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RETRACTED: mTORC1-Induced HK1-Dependent Glycolysis Regulates NLRP3 Inflammasome Activation
Open accessAbstract
The mammalian target of rapamycin complex 1 (mTORC1) regulates activation of immune cells and cellular energy metabolism. Although glycolysis has been linked to immune functions, the mechanisms by which glycolysis regulates NLRP3 inflammasome activation remain unclear. Here, we demonstrate that mTORC1-induced glycolysis provides an essential mechanism for NLRP3 inflammasome activation. Moreover, we demonstrate that hexokinase 1 (HK1)-dependent glycolysis, under the regulation of mTORC1, represents a critical metabolic pathway for NLRP3 inflammasome activation. Downregulation of glycolysis by inhibition of Raptor/mTORC1 or HK1 suppressed both pro-IL-1β maturation and caspase-1 activation in macrophages in response to LPS and ATP. These results suggest that upregulation of HK1-dependent glycolysis by mTORC1 regulates NLRP3 inflammasome activation.
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Self-citationActivation and regulation of the inflammasomes
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Metadata
- Authors
- Moon, J.-S., Hisata, S., Park, M.-A., DeNicola, G. M., Ryter, S. W., Nakahira, K., & Choi, A. M. K.
- Venue
- Cell Reports
- Publisher
- Elsevier BV
- Published
- 2015-07
- Volume
- 12
- Issue
- 1
- Pages
- 102-115
- ISSN
- 2211-1247 (ISSN-L)
- OpenAlex
- W1916611915
- Cited by
- 374
- References
- 17
- FWCI
- 10.29
- Type
- journal article
- Language
- en
- Status
- Retracted
- Open access
- gold
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- CoChat. (2026). Citation check: RETRACTED: mTORC1-Induced HK1-Dependent Glycolysis Regulates NLRP3 Inflammasome Activation. https://app.cochat.ai/papers/10.1016/j.celrep.2015.05.046
- The paper
- Moon, J.-S., Hisata, S., Park, M.-A., DeNicola, G. M., Ryter, S. W., Nakahira, K., & Choi, A. M. K. (2015). RETRACTED: mTORC1-Induced HK1-Dependent Glycolysis Regulates NLRP3 Inflammasome Activation. Cell Reports. https://doi.org/10.1016/j.celrep.2015.05.046
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