NLRP3 Inflammasome and the IL-1 Pathway in Atherosclerosis

Summary of the second report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel II)

Grundy, S. M., Bilheimer, D. W., Chait, A., Clark, L. T., Denke, M. A., Havel, R. J., Hazzard, W. R., Hulley, S. B., Hunninghake, D. B., Kreisberg, R. A., et al. (1993) · JAMA · doi:10.1001/jama.269.23.3015 · Cited by 27,944 · see citing works

Atherosclerosis--an inflammatory disease

Ross, R. (1999) · New England Journal of Medicine · doi:10.1056/nejm199901143400207 · Cited by 21,725 · see citing works

Heart Disease and Stroke Statistics—2017 Update: A Report From the American Heart Association

Benjamin, E. J., Blaha, M. J., Chiuve, S. E., Cushman, M., Das, S. R., Deo, R., de Ferranti, S. D., Floyd, J., Fornage, M., Gillespie, C., et al. (2017) · Circulation · doi:10.1161/cir.0000000000000485 · Cited by 12,591 · see citing works

Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease

Ridker, P. M., Everett, B. M., Thuren, T., MacFadyen, J. G., Chang, W. H., Ballantyne, C., Fonseca, F., Nicolau, J., Koenig, W., Anker, S. D., et al. (2017) · New England Journal of Medicine · doi:10.1056/nejmoa1707914 · Cited by 9,482 · see citing works

Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death

Shi, J., Zhao, Y., Wang, K., Shi, X., Wang, Y., Huang, H., Zhuang, Y., Cai, T., Wang, F., & Shao, F. (2015) · Nature · doi:10.1038/nature15514 · Cited by 6,659 · see citing works

Evolocumab and Clinical Outcomes in Patients with Cardiovascular Disease

Sabatine, M. S., Giugliano, R. P., Keech, A. C., Honarpour, N., Wiviott, S. D., Murphy, S. A., Kuder, J. F., Wang, H., Liu, T., Wasserman, S. M., et al. (2017) · New England Journal of Medicine · doi:10.1056/nejmoa1615664 · Cited by 6,138 · see citing works

The Inflammasome

Martinon, F., Burns, K., & Tschopp, J. (2002) · Molecular Cell · doi:10.1016/s1097-2765(02)00599-3 · Cited by 6,066 · see citing works

A role for mitochondria in nlrp3 inflammasome activation

Zhou, R., Yazdi, A. S., Menu, P., & Tschopp, J. (2011) · Nature · doi:10.1038/nature09663 · Cited by 5,602 · see citing works

Inflammation, aspirin, and the risk of cardiovascular disease in apparently healthy men

Ridker, P. M., Cushman, M., Stampfer, M. J., Tracy, R. P., & Hennekens, C. H. (1997) · New England Journal of Medicine · doi:10.1056/nejm199704033361401 · Cited by 5,504 · see citing works

Gout-associated uric acid crystals activate the NALP3 inflammasome

Martinon, F., Pétrilli, V., Mayor, A., Tardivel, A., & Tschopp, J. (2006) · Nature · doi:10.1038/nature04516 · Cited by 5,326 · see citing works

Ezetimibe Added to Statin Therapy after Acute Coronary Syndromes

Cannon, C. P., Blazing, M. A., Giugliano, R. P., McCagg, A., White, J. A., Theroux, P., Darius, H., Lewis, B. S., Ophuis, T. O., Jukema, J. W., et al. (2015) · New England Journal of Medicine · doi:10.1056/nejmoa1410489 · Cited by 4,487 · see citing works

NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals

Duewell, P., Kono, H., Rayner, K. J., Sirois, C. M., Vladimer, G., Bauernfeind, F. G., Abela, G. S., Franchi, L., Nuñez, G., Schnurr, M., et al. (2010) · Nature · doi:10.1038/nature08938 · Cited by 4,026 · cited 6× · see citing works

Low-density lipoproteins cause atherosclerotic cardiovascular disease. 1. Evidence from genetic, epidemiologic, and clinical studies. A consensus statement from the European Atherosclerosis Society Consensus Panel

Ference, B. A., Ginsberg, H. N., Graham, I., Ray, K. K., Packard, C. J., Bruckert, E., Hegele, R. A., Krauss, R. M., Raal, F. J., Schunkert, H., et al. (2017) · European Heart Journal · doi:10.1093/eurheartj/ehx144 · Cited by 3,962 · see citing works

Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling

Kayagaki, N., Stowe, I. B., Lee, B. L., O’Rourke, K., Anderson, K., Warming, S., Cuellar, T., Haley, B., Roose-Girma, M., Phung, Q. T., et al. (2015) · Nature · doi:10.1038/nature15541 · Cited by 3,686 · see citing works

Inflammasomes: mechanism of assembly, regulation and signalling

Broz, P., & Dixit, V. M. (2016) · Nature Reviews Immunology · doi:10.1038/nri.2016.58 · Cited by 3,500 · see citing works

Immunological and inflammatory functions of the interleukin-1 family

Dinarello, C. A. (2009) · Annual Review of Immunology · doi:10.1146/annurev.immunol.021908.132612 · Cited by 3,466 · see citing works

Inflammasomes: mechanism of action, role in disease, and therapeutics

Guo, H., Callaway, J. B., & Ting, J. P.-Y. (2015) · Nature Medicine · doi:10.1038/nm.3893 · Cited by 3,340 · see citing works

A guide to immunometabolism for immunologists

O'Neill, L. A. J., Kishton, R. J., & Rathmell, J. (2016) · Nature Reviews Immunology · doi:10.1038/nri.2016.70 · Cited by 3,315 · see citing works

Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores

Liu, X., Zhang, Z., Ruan, J., Pan, Y., Magupalli, V. G., Wu, H., & Lieberman, J. (2016) · Nature · doi:10.1038/nature18629 · Cited by 3,202 · see citing works

Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization

Hornung, V., Bauernfeind, F., Halle, A., Samstad, E. O., Kono, H., Rock, K. L., Fitzgerald, K. A., & Latz, E. (2008) · Nature Immunology · doi:10.1038/ni.1631 · Cited by 3,065 · see citing works

Cutting Edge: NF-κB Activating Pattern Recognition and Cytokine Receptors License NLRP3 Inflammasome Activation by Regulating NLRP3 Expression

Bauernfeind, F. G., Horvath, G. L., Stutz, A., Alnemri, E. S., MacDonald, K. L., Speert, D. P., Fernandes‐Alnemri, T., Wu, J., Monks, B. G., Fitzgerald, K. A., et al. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0901363 · Cited by 3,006 · see citing works

Activation and regulation of the inflammasomes

Latz, E., Xiao, T. S., & Stutz, A. (2013) · Nature Reviews Immunology · doi:10.1038/nri3452 · Cited by 2,884 · see citing works

Recognition of microorganisms and activation of the immune response

Medzhitov, R. (2007) · Nature · doi:10.1038/nature06246 · Cited by 2,862 · see citing works

Pore-forming activity and structural autoinhibition of the gasdermin family

Ding, J., Wang, K., Liu, W., She, Y., Sun, Q., Shi, J., Sun, H., Wang, D.-C., & Shao, F. (2016) · Nature · doi:10.1038/nature18590 · Cited by 2,771 · see citing works

A novel heterodimeric cysteine protease is required for interleukin-1βprocessing in monocytes

Thornberry, N., Bull, H., Calaycay, J., Chapman, K., Howard, A., Kostura, M., Miller, D. K., Molineaux, S., Weidner, J., Auniņš, J., et al. (1992) · Nature · doi:10.1038/356768a0 · Cited by 2,725 · see citing works

Innate Immune Activation Through Nalp3 Inflammasome Sensing of Asbestos and Silica

Dostert, C., Pétrilli, V., Van Bruggen, R., Steele, C., Mossman, B. T., & Tschopp, J. (2008) · Science · doi:10.1126/science.1156995 · Cited by 2,658 · see citing works

The immune system in atherosclerosis

Hansson, G. K., & Hermansson, A. (2011) · Nature Immunology · doi:10.1038/ni.2001 · Cited by 2,331 · see citing works

Inflammatory caspases are innate immune receptors for intracellular LPS

Shi, J., Zhao, Y., Wang, Y., Gao, W., Ding, J., Li, P., Hu, L., & Shao, F. (2014) · Nature · doi:10.1038/nature13683 · Cited by 2,285 · see citing works

Oxidized mitochondrial DNA activates the NLRP3 inflammasome during apoptosis

Shimada, K., Crother, T. R., Karlin, J., Dagvadorj, J., Chiba, N., Chen, S., Ramanujan, V. K., Wolf, A. J., Vergnes, L., Ojcius, D. M., et al. (2012) · Immunity · doi:10.1016/j.immuni.2012.01.009 · Cited by 2,282 · see citing works

The ketone metabolite β-hydroxybutyrate blocks NLRP3 inflammasome-mediated inflammatory disease

Youm, Y.-H., Nguyen, K. Y., Grant, R. W., Goldberg, E. L., Bodogai, M., Kim, D., D'Agostino, D., Planavsky, N., Lupfer, C., Kanneganti, T. D., et al. (2015) · Nature Medicine · doi:10.1038/nm.3804 · Cited by 2,172 · see citing works

K+ Efflux Is the Common Trigger of NLRP3 Inflammasome Activation by Bacterial Toxins and Particulate Matter

Muñoz-Planillo, R., Kuffa, P., Martínez-Colón, G. J., Smith, B. L., Rajendiran, T. M., & Núñez, G. (2013) · Immunity · doi:10.1016/j.immuni.2013.05.016 · Cited by 2,167 · see citing works

The interleukin-1 family: back to the future

Garlanda, C., Dinarello, C. A., & Mantovani, A. (2013) · Immunity · doi:10.1016/j.immuni.2013.11.010 · Cited by 1,945 · cited 4× · see citing works

Overview of the <scp>IL</scp> ‐1 family in innate inflammation and acquired immunity

Dinarello, C. A. (2018) · Immunological Reviews · doi:10.1111/imr.12621 · Cited by 1,866 · see citing works

Biological Applications of Ionophores

Bc, P. (1976) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.45.070176.002441 · Cited by 1,842 · see citing works

Fatty acid–induced NLRP3-ASC inflammasome activation interferes with insulin signaling

Wen, H., Gris, D., Lei, Y. L., Jha, S., Zhang, L., Huang, M. T.-H., Brickey, W. J., & Ting, J. P. ‐. (2011) · Nature Immunology · doi:10.1038/ni.2022 · Cited by 1,814 · see citing works

Molecular mechanisms and functions of pyroptosis, inflammatory caspases and inflammasomes in infectious diseases

Man, S. M., Karki, R., & Kanneganti, T. (2017) · Immunological Reviews · doi:10.1111/imr.12534 · Cited by 1,659 · see citing works

Noncanonical Inflammasome Activation by Intracellular LPS Independent of TLR4

Kayagaki, N., Wong, M. T., Stowe, I. B., Ramani, S. R., Gonzalez, L. C., Akashi‐Takamura, S., Miyake, K., Zhang, J., Lee, W. P., Muszyński, A., et al. (2013) · Science · doi:10.1126/science.1240248 · Cited by 1,544 · see citing works

CD36 ligands promote sterile inflammation through assembly of a Toll-like receptor 4 and 6 heterodimer

Stewart, C. R., Stuart, L. M., Wilkinson, K., van Gils, J. M., Deng, J., Halle, A., Rayner, K. J., Boyer, L., Zhong, R., Frazier, W. A., et al. (2010) · Nature Immunology · doi:10.1038/ni.1836 · Cited by 1,513 · see citing works

Atherosclerosis and the Arterial Smooth Muscle Cell

Ross, R., & Glomset, J. A. (1973) · Science · doi:10.1126/science.180.4093.1332 · Cited by 1,504 · see citing works

Inflammatory Cytokines and the Risk to Develop Type 2 Diabetes

Spranger, J., Kroke, A., Möhlig, M., Hoffmann, K., Bergmann, M. M., Ristow, M., Boeing, H., & Pfeiffer, A. F. H. (2003) · Diabetes · doi:10.2337/diabetes.52.3.812 · Cited by 1,493 · see citing works

Cholesterol, inflammation and innate immunity.

Tall, A. R., & Yvan-Charvet, L. (2015) · Nature Reviews Immunology · doi:10.1038/nri3793 · Cited by 1,479 · see citing works

Cardiovascular Medicine at the Turn of the Millennium: Triumphs, Concerns, and Opportunities

D, E. B. M. (1997) · New England Journal of Medicine · doi:10.1056/nejm199711063371906 · Cited by 1,428 · see citing works

Inflammation, Pravastatin, and the Risk of Coronary Events After Myocardial Infarction in Patients With Average Cholesterol Levels

Ridker, P. M., Rifai, N., Pfeffer, M. A., Sacks, F. M., Moye, L. A., Goldman, S., Flaker, G. C., & Braunwald, E. (1998) · Circulation · doi:10.1161/01.cir.98.9.839 · Cited by 1,389 · see citing works

Risk of Myocardial Infarction and Stroke after Acute Infection or Vaccination

Smeeth, L. L., Thomas, S. L., Hall, A. J., Hubbard, R., Farrington, P., & Vallance, P. J. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa041747 · Cited by 1,375 · see citing works

Unified Polymerization Mechanism for the Assembly of ASC-Dependent Inflammasomes

Lu, A., Magupalli, V. G., Ruan, J., Yin, Q., Atianand, M. K., Vos, M. R., Schröder, G. F., Fitzgerald, K. A., Wu, H., & Egelman, E. H. (2014) · Cell · doi:10.1016/j.cell.2014.02.008 · Cited by 1,353 · see citing works

Effect of interleukin-1β inhibition with canakinumab on incident lung cancer in patients with atherosclerosis: exploratory results from a randomised, double-blind, placebo-controlled trial

Ridker, P. M., MacFadyen, J. G., Thuren, T., Everett, B. M., Libby, P., Glynn, R. J., Ridker, P., Lorenzatti, A., Krum, H., Varigos, J., et al. (2017) · The Lancet · doi:10.1016/s0140-6736(17)32247-x · Cited by 1,344 · see citing works

Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1β in type 2 diabetes

Masters, S. L., Dunne, A., Subramanian, S. L., Hull, R. L., Tannahill, G. M., Sharp, F. A., Becker, C., Franchi, L., Yoshihara, E., Chen, Z., et al. (2010) · Nature Immunology · doi:10.1038/ni.1935 · Cited by 1,330 · cited 1× · see citing works

Statin Therapy, LDL Cholesterol, C-Reactive Protein, and Coronary Artery Disease

Nissen, S. E., Tuzcu, E. M., Schoenhagen, P., Crowe, T., Sasiela, W. J., Tsai, J., Orazem, J., Magorien, R. D., O'Shaughnessy, C., & Ganz, P. (2005) · New England Journal of Medicine · doi:10.1056/nejmoa042000 · Cited by 1,325 · see citing works

Cholesterol in the Prediction of Atherosclerotic Disease

Kannel, W. B., Castelli, W. P., & Gordon, T. (1979) · Annals of Internal Medicine · doi:10.7326/0003-4819-90-1-85 · Cited by 1,314 · see citing works

Inflammation as a Cardiovascular Risk Factor

Willerson, J. T., & Ridker, P. M. (2004) · Circulation · doi:10.1161/01.cir.0000129535.04194.38 · Cited by 1,304 · see citing works

NEK7 is an essential mediator of NLRP3 activation downstream of potassium efflux

He, Y., Zeng, M. Y., Yang, D., Motro, B., & Núñez, G. (2016) · Nature · doi:10.1038/nature16959 · Cited by 1,295 · see citing works

Neutrophil extracellular traps license macrophages for cytokine production in atherosclerosis

Warnatsch, A., Ιωάννου, Μ., Wang, Q., & Papayannopoulos, V. (2015) · Science · doi:10.1126/science.aaa8064 · Cited by 1,280 · see citing works

Cytoplasmic LPS Activates Caspase-11: Implications in TLR4-Independent Endotoxic Shock

Hagar, J. A., Powell, D. A., Aachoui, Y., Ernst, R. K., & Miao, E. A. (2013) · Science · doi:10.1126/science.1240988 · Cited by 1,265 · see citing works

Caspase-1 processes IFN-γ-inducing factor and regulates LPS-induced IFN- γ production

Ghayur, T., Banerjee, S., Hugunin, M., Butler, D., Herzog, L., Carter, A. B., Quintal, L. J., Sekut, L., Talanian, R. V., Paskind, M. P., et al. (1997) · Nature · doi:10.1038/386619a0 · Cited by 1,204 · see citing works

Interleukin 1 acts on cultured human vascular endothelium to increase the adhesion of polymorphonuclear leukocytes, monocytes, and related leukocyte cell lines.

Bevilacqua, M. P., Pober, J. S., Wheeler, M. E., Cotran, R. S., & Gimbrone, M. A. (1985) · Journal of Clinical Investigation · doi:10.1172/jci112200 · Cited by 1,102 · see citing works

Western Diet Triggers NLRP3-Dependent Innate Immune Reprogramming

Christ, A., Günther, P. S., Lauterbach, M. A. R., Duewell, P., Biswas, D., Pelka, K., Scholz, C. J., Oosting, M., Händler, K., Bassler, K. E., et al. (2018) · Cell · doi:10.1016/j.cell.2017.12.013 · Cited by 1,099 · see citing works

Scavenger Receptors Class A-I/II and CD36 Are the Principal Receptors Responsible for the Uptake of Modified Low Density Lipoprotein Leading to Lipid Loading in Macrophages*

Kunjathoor, V., Febbraio, M., Podrez, E., Moore, K., Andersson, L., Koehn, S. L., Rhee, J. S., Silverstein, R., Hoff, H., & Freeman, M. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m209649200 · Cited by 1,064 · see citing works

Immunity, atherosclerosis and cardiovascular disease

Frostegård, J. (2013) · BMC Medicine · doi:10.1186/1741-7015-11-117 · Cited by 1,040 · see citing works

Cholesterol Crystals Activate the NLRP3 Inflammasome in Human Macrophages: A Novel Link between Cholesterol Metabolism and Inflammation

Rajamäki, K., Lappalainen, J., Öörni, K., Välimäki, E., Matikainen, S., Kovanen, P. T., & Eklund, K. K. (2010) · PLoS ONE · doi:10.1371/journal.pone.0011765 · Cited by 1,039 · see citing works

The pyroptosome: a supramolecular assembly of ASC dimers mediating inflammatory cell death via caspase-1 activation

Fernandes-Alnemri, T., Wu, J., Yu, J.-W., Datta, P., Miller, B., Jankowski, W., Rosenberg, S., Zhang, J., & Alnemri, E. S. (2007) · Cell Death &amp; Differentiation · doi:10.1038/sj.cdd.4402194 · Cited by 1,026 · see citing works

Lack of Toll-like receptor 4 or myeloid differentiation factor 88 reduces atherosclerosis and alters plaque phenotype in mice deficient in apolipoprotein E

Michelsen, K. S., Wong, M. H., Shah, P. K., Zhang, W., Yano, J., Doherty, T. M., Akira, S., Rajavashisth, T. B., & Arditi, M. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0403249101 · Cited by 1,019 · see citing works

The interactions between inflammation and coagulation

Esmon, C. T. (2005) · British Journal of Haematology · doi:10.1111/j.1365-2141.2005.05753.x · Cited by 1,004 · see citing works

Mitochondrial Cardiolipin Is Required for Nlrp3 Inflammasome Activation

Iyer, S. S., He, Q., Janczy, J. R., Elliott, E. I., Zhong, Z., Olivier, A. K., Sadler, J. J., Knepper-Adrian, V., Han, R., Qiao, L., et al. (2013) · Immunity · doi:10.1016/j.immuni.2013.08.001 · Cited by 938 · see citing works

CD36 coordinates NLRP3 inflammasome activation by facilitating intracellular nucleation of soluble ligands into particulate ligands in sterile inflammation

Sheedy, F. J., Grebe, A., Rayner, K. J., Kalantari, P., Ramkhelawon, B., Carpenter, S. B., Becker, C. E., Ediriweera, H. N., Mullick, A. E., Golenbock, D. T., et al. (2013) · Nature Immunology · doi:10.1038/ni.2639 · Cited by 935 · see citing works

Interleukin 1 (IL-1) induces biosynthesis and cell surface expression of procoagulant activity in human vascular endothelial cells.

Bevilacqua, M. P., Pober, J. S., Majeau, G. R., Cotran, R. S., & Gimbrone, M. A. (1984) · The Journal of Experimental Medicine · doi:10.1084/jem.160.2.618 · Cited by 934 · see citing works

Relationship of C-reactive protein reduction to cardiovascular event reduction following treatment with canakinumab: a secondary analysis from the CANTOS randomised controlled trial

Ridker, P. M., MacFadyen, J. G., Everett, B. M., Libby, P., Thuren, T. Y., Glynn, R. J., Ridker, P. M., MacFadyen, J. G., Everett, B. M., Libby, P., et al. (2017) · The Lancet · doi:10.1016/s0140-6736(17)32814-3 · Cited by 924 · see citing works

The Nalp3 inflammasome is essential for the development of silicosis

Cassel, S. L., Eisenbarth, S. C., Iyer, S. S., Sadler, J. J., Colegio, O. R., Tephly, L. A., Carter, A. B., Rothman, P. B., Flavell, R. A., & Sutterwala, F. S. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0803933105 · Cited by 907 · see citing works

GsdmD p30 elicited by caspase-11 during pyroptosis forms pores in membranes

Aglietti, R. A., Estevez, A., Gupta, A., Ramirez, M. G., Liu, P. S., Kayagaki, N., Ciferri, C., Dixit, V. M., & Dueber, E. C. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1607769113 · Cited by 898 · see citing works

Identification of a key pathway required for the sterile inflammatory response triggered by dying cells

Chen, C.-J., Kono, H., Golenbock, D., Reed, G., Akira, S., & Rock, K. L. (2007) · Nature Medicine · doi:10.1038/nm1603 · Cited by 876 · see citing works

Use of Canakinumab in the Cryopyrin-Associated Periodic Syndrome

Lachmann, H. J., Kone-Paut, I., Kuemmerle-Deschner, J. B., Leslie, K. S., Hachulla, E., Quartier, P., Gitton, X., Widmer, A., Patel, N., & Hawkins, P. N. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0810787 · Cited by 869 · see citing works

Expression of toll-like receptors in human atherosclerotic lesions: a possible pathway for plaque activation.

Edfeldt, K., Swedenborg, J., Hansson, G. K., & Yan, Z.-Q. (2002) · PubMed · Cited by 847 · see citing works

Genetically elevated C-reactive protein and ischemic vascular disease

Zacho, J., Tybjærg-Hansen, A., Jensen, J. S., Grande, P., Sillesen, H., & Nordestgaard, B. G. (2008) · New England Journal of Medicine · doi:10.1056/nejmoa0707402 · Cited by 839 · see citing works

Pancreatic islet cell toxicity of amylin associated with type-2 diabetes mellitus

Lorenzo, A., Razzaboni, B. L., Weir, G. C., & Yankner, B. A. (1994) · Nature · doi:10.1038/368756a0 · Cited by 819 · see citing works

Omega-3 fatty acids prevent inflammation and metabolic disorder through inhibition of NLRP3 inflammasome activation

Yan, Y., Jiang, W., Spinetti, T., Tardivel, A., Castillo, R., Bourquin, C., Guarda, G., Tian, Z., Tschopp, J., & Zhou, R. (2013) · Immunity · doi:10.1016/j.immuni.2013.05.015 · Cited by 784 · see citing works

Non-transcriptional Priming and Deubiquitination Regulate NLRP3 Inflammasome Activation

Juliana, C. A., Fernandes‐Alnemri, T., Kang, S., Farias, A., Qin, F., & Alnemri, E. S. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.407130 · Cited by 771 · see citing works

Interleukin-1 beta maturation and release in response to ATP and nigericin. Evidence that potassium depletion mediated by these agents is a necessary and common feature of their activity.

Perregaux, D. G., & Gabel, C. A. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)36591-2 · Cited by 760 · see citing works

Acute-phase response of human hepatocytes: Regulation of acute-phase protein synthesis by interleukin-6

Castell, J. V., Gómez-Lechón, M. J., David, M., Fabra, R., Trullenque, R., & Heinrich, P. C. (1990) · Hepatology · doi:10.1002/hep.1840120517 · Cited by 759 · see citing works

NLRP3 activation and mitosis are mutually exclusive events coordinated by NEK7, a new inflammasome component

Shi, H., Wang, Y., Li, X., Zhan, X., Tang, M., Fina, M., Su, L., Pratt, D., Bu, C. H., Hildebrand, S., et al. (2015) · Nature Immunology · doi:10.1038/ni.3333 · Cited by 751 · see citing works

Lack of Interleukin-1β Decreases the Severity of Atherosclerosis in ApoE-Deficient Mice

Kirii, H., Niwa, T., Yamada, Y., Wada, H., Saito, K., Iwakura, Y., Asano, M., Moriwaki, H., & Seishima, M. (2003) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000064374.15232.c3 · Cited by 748 · see citing works

Deubiquitination of NLRP3 by BRCC3 Critically Regulates Inflammasome Activity

Py, B. F., Kim, M.-S., Vakifahmetoglu-Norberg, H., & Yuan, J. (2012) · Molecular Cell · doi:10.1016/j.molcel.2012.11.009 · Cited by 718 · see citing works

Expression of Toll-Like Receptors in Human Atherosclerotic Lesions

Edfeldt, K., Swedenborg, J., Hansson, G. K., & Yan, Z.-Q. (2002) · Circulation · doi:10.1161/circ.105.10.1158 · Cited by 706 · see citing works

Toll-Like Receptor-4 Is Expressed by Macrophages in Murine and Human Lipid-Rich Atherosclerotic Plaques and Upregulated by Oxidized LDL

Xu, X.-O. H., Shah, P. K., Faure, E., Equils, O., Thomas, L. S., Fishbein, M. C., Luthringer, D., Xu, X., Rajavashisth, T. B., Yano, J., et al. (2001) · Circulation · doi:10.1161/hc5001.100631 · Cited by 668 · see citing works

Immune Effector Mechanisms Implicated in Atherosclerosis: From Mice to Humans

Libby, P., Lichtman, A. H., & Hansson, G. K. (2013) · Immunity · doi:10.1016/j.immuni.2013.06.009 · Cited by 667 · see citing works

The DNA Inflammasome in Human Myeloid Cells Is Initiated by a STING-Cell Death Program Upstream of NLRP3

Gaidt, M. M., Ebert, T. S., Chauhan, D., Ramshorn, K., Pinci, F., Zuber, S., O’Duill, F., Schmid-Burgk, J. L., Hoss, F., Buhmann, R., et al. (2017) · Cell · doi:10.1016/j.cell.2017.09.039 · Cited by 638 · see citing works

Reduced atherosclerosis in MyD88-null mice links elevated serum cholesterol levels to activation of innate immunity signaling pathways

Björkbacka, H., Kunjathoor, V. V., Moore, K. J., Koehn, S., Ordija, C. M., Lee, M. A., Means, T., Halmen, K., Luster, A. D., Golenbock, D. T., et al. (2004) · Nature Medicine · doi:10.1038/nm1008 · Cited by 634 · see citing works

Cardiovascular Efficacy and Safety of Bococizumab in High-Risk Patients

Ridker, P. M., Revkin, J., Amarenco, P., Brunell, R., Curto, M., Civeira, F., Flather, M., Glynn, R. J., Gregoire, J., Jukema, J. W., et al. (2017) · New England Journal of Medicine · doi:10.1056/nejmoa1701488 · Cited by 624 · see citing works

Autophagy Links Inflammasomes to Atherosclerotic Progression

Razani, B., Feng, C., Coleman, T., Emanuel, R., Wen, H., Hwang, S., Ting, J. P., Virgin, H. W., Kastan, M. B., & Semenkovich, C. F. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.02.011 · Cited by 601 · see citing works

Intracellular Complement Activation Sustains T Cell Homeostasis and Mediates Effector Differentiation

Liszewski, M. K., Kolev, M. V., Friec, G. L., Leung, M. K., Bertram, P. G., Fara, A. F., Subías, M., Pickering, M. C., Drouet, C., Meri, S., et al. (2013) · Immunity · doi:10.1016/j.immuni.2013.10.018 · Cited by 585 · see citing works

An endogenous caspase-11 ligand elicits interleukin-1 release from living dendritic cells

Zanoni, I., Tan, Y., Di Gioia, M., Broggi, A., Ruan, J., Shi, J., Donado, C. A., Shao, F., Wu, H., Springstead, J. R., et al. (2016) · Science · doi:10.1126/science.aaf3036 · Cited by 583 · see citing works

The PYRIN-CARD Protein ASC Is an Activating Adaptor for Caspase-1

Srinivasula, S. M., Poyet, J.-L., Razmara, M., Datta, P., Zhang, Z., & Alnemri, E. S. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.c200179200 · Cited by 573 · see citing works

Nitric oxide controls the immunopathology of tuberculosis by inhibiting NLRP3 inflammasome–dependent processing of IL-1β

Mishra, B. B., Rathinam, V. A. K., Martens, G. W., Martinot, A. J., Kornfeld, H., Fitzgerald, K. A., & Sassetti, C. M. (2013) · Nature Immunology · doi:10.1038/ni.2474 · Cited by 571 · see citing works

Prion-like Polymerization Underlies Signal Transduction in Antiviral Immune Defense and Inflammasome Activation

Cai, X., Chen, J., Xu, H., Liu, S., Jiang, Q., Halfmann, R., & Chen, Z. J. (2014) · Cell · doi:10.1016/j.cell.2014.01.063 · Cited by 567 · see citing works

PKM2-dependent glycolysis promotes NLRP3 and AIM2 inflammasome activation

Xie, M., Yu, Y., Kang, R., Zhu, S., Yang, L., Zeng, L., Sun, X., Yang, M., Billiar, T. R., Wang, H., et al. (2016) · Nature Communications · doi:10.1038/ncomms13280 · Cited by 567 · see citing works

Anti-inflammatory therapies for cardiovascular disease

Ridker, P. M., & Lüscher, T. F. (2014) · European Heart Journal · doi:10.1093/eurheartj/ehu203 · Cited by 558 · see citing works

Hexokinase Is an Innate Immune Receptor for the Detection of Bacterial Peptidoglycan

Wolf, A. J., Reyes, C. N., Liang, W., Becker, C. A., Shimada, K., Wheeler, M. L., Cho, H. C., Popescu, N. I., Coggeshall, K. M., Arditi, M., et al. (2016) · Cell · doi:10.1016/j.cell.2016.05.076 · Cited by 554 · see citing works

Modulation of atherosclerosis in mice by Toll-like receptor 2

Mullick, A. E. (2005) · Journal of Clinical Investigation · doi:10.1172/jci25482 · Cited by 549 · see citing works

Systematic Review and Meta-Analysis of Methotrexate Use and Risk of Cardiovascular Disease

Micha, R., Imamura, F., von Ballmoos, M. C. W., Solomon, D. H., Hernán, M. Á., Ridker, P. M., & Mozaffarian, D. (2011) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2011.06.054 · Cited by 535 · see citing works

Interleukin 1: a mitogen for human vascular smooth muscle cells that induces the release of growth-inhibitory prostanoids.

Libby, P., Warner, S. J., & Friedman, G. B. (1988) · Journal of Clinical Investigation · doi:10.1172/jci113346 · Cited by 532 · see citing works

Effects of Interleukin-1β Inhibition With Canakinumab on Hemoglobin A1c, Lipids, C-Reactive Protein, Interleukin-6, and Fibrinogen: A Phase IIb Randomized, Placebo-Controlled Trial

Ridker, P. M., Howard, C. P., Walter, V., Everett, B., Libby, P., Hensen, J., & Thuren, T. (2012) · Circulation · doi:10.1161/circulationaha.112.122556 · Cited by 530 · see citing works

Neutrophil Extracellular Trap–Associated Protein Activation of the NLRP3 Inflammasome Is Enhanced in Lupus Macrophages

Kahlenberg, J. M., Carmona‐Rivera, C., Smith, C. K., & Kaplan, M. J. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1202388 · Cited by 511 · see citing works

Expression of Interleukin (IL)-18 and Functional IL-18 Receptor on Human Vascular Endothelial Cells, Smooth Muscle Cells, and Macrophages

Gerdes, N., Sukhova, G. K., Libby, P., Reynolds, R. S., Young, J. L., & Schönbeck, U. (2002) · The Journal of Experimental Medicine · doi:10.1084/jem.20011022 · Cited by 508 · see citing works

Endotoxin and tumor necrosis factor induce interleukin-1 gene expression in adult human vascular endothelial cells.

Libby, P., Ordovás, J. M., Auger, K. R., Robbins, A. H., Birinyi, L. K., & Dinarello, C. A. (1986) · PubMed Central · Cited by 494 · see citing works

Identification of a membrane-associated interleukin 1 in macrophages.

Kurt‐Jones, E. A., Beller, D. I., Mizel, S. B., & Unanue, E. R. (1985) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.82.4.1204 · Cited by 492 · see citing works

Interleukin-18 and Interleukin-1β: Two Cytokine Substrates for ICE (Caspase-1)

Fantuzzi, G., & Dinarello, C. A. (1999) · Journal of Clinical Immunology · doi:10.1023/a:1020506300324 · Cited by 467 · see citing works

Auto-Antigenic Protein-DNA Complexes Stimulate Plasmacytoid Dendritic Cells to Promote Atherosclerosis

Döring, Y., Manthey, H. D., Drechsler, M. D., Lievens, D., Megens, R. T. A., Soehnlein, O., Busch, M., Manca, M., Koenen, R. R., Pelisek, J., et al. (2012) · Circulation · doi:10.1161/circulationaha.111.046755 · Cited by 459 · see citing works

Peptidylarginine Deiminase Inhibition Reduces Vascular Damage and Modulates Innate Immune Responses in Murine Models of Atherosclerosis

Knight, J. S., Luo, W., O’Dell, A. A., Yalavarthi, S., Zhao, W., Subramanian, V., Guo, C., Grenn, R. C., Thompson, P. R., Eitzman, D. T., et al. (2014) · Circulation Research · doi:10.1161/circresaha.114.303312 · Cited by 459 · see citing works

Homeostasis-altering molecular processes as mechanisms of inflammasome activation

Liston, A., & Masters, S. L. (2017) · Nature Reviews Immunology · doi:10.1038/nri.2016.151 · Cited by 459 · see citing works

A Genome-wide CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) Screen Identifies NEK7 as an Essential Component of NLRP3 Inflammasome Activation

Schmid-Burgk, J. L., Chauhan, D., Schmidt, T., Ebert, T. S., Reinhardt, J., Endl, E., & Hornung, V. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.c115.700492 · Cited by 456 · see citing works

Elevated Levels of Circulating DNA and Chromatin Are Independently Associated With Severe Coronary Atherosclerosis and a Prothrombotic State

Borissoff, J. I., Joosen, I. A., Versteylen, M. O., Brill, A. G., Fuchs, T. A., Savchenko, A. S., Gallant, M., Martinod, K., Cate, H. T., Hofstra, L., et al. (2013) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.113.301627 · Cited by 448 · see citing works

Cardiovascular disease in patients with chronic inflammation: mechanisms underlying premature cardiovascular events in rheumatologic conditions

Mason, J. C., & Libby, P. (2015) · European Heart Journal · doi:10.1093/eurheartj/ehu403 · Cited by 420 · see citing works

Baseline C-Reactive Protein Is Associated With Incident Cancer and Survival in Patients With Cancer

Allin, K. H., Bojesen, S. E., & Nordestgaard, B. G. (2009) · Journal of Clinical Oncology · doi:10.1200/jco.2008.19.8440 · Cited by 419 · see citing works

Interleukin-18/Interleukin-18 Binding Protein Signaling Modulates Atherosclerotic Lesion Development and Stability

Mallat, Z., Corbaz, A., Scoazec, A., Graber, P., Alouani, S., Esposito, B., Humbert, Y., Chvatchko, Y., & Tedgui, A. (2001) · Circulation Research · doi:10.1161/hh1901.098735 · Cited by 404 · see citing works

Crystal Structure of NLRC4 Reveals Its Autoinhibition Mechanism

Hu, Z., Yan, C., Liu, P., Huang, Z., Ma, R., Zhang, C., Wang, R., Zhang, Y., Martinon, F., Miao, D., et al. (2013) · Science · doi:10.1126/science.1236381 · Cited by 401 · see citing works

Nitric oxide suppresses NLRP3 inflammasome activation and protects against LPS-induced septic shock

Mao, K., Chen, S., Chen, M., Ma, Y., Wang, Y., Huang, B., He, Z., Zeng, Y., Hu, Y., Sun, S., et al. (2013) · Cell Research · doi:10.1038/cr.2013.6 · Cited by 397 · see citing works

Malarial Hemozoin Is a Nalp3 Inflammasome Activating Danger Signal

Dostert, C., Guarda, G., Romero, J. F., Menu, P., Groß, O., Tardivel, A., Suvà, M.-L., Stehle, J., Köpf, M., Stamenkovic, I., et al. (2009) · PLoS ONE · doi:10.1371/journal.pone.0006510 · Cited by 397 · see citing works

Interleukin-18 Enhances Atherosclerosis in Apolipoprotein E −/− Mice Through Release of Interferon-γ

Whitman, S. C., Ravisankar, P., & Daugherty, A. (2002) · Circulation Research · doi:10.1161/hh0202.105292 · Cited by 386 · see citing works

The gramicidin ion channel: A model membrane protein

Kelkar, D. A., & Chattopadhyay, A. (2007) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2007.05.011 · Cited by 381 · see citing works

Anti-inflammatory therapies for atherosclerosis

Bäck, M., & Hansson, G. K. (2015) · Nature Reviews Cardiology · doi:10.1038/nrcardio.2015.5 · Cited by 380 · see citing works

Reduced atherosclerosis in interleukin-18 deficient apolipoprotein E-knockout mice

Elhage, R. (2003) · Cardiovascular Research · doi:10.1016/s0008-6363(03)00343-2 · Cited by 374 · see citing works

Regulation of Toll-like receptor–mediated inflammatory response by complement in vivo

Zhang, X., Kimura, Y., Fang, C., Zhou, L., Sfyroera, G., Lambris, J. D., Wetsel, R. A., Miwa, T., & Song, W. (2007) · Blood · doi:10.1182/blood-2006-12-063636 · Cited by 373 · see citing works

Rationale and design of the Cardiovascular Inflammation Reduction Trial: A test of the inflammatory hypothesis of atherothrombosis

Everett, B. M., Pradhan, A. D., Solomon, D. H., Paynter, N., MacFadyen, J., Zaharris, E., Gupta, M., Clearfield, M., Libby, P., Hasan, A. A. K., et al. (2013) · American Heart Journal · doi:10.1016/j.ahj.2013.03.018 · Cited by 368 · see citing works

Converting enzyme-independent release of tumor necrosis factor α and IL-1β from a stimulated human monocytic cell line in the presence of activated neutrophils or purified proteinase 3

Coeshott, C. M., Ohnemus, C., Pilyavskaya, A., Ross, S., Wieczorek, M., Kroona, H., Leimer, A. H., & Cheronis, J. C. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.11.6261 · Cited by 365 · see citing works

Pathogens and atherosclerosis: Update on the potential contribution of multiple infectious organisms to the pathogenesis of atherosclerosis

Campbell, L. A., & Rosenfeld, M. E. (2011) · Thrombosis and Haemostasis · doi:10.1160/th11-06-0392 · Cited by 363 · see citing works

The complement membrane attack complex triggers intracellular Ca2+ fluxes leading to NLRP3 inflammasome activation

Triantafilou, K., Hughes, T. R., Triantafilou, M., & Morgan, B. P. (2013) · Journal of Cell Science · doi:10.1242/jcs.124388 · Cited by 361 · see citing works

NLRP3 (NALP3, Cryopyrin) Facilitates In Vivo Caspase-1 Activation, Necrosis, and HMGB1 Release via Inflammasome-Dependent and -Independent Pathways

Willingham, S. B., Allen, I. C., Bergstralh, D. T., Brickey, W. J., Huang, M. T.-H., Taxman, D. J., Duncan, J. A., & Ting, J. P. ‐. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0900138 · Cited by 348 · see citing works

NLRP3 Inflammasome Inhibition by MCC950 Reduces Atherosclerotic Lesion Development in Apolipoprotein E–Deficient Mice—Brief Report

van der Heijden, T., Kritikou, E., Venema, W., van Duijn, J., van Santbrink, P. J., Slütter, B., Foks, A. C., Bot, I., & Kuiper, J. (2017) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/atvbaha.117.309575 · Cited by 348 · see citing works

Oxysterol Restraint of Cholesterol Synthesis Prevents AIM2 Inflammasome Activation

Dang, E. V., McDonald, J. G., Russell, D. W., & Cyster, J. G. (2017) · Cell · doi:10.1016/j.cell.2017.09.029 · Cited by 348 · see citing works

Cyclodextrin promotes atherosclerosis regression via macrophage reprogramming

Zimmer, S., Grebe, A., Bakke, S. S., Bode, N., Halvorsen, B., Ulas, T., Skjelland, M., Nardo, D. D., Labzin, L. I., Kerksiek, A., et al. (2016) · Science Translational Medicine · doi:10.1126/scitranslmed.aad6100 · Cited by 334 · see citing works

The <scp>AIM</scp>2 inflammasome: Sensor of pathogens and cellular perturbations

Lugrin, J., & Martinon, F. (2018) · Immunological Reviews · doi:10.1111/imr.12618 · Cited by 333 · see citing works

Cholesterol Efflux Pathways Suppress Inflammasome Activation, NETosis, and Atherogenesis

Westerterp, M., Fotakis, P., Ouimet, M., Bochem, A. E., Zhang, H., Molusky, M. M., Wang, W., Abramowicz, S., la Bastide-van Gemert, S., Wang, N., et al. (2018) · Circulation · doi:10.1161/circulationaha.117.032636 · Cited by 331 · see citing works

IL-1-converting enzyme requires aspartic acid residues for processing of the IL-1 beta precursor at two distinct sites and does not cleave 31-kDa IL-1 alpha

Howard, A. D., Kostura, M. J., Thornberry, N. A., DING, G. J.-F., Limjuco, G. A., Weidner, J. R., Salley, J. P., Hogquist, K. A., Chaplin, D., & Mumford, R. A. (1991) · The Journal of Immunology · doi:10.4049/jimmunol.147.9.2964 · Cited by 323 · see citing works

Arterial Inflammation in Mice Lacking the Interleukin 1 Receptor Antagonist Gene

Nicklin, M. J. H., Hughes, D. E., Barton, J. L., Ure, J. M., & Duff, G. W. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.191.2.303 · Cited by 319 · see citing works

NLRP3 inflammasome assembly is regulated by phosphorylation of the pyrin domain

Stutz, A., Kolbe, C., Stahl, R., Horvath, G. L., Franklin, B. S., van Ray, O., Brinkschulte, R., Geyer, M., Meissner, F., & Latz, E. (2017) · The Journal of Experimental Medicine · doi:10.1084/jem.20160933 · Cited by 318 · see citing works

Rapid and specific conversion of precursor interleukin 1 beta (IL-1 beta) to an active IL-1 species by human mast cell chymase.

Mizutani, H., Schechter, N. M., Lazarus, G. S., Black, R. A., & Kupper, T. S. (1991) · The Journal of Experimental Medicine · doi:10.1084/jem.174.4.821 · Cited by 317 · see citing works

IRGB10 Liberates Bacterial Ligands for Sensing by the AIM2 and Caspase-11-NLRP3 Inflammasomes

Man, S. M., Karki, R., Sasai, M., Place, D. E., Kesavardhana, S., Temirov, J., Frase, S., Zhu, Q., Malireddi, R. K. S., Kuriakose, T., et al. (2016) · Cell · doi:10.1016/j.cell.2016.09.012 · Cited by 312 · see citing works

Interleukin-1β in Coronary Arteries of Patients With Ischemic Heart Disease

Galea, J., Armstrong, J., Gadsdon, P., Holden, H. M., Francis, S., & Holt, C. M. (1996) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.16.8.1000 · Cited by 310 · see citing works

NLRP3 Inflammasome Expression and Activation in Human Atherosclerosis

Paramel, G. V., Folkersen, L., Strawbridge, R. J., Halvorsen, B. L., Yndestad, A., Ranheim, T., Krohg‐Sørensen, K., Skjelland, M., Espevik, T., Aukrust, P., et al. (2016) · Journal of the American Heart Association · doi:10.1161/jaha.115.003031 · Cited by 308 · see citing works

Fatty acid–induced mitochondrial uncoupling elicits inflammasome-independent IL-1α and sterile vascular inflammation in atherosclerosis

Freigang, S., Ampenberger, F., Weiss, A., Kanneganti, T., Iwakura, Y., Hersberger, M., & Köpf, M. (2013) · Nature Immunology · doi:10.1038/ni.2704 · Cited by 304 · see citing works

Clinical Relevance of C-Reactive Protein During Follow-Up of Patients With Acute Coronary Syndromes in the Aggrastat-to-Zocor Trial

Morrow, D. A., de Lemos, J. A., Sabatine, M. S., Wiviott, S. D., Blazing, M. A., Shui, A. M., Rifai, N., Califf, R. M., & D, E. B. M. (2006) · Circulation · doi:10.1161/circulationaha.106.628909 · Cited by 304 · see citing works

Neutrophil Proteinase 3-Mediated Induction of Bioactive IL-18 Secretion by Human Oral Epithelial Cells

Sugawara, S., Uehara, A., Nochi, T., Yamaguchi, T., Ueda, H., Sugiyama, A., Hanzawa, K., Kumagai, K., Okamura, H., & Takada, H. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.167.11.6568 · Cited by 297 · see citing works

Inflammasomes on the Crossroads of Innate Immune Recognition and Metabolic Control

Próchnicki, T., & Latz, E. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2017.06.018 · Cited by 297 · see citing works

Inflammatory arthritis in caspase 1 gene–deficient mice: Contribution of proteinase 3 to caspase 1–independent production of bioactive interleukin‐1β

Joosten, L. A. B., Netea, M. G., Fantuzzi, G., Koenders, M. I., Helsen, M. M. A., Sparrer, H., Pham, C. T. N., van der Meer, J. W. M., Dinarello, C. A., & van den Berg, W. B. (2009) · Arthritis & Rheumatism · doi:10.1002/art.25006 · Cited by 296 · see citing works

The Inflammasomes and Autoinflammatory Syndromes

Broderick, L., Nardo, D. D., Franklin, B. S., Hoffman, H. M., & Latz, E. (2014) · Annual Review of Pathology Mechanisms of Disease · doi:10.1146/annurev-pathol-012414-040431 · Cited by 296 · see citing works

NLRP3 at the interface of metabolism and inflammation

Haneklaus, M., & O'Neill, L. A. J. (2015) · Immunological Reviews · doi:10.1111/imr.12285 · Cited by 294 · see citing works

Chronic treatment with interleukin-1 beta induces coronary intimal lesions and vasospastic responses in pigs in vivo. The role of platelet-derived growth factor.

Shimokawa, H., Itô, A., Fukumoto, Y., Kadokami, T., Nakaike, R., Sakata, M., Takayanagi, T., Egashira, K., & Takeshita, A. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118476 · Cited by 292 · see citing works

Metabolic and Epigenetic Coordination of T Cell and Macrophage Immunity

Phan, A. T., Goldrath, A. W., & Glass, C. K. (2017) · Immunity · doi:10.1016/j.immuni.2017.04.016 · Cited by 291 · see citing works

Cholesterol Crystals Induce Complement-Dependent Inflammasome Activation and Cytokine Release

Samstad, E. O., Niyonzima, N., Nymo, S. H., Aune, M. H., Ryan, L., Bakke, S. S., Lappegård, K. T., Brekke, O., Lambris, J. D., Damås, J. K., et al. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1302484 · Cited by 286 · see citing works

Presence of luminal neutrophil extracellular traps in atherosclerosis

Megens, R. T. A., Vijayan, S., Lievens, D., Döring, Y., van Zandvoort, M. A. M. J., Grommes, J., Weber, C., & Soehnlein, O. (2012) · Thrombosis and Haemostasis · doi:10.1160/th11-09-0650 · Cited by 281 · see citing works

Interleukin 1 induces interleukin 1. II. Recombinant human interleukin 1 induces interleukin 1 production by adult human vascular endothelial cells.

Warner, S. J. C., Auger, K. R., & Libby, P. (1987) · The Journal of Immunology · doi:10.4049/jimmunol.139.6.1911 · Cited by 280 · see citing works

Human caspase-4 mediates noncanonical inflammasome activation against gram-negative bacterial pathogens

Casson, C. N., Yu, J. M., Reyes, V. M., Taschuk, F., Yadav, A., Copenhaver, A. M., Nguyen, H. T., Collman, R. G., & Shin, S. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1421699112 · Cited by 276 · see citing works

NLRP3 inflammasome inhibition is disrupted in a group of auto-inflammatory disease CAPS mutations

Mortimer, L. M., Moreau, F., MacDonald, J. A., & Chadee, K. (2016) · Nature Immunology · doi:10.1038/ni.3538 · Cited by 259 · see citing works

Inducible interleukin-1 gene expression in human vascular smooth muscle cells.

Libby, P., Ordovás, J. M., Birinyi, L. K., Auger, K. R., & Dinarello, C. A. (1986) · Journal of Clinical Investigation · doi:10.1172/jci112732 · Cited by 258 · see citing works

Atherosclerosis in ApoE-deficient mice progresses independently of the NLRP3 inflammasome

Menu, P., Pellegrin, M., Aubert, J.-F., Bouzourène, K., Tardivel, A., Mazzolai, L., & Tschopp, J. (2011) · Cell Death and Disease · doi:10.1038/cddis.2011.18 · Cited by 249 · see citing works

Response to local inflammation of IL-1 beta-converting enzyme- deficient mice

Fantuzzi, G., Ku, G., Harding, M. W., Livingston, D. J., Sipe, J. D., Kuida, K., Flavell, R. A., & Dinarello, C. A. (1997) · The Journal of Immunology · doi:10.4049/jimmunol.158.4.1818 · Cited by 232 · see citing works

Induction of Lysosomal Biogenesis in Atherosclerotic Macrophages Can Rescue Lipid-Induced Lysosomal Dysfunction and Downstream Sequelae

Emanuel, R., Sergin, I., Bhattacharya, S., Turner, J. N., Epelman, S., Settembre, C., Diwan, A., Ballabio, A., & Razani, B. (2014) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.114.303342 · Cited by 228 · see citing works

Monoclonal antibodies targeting IL-1 beta reduce biomarkers of atherosclerosis in vitro and inhibit atherosclerotic plaque formation in Apolipoprotein E-deficient mice

Bhaskar, V., Yin, J., Mirza, A. M., Phan, D., Vanegas, S., Issafras, H., Michelson, K. S., Hunter, J., & Kantak, S. S. (2011) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2011.02.026 · Cited by 226 · see citing works

NLRP3 tyrosine phosphorylation is controlled by protein tyrosine phosphatase PTPN22

Spalinger, M. R., Kasper, S., Gottier, C., Lang, S., Atrott, K., Vavricka, S. R., Scharl, S., Gutte, P. M., Grütter, M. G., Beer, H., et al. (2016) · Journal of Clinical Investigation · doi:10.1172/jci83669 · Cited by 225 · see citing works

Increased endothelial expression of Toll-like receptor 2 at sites of disturbed blood flow exacerbates early atherogenic events

Mullick, A. E., Soldau, K., Kiosses, W. B., Bell, T. A., Tobias, P. S., & Curtiss, L. K. (2008) · The Journal of Experimental Medicine · doi:10.1084/jem.20071096 · Cited by 223 · see citing works

Structural mechanisms of inflammasome assembly

Lu, A. Z., & Wu, H. (2014) · FEBS Journal · doi:10.1111/febs.13133 · Cited by 219 · see citing works

Genetic inactivation of IL-1 signaling enhances atherosclerotic plaque instability and reduces outward vessel remodeling in advanced atherosclerosis in mice

Alexander, M. R., Moehle, C. W., Johnson, J. L., Yang, Z., Lee, J. K., Jackson, C. L., & Owens, G. K. (2011) · Journal of Clinical Investigation · doi:10.1172/jci43713 · Cited by 218 · see citing works

C-Reactive Protein and Risk of Lung Cancer

Chaturvedi, A. K., Caporaso, N. E., Katki, H. A., Wong, H., Chatterjee, N., Pine, S. R., Chanock, S. J., Goedert, J. J., & Engels, E. A. (2010) · Journal of Clinical Oncology · doi:10.1200/jco.2009.27.0454 · Cited by 216 · see citing works

Omega-3 Free Fatty Acids Suppress Macrophage Inflammasome Activation by Inhibiting NF-κB Activation and Enhancing Autophagy

Williams-Bey, Y., Boularan, C., Vural, A., Huang, N.-N., Hwang, I.-Y., Shan-Shi, C., & Kehrl, J. H. (2014) · PLoS ONE · doi:10.1371/journal.pone.0097957 · Cited by 215 · see citing works

Effect of Cholesterol Crystals on Plaques and Intima in Arteries of Patients With Acute Coronary and Cerebrovascular Syndromes

Abela, G. S., Aziz, K. S., Vedre, A., Pathak, D. R., Talbott, J. D., & deJong, J. L. (2009) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2008.12.019 · Cited by 215 · see citing works

The Lysosome Rupture-activated TAK1-JNK Pathway Regulates NLRP3 Inflammasome Activation

Okada, M., Matsuzawa, A., Yoshimura, A., & Ichijo, H. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.579961 · Cited by 213 · see citing works

Differential Effects of Interleukin-1 Receptor Antagonist and Tumor Necrosis Factor Binding Protein on Fatty-Streak Formation in Apolipoprotein E–Deficient Mice

Elhage, R., Maret, A., Pieraggi, M. T., Thiers, J., Arnal, J., & Bayard, F. (1998) · Circulation · doi:10.1161/01.cir.97.3.242 · Cited by 209 · see citing works

Inefficient star formation in extremely metal poor galaxies

Shi, Y., Armus, L., Hélou, G., Stierwalt, S., Gao, Y., Wang, J., Zhang, Z.-Y., & Gu, Q. (2014) · Nature · doi:10.1038/nature13820 · Cited by 207 · see citing works

Associations of functional NLRP3 polymorphisms with susceptibility to food-induced anaphylaxis and aspirin-induced asthma

Hitomi, Y., Ebisawa, M., Tomikawa, M., Imai, T., Komata, T., Hirota, T., Harada, M., Sakashita, M., Suzuki, Y., Shimojo, N., et al. (2009) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2009.07.044 · Cited by 206 · see citing works

Inflammasome Priming by Lipopolysaccharide Is Dependent upon ERK Signaling and Proteasome Function

Ghonime, M. G., Shamaa, O. R., Das, S., El-Domany, R. A., Fernandes‐Alnemri, T., Alnemri, E. S., Gavrilin, M. A., & Wewers, M. D. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1301974 · Cited by 200 · see citing works

Cutting Edge: The NLRP3 Inflammasome Links Complement-Mediated Inflammation and IL-1β Release

Laudisi, F., Spreafico, R., Evrard, M., Hughes, T. R., Mandriani, B., Kandasamy, M., Morgan, B. P., Sivasankar, B., & Mortellaro, A. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1300489 · Cited by 198 · see citing works

Do the <i>Apoe</i> ^{<i>−/−</i>} and <i>Ldlr</i> ^{<i>−/–</i>} Mice Yield the Same Insight on Atherogenesis?

Getz, G. S., & Reardon, C. A. (2016) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/atvbaha.116.306874 · Cited by 198 · see citing works

NLRP3 Inflammasomes Show High Expression in Aorta of Patients with Atherosclerosis

Zheng, F. Y., Xing, S., Gong, Z., & Xing, Q. (2013) · Heart Lung and Circulation · doi:10.1016/j.hlc.2013.01.012 · Cited by 191 · see citing works

Cholesterol crystals piercing the arterial plaque and intima trigger local and systemic inflammation

Abela, G. S. (2010) · Journal of clinical lipidology · doi:10.1016/j.jacl.2010.03.003 · Cited by 189 · see citing works

Cutting Edge: Nitric Oxide Inhibits the NLRP3 Inflammasome

Hernandez-Cuellar, E., Tsuchiya, K., Hara, H., Fang, R., Sakai, S., Kawamura, I., Akira, S., & Mitsuyama, M. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1202479 · Cited by 184 · see citing works

Infections and Atherosclerosis: New Clues from an Old Hypothesis?

Nieto, F. J. (1998) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a009570 · Cited by 184 · see citing works

Critical role of caspase-1 in vascular inflammation and development of atherosclerosis in Western diet-fed apolipoprotein E-deficient mice

Usui, F., Shirasuna, K., Kimura, H. J., Tatsumi, K., Kawashima, A., Karasawa, T., Hida, S., Sagara, J., Taniguchi, S., & Takahashi, M. (2012) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2012.07.058 · Cited by 183 · see citing works

The Expression and Functions of Toll-Like Receptors in Atherosclerosis

Cole, J. E., Georgiou, E. X., & Monaco, C. G. (2010) · Mediators of Inflammation · doi:10.1155/2010/393946 · Cited by 176 · see citing works

Infectious Agents Are Not Necessary for Murine Atherogenesis

Wright, S. D., Burton, C., Hernandez, M., Hassing, H., Montenegro, J., Mundt, S., Patel, S., Card, D. J., Hermanowski-Vosatka, A., Bergstrom, J. D., et al. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.191.8.1437 · Cited by 176 · see citing works

Atherosclerosis research from past to present—on the track of two pathologists with opposing views, Carl von Rokitansky and Rudolf Virchow

Mayerl, C., Lukasser, M., Sedivy, R., Niederegger, H., Seiler, R., & Wick, G. (2006) · Archiv für Pathologische Anatomie und Physiologie und für Klinische Medicin · doi:10.1007/s00428-006-0176-7 · Cited by 175 · see citing works

Expression of the NLRP3 Inflammasome in Carotid Atherosclerosis

Shi, X., Xie, W., Kong, W.-W., Chen, D., & Qu, P. (2015) · Journal of Stroke and Cerebrovascular Diseases · doi:10.1016/j.jstrokecerebrovasdis.2015.03.024 · Cited by 173 · see citing works

A single domain antibody fragment that recognizes the adaptor ASC defines the role of ASC domains in inflammasome assembly

Schmidt, F. I., Lu, A. Z., Chen, J. W., Ruan, J., Tang, C., Wu, H., & Ploegh, H. L. (2016) · The Journal of Experimental Medicine · doi:10.1084/jem.20151790 · Cited by 173 · see citing works

Recent insights into the molecular mechanisms of the NLRP3 inflammasome activation

Próchnicki, T., Mangan, M., & Latz, E. (2016) · F1000Research · doi:10.12688/f1000research.8614.1 · Cited by 173 · see citing works

Lack of Interleukin-1 Receptor Antagonist Modulates Plaque Composition in Apolipoprotein E–Deficient Mice

Isoda, K., Sawada, S., Ishigami, N., Matsuki, T., Miyazaki, K., Kusuhara, M., Iwakura, Y., & Ohsuzu, F. (2004) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000127025.48140.a3 · Cited by 164 · see citing works

Ogg1-Dependent DNA Repair Regulates NLRP3 Inflammasome and Prevents Atherosclerosis

Tumurkhuu, G., Shimada, K., Dagvadorj, J., Crother, T., Zhang, W., Luthringer, D., Gottlieb, R., Chen, S., & Arditi, M. (2016) · Circulation Research · doi:10.1161/circresaha.116.308362 · Cited by 164 · see citing works

Targeting inflammation to reduce cardiovascular disease risk: A realistic clinical prospect?

Welsh, P., Grassia, G., Botha, S., Sattar, N., & Maffia, P. (2017) · British Journal of Pharmacology · doi:10.1111/bph.13818 · Cited by 164 · see citing works

Role of lysosome rupture in controlling Nlrp3 signaling and necrotic cell death

Lima, H., Jacobson, L. S., Goldberg, M. F., Chandran, K., Diaz‐Griffero, F., Lisanti, M. P., & Brojatsch, J. (2013) · Cell Cycle · doi:10.4161/cc.24903 · Cited by 163 · see citing works

The airway epithelium nucleotide-binding domain and leucine-rich repeat protein 3 inflammasome is activated by urban particulate matter

Hirota, J. A., Hirota, S. A., Warner, S., Stefanowicz, D., Shaheen, F., Beck, P. L., MacDonald, J. A., Hackett, T., Sin, D. D., van Eeden, S. F., et al. (2012) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2011.11.033 · Cited by 161 · see citing works

Structure and assembly of the mouse ASC inflammasome by combined NMR spectroscopy and cryo-electron microscopy

Sborgi, L., Ravotti, F., Dandey, V., Dick, M. S., Mazur, A., Reckel, S., Chami, M., Scherer, S. A., Huber, M., Böckmann, A., et al. (2015) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.1507579112 · Cited by 153 · see citing works

Assembly and regulation of ASC specks

Hoß, F., Rodríguez-Alcázar, J. F., & Latz, E. (2016) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-016-2396-6 · Cited by 153 · see citing works

Genetic alterations of IL-1 receptor antagonist in mice affect plasma cholesterol level and foam cell lesion size

Devlin, C. M., Kuriakose, G., Hirsch, E., & Tabas, I. A. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.092324399 · Cited by 147 · see citing works

Silence of NLRP3 Suppresses Atherosclerosis and Stabilizes Plaques in Apolipoprotein E-Deficient Mice

Zheng, F. Y., Xing, S., Gong, Z., Mu, W., & Xing, Q. (2014) · Mediators of Inflammation · doi:10.1155/2014/507208 · Cited by 147 · see citing works

The JUPITER Trial

Ridker, P. M. (2009) · Circulation Cardiovascular Quality and Outcomes · doi:10.1161/circoutcomes.109.868299 · Cited by 146 · see citing works

Inhibiting the Inflammasome: A Chemical Perspective

Baldwin, A. G., Brough, D., & Freeman, S. (2015) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.5b01091 · Cited by 140 · see citing works

Caspase-1 Deficiency Decreases Atherosclerosis in Apolipoprotein E-Null Mice

Gage, J., Hasu, M., Thabet, M., & Whitman, S. C. (2012) · Canadian Journal of Cardiology · doi:10.1016/j.cjca.2011.10.013 · Cited by 136 · see citing works

P2X7R is involved in the progression of atherosclerosis by promoting NLRP3 inflammasome activation

Kuang, P., Liu, L.-S., Wei, D., Lv, Y.-C., Wang, G., Xiong, W., Wang, X., Altaf, A., Wang, L., He, D., et al. (2015) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2015.2129 · Cited by 131 · see citing works

Intracellular sensing of microbes and danger signals by the inflammasomes

Horvath, G. L., Schrum, J. E., Nardo, C. M. D., & Latz, E. (2011) · Immunological Reviews · doi:10.1111/j.1600-065x.2011.01050.x · Cited by 125 · see citing works

Role of HMGB1 in cardiovascular diseases

Li, W., Sama, A., & Wang, H. (2006) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2005.10.010 · Cited by 120 · see citing works

Interleukin-1β and Signaling of Interleukin-1 in Vascular Wall and Circulating Cells Modulates the Extent of Neointima Formation in Mice

Chamberlain, J., EVANS, D. B., King, A. R., Dewberry, R. M., Dower, S., Crossman, D. C., & Francis, S. (2006) · American Journal Of Pathology · doi:10.2353/ajpath.2006.051054 · Cited by 116 · see citing works

Oxidized Low-Density Lipoprotein Immune Complex Priming of the Nlrp3 Inflammasome Involves TLR and FcγR Cooperation and Is Dependent on CARD9

Rhoads, J. P., Lukens, J. R., Wilhelm, A. J., Moore, J. L., Mendez-Fernandez, Y., Kanneganti, T., & Major, A. S. (2017) · The Journal of Immunology · doi:10.4049/jimmunol.1601563 · Cited by 107 · see citing works

Differential role and tissue specificity of interleukin-1α gene expression in atherogenesis and lipid metabolism

Kamari, Y., Werman-Venkert, R., Shaish, A., Werman, A., Harari, A., Gonen, A., Voronov, E., Grosskopf, I., Sharabi, Y., Grossman, E., et al. (2006) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2006.11.026 · Cited by 106 · see citing works

Inflammation and its resolution in atherosclerosis: mediators and therapeutic opportunities

Bäck, M., Yurdagul, A., Tabas, I., Öörni, K., & Kovanen, P. T. (2019) · Nature Reviews Cardiology · doi:10.1038/s41569-019-0169-2 · Cited by 1,341 · see citing works

TLR4 Cross-Talk With NLRP3 Inflammasome and Complement Signaling Pathways in Alzheimer's Disease

Yang, J., Wise, L., & Fukuchi, K.-I. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.00724 · Cited by 387 · see citing works

Trimethylamine-N-Oxide Promotes Vascular Calcification Through Activation of NLRP3 (Nucleotide-Binding Domain, Leucine-Rich-Containing Family, Pyrin Domain-Containing-3) Inflammasome and NF-κB (Nuclear Factor κB) Signals

Zhang, X., Li, Y., Yang, P., Liu, X., Lu, L., Chen, Y., Zhong, X., Li, Z., Liu, H., Ou, C., et al. (2020) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/atvbaha.119.313414 · Cited by 291 · see citing works

Interactions Between the Gut Microbiota and the Host Innate Immune Response Against Pathogens

Cheng, H.-Y., Ning, M.-X., Chen, D.-K., & Ma, W.-T. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00607 · Cited by 244 · see citing works

Optineurin inhibits NLRP3 inflammasome activation by enhancing mitophagy of renal tubular cells in diabetic nephropathy

Chen, K., Feng, L., Hu, W., Chen, J., Wang, X., Wang, L., & He, Y. (2019) · The FASEB Journal · doi:10.1096/fj.201801749rrr · Cited by 85 · see citing works

The ligand-gated ion channel P2X7 receptor mediates NLRP3/caspase-1-mediated pyroptosis in cerebral cortical neurons of juvenile rats with sepsis

Sun, X., Zhou, R., Lei, Y., Hu, J., & Li, X. (2020) · Brain Research · doi:10.1016/j.brainres.2020.147109 · Cited by 28 · see citing works

ИСПОЛЬЗОВAНИЕ ПОТЕНЦИAЛA СОЦИAЛЬНЫХ ПAРТНЕРОВ В ПОДГОТОВКЕ БУДУЩИХ ПЕДAГОГОВ

Атабекова, Б. Б. (2024) · Habaršy. Pedagogika ġylymdary seriâsy · doi:10.51889/2959-5762.2023.80.4.019

Molecular mechanisms regulating NLRP3 inflammasome activation

Eun-Kyeong, Jo, Jin, et al. (2016) · 中国免疫学杂志：英文版 · Cited by 2 · see citing works

The inflammasome as future therapeutic target: Development of inflammasome challenge tests

Dillingh, M. R. (2014) · Journal of Clinical & Cellular Immunology

Cloning and Characterization of Rat BAT3 cDNA

Ozaki, T., Hanaoka, E., Naka, M., et al. (1999) · DNA and Cell Biology · doi:10.1089/104454999315222 · Cited by 22 · see citing works

NLRP3 licenses NLRP11 for inflammasome activation in human macrophages

Gangopadhyay, A., Devi, S., Tenguria, S., Carrière, J., Nguyen, H., Jäger, E., Khatri, H., Chu, L. H., Ratsimandresy, R. A., Dorfleutner, A., et al. (2022) · Nature Immunology · doi:10.1038/s41590-022-01220-3 · Cited by 61 · see citing works