Signaling from Mus81-Eme2-Dependent DNA Damage Elicited by Chk1 Deficiency Modulates Replication Fork Speed and Origin Usage

The DNA Damage Response: Making It Safe to Play with Knives

Ciccia, A., & Elledge, S. J. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.09.019 · Cited by 4,368 · see citing works

Causes and consequences of replication stress

Zeman, M. K., & Cimprich, K. A. (2014) · Nature Cell Biology · doi:10.1038/ncb2897 · Cited by 2,079 · see citing works

ATR prohibits replication catastrophe by preventing global exhaustion of RPA

Toledo, L. I., Altmeyer, M., Rask, M.-B., Lukas, C., Larsen, D. H., Povlsen, L. K., Bekker-Jensen, S., Mailand, N., Bartek, J., & Lukas, J. (2013) · Cell · doi:10.1016/j.cell.2013.10.043 · Cited by 911 · see citing works

A ribonucleotide reductase gene involved in a p53-dependent cell-cycle checkpoint for DNA damage

Tanaka, H., Arakawa, H., Yamaguchi, T., Shiraishi, K., Fukuda, S., Matsui, K., Takei, Y., & Nakamura, Y. (2000) · Nature · doi:10.1038/35003506 · Cited by 904 · see citing works

Replication stress links structural and numerical cancer chromosomal instability

Burrell, R. A., McClelland, S. E., Endesfelder, D., Groth, P., Weller, M.-C., Shaikh, N., Domingo, E., Kanu, N., Dewhurst, S. M., Gronroos, E. C., et al. (2013) · Nature · doi:10.1038/nature11935 · Cited by 868 · see citing works

Nucleotide deficiency promotes genomic instability in early stages of cancer development

Bester, A. C., Roniger, M., Oren, Y. S., Im, M. M., Sarni, D., Chaoat, M., Bensimon, A., Zamir, G., Shewach, D. S., & Kerem, B. (2011) · Cell · doi:10.1016/j.cell.2011.03.044 · Cited by 858 · see citing works

Genome instability: a mechanistic view of its causes and consequences

Aguilera, A., & Gómez‐González, B. (2008) · Nature Reviews Genetics · doi:10.1038/nrg2268 · Cited by 806 · see citing works

A role for the Tip60 histone acetyltransferase in the acetylation and activation of ATM

Sun, Y., Jiang, X., Chen, S., Fernandes, N., & Price, B. D. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0504211102 · Cited by 738 · see citing works

Liquid demixing of intrinsically disordered proteins is seeded by poly(ADP-ribose)

Altmeyer, M., Neelsen, K. J., Teloni, F., Pozdnyakova, I., Pellegrino, S., Grøfte, M., Rask, M., Streicher, W. W., Jungmichel, S., Nielsen, M. L., et al. (2015) · Nature Communications · doi:10.1038/ncomms9088 · Cited by 581 · see citing works

DNA Double-Strand Break Repair Pathway Choice Is Directed by Distinct MRE11 Nuclease Activities

Shibata, A., Moiani, D., Arvai, A. S., Perry, J. J. P., Harding, S. M., Genois, M., Maity, R., van Rossum-Fikkert, S. E., Kertokalio, A., Romoli, F., et al. (2013) · Molecular Cell · doi:10.1016/j.molcel.2013.11.003 · Cited by 564 · see citing works

Chk1 regulates the S phase checkpoint by coupling the physiological turnover and ionizing radiation-induced accelerated proteolysis of Cdc25A

Sørensen, C. S., Syljuåsen, R. G., Falck, J., Schroeder, T., Rönnstrand, L., Khanna, K. K., Zhou, B.-B., Bártek, J., & Lukas, J. (2003) · Cancer Cell · doi:10.1016/s1535-6108(03)00048-5 · Cited by 560 · see citing works

Inhibition of Human Chk1 Causes Increased Initiation of DNA Replication, Phosphorylation of ATR Targets, and DNA Breakage

Syljuåsen, R. G., Sørensen, C. S., Hansen, L. T., Fugger, K., Lundin, C., Johansson, F., Helleday, T., Sehested, M., Lukas, J., & Bártek, J. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.9.3553-3562.2005 · Cited by 550 · see citing works

Human CtIP Mediates Cell Cycle Control of DNA End Resection and Double Strand Break Repair

Huertas, P., & Jackson, S. P. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m808906200 · Cited by 511 · see citing works

Disruption of the checkpoint kinase 1/cell division cycle 25A pathway abrogates ionizing radiation-induced S and G 2 checkpoints

Zhao, H., Watkins, J. L., & Piwnica-Worms, H. M. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.182557299 · Cited by 459 · see citing works

Erratum: Corrigendum: Replication stress links structural and numerical cancer chromosomal instability

Burrell, R. A., McClelland, S. E., Endesfelder, D., Groth, P., Weller, M.-C., Shaikh, N., Domingo, E., Kanu, N., Dewhurst, S. M., Gronroos, E. C., et al. (2013) · Nature · doi:10.1038/nature12369 · Cited by 451 · see citing works

ATR phosphorylates SMARCAL1 to prevent replication fork collapsePreprint

Couch, F. B., Bansbach, C. E., Driscoll, R., Luzwick, J. W., Glick, G. G., Betous, R., Carroll, C. M., Jung, S. Y., Qin, J., Cimprich, K. A., et al. (2013) · Genes & Development · doi:10.1101/gad.214080.113 · Cited by 409 · see citing works

Cyclin F-Mediated Degradation of Ribonucleotide Reductase M2 Controls Genome Integrity and DNA Repair

D’Angiolella, V., Donato, V., Forrester, F. M., Jeong, Y., Pellacani, C., Kudo, Y., Saraf, A., Florens, L. A., Washburn, M. P., & Pagano, M. (2012) · Cell · doi:10.1016/j.cell.2012.03.043 · Cited by 396 · see citing works

ATR and ATM regulate the timing of DNA replication origin firing

Shechter, D., Costanzo, V., & Gautier, J. (2004) · Nature Cell Biology · doi:10.1038/ncb1145 · Cited by 383 · see citing works

Tip60 is a haplo-insufficient tumour suppressor required for an oncogene-induced DNA damage response

Gorrini, C., Squatrito, M., Luise, C., Syed, N., Perna, D., Wark, L., Martinato, F., Sardella, D., Verrecchia, A., Bennett, S., et al. (2007) · Nature · doi:10.1038/nature06055 · Cited by 341 · see citing works

Chromatin Dynamics During DNA Replication and Uncharacterized Replication Factors determined by Nascent Chromatin Capture (NCC) Proteomics

Alabert, C., Bukowski-Wills, J.-C., Lee, S.-B., Kustatscher, G., Nakamura, K., Alves, F. D. L., Ménard, P., Mejlvang, J., Rappsilber, J., & Groth, A. (2014) · Nature Cell Biology · doi:10.1038/ncb2918 · Cited by 334 · see citing works

Distinct but Concerted Roles of ATR, DNA-PK, and Chk1 in Countering Replication Stress during S Phase

Buisson, R., Boisvert, J. L., Benes, C. H., & Zou, L. (2015) · Molecular Cell · doi:10.1016/j.molcel.2015.07.029 · Cited by 316 · see citing works

Chk1 promotes replication fork progression by controlling replication initiation

Petermann, E., Woodcock, M., & Helleday, T. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1005031107 · Cited by 308 · see citing works

Cyclin-Dependent Kinase Suppression by WEE1 Kinase Protects the Genome through Control of Replication Initiation and Nucleotide Consumption

Beck, H., Nähse, V., Larsen, M. S. Y., O’Hanlon, K. A., Patzke, S., Holmberg, C., Mejlvang, J., Groth, A., Nielsen, O., Syljuåsen, R. G., et al. (2012) · Molecular and Cellular Biology · doi:10.1128/mcb.00412-12 · Cited by 303 · see citing works

Regulation of Mammalian Ribonucleotide Reduction and dNTP Pools after DNA Damage and in Resting Cells

Håkansson, P., Hofer, A., & Thelander, L. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m512894200 · Cited by 290 · see citing works

Effects of Hydroxyurea and 1‐β‐D‐Arabinofuranosyl‐cytosine on Deoxyribonucleotide Pools in Mouse Embryo Cells

Skoog, L. K., & Nordenskjöld, B. A. (1971) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1971.tb01290.x · Cited by 278 · see citing works

Replication fork movement sets chromatin loop size and origin choice in mammalian cells

Courbet, S., Gay, S., Arnoult, N., Wronka, G., Anglana, M., Brison, O., & Debatisse, M. (2008) · Nature · doi:10.1038/nature07233 · Cited by 237 · see citing works

Chk1 regulates the density of active replication origins during the vertebrate S phase

Maya‐Mendoza, A., Petermann, E., Gillespie, D. A., Caldecott, K. W., & Jackson, D. A. (2007) · The EMBO Journal · doi:10.1038/sj.emboj.7601714 · Cited by 236 · see citing works

Visualization of Altered Replication Dynamics after DNA Damage in Human Cells

Merrick, C. J., Jackson, D. A., & Diffley, J. F. X. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m400022200 · Cited by 228 · see citing works

The intra-S phase checkpoint affects both DNA replication initiation and elongation: single-cell and -DNA fiber analyses

Seiler, J. A., Conti, C., Syed, A., Aladjem, M. I., & Pommier, Y. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.02278-06 · Cited by 226 · see citing works

Enzymatic assay for deoxyribonucleoside triphosphates using synthetic oligonucleotides as template primers

Sherman, P. A., & Fyfe, J. A. (1989) · Analytical Biochemistry · doi:10.1016/0003-2697(89)90420-x · Cited by 218 · see citing works

Deoxyribonucleotide metabolism, mutagenesis and cancer

Mathews, C. K. (2015) · Nature reviews. Cancer · doi:10.1038/nrc3981 · Cited by 200 · see citing works

Wee1 controls genomic stability during replication by regulating the Mus81-Eme1 endonuclease

Domínguez-Kelly, R., Martín, Y., Koundrioukoff, S., Tanenbaum, M. E., Smits, V. A. J., Medema, R. H., Debatisse, M., & Freire, R. (2011) · The Journal of Cell Biology · doi:10.1083/jcb.201101047 · Cited by 193 · see citing works

Regulators of cyclin-dependent kinases are crucial for maintaining genome integrity in S phase

Beck, H., Nähse, V., Larsen, M. S. Y., Groth, P., Clancy, T., Lees, M. J., Jørgensen, M., Helleday, T., Syljuåsen, R. G., & Sørensen, C. S. (2010) · The Journal of Cell Biology · doi:10.1083/jcb.200905059 · Cited by 169 · see citing works

Cyclin A–Cdk1 regulates the origin firing program in mammalian cells

Katsuno, Y., Suzuki, A., Sugimura, K., Okumura, K., Zineldeen, D. H., Shimada, M., Niida, H., Mizuno, T., Hanaoka, F., & Nakanishi, M. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0809350106 · Cited by 161 · see citing works

Control of Replication Origin Density and Firing Time in Xenopus Egg Extracts

Marheineke, K., & Hyrien, O. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m401574200 · Cited by 152 · see citing works

Implication of Checkpoint Kinase-dependent Up-regulation of Ribonucleotide Reductase R2 in DNA Damage Response

Zhang, Y., Jones, T. L., Martin, S. E., Caplen, N. J., & Pommier, Y. G. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.003020 · Cited by 146 · see citing works

NEK8 Links the ATR-Regulated Replication Stress Response and S Phase CDK Activity to Renal Ciliopathies

Choi, H. J. C., Lin, J., Vannier, J., Slaats, G. G. G., Kile, A. C., Paulsen, R. D., Manning, D. K., Beier, D. R., Giles, R. H., Boulton, S. J., et al. (2013) · Molecular Cell · doi:10.1016/j.molcel.2013.08.006 · Cited by 142 · see citing works

Replication Dynamics: Biases and Robustness of DNA Fiber Analysis

Técher, H., Koundrioukoff, S., Azar, D., Wilhelm, T., Carignon, S., Brison, O., Debatisse, M., & Tallec, B. L. (2013) · Journal of Molecular Biology · doi:10.1016/j.jmb.2013.03.040 · Cited by 140 · see citing works

Stepwise Activation of the ATR Signaling Pathway upon Increasing Replication Stress Impacts Fragile Site Integrity

Koundrioukoff, S., Carignon, S., Técher, H., Letessier, A., Brison, O., & Debatisse, M. (2013) · PLoS Genetics · doi:10.1371/journal.pgen.1003643 · Cited by 137 · see citing works

Essential role of Tip60-dependent recruitment of ribonucleotide reductase at DNA damage sites in DNA repair during G1 phasePreprint

Niida, H., Katsuno, Y., Sengoku, M., Shimada, M., Yukawa, M., Ikura, M., Ikura, T., Kohno, K., Shima, H., Suzuki, H., et al. (2010) · Genes & Development · doi:10.1101/gad.1863810 · Cited by 136 · see citing works

Controlling DNA replication origins in response to DNA damage – inhibit globally, activate locally

Yekezare, M., Gómez‐González, B., & Diffley, J. F. X. (2013) · Journal of Cell Science · doi:10.1242/jcs.096701 · Cited by 134 · see citing works

MUS81-EME2 Promotes Replication Fork Restart

Pepe, A., & West, S. C. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.04.007 · Cited by 131 · see citing works

Structure-Specific DNA Endonuclease Mus81/Eme1 Generates DNA Damage Caused by Chk1 Inactivation

Forment, J. V., Blasius, M., Guerini, I., & Jackson, S. P. (2011) · PLoS ONE · doi:10.1371/journal.pone.0023517 · Cited by 126 · see citing works

Cell cycle-dependent regulation of the nuclease activity of Mus81–Eme1/Mms4

Gallo-Fernández, M., Saugar, I., Ortiz-Bazán, M. Á., Vázquez, M. V., & Tercero, J. A. (2012) · Nucleic Acids Research · doi:10.1093/nar/gks599 · Cited by 119 · see citing works

Claspin Promotes Normal Replication Fork Rates in Human Cells

Petermann, E., Helleday, T., & Caldecott, K. W. (2008) · Molecular Biology of the Cell · doi:10.1091/mbc.e07-10-1035 · Cited by 116 · see citing works

Mre11 regulates CtIP-dependent double-strand break repair by interaction with CDK2

Buis, J. M., Stoneham, T., Spehalski, E. I., & Ferguson, D. O. (2012) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.2212 · Cited by 113 · see citing works

ATR Activates the S-M Checkpoint during Unperturbed Growth to Ensure Sufficient Replication Prior to Mitotic Onset

Eykelenboom, J. K., Harte, E. C., Canavan, L. E., Pastor-Peidro, A., Calvo‐Asensio, I., Llorens-Agost, M., & Lowndes, N. F. (2013) · Cell Reports · doi:10.1016/j.celrep.2013.10.027 · Cited by 112 · see citing works

Ribonucleotide reduction is a cytosolic process in mammalian cells independently of DNA damage

Pontarin, G., Fijolek, A., Pizzo, P., Ferraro, P., Rampazzo, C., Pozzan, T., Thelander, L., Reichard, P. A., & Bianchi, V. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0808198105 · Cited by 109 · see citing works

Initiation of Genome Instability and Preneoplastic Processes through Loss of Fhit Expression

Saldivar, J. C., Miuma, S., Bene, J., Hosseini, S. A., Shibata, H., Sun, J., Wheeler, L. J., Mathews, C. K., & Huebner, K. (2012) · PLoS Genetics · doi:10.1371/journal.pgen.1003077 · Cited by 96 · see citing works

Spontaneous slow replication fork progression elicits mitosis alterations in homologous recombination-deficient mammalian cells

Wilhelm, T., Magdalou, I., Barascu, A., Técher, H., Debatisse, M., & López, B. S. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1311520111 · Cited by 89 · see citing works

Cell-Cycle Kinases Coordinate the Resolution of Recombination Intermediates with Chromosome Segregation

Matos, J., Blanco, M. G., & West, S. C. (2013) · Cell Reports · doi:10.1016/j.celrep.2013.05.039 · Cited by 85 · see citing works

Pyrimidine pool imbalance induced by BLM helicase deficiency contributes to genetic instability in Bloom syndrome

CHABOSSEAU, P. L., Buhagiar‐Labarchède, G., Onclercq, R., Lambert, S., Debatisse, M., Brison, O., & Amor-Guéret, M. (2011) · Nature Communications · doi:10.1038/ncomms1363 · Cited by 84 · see citing works

Claspin and Chk1 regulate replication fork stability by different mechanisms

Scorah, J., & McGowan, C. H. (2009) · Cell Cycle · doi:10.4161/cc.8.7.8040 · Cited by 83 · see citing works

Cdk1 uncouples CtIP-dependent resection and Rad51 filament formation during M-phase double-strand break repair

Peterson, S., Li, Y., Chait, B. T., Gottesman, M. E., Baer, R. J., & Gautier, J. (2011) · The Journal of Cell Biology · doi:10.1083/jcb.201103103 · Cited by 83 · see citing works

The RBBP6/ZBTB38/MCM10 Axis Regulates DNA Replication and Common Fragile Site Stability

Miotto, B., Chibi, M., Xie, P., Koundrioukoff, S., Moolman-Smook, H., Pugh, D. J. R., Debatisse, M., He, F.-C., Zhang, L., & Defossez, P. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.03.030 · Cited by 74 · see citing works

Survival of the Replication Checkpoint Deficient Cells Requires MUS81-RAD52 Function

Murfuni, I., Basile, G., Subramanyam, S. V., Malacaria, E., Bignami, M., Spies, M., Franchitto, A., & Pichierri, P. (2013) · PLoS Genetics · doi:10.1371/journal.pgen.1003910 · Cited by 74 · see citing works

The fork and the kinase: A DNA replication tale from a CHK1 perspective

Besteiro, M. A. G., & Gottifredi, V. (2014) · Mutation Research/Reviews in Mutation Research · doi:10.1016/j.mrrev.2014.10.003 · Cited by 71 · see citing works

Tumor Cells Require Thymidylate Kinase to Prevent dUTP Incorporation during DNA Repair

Hu, C.-M., Yeh, M.-T., Tsao, N., Chen, C., Gao, Q.-Z., Chang, C.-Y., Lee, M.-H., Fang, J., Sheu, S., Lin, C.-J., et al. (2012) · Cancer Cell · doi:10.1016/j.ccr.2012.04.038 · Cited by 65 · see citing works

The Mre11 Nuclease Is Critical for the Sensitivity of Cells to Chk1 Inhibition

Thompson, R. H., Montano, R. E., & Eastman, A. R. (2012) · PLoS ONE · doi:10.1371/journal.pone.0044021 · Cited by 61 · see citing works

Are DNA precursors concentrated at replication sites?

Mathews, C. K., & Sinha, N. K. (1982) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.79.2.302 · Cited by 52 · see citing works

Kinase-independent function of checkpoint kinase 1 (Chk1) in the replication of damaged DNA

Speroni, J., Federico, M. B., Mansilla, S. F., Soria, G., & Gottifredi, V. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1116345109 · Cited by 51 · see citing works

Deoxynucleoside triphosphate (dNTP) synthesis and destruction regulate the replication of both cell and virus genomes

Stillman, B. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1312901110 · Cited by 36 · see citing works

Suppression of replication fork progression in low-dose-specific p53-dependent S-phase DNA damage checkpoint

Shimura, T., Toyoshima, M., Adiga, S. K., Kunoh, T., Nagai, H., Shimizu, N., Inoue, M., & Niwa, O. (2006) · Oncogene · doi:10.1038/sj.onc.1209624 · Cited by 34 · see citing works

A Functional Approach Reveals a Genetic and Physical Interaction between Ribonucleotide Reductase and CHK1 in Mammalian Cells

Taricani, L., Shanahan, F., Malinao, M.-C., Beaumont, M., & Parry, D. (2014) · PLoS ONE · doi:10.1371/journal.pone.0111714 · Cited by 15 · see citing works

The essential kinase ATR: ensuring faithful duplication of a challenging genome

Saldivar, J. C., Cortez, D., & Cimprich, K. A. (2017) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2017.67 · Cited by 829 · see citing works

Increased global transcription activity as a mechanism of replication stress in cancer

Kotsantis, P., Silva, L. M., Irmscher, S., Jones, R. M., Folkes, L. K., Gromak, N., & Petermann, E. (2016) · Nature Communications · doi:10.1038/ncomms13087 · Cited by 333 · see citing works

The impact of replication stress on replication dynamics and DNA damage in vertebrate cells

Técher, H., Koundrioukoff, S., Nicolas, A. G., & Debatisse, M. (2017) · Nature Reviews Genetics · doi:10.1038/nrg.2017.46 · Cited by 271 · see citing works

Replication Catastrophe: When a Checkpoint Fails because of Exhaustion

Toledo, L. I., Neelsen, K. J., & Lukas, J. (2017) · Molecular Cell · doi:10.1016/j.molcel.2017.05.001 · Cited by 228 · see citing works

Control of structure-specific endonucleases to maintain genome stability

Dehé, P.-M., & Gaillard, P.-H. L. (2017) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2016.177 · Cited by 174 · see citing works

Functions, Regulation, and Therapeutic Implications of the ATR Checkpoint Pathway

Yazinski, S. A., & Zou, L. (2016) · Annual Review of Genetics · doi:10.1146/annurev-genet-121415-121658 · Cited by 173 · see citing works

DNA damage response inhibitors: Mechanisms and potential applications in cancer therapy

Carrassa, L., & Damia, G. L. M. (2017) · Cancer Treatment Reviews · doi:10.1016/j.ctrv.2017.08.013 · Cited by 170 · see citing works

Defining and Modulating ‘BRCAness’

Byrum, A. K., Vindigni, A., & Mosammaparast, N. (2019) · Trends in Cell Biology · doi:10.1016/j.tcb.2019.06.005 · Cited by 164 · see citing works

A Critical Balance: dNTPs and the Maintenance of Genome Stability

Pai, C., & Kearsey, S. E. (2017) · Genes · doi:10.3390/genes8020057 · Cited by 158 · see citing works

Hydroxyurea—The Good, the Bad and the Ugly

Musiałek, M. W., & Rybaczek, D. (2021) · Genes · doi:10.3390/genes12071096 · Cited by 140 · see citing works

A Mechanism for Controlled Breakage of Under-replicated Chromosomes during Mitosis

Duda, H., Arter, M., Gloggnitzer, J., Teloni, F., Wild, P. S., Blanco, M. G., Altmeyer, M., & Matos, J. (2016) · Developmental Cell · doi:10.1016/j.devcel.2016.11.017 · Cited by 136 · see citing works

Inhibiting Wee1 and ATR kinases produces tumor-selective synthetic lethality and suppresses metastasis

Bukhari, A. B., Lewis, C. W., Pearce, J. J., Luong, D., Chan, G. K. T., & Gamper, A. M. (2019) · Journal of Clinical Investigation · doi:10.1172/jci122622 · Cited by 138 · see citing works

Nucleases Acting at Stalled Forks: How to Reboot the Replication Program with a Few Shortcuts

Pasero, P., & Vindigni, A. (2017) · Annual Review of Genetics · doi:10.1146/annurev-genet-120116-024745 · Cited by 120 · see citing works

Enhancing transcription–replication conflict targets ecDNA-positive cancers

Tang, J., Weiser, N. E., Wang, G., Chowdhry, S., Curtis, E. J., Zhao, Y., Wong, I. T.-L., Marinov, G. K., Li, R., Hanoian, P., et al. (2024) · Nature · doi:10.1038/s41586-024-07802-5 · Cited by 117 · see citing works

Cell cycle checkpoints and beyond: Exploiting the ATR/CHK1/WEE1 pathway for the treatment of PARP inhibitor–resistant cancer

Gupta, N., Huang, T., Horibata, S., & Lee, J. (2022) · Pharmacological Research · doi:10.1016/j.phrs.2022.106162 · Cited by 113 · see citing works

MUS81 nuclease activity is essential for replication stress tolerance and chromosome segregation in BRCA2-deficient cells

Lai, X., Broderick, R., Bergoglio, V., Zimmer, J., Badie, S., Niedźwiedź, W., Hoffmann, J., & Tarsounas, M. (2017) · Nature Communications · doi:10.1038/ncomms15983 · Cited by 107 · see citing works

Homologous Recombination and the Formation of Complex Genomic Rearrangements

Piazza, A., & Heyer, W. (2018) · Trends in Cell Biology · doi:10.1016/j.tcb.2018.10.006 · Cited by 102 · see citing works

Chromatin conformation regulates the coordination between DNA replication and transcription

Almeida, R., Fernández-Justel, J. M., Santa-María, C., Cadoret, J., Cano-Aroca, L., Lombraña, R., Herranz, G., Agresti, A., & Gómez, M. (2018) · Nature Communications · doi:10.1038/s41467-018-03539-8 · Cited by 92 · see citing works

Genome-wide Control of Heterochromatin Replication by the Telomere Capping Protein TRF2

Méndez-Bermúdez, A., Lototska, L., Bauwens, S., Giraud-Panis, M.-J. E., Croce, O., Jamet, K., Irizar, A., Mowinckel, M., Koundrioukoff, S., Nottet, N., et al. (2018) · Molecular Cell · doi:10.1016/j.molcel.2018.03.036 · Cited by 68 · see citing works

Wee1 Kinase: A Potential Target to Overcome Tumor Resistance to Therapy

Esposito, F., Giuffrida, R., Raciti, G., Puglisi, C., & Forte, S. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms221910689 · Cited by 69 · see citing works

S-phase checkpoint regulations that preserve replication and chromosome integrity upon dNTP depletion

Giannattasio, M., & Branzei, D. (2017) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-017-2474-4 · Cited by 67 · see citing works

Genomic rearrangements induced by unscheduled DNA double strand breaks in somatic mammalian cells

So, A., Guen, T. L., López, B. S., & Guirouilh‐Barbat, J. (2017) · FEBS Journal · doi:10.1111/febs.14053 · Cited by 62 · see citing works

Mrc1 and Rad9 cooperate to regulate initiation and elongation of DNA replication in response to DNA damage

Bacal, J., Moriel‐Carretero, M., Pardo, B., Barthe, A., Sharma, S., Chabes, A., Lengronne, A., & Pasero, P. (2018) · The EMBO Journal · doi:10.15252/embj.201899319 · Cited by 63 · see citing works

Mec1 Is Activated at the Onset of Normal S Phase by Low-dNTP Pools Impeding DNA Replication

Forey, R., Poveda, A., Sharma, S., Barthe, A., Padioleau, I., Renard, C., Lambert, R., Skrzypczak, M., Ginalski, K., Lengronne, A., et al. (2019) · Molecular Cell · doi:10.1016/j.molcel.2020.02.021 · Cited by 56 · see citing works

TRIM21 suppresses CHK1 activation by preferentially targeting CLASPIN for K63-linked ubiquitination

Zhu, X., Xue, J., Jiang, X. Y., Gong, Y., Gao, C., Cao, T., Li, Q., Bai, L., Li, Y., Xu, G., et al. (2022) · Nucleic Acids Research · doi:10.1093/nar/gkac011 · Cited by 55 · see citing works

Randomized phase II trial of cytosine arabinoside with and without the CHK1 inhibitor MK-8776 in relapsed and refractory acute myeloid leukemia

Webster, J. A., Tibes, R., Morris, L., Blackford, A. L., Litzow, M. R., Patnaik, M. M., Rosner, G. L., Gojo, I., Kinders, R. J., Wang, L., et al. (2017) · Leukemia Research · doi:10.1016/j.leukres.2017.09.005 · Cited by 54 · see citing works

The Protective Role of Dormant Origins in Response to Replicative Stress

Courtot, L., Hoffmann, J., & Bergoglio, V. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19113569 · Cited by 48 · see citing works

Cyclin Kinase-independent role of p21CDKN1A in the promotion of nascent DNA elongation in unstressed cells

Mansilla, S. F., Bertolin, A. P., Bergoglio, V., Pillaire, M.-J., González Besteiro, M. A., Luzzani, C., Miriuka, S. G., Cazaux, C., Hoffmann, J.-S., & Gottifredi, V. (2016) · eLife · doi:10.7554/elife.18020 · Cited by 43 · see citing works

The Replication Stress Response on a Narrow Path Between Genomic Instability and Inflammation

Técher, H., & Pasero, P. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.702584 · Cited by 36 · see citing works

Structure-Specific Endonucleases and the Resolution of Chromosome Underreplication

Falquet, B., & Rass, U. (2019) · Genes · doi:10.3390/genes10030232 · Cited by 36 · see citing works

Mus81-Eme1–dependent aberrant processing of DNA replication intermediates in mitosis impairs genome integrity

Calzetta, N. L., Besteiro, M. A. G., & Gottifredi, V. (2020) · Science Advances · doi:10.1126/sciadv.abc8257 · Cited by 35 · see citing works

The contribution of DNA replication stress marked by high-intensity, pan-nuclear γH2AX staining to chemosensitization by CHK1 and WEE1 inhibitors

Parsels, L. A., Parsels, J. D., Tanska, D. M., Maybaum, J., Lawrence, T. S., & Morgan, M. A. (2018) · Cell Cycle · doi:10.1080/15384101.2018.1475827 · Cited by 31 · see citing works

Pharmacological targeting of differential DNA repair, radio-sensitizes WRN-deficient cancer cells in vitro and in vivo

Gupta, P., Saha, B., Chattopadhyay, S., & Patro, B. S. (2021) · Biochemical Pharmacology · doi:10.1016/j.bcp.2021.114450 · Cited by 28 · see citing works

Chk1 loss creates replication barriers that compromise cell survival independently of excess origin firing

Besteiro, M. A. G., Calzetta, N. L., Loureiro, S. M., Habif, M., Betous, R., Pillaire, M., Maffia, A., Sabbioneda, S., Hoffmann, J., & Gottifredi, V. (2019) · The EMBO Journal · doi:10.15252/embj.2018101284 · Cited by 27 · see citing works

Dihydropyrimidinase protects from DNA replication stress caused by cytotoxic metabolites

Basbous, J., Aze, A., Chaloin, L., Lebdy, R., Hodroj, D., Ribeyre, C., Larroque, M., Shepard, C., Kim, B., Pruvost, A., et al. (2019) · Nucleic Acids Research · doi:10.1093/nar/gkz1162 · Cited by 27 · see citing works

Gene losses may contribute to subterranean adaptations in naked mole-rat and blind mole-rat

Zheng, Z., Hua, R., Xu, G., Yang, H., & Shi, P. (2022) · BMC Biology · doi:10.1186/s12915-022-01243-0 · Cited by 26 · see citing works

BLM overexpression as a predictive biomarker for CHK1 inhibitor response in PARP inhibitor–resistant BRCA -mutant ovarian cancer

Gupta, N., Huang, T., Nair, J. R., An, D., Zurcher, G., Lampert, E. J., McCoy, A., Cimino‐Mathews, A., Swisher, E. M., Radke, M. R., et al. (2023) · Science Translational Medicine · doi:10.1126/scitranslmed.add7872 · Cited by 27 · see citing works

Replication Stress and Consequential Instability of the Genome and Epigenome

Tsegay, P. S., Lai, Y., & Liu, Y. (2019) · Molecules · doi:10.3390/molecules24213870 · Cited by 26 · see citing works

Identification of transcription factor co-regulators that drive prostate cancer progression

Manjunath, S., Wani, S. A., Long, M. D., Leach, D. A., Mathé, E. A., Bevan, C. L., & Campbell, M. J. (2020) · Scientific Reports · doi:10.1038/s41598-020-77055-5 · Cited by 26 · see citing works

The Adaptive Mechanisms and Checkpoint Responses to a Stressed DNA Replication Fork

Saldanha, J., Rageul, J., Patel, J. A., & Kim, H. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241310488 · Cited by 26 · see citing works

Replication stress: Driver and therapeutic target in genomically instable cancers

Schoonen, P. M., Llobet, S. G., & van Vugt, M. A. T. M. (2018) · Advances in protein chemistry and structural biology · doi:10.1016/bs.apcsb.2018.10.006 · Cited by 24 · see citing works

Combined use of subclinical hydroxyurea and CHK1 inhibitor effectively controls melanoma and lung cancer progression, with reduced normal tissue toxicity compared to gemcitabine

Oo, Z. Y., Proctor, M. A., Stevenson, A. J., Nazareth, D., Fernando, M., Daignault, S. M., Lanagan, C. M., Walpole, S., Bonazzi, V., Škalamera, D., et al. (2019) · Molecular Oncology · doi:10.1002/1878-0261.12497 · Cited by 25 · see citing works

Impact of the interplay between stemness features, p53 and pol iota on replication pathway choices

Ihle, M., Biber, S., Schroeder, I. S., Blattner, C., Deniz, M., Damia, G. L. M., Gottifredi, V., & Wiesmüller, L. (2021) · Nucleic Acids Research · doi:10.1093/nar/gkab526 · Cited by 24 · see citing works

Topoisomerase 1-dependent R-loop deficiency drives accelerated replication and genomic instability

Sarni, D., Barroso, S. I., Shtrikman, A., Sinai, M. I., Oren, Y. S., Aguilera, A., & Kerem, B. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.111397 · Cited by 22 · see citing works

Inhibition of Chk1 with the small molecule inhibitor V158411 induces DNA damage and cell death in an unperturbed S-phase

Wayne, J., Brooks, T., & Massey, A. J. (2016) · Oncotarget · doi:10.18632/oncotarget.13119 · Cited by 21 · see citing works

Beyond interstrand crosslinks repair: contribution of FANCD2 and other Fanconi Anemia proteins to the replication of DNA

Federico, M. B., Campodónico, P. B., Paviolo, N. S., & Gottifredi, V. (2017) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2017.09.004 · Cited by 19 · see citing works

Exo1 phosphorylation inhibits exonuclease activity and prevents fork collapse in rad53 mutants independently of the 14-3-3 proteins

Morafraile, E. C., Bugallo, A., Carreira, R., Fernández-García, M., Martı́n-Castellanos, C., Blanco, M. G., & Segurado, M. (2020) · Nucleic Acids Research · doi:10.1093/nar/gkaa054 · Cited by 13 · see citing works

Replisome dysfunction upon inducible TIMELESS degradation synergizes with ATR inhibition to trigger replication catastrophe

Patel, J. A., Zezelic, C., Rageul, J., Saldanha, J., Khan, A., & Kim, H. (2023) · Nucleic Acids Research · doi:10.1093/nar/gkad363 · Cited by 15 · see citing works

Regulation of Structure-Specific Endonucleases in Replication Stress

Kim, S. M., & Forsburg, S. L. (2018) · Genes · doi:10.3390/genes9120634 · Cited by 13 · see citing works

Mistimed origin licensing and activation stabilize common fragile sites under tight DNA-replication checkpoint activation

Brison, O., Gnan, S., Azar, D., Koundrioukoff, S., García, R. M., Kim, S.-J., Schmidt, M., El-Hilali, S., Jaszczyszyn, Y., Lachagès, A.-M., et al. (2023) · Nature Structural & Molecular Biology · doi:10.1038/s41594-023-00949-1 · Cited by 12 · see citing works

The Spi1/PU.1 transcription factor accelerates replication fork progression by increasing PP1 phosphatase in leukemia

Rimmelé, P., Esposito, M., Delestré, L., Guervilly, J.-H., Ridinger-Saison, M., Despras, E., Moreau-Gachelin, F., Rosselli, F., & Guillouf, C. (2017) · Oncotarget · doi:10.18632/oncotarget.16183 · Cited by 11 · see citing works

PARP inhibition-associated heterochromatin confers increased DNA replication stress and vulnerability to ATR inhibition in SMARCA4-deficient cells

Yano, K., Kato, M., Endo, S., Igarashi, T., Wada, R., Kohno, T., Zimmermann, A., Dahmen, H., Zenke, F. T., & Shiotani, B. (2025) · Cell Death Discovery · doi:10.1038/s41420-025-02306-1 · Cited by 11 · see citing works

Identification of DNA Damage Repair-Associated Prognostic Biomarkers for Prostate Cancer Using Transcriptomic Data Analysis

Teng, P., Huang, S., Liu, C.-H., Lin, T.-Y., Cho, Y.-C., Lai, Y.-L., Wang, S., Yeh, H., Chuu, C., Chen, D., et al. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222111771 · Cited by 11 · see citing works

Oncogenic RAS in Cancers from the DNA Replication Stress and Senescence Perspective

Técher, H., Kemiha, S., Xieraili, A., & Kolinjivadi, A. M. (2024) · Cancers · doi:10.3390/cancers16233993 · Cited by 10 · see citing works

A Catalytically Independent Function of Human DNA Polymerase Kappa Controls the Stability and Abundance of Checkpoint Kinase 1

Dall’Osto, M., Pierini, L., Valery, N., Hoffmann, J., & Pillaire, M. (2021) · Molecular and Cellular Biology · doi:10.1128/mcb.00090-21 · Cited by 9 · see citing works

Phosphorylation status of MUS81 is a modifier of Olaparib sensitivity in BRCA2-deficient cells

Blandino, F., Malacaria, E., Figlioli, C., Noto, A., Pugliese, G. M., Franchitto, A., & Pichierri, P. (2023) · Nucleic Acids Research · doi:10.1093/nar/gkad470 · Cited by 9 · see citing works

Feedback regulation of methyl methanesulfonate and ultraviolet-sensitive gene clone 81 via ATM/Chk2 pathway contributes to the resistance of MCF-7 breast cancer cells to cisplatin

Lv, J., Qian, Y., Ni, X., Xu, X., & Dong, X. (2017) · Tumor Biology · doi:10.1177/1010428317694307 · Cited by 7 · see citing works

Germline Mutation in MUS81 Resulting in Impaired Protein Stability is Associated with Familial Breast and Thyroid Cancer

Pinheiro, M., Lupinacci, F. C. S., Santiago, K. M., Drigo, S. A., Marchi, F. A., Fonseca‐Alves, C. E., Andrade, S. C. S., Aagaard, M. M., Basso, T. R., dos Reis, M. B., et al. (2020) · Cancers · doi:10.3390/cancers12051289 · Cited by 6 · see citing works

Phospholipase C-ε regulates bladder cancer cells via ATM/EXO1.

Fan, J., Zhao, Y. F., Yuan, H., Yang, J., Li, T., He, Z., Wu, X., & Luo, C. (2020) · PubMed Central · Cited by 6 · see citing works

The need to regulate replication fork speed

Gómez‐González, B., & Aguilera, A. (2017) · Science · doi:10.1126/science.aaq0678 · Cited by 5 · see citing works

The balance between ATR and DDK activities controls TopBP1-mediated locking of dormant origins at the pre-IC stagePreprint

Koundrioukoff, S., Kim, S.-J., Alary, N., Toffano, A., García, R. M., Wu, X., Liu, Y., Gnan, S., El-Hilali, S., Brison, O., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.11.29.569233 · Cited by 5 · see citing works

Unscheduled origin building in S-phase upon tight CDK1 inhibition suppresses CFS instabilityPreprint

Brison, O., Gnan, S., Azar, D., Schmidt, M., Koundrioukoff, S., El-Hilali, S., Jaszczyszyn, Y., Lachagès, A.-M., Thermes, C., Chen, C.-L., et al. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.11.19.390054 · Cited by 4 · see citing works

Dihydropyrimidinase Protects from DNA Replication Stress Caused by Cytotoxic Metabolites

Basbous, J., Aze, A., Chaloin, L., Lebdy, R., Hodroj, D., Ribeyre, C., Larroque, M., Shepard, C., Kim, B., Pruvost, A., et al. (2021) · Vide Leaf, Hyderabad eBooks · doi:10.37247/imcac.1.2021.13 · Cited by 3 · see citing works

Rampant transcription replication conflict creates therapeutic vulnerability in extrachromosomal DNA containing cancersPreprint

Tang, J., Weiser, N. E., Wang, G., Chowdhry, S., Curtis, E. J., Zhao, Y., Wong, I. T.-L., Marinov, G. K., Li, R., Hanoian, P., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.03.29.586681 · Cited by 3 · see citing works

PARP Activity Fine-tunes the DNA Replication Choreography of Chk1-depleted Cells

Calzetta, N. L., Besteiro, M. A. G., & Gottifredi, V. (2021) · Journal of Molecular Biology · doi:10.1016/j.jmb.2021.166949 · Cited by 2 · see citing works

Interferon stimulatory DNA activates the DNA damage signaling through ATM and DNA-PK sensing

Kemiha, S., Rejón-Franco, L., Ghibaudo, E., Eloiflin, R.-J., Chemarin, M., Hawillo, K., Laguette, N., & Técher, H. (2026) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2026.111362 · Cited by 1 · see citing works

Topoisomerase 1-dependent R-loop deficiency drives accelerated replication and genomic instability

Sarni, D., Barroso Ceballos, S. I., Shtrikman, A., Irony-Tur Sinai, M., Oren, Y. S., Aguilera López, A., & Kerem, B. (2022) · Deposito de Investigacion Universidad de Sevilla (University of Seville) · Cited by 1 · see citing works

dTMP imbalance through thymidylate 5′-phosphohydrolase activity induces apoptosis in triple-negative breast cancers

Kim, D.-H., Kim, J.-S., Mok, C.-S., Chang, E.-H., Choi, J., Lim, J., Kim, C., Park, A.-R., Bae, Y.-J., Koo, B.-S., et al. (2022) · Scientific Reports · doi:10.1038/s41598-022-24706-4 · Cited by 2 · see citing works

Genome-wide analyses of transcription factors and co-regulators across seven cohorts identified reduced PPARGC1A expression as a driver of prostate cancer progressionPreprint

Manjunath, S., Wani, S. A., Long, M. D., Leach, D. A., Mathé, E. A., Bevan, C. L., & Campbell, M. J. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.05.12.091066 · Cited by 1 · see citing works

CHK2 regulates MUS81-dependent DSBs in response to replication stress and BRCA2 deficiencyPreprint

Malacaria, E., Figlioli, C., Palma, A., Rinalducci, S., Semproni, M., Franchitto, A., & Pichierri, P. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.10.08.511087 · Cited by 1 · see citing works

WITHDRAWN: Beyond interstrand crosslinks repair: Contribution of FANCD2 and other Fanconi Anemia proteins to the replication of DNA

Federico, M. B., Campodónico, P. B., Paviolo, N. S., & Gottifredi, V. (2017) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2017.09.006

Replication stress: mechanisms and molecules involved in dna replication progression and reinitiation

Feu, S. (2019) · LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas)

Faculty Opinions recommendation of The essential kinase ATR: ensuring faithful duplication of a challenging genome.

Kaufmann, S. H. (2019) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.728649753.793565220

Faculty Opinions recommendation of Chromatin conformation regulates the coordination between DNA replication and transcription.

Aladjem, M. I., & Fu, H. (2018) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.733101286.793549795

Characterisation of the role of the ATR kinase homolog in L. major response to replication stress

da Silva, G. L. A. (2022) · doi:10.11606/t.17.2022.tde-01122022-121302

Chronic treatment with ATR and CHK1 inhibitors does not substantially increase the mutational burden of human cells

Casimir, L., Zimmer, S., Racine-Brassard, F., Goudreau, F., Jacques, P., & Maréchal, A. (2023) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2023.111834

Linking replication stress with replication dynamics in Vicia faba root meristem cellsPreprint

Musiałek, M. W., & Rybaczek, D. (2023) · Research Square · doi:10.21203/rs.3.rs-3137592/v1

Etude de l'effondrement rapide des fourches de réplication lors d'un stress réplicatif

de Rugy, T. G. (2016) · theses.fr (ABES) · doi:10.70675/a5dcd5aaz6bd9z4846z9da6z0dd36ab82aa0

RAD51 Protects Against RAD52-Dependent Non-Conservative Double-Strand Break Repair Processes, by Impeding the Annealing Step

So, A. (2018) · theses.fr (ABES) · doi:10.70675/2db5ae5fzd2c0z4df3zb852zec2a10a44314

Mutations de la voie ATR-CHK1, réponse au stress réplicatif et cancer

Egger, T. (2018) · theses.fr (ABES) · doi:10.70675/eb51eb1ezc51dz4737zaf38z954d1a68dbea

Couplage temporel entre la réplication et l’entrée en mitose en conditions normales ou perturbées : rôles de la signalisation Chk1

Lebrec, V. (2021) · theses.fr (ABES) · doi:10.70675/23bc9a0ezaf94z4804z9f0eza46407769553

Impact of low replication stress on the replication program of cancer and non-tumor cells

Courtot, L. (2020) · theses.fr (ABES) · doi:10.70675/74d8bf42zeebdz4323zb869zec66e6e29157

Mécanismes de contrôle de l’endonucléase Mus81- Eme1 et maintien de la stabilité du génome dans la levure Schizosaccharomyces pombe

Giaccherini, C. (2021) · doi:10.70675/b21b4cebze26cz412bz8d39z1c24f5f3c7b3

Exploration de la sensibilité au stress réplicatif dans les cancers du sein triple négatifs BRCA déficients

Tabet, I. (2023) · theses.fr (ABES) · doi:10.70675/6e16481fzaeeez423bza183z8aa5b5314c7f

ATR and TopBP1 oppose to control dormant origin activity and global replication dynamics, providing a first defense against replication stress

Koundrioukoff, S., Alary, N., Kim, S.-J., Collin, T., Toffano, A., García, R. M., Wu, X., Liu, Y., Gnan, S., El-Hilali, S., et al. (2026) · Nucleic Acids Research · doi:10.1093/nar/gkag315

RTF2 and CLASPIN localize CHK1 to the replication fork to control S-phase progression

Broton, C., Weiner, C. L., Ruiz, P. D., Blobel, N. J., Yao, Y., Conti, B. A., Schmid, E. W., Walter, J. C., & Smogorzewska, A. (2026) · Science Advances · doi:10.1126/sciadv.aec3174

CHK2 regulates MUS81-dependent DSBs in response to replication stress and BRCA2 deficiency

Malacaria, E., Figlioli, C., Palma, A., Honda, M., Valenzisi, P., Casella, M., Camerini, S., Pucci, F., Rinalducci, S., Semproni, M., et al. (2026) · Nucleic Acids Research · doi:10.1093/nar/gkag766

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR / DNA ‐ PKcs / CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Shreim, A., Genoux, A., Zubchuk, N., Zheng, H., Salameh, P., Ziegelmeyer, T., Dalonneau, F., Rouchette, M., Oddou, C. I., Miron, S. M., et al. (2026) · Molecular Oncology · doi:10.1002/1878-0261.70339

Structure-Specific DNA Endonuclease Mus81/Eme1 Generates DNA Damage Caused by Chk1 Inactivation

Forment, J. V., Blasius, M., Guerini, I., & Jackson, S. P. (2011) · PLoS ONE · doi:10.1371/journal.pone.0023517 · Cited by 126 · see citing works

An ATR and CHK1 kinase signaling mechanism that limits origin firing during unperturbed DNA replication

Moiseeva, T. N., Yin, Y., Calderon, M. J., Qian, C., Schamus-Haynes, S., Sugitani, N., Osmanbeyoglu, H. U., Rothenberg, E., Watkins, S. C., & Bakkenist, C. J. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1903418116 · Cited by 149 · see citing works

The Mammalian DNA Replication Elongation Checkpoint: Implication of Chk1 and Relationship with Origin Firing as Determined by Single DNA Molecule and Single Cell Analyses

Conti, C., Seiler, J. A., & Pommier, Y. G. (2007) · Cell Cycle · doi:10.4161/cc.6.22.4932 · Cited by 75 · see citing works

Evidence That the ATR/Chk1 Pathway Maintains Normal Replication Fork Progression during Unperturbed S Phase

Petermann, E., & Caldecott, K. W. (2006) · Cell Cycle · doi:10.4161/cc.5.19.3256 · Cited by 163 · see citing works

Chk1 promotes replication fork progression by controlling replication initiation

Petermann, E., Woodcock, M., & Helleday, T. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1005031107 · Cited by 308 · see citing works