The DOI matches its Crossref record; 17 of the 17 references it cites were found in a registry or an index.
TNF Counterbalances the Emergence of M2 Tumor Macrophages
Open accessAbstract
Cancer can involve non-resolving, persistent inflammation where varying numbers of tumor-associated macrophages (TAMs) infiltrate and adopt different activation states between anti-tumor M1 and pro-tumor M2 phenotypes. Here, we resolve a cascade causing differential macrophage phenotypes in the tumor microenvironment. Reduction in TNF mRNA production or loss of type I TNF receptor signaling resulted in a striking pattern of enhanced M2 mRNA expression. M2 gene expression was driven in part by IL-13 from eosinophils co-recruited with inflammatory monocytes, a pathway that was suppressed by TNF. Our data define regulatory nodes within the tumor microenvironment that balance M1 and M2 populations. Our results show macrophage polarization in cancer is dynamic and dependent on the balance between TNF and IL-13, thus providing a strategy for manipulating TAMs.
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Cites
Obesity is associated with macrophage accumulation in adipose tissue
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Self-citationThe immune contexture in human tumours: impact on clinical outcome
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Macrophage biology in development, homeostasis and disease
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“In resolving inflammation, M1 macrophages can convert into M2 macrophages to restore tissue homeostasis and integrity during and after removal of the inciting entity (Wynn et al., 2013).”
BackgroundInfluentialObesity induces a phenotypic switch in adipose tissue macrophage polarization
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Accessories to the Crime: Functions of Cells Recruited to the Tumor Microenvironment
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Tumors: Wounds That Do Not Heal
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“In doing so macrophages may aid and abet an enemy within as proposed by the Dvorak in the ‘wounds that don’t heal’ model (Bissell and Hines, 2011; Dvorak, 1986).”
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Functional Polarization of Tumour-Associated Macrophages by Tumour-Derived Lactic Acid
Colegio, O. R., Chu, N.-Q., Szabo, A. L., Chu, T., Rhebergen, A. M., Jairam, V., Cyrus, N., Brokowski, C. E., Eisenbarth, S. C., Phillips, G. M., et al. (2014) · Nature · doi:10.1038/nature13490 · Cited by 3,046
Cited by
Macrophages in Tissue Repair, Regeneration, and Fibrosis
Wynn, T. A., & Vannella, K. M. (2016) · Immunity · doi:10.1016/j.immuni.2016.02.015 · Cited by 4,481
Murray, P. J. (2017) · Annual Review of Physiology · doi:10.1146/annurev-physiol-022516-034339 · Cited by 2,981
Self-citationRecommendations for myeloid-derived suppressor cell nomenclature and characterization standards
Bronte, V., Brandau, S., Chen, S.-H., Colombo, M. P., Frey, A. B., Greten, T. F., Mandruzzato, S., Murray, P. J., Ochoa, A., Ostrand-Rosenberg, S., et al. (2016) · Nature Communications · doi:10.1038/ncomms12150 · Cited by 2,751
Self-citationMacrophage Polarization States in the Tumor Microenvironment
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The Immunology of Macrophage Activation Syndrome
Crayne, C. B., Albeituni, S., Nichols, K. E., & Cron, R. Q. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00119 · Cited by 633
Metadata
- Authors
- Kratochvill, F., Neale, G., Haverkamp, J. M., Van de Velde, L.-A., Smith, A. M., Kawauchi, D., McEvoy, J., Roussel, M. F., Dyer, M. A., Qualls, J. E., & Murray, P. J.
- Venue
- Cell Reports
- Publisher
- Elsevier BV
- Published
- 2015-09
- Volume
- 12
- Issue
- 11
- Pages
- 1902-1914
- ISSN
- 2211-1247 (ISSN-L)
- OpenAlex
- W2149813574
- Cited by
- 277
- References
- 17
- FWCI
- 8.52
- Type
- journal article
- Language
- en
- Open access
- gold
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- Kratochvill, F., Neale, G., Haverkamp, J. M., Van de Velde, L.-A., Smith, A. M., Kawauchi, D., McEvoy, J., Roussel, M. F., Dyer, M. A., Qualls, J. E., & Murray, P. J. (2015). TNF Counterbalances the Emergence of M2 Tumor Macrophages. Cell Reports. https://doi.org/10.1016/j.celrep.2015.08.033
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