, L., Bourgeron, T., Montcouquiol, M., & Sans, N. (2012) · Molecular Psychiatry · doi:10.1038/mp.2011.57 · Cited by 316 · see citing works
Bonaglia, M. C., Giorda, R., Borgatti, R., Felisari, G., Gagliardi, C., Selicorni, A., & Zuffardi, O. (2001) · The American Journal of Human Genetics · doi:10.1086/321293 · Cited by 309 · see citing works
Kouser, M., Speed, H. E., Dewey, C. M., Reimers, J. M., Widman, A. J., Gupta, N., Liu, S., Jaramillo, T. C., Bangash, M. A., Xiao, B., et al. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.3017-13.2013 · Cited by 283 · see citing works
Hayashi, M. L., Choi, S.-Y., Rao, B. S. S., Jung, H.-Y., Lee, H.-K., Zhang, D., Chattarji, S., Kirkwood, A., & Tonegawa, S. (2004) · Neuron · doi:10.1016/j.neuron.2004.05.003 · Cited by 280 · see citing works
Development and Regulation of Dendritic Spine Synapses
Calabrese, B., Wilson, M. S., & Halpain, S. (2006) · Physiology · doi:10.1152/physiol.00042.2005 · Cited by 267 · see citing works
Frost, N. A., Shroff, H., Kong, H., Betzig, E., & Blanpied, T. A. (2010) · Neuron · doi:10.1016/j.neuron.2010.05.026 · Cited by 263 · see citing works
Targeting and activation of Rac1 are mediated by the exchange factor β-Pix
ten Klooster, J. P., Jaffer, Z. M., Chernoff, J., & Hordijk, P. L. (2006) · The Journal of Cell Biology · doi:10.1083/jcb.200509096 · Cited by 250 · see citing works
Rocca, D. L., Martin, S., Jenkins, E. L., & Hanley, J. (2008) · Nature Cell Biology · doi:10.1038/ncb1688 · Cited by 228 · see citing works
Betancur, C., & Buxbaum, J. D. (2013) · Molecular Autism · doi:10.1186/2040-2392-4-17 · Cited by 189 · see citing works
Self-citationDistinct triggering and expression mechanisms underlie LTD of AMPA and NMDA synaptic responses
Morishita, W., Marie, H., & Malenka, R. C. (2005) · Nature Neuroscience · doi:10.1038/nn1506 · Cited by 188 · see citing works
Rac1 is essential in cocaine-induced structural plasticity of nucleus accumbens neurons
Dietz, D., Sun, H., Lobo, M. K., Cahill, M. E., Chadwick, B. J., Gao, V., Koo, J. W., Mazei‐Robison, M. S., Dias, C., Maze, I. S., et al. (2012) · Nature Neuroscience · doi:10.1038/nn.3094 · Cited by 181 · see citing works
Self-citationPark, E., Na, M., Choi, J., Kim, S., Lee, J.-R., Yoon, J., Park, D., Sheng, M., & Kim, E. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m301052200 · Cited by 175 · see citing works
Shank3 Deficiency Induces NMDA Receptor Hypofunction via an Actin-Dependent Mechanism
Duffney, L. J., Wei, J., Cheng, J., Liu, W., Smith, K. R., Kittler, J. T., & Yan, Z. (2013) · The Journal of Neuroscience · doi:10.1523/jneurosci.1175-13.2013 · Cited by 115 · see citing works
Self-citationGlutamate receptor dysfunction and drug targets across models of autism spectrum disorders
Carlson, G. C. (2012) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2011.02.003 · Cited by 102 · see citing works
Synapse structure: glutamate receptors connected by the shanks
Ehlers, M. D. (1999) · Current Biology · doi:10.1016/s0960-9822(00)80043-3 · Cited by 93 · see citing works
Yuen, E. Y., Liu, W., Kafri, T., van Praag, H., & Yan, Z. (2010) · The Journal of Physiology · doi:10.1113/jphysiol.2009.186353 · Cited by 54 · see citing works
Self-citationLow dose MK-801 reduces social investigation in mice
Zou, H., ZHANG, C., XIE, Q., ZHANG, M., SHI, J., JIN, M., & Yu, L. (2008) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2008.06.002 · Cited by 36 · see citing works
Interfering with Ras Signaling Using Membrane-Permeable Peptides or Drugs
Maruta, H., He, H. Z., & Nheu, T. V. (2003) · Humana Press eBooks · doi:10.1385/1-59259-281-3:075 · Cited by 16 · see citing works
Flagged first, then by citations
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Advancing the understanding of autism disease mechanisms through genetics
de la Torre-Ubieta, L., Won, H., Stein, J. L., & Geschwind, D. H. (2016) · Nature Medicine · doi:10.1038/nm.4071 · Cited by 827 · see citing works
SHANK proteins: roles at the synapse and in autism spectrum disorder
Monteiro, P., & Feng, G. (2017) · Nature Reviews Neuroscience · doi:10.1038/nrn.2016.183 · Cited by 681 · see citing works
Autism spectrum disorder: neuropathology and animal models
Varghese, M., Keshav, N., Jacot-Descombes, S., Warda, T., Wicinski, B., Dickstein, D. L., Harony-Nicolas, H., De Rubeis, S., Drapeau, E., Buxbaum, J. D., et al. (2017) · Acta Neuropathologica · doi:10.1007/s00401-017-1736-4 · Cited by 536 · see citing works
Self-citationExcitation/Inhibition Imbalance in Animal Models of Autism Spectrum Disorders
Lee, E., Lee, J., & Kim, E. (2017) · Biological Psychiatry · doi:10.1016/j.biopsych.2016.05.011 · Cited by 468 · see citing works
Prefrontal Cortex and Social Cognition in Mouse and Man
Bicks, L. K., Koike, H., Akbarian, S., & Morishita, H. (2015) · Frontiers in Psychology · doi:10.3389/fpsyg.2015.01805 · Cited by 491 · see citing works
Sex differences in autism spectrum disorder: a review
Ferri, S. L., Abel, T., & Brodkin, E. S. (2018) · Current Psychiatry Reports · doi:10.1007/s11920-018-0874-2 · Cited by 392 · see citing works
Marmosets: A Neuroscientific Model of Human Social Behavior
Miller, C. T., Freiwald, W. A., Leopold, D. A., Mitchell, J. F., Silva, A. C., & Wang, X. (2016) · Neuron · doi:10.1016/j.neuron.2016.03.018 · Cited by 329 · see citing works
A synaptic perspective of fragile X syndrome and autism spectrum Disorders.
Bagni, C., & Zukin, R. S. (2019) · Neuron · doi:10.1016/j.neuron.2019.02.041 · Cited by 326 · see citing works
Wang, X., Bey, A. L., Katz, B. M., Badea, A., Kim, N., David, L. K., Duffney, L. J., Kumar, S., Mague, S. D., Hulbert, S. W., et al. (2016) · Nature Communications · doi:10.1038/ncomms11459 · Cited by 318 · see citing works
Self-citationYan, Z., & Rein, B. (2022) · Molecular Psychiatry · doi:10.1038/s41380-021-01092-3 · Cited by 300 · see citing works
Self-citationSignalling pathways in autism spectrum disorder: mechanisms and therapeutic implications
Jiang, C.-C., Lin, L., Long, S., Ke, X., Fukunaga, K., Lu, Y., & Han, F. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-01081-0 · Cited by 272 · see citing works
Qin, L., Ma, K., Wang, Z.-J., Hu, Z., Matas, E., Wei, J., & Yan, Z. (2018) · Nature Neuroscience · doi:10.1038/s41593-018-0110-8 · Cited by 240 · see citing works
Self-citationWang, X., Wang, B., Wu, C., Wang, J., & Sun, M. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24031819 · Cited by 274 · see citing works
A standardized social preference protocol for measuring social deficits in mouse models of autism
Rein, B. A., Ma, K., & Yan, Z. (2020) · Nature Protocols · doi:10.1038/s41596-020-0382-9 · Cited by 238 · see citing works
Self-citationCellular and molecular basis for stress-induced depression
Seo, J.-S., Wei, J., Qin, L., Kim, Y., Yan, Z., & Greengard, P. (2017) · Molecular Psychiatry · doi:10.1038/mp.2016.118 · Cited by 235 · see citing works
Self-citationStriatopallidal dysfunction underlies repetitive behavior in Shank3-deficient model of autism
Wang, W., Li, C., Chen, Q., van der Goes, M.-S. H., Hawrot, J., Yao, A. Y., Gao, X., Lu, C., Zang, Y., Zhang, Q., et al. (2017) · Journal of Clinical Investigation · doi:10.1172/jci87997 · Cited by 177 · see citing works
Borovac, J., Bosch, M., & Okamoto, K. (2018) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2018.07.001 · Cited by 180 · see citing works
Inhibition of EHMT1/2 rescues synaptic and cognitive functions for Alzheimer’s disease
Zheng, Y., Liu, A., Wang, Z.-J., Cao, Q., Wang, W., Lin, L., Ma, K., Zhang, F., Wei, J., Matas, E., et al. (2019) · Brain · doi:10.1093/brain/awy354 · Cited by 168 · see citing works
Self-citationDhamne, S. C., Silverman, J. L., Super, C. E., Lammers, S. H. T., Hameed, M. Q., Modi, M. E., Copping, N. A., Pride, M. C., Smith, D. G., Rotenberg, A., et al. (2017) · Molecular Autism · doi:10.1186/s13229-017-0142-z · Cited by 166 · see citing works
Enhanced Neuronal Activity in the Medial Prefrontal Cortex during Social Approach Behavior
Lee, E., Rhim, I., Lee, J. W., Ghim, J.-W., Lee, S., Kim, E., & Jung, M. W. (2016) · Journal of Neuroscience · doi:10.1523/jneurosci.0307-16.2016 · Cited by 170 · see citing works
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Liang, B., Zhang, L., Barbera, G., Fang, W., Zhang, J., Chen, X., Chen, R., Li, Y., & Lin, D. (2018) · Neuron · doi:10.1016/j.neuron.2018.08.043 · Cited by 170 · see citing works
CLK2 inhibition ameliorates autistic features associated with SHANK3 deficiency
Bidinosti, M., Botta, P., Krüttner, S., Proenca, C. C., Stoehr, N., Bernhard, M., Fruh, I., Mueller, M., Bonenfant, D., Voshol, H., et al. (2016) · Science · doi:10.1126/science.aad5487 · Cited by 151 · see citing works
Pharmacological enhancement of mGlu5 receptors rescues behavioral deficits in SHANK3 knock-out mice
Vicidomini, C., Ponzoni, L., Lim, D., Schmeißer, M. J., Reim, D., Morello, N., Orellana, D. I., Tozzi, A., Durante, V., Scalmani, P., et al. (2016) · Molecular Psychiatry · doi:10.1038/mp.2016.30 · Cited by 141 · see citing works
Santos, S., Ferreira, H., Martins, J., Gonçalves, J., & Castelo-Branco, M. S. (2022) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2022.104577 · Cited by 141 · see citing works
Choi, J., Lee, S., Won, J., Jin, Y., Hong, Y., Hur, T.-Y., Kim, J.-H., Lee, S.-R., & Hong, Y. (2018) · PLOS ONE · doi:10.1371/journal.pone.0192925 · Cited by 139 · see citing works
Xu, X., Li, C., Gao, X., Xia, K., Guo, H., Li, Y., Hao, Z., Zhang, L., Gao, D., Xu, C., et al. (2017) · Cell Research · doi:10.1038/cr.2017.132 · Cited by 131 · see citing works
SHANK proteins limit integrin activation by directly interacting with Rap1 and R-Ras
Lilja, J., Zacharchenko, T., Γεωργιάδου, Μ., Jacquemet, G., Franceschi, N. D., Peuhu, E., Hamidi, H., Pouwels, J., Martens, V., Nia, F. H., et al. (2017) · Nature Cell Biology · doi:10.1038/ncb3487 · Cited by 125 · see citing works
Deletion of Autism Risk Gene Shank3 Disrupts Prefrontal Connectivity
Pagani, M., Bertero, A., Liska, A., Galbusera, A., Sabbioni, M., Barsotti, N., Colenbier, N., Marinazzo, D., Scattoni, M. L., Pasqualetti, M., et al. (2019) · The Journal of Neuroscience · doi:10.1523/jneurosci.2529-18.2019 · Cited by 111 · see citing works
Autism-Associated Shank3 Is Essential for Homeostatic Compensation in Rodent V1
Tatavarty, V., Pacheco, A. T., Kuhnle, C. G., Lin, H. K., Koundinya, P., Miska, N. J., Hengen, K. B., Wagner, F. F., Hooser, S. D. V., & Turrigiano, G. G. (2020) · Neuron · doi:10.1016/j.neuron.2020.02.033 · Cited by 122 · see citing works
Synaptic Actin Dysregulation, a Convergent Mechanism of Mental Disorders?
Yan, Z., Kim, E., Datta, D., Lewis, D. A., & Soderling, S. H. (2016) · The Journal of Neuroscience · doi:10.1523/jneurosci.2360-16.2016 · Cited by 120 · see citing works
Self-citationBey, A. L., Wang, X., Yan, H., Kim, N., Passman, R. L., Yang, Y., Cao, X., Towers, A. J., Hulbert, S. W., Duffney, L. J., et al. (2018) · Translational Psychiatry · doi:10.1038/s41398-018-0142-6 · Cited by 113 · see citing works
Self-citationAn autism spectrum disorder-related de novo mutation hotspot discovered in the GEF1 domain of Trio
Sadybekov, A., Tian, C., Arnesano, C., Katritch, V., & Herring, B. E. (2017) · Nature Communications · doi:10.1038/s41467-017-00472-0 · Cited by 111 · see citing works
Kathuria, A., Nowosiad, P., Jagasia, R., Aigner, S., Taylor, R. D., Andreae, L. C., Gatford, N. J. F., Lucchesi, W., Srivastava, D. P., & Price, J. (2017) · Molecular Psychiatry · doi:10.1038/mp.2017.185 · Cited by 114 · see citing works
Cao, Q., Wang, W., Williams, J. B., Yang, F., Wang, Z.-J., & Yan, Z. (2020) · Science Advances · doi:10.1126/sciadv.abc8096 · Cited by 108 · see citing works
Self-citationDrapeau, E., Riad, M., Kajiwara, Y., & Buxbaum, J. D. (2018) · eNeuro · doi:10.1523/eneuro.0046-18.2018 · Cited by 104 · see citing works
Self-citationThe Cerebellar Involvement in Autism Spectrum Disorders: From the Social Brain to Mouse Models
Mapelli, L., Soda, T., D'Angelo, E. U., & Prestori, F. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23073894 · Cited by 103 · see citing works
Guo, D., Peng, Y., Wang, L., Sun, X., Wang, X., Liang, C., Yang, X., Li, S., Xu, J., Ye, W.-C., et al. (2021) · Molecular Psychiatry · doi:10.1038/s41380-019-0472-7 · Cited by 102 · see citing works
PAK2 Haploinsufficiency Results in Synaptic Cytoskeleton Impairment and Autism-Related Behavior
Wang, Y., Zeng, C., Li, J., Zhou, Z., Ju, X., Xia, S., Li, Y., Liu, A., Teng, H., Zhang, K., et al. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.07.061 · Cited by 96 · see citing works
The role of interneurons in autism and Tourette Syndrome
Rapanelli, M., Frick, L. R., & Pittenger, C. (2017) · Trends in Neurosciences · doi:10.1016/j.tins.2017.05.004 · Cited by 93 · see citing works
A Subset of Autism-Associated Genes Regulate the Structural Stability of Neurons
Lin, Y., Frei, J. A., Kilander, M. B. C., Shen, W., & Blatt, G. J. (2016) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2016.00263 · Cited by 91 · see citing works
Delling, J. P., & Boeckers, T. M. (2021) · Journal of Neurodevelopmental Disorders · doi:10.1186/s11689-021-09397-8 · Cited by 96 · see citing works
Kabir, Z. D., Che, A., Fischer, D. K., Rice, R. C., Rizzo, B. K., Byrne, M., Glass, M. J., García, N. V. D. M., & Rajadhyaksha, A. M. (2017) · Molecular Psychiatry · doi:10.1038/mp.2017.124 · Cited by 86 · see citing works
Wang, Z.-J., Zhong, P., Ma, K., Seo, J.-S., Yang, F., Hu, Z., Zhang, F., Lin, L., Wang, J., Liu, T., et al. (2020) · Molecular Psychiatry · doi:10.1038/s41380-019-0351-2 · Cited by 82 · see citing works
Self-citationHolder, J. L., & Quach, M. M. (2016) · Epilepsia · doi:10.1111/epi.13506 · Cited by 78 · see citing works
Copping, N. A., Berg, E. L., Foley, G. M., Schaffler, M. D., Onaga, B., Buscher, N., Silverman, J. L., & Yang, M. (2016) · Neuroscience · doi:10.1016/j.neuroscience.2016.05.016 · Cited by 73 · see citing works
Monogenic mouse models of autism spectrum disorders: Common mechanisms and missing links
Hulbert, S. W., & Jiang, Y. (2015) · Neuroscience · doi:10.1016/j.neuroscience.2015.12.040 · Cited by 72 · see citing works
Wang, W., Rein, B., Zhang, F., Tan, T., Zhong, P., Qin, L., & Yan, Z. (2018) · The Journal of Neuroscience · doi:10.1523/jneurosci.0149-18.2018 · Cited by 74 · see citing works
Self-citationRapanelli, M., Tan, T., Wang, W., Wang, X., Wang, Z.-J., Zhong, P., Frick, L., Qin, L., Ma, K., Qu, J., et al. (2021) · Molecular Psychiatry · doi:10.1038/s41380-019-0498-x · Cited by 74 · see citing works
Self-citationCheng, J., Liu, A., Shi, M. Y., & Yan, Z. (2017) · Neuropsychopharmacology · doi:10.1038/npp.2017.30 · Cited by 73 · see citing works
Self-citationChung, C., Ha, S., Kang, H., Lee, J., Um, S. M., Yan, H., Yoo, Y.-E., Yoo, T., Jung, H., Lee, D., et al. (2018) · Biological Psychiatry · doi:10.1016/j.biopsych.2018.09.025 · Cited by 73 · see citing works
Self-citationAutism-associated SHANK3 mutations impair maturation of neuromuscular junctions and striated muscles
Lutz, A.-K., Pfaender, S., Incearap, B., Ioannidis, V., Ottonelli, I., Föhr, K. J., Cammerer, J., Zoller, M., Higelin, J., Giona, F., et al. (2020) · Science Translational Medicine · doi:10.1126/scitranslmed.aaz3267 · Cited by 73 · see citing works
Ma, K., Qin, L., Matas, E., Duffney, L. J., Liu, A., & Yan, Z. (2018) · Neuropsychopharmacology · doi:10.1038/s41386-018-0073-1 · Cited by 71 · see citing works
Self-citationThe Role of ADF/Cofilin in Synaptic Physiology and Alzheimer’s Disease
Zablah, Y. B., Merovitch, N., & Jia, Z. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.594998 · Cited by 69 · see citing works
Rho Signaling in Synaptic Plasticity, Memory, and Brain Disorders
Zhang, H., Zablah, Y. B., Zhang, H., & Jia, Z. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.729076 · Cited by 69 · see citing works
Mohapatra, A. N., & Wagner, S. (2023) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2023.1205199 · Cited by 67 · see citing works
Jing, W., Zhong, P., Qin, L., Tan, T., & Yan, Z. (2017) · Cerebral Cortex · doi:10.1093/cercor/bhx104 · Cited by 66 · see citing works
Self-citationDendritic spine actin cytoskeleton in autism spectrum disorder
Joensuu, M., Lanoue, V., & Hotulainen, P. (2018) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2017.08.023 · Cited by 65 · see citing works
Fan, C., Song, Q., Wang, P., Li, Y., Yang, M., Liu, B., & Yu, S. Y. (2018) · Neuroscience · doi:10.1016/j.neuroscience.2018.09.028 · Cited by 65 · see citing works
An autism-linked missense mutation in SHANK3 reveals the modularity of Shank3 function
Wang, L., Pang, K., Han, K., Adamski, C. J., Wang, W., He, L.-J., Lai, J. K. H., Bondar, V. V., Duman, J. G., Richman, R., et al. (2019) · Molecular Psychiatry · doi:10.1038/s41380-018-0324-x · Cited by 65 · see citing works
Shank3 Is Part of a Zinc-Sensitive Signaling System That Regulates Excitatory Synaptic Strength
Arons, M. H., Lee, K. C., Thynne, C. J., Kim, S. A., Schob, C., Kindler, S., Montgomery, J. M., & Garner, C. C. (2016) · Journal of Neuroscience · doi:10.1523/jneurosci.0116-16.2016 · Cited by 67 · see citing works
Song, T.-J., Lan, X.-Y., Wei, M., Zhai, F.-J., Boeckers, T. M., Wang, J., Yuan, S., Jin, M.-Y., Xie, Y., Dang, W.-W., et al. (2019) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2019.00111 · Cited by 64 · see citing works
Qin, L., Williams, J. B., Tan, T., Liu, T., Cao, Q., Ma, K., & Yan, Z. (2021) · Nature Communications · doi:10.1038/s41467-021-26972-8 · Cited by 62 · see citing works
Self-citationWhat we can learn from a genetic rodent model about autism
Möhrle, D., Fernández, M. C., Peñagarikano, O., Frick, A., Allman, B. L., & Schmid, S. (2019) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2019.12.015 · Cited by 59 · see citing works
Multisensory cortical processing and dysfunction across the neuropsychiatric spectrum
Hornix, B., Havekes, R., & Kas, M. J. (2018) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2018.02.010 · Cited by 60 · see citing works
MacGillavry, H. D., Kerr, J. M., Kassner, J. D., Frost, N. A., & Blanpied, T. A. (2015) · European Journal of Neuroscience · doi:10.1111/ejn.13129 · Cited by 60 · see citing works
Major motor and gait deficits with sexual dimorphism in a Shank3 mutant mouse model
Matas, E., Maïsterrena, A., Thabault, M., Balado, É., Francheteau, M., Balbous, A., Galvan, L., & Jaber, M. (2021) · Molecular Autism · doi:10.1186/s13229-020-00412-8 · Cited by 58 · see citing works
Self-citationDong, T., He, J., Wang, S., Wang, L., Cheng, Y., & Zhong, Y. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1602152113 · Cited by 60 · see citing works
LIM-Kinases in Synaptic Plasticity, Memory, and Brain Diseases
Zablah, Y. B., Zhang, H., Gugustea, R., & Jia, Z. (2021) · Cells · doi:10.3390/cells10082079 · Cited by 56 · see citing works
Halbedl, S., Schoen, M., Feiler, M. S., Boeckers, T. M., & Schmeißer, M. J. (2016) · Journal of Neurochemistry · doi:10.1111/jnc.13523 · Cited by 55 · see citing works
Cope, E. C., Briones, B. A., Brockett, A. T., Martinez, S., Vigneron, P.-A., Opendak, M. M., Wang, S. S. ‐., & Gould, E. (2016) · eNeuro · doi:10.1523/eneuro.0196-16.2016 · Cited by 52 · see citing works
Qin, L., Ma, K., & Yan, Z. (2019) · iScience · doi:10.1016/j.isci.2019.06.014 · Cited by 51 · see citing works
Self-citationWurz, A. I., Schulz, A. M., O’Bryant, C. T., Sharp, J. F., & Hughes, R. M. (2022) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2022.982074 · Cited by 53 · see citing works
Oxytocin as a Modulator of Synaptic Plasticity: Implications for Neurodevelopmental Disorders
Rajamani, K. T., Wagner, S., Grinevich, V., & Harony-Nicolas, H. (2018) · Frontiers in Synaptic Neuroscience · doi:10.3389/fnsyn.2018.00017 · Cited by 53 · see citing works
Shaw, A. E., & Bamburg, J. R. (2017) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2017.02.031 · Cited by 50 · see citing works
Lo, L. H.-Y., Dong, R., Lyu, Q., & Lai, K. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.107744 · Cited by 49 · see citing works
Resolving the Synaptic versus Developmental Dichotomy of Autism Risk Genes
Heavner, W. E., & Smith, S. E. P. (2020) · Trends in Neurosciences · doi:10.1016/j.tins.2020.01.009 · Cited by 48 · see citing works
Wang, Z., Rein, B. A., Zhong, P., Williams, J. B., Cao, Q., Yang, F., Zhang, F., Ma, K., & Yan, Z. (2021) · Neuropsychopharmacology · doi:10.1038/s41386-021-01029-y · Cited by 51 · see citing works
Self-citationActin-Dependent Alterations of Dendritic Spine Morphology in Shankopathies
Sarowar, T., & Grabrucker, A. M. (2016) · Neural Plasticity · doi:10.1155/2016/8051861 · Cited by 46 · see citing works
Singh, M. D., Jensen, M., Lasser, M. C., Huber, E., Yusuff, T., Pizzo, L., Lifschutz, B., Desai, I., Kubina, A., Yennawar, S., et al. (2020) · PLoS Genetics · doi:10.1371/journal.pgen.1008590 · Cited by 45 · see citing works
Evaluating the Potential Use of Serotonergic Psychedelics in Autism Spectrum Disorder
Markopoulos, A., Inserra, A., De Gregorio, D., & Gobbi, G. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.749068 · Cited by 46 · see citing works
Actin(g) on mitochondria – a role for cofilin1 in neuronal cell death pathways
Hoffmann, L., Rust, M. B., & Culmsee, C. (2019) · Biological Chemistry · doi:10.1515/hsz-2019-0120 · Cited by 45 · see citing works
Cofilin1 oxidation links oxidative distress to mitochondrial demise and neuronal cell death
Hoffmann, L., Waclawczyk, M. S., Tang, S., Hanschmann, E.-M., Gellert, M., Rust, M. B., & Culmsee, C. (2021) · Cell Death and Disease · doi:10.1038/s41419-021-04242-1 · Cited by 45 · see citing works
The Synapse as a Central Target for Neurodevelopmental Susceptibility to Pesticides
Vester, A. I., & Caudle, W. M. (2016) · Toxics · doi:10.3390/toxics4030018 · Cited by 43 · see citing works
Taylor, S. C., Ferri, S. L., Grewal, M., Smernoff, Z., Bućan, M., Weiner, J. A., Abel, T. G., & Brodkin, E. S. (2020) · Biological Psychiatry · doi:10.1016/j.biopsych.2020.02.012 · Cited by 43 · see citing works
de Chaumont, F., Lemière, N., Coqueran, S., Bourgeron, T., & Ey, E. (2021) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2021.735920 · Cited by 43 · see citing works
Scala, M., Nishikawa, M., Nagata, K., & Striano, P. (2021) · Cells · doi:10.3390/cells10123395 · Cited by 43 · see citing works
Tian, C., Paskus, J. D., Fingleton, E., Roche, K. W., & Herring, B. E. (2021) · Journal of Neuroscience · doi:10.1523/jneurosci.3148-20.2021 · Cited by 37 · see citing works
Home-cage hypoactivity in mouse genetic models of autism spectrum disorder
Angelakos, C. C., Tudor, J. C., Ferri, S. L., Jongens, T. A., & Abel, T. G. (2019) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2019.02.010 · Cited by 42 · see citing works
Yoo, Y.-E., Yoo, T., Lee, S., Lee, J., Kim, D., Han, H.-M., Bae, Y.-C., & Kim, E. (2019) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2019.00155 · Cited by 41 · see citing works
Targeting histone demethylase LSD1 for treatment of deficits in autism mouse models
Rapanelli, M., Williams, J. B., Ma, K., Yang, F., Zhong, P., Patel, R., Kumar, M., Qin, L., Rein, B. A., Wang, Z., et al. (2022) · Molecular Psychiatry · doi:10.1038/s41380-022-01508-8 · Cited by 42 · see citing works
Self-citationAltered synaptic ultrastructure in the prefrontal cortex of Shank3-deficient rats
Jacot-Descombes, S., Keshav, N. U., Dickstein, D. L., Wicinski, B., Janssen, W. G. M., Hiester, L. L., Sarfo, E. K., Warda, T., Fam, M. M., Harony-Nicolas, H., et al. (2020) · Molecular Autism · doi:10.1186/s13229-020-00393-8 · Cited by 41 · see citing works
Self-citationNGL-2 Deletion Leads to Autistic-like Behaviors Responsive to NMDAR Modulation
Um, S. M., Ha, S., Lee, H., Kim, J., Kim, K., Shin, W., Cho, Y. S., Roh, J. D., Kang, J., Yoo, T., et al. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.05.087 · Cited by 40 · see citing works
Jin, C., Kang, H., Ryu, J. R., Kim, S., Zhang, Y., Lee, Y., Kim, Y., & Han, K. (2018) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2018.00250 · Cited by 41 · see citing works
Yoo, T., Cho, H., Park, H., Lee, J., & Kim, E. (2019) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2019.00458 · Cited by 41 · see citing works
Moutin, E., Sakkaki, S., Compan, V., Bouquier, N., Giona, F., Areias, J., Goyet, E., Hemonnot-Girard, A.-L., Seube, V., Glasson, B., et al. (2021) · Molecular Psychiatry · doi:10.1038/s41380-021-01230-x · Cited by 41 · see citing works
Liaci, C., Camera, M., Caslini, G., Rando, S., Contino, S., Romano, V., & Merlo, G. R. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22116167 · Cited by 39 · see citing works
Hypothesis‐driven investigations of diverse pharmacological targets in two mouse models of autism
Rhine, M. A., Parrott, J. M., Schultz, M. N., Kazdoba, T. M., & Crawley, J. N. (2019) · Autism Research · doi:10.1002/aur.2066 · Cited by 40 · see citing works
Shankopathies in the Developing Brain in Autism Spectrum Disorders
Vyas, Y., Cheyne, J. E., Lee, K., Jung, Y., Cheung, P. Y., & Montgomery, J. M. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.775431 · Cited by 42 · see citing works
Qin, L., Ma, K., & Yan, Z. (2021) · Neuropsychopharmacology · doi:10.1038/s41386-021-01212-1 · Cited by 41 · see citing works
Self-citationFrost, N. A., Haggart, A., & Sohal, V. S. (2021) · PLoS Biology · doi:10.1371/journal.pbio.3001235 · Cited by 43 · see citing works
- Authors
- Duffney, L. J., Zhong, P., Wei, J., Matas, E., Cheng, J., Qin, L., Ma, K., Dietz, D. M., Kajiwara, Y., Buxbaum, J. D., & Yan, Z.
- Affiliations
- University at Buffalo, State University of New York (US)
- Icahn School of Medicine at Mount Sinai (US)
- Corresponding author
- Yan, Zhen
- ORCID
- Venue
- Cell Reports
- Publisher
- Elsevier BV
- Published
- 2015-06
- Volume
- 11
- Issue
- 9
- Pages
- 1400-1413
- ISSN
- 2211-1247 (ISSN-L)
- PMC
- PMC4464902
- OpenAlex
- W1580790875
- Cited by
- 281
- References
- 58
- Citations by year
- 2026: 10 · 2025: 14 · 2024: 26 · 2023: 23 · 2022: 32 · 2021: 39 · 2020: 23 · 2019: 29 · 2018: 30 · 2017: 24 · 2016: 24 · 2015: 7
- FWCI
- 19.36
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Cell Reports (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Foundation for the National Institutes of Health
- Icahn School of Medicine at Mount Sinai
- National Institutes of Health (5r21mh101690-02)
- National Institute of Mental Health (R21-MH101690, R01MH093725, MH101690, MH093725, R01MH108842)
- National Institute on Drug Abuse (R01DA037618)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- SHANK3, autism spectrum disorder, haploinsufficiency, actin cytoskeleton, NMDA receptor, Rac1, PAK, cofilin, social dysfunction, repetitive behavior, prefrontal cortex, glutamatergic synapses
- MeSH terms
- Animals, Autistic Disorder, Disease Models, Animal, Male, Mice, Inbred C57BL, Microfilament Proteins, Nerve Tissue Proteins, Neuropeptides, Receptors, N-Methyl-D-Aspartate, Prefrontal Cortex, Mice, Knockout, Patch-Clamp Techniques, rac1 GTP-Binding Protein, Actin Depolymerizing Factors, Mice, p21-Activated Kinases
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