The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
Genomic Correlates of Immune-Cell Infiltrates in Colorectal Carcinoma
Open accessAbstract
Large-scale genomic characterization of tumors from prospective cohort studies may yield new insights into cancer pathogenesis. We performed whole-exome sequencing of 619 incident colorectal cancers (CRCs) and integrated the results with tumor immunity, pathology, and survival data. We identified recurrently mutated genes in CRC, such as BCL9L, RBM10, CTCF, and KLF5, that were not previously appreciated in this disease. Furthermore, we investigated the genomic correlates of immune-cell infiltration and found that higher neoantigen load was positively associated with overall lymphocytic infiltration, tumor-infiltrating lymphocytes (TILs), memory T cells, and CRC-specific survival. The association with TILs was evident even within microsatellite-stable tumors. We also found positive selection of mutations in HLA genes and other components of the antigen-processing machinery in TIL-rich tumors. These results may inform immunotherapeutic approaches in CRC. More generally, this study demonstrates a framework for future integrative molecular epidemiology research in colorectal and other malignancies.
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Citations
Cites
PD-1 Blockade in Tumors with Mismatch-Repair Deficiency
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“Long Tail of Significantly Mutated Genes in Non-hypermutated CRC Dark blue: genes identified in the NHS and HPFS but also previously reported in other large-scale sequencing studies of CRC (Cancer Genome Atlas Network, 2012; Seshagiri et al., 2012; Lawrence et al., 2014).”
BackgroundMethodResultInfluentialSelf-citationEffector Memory T Cells, Early Metastasis, and Survival in Colorectal Cancer
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“Supporting this premise, CD45RO cell density was previously identified as an independent favorable prognostic factor in CRC (Nosho et al., 2010; Pagès et al., 2005).”
BackgroundLong-term colorectal-cancer incidence and mortality after lower endoscopy
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Self-citationWhole-exome sequencing of pancreatic cancer defines genetic diversity and therapeutic targets
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“Mutations in RBM10 were described in lung and pancreatic adenocarcinomas and shown to be associated with male sex and an improved prognosis, respectively (Cancer Genome Atlas Research Network, 2014; Witkiewicz et al., 2015).”
BackgroundRecurrent R-spondin fusions in colon cancer
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CTCF/cohesin-binding sites are frequently mutated in cancer
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Cited by
Overman, M. J., McDermott, R., Leach, J. L., Lonardi, S., Lenz, H.-J., Morse, M. A., Desai, J., Hill, A., Axelson, M., Moss, R. A., et al. (2017) · The Lancet Oncology · doi:10.1016/s1470-2045(17)30422-9 · Cited by 2,836
Chapuy, B., Stewart, C., Dunford, A. J., Kim, J., Kamburov, A., Redd, R. A., Lawrence, M. S., Roemer, M. G. M., Li, A. J., Ziepert, M., et al. (2018) · Nature Medicine · doi:10.1038/s41591-018-0016-8 · Cited by 1,941
Self-citationComprehensive review of targeted therapy for colorectal cancer
Xie, Y.-H., Chen, Y.-X., & Fang, J.-Y. (2020) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-020-0116-z · Cited by 1,687
Conserved pan-cancer microenvironment subtypes predict response to immunotherapy
Bagaev, A., Kotlov, N., Nomie, K., Svekolkin, V., Gafurov, A., Isaeva, O., Osokin, N., Kozlov, I., Frenkel, F., Gancharova, O., et al. (2021) · Cancer Cell · doi:10.1016/j.ccell.2021.04.014 · Cited by 1,302
Targeting KRAS mutant cancers with a covalent G12C-specific inhibitor
Janes, M. R., Zhang, J., Li, L.-S., Hansen, R., Peters, U., Guo, X., Chen, Y., Babbar, A., Firdaus, S. J., Darjania, L., et al. (2018) · Cell · doi:10.1016/j.cell.2018.01.006 · Cited by 1,172
Metadata
- Authors
- Giannakis, M., Mu, X. J., Shukla, S. A., Qian, Z. R., Cohen, O., Nishihara, R., Bahl, S., Cao, Y., Amin-Mansour, A., Yamauchi, M., Sukawa, Y., Stewart, C., Rosenberg, M., Mima, K., Inamura, K., Nosho, K., Nowak, J. A., Lawrence, M. S., Giovannucci, E. L., Chan, A. T., Ng, K., Meyerhardt, J. A., Van Allen, E. M., Getz, G., Gabriel, S. B., Lander, E. S., Wu, C. J., Fuchs, C. S., Ogino, S., & Garraway, L. A.
- Venue
- Cell Reports
- Publisher
- Elsevier BV
- Published
- 2016-04
- Volume
- 15
- Issue
- 4
- Pages
- 857-865
- ISSN
- 2211-1247 (ISSN-L)
- OpenAlex
- W2339723519
- Cited by
- 913
- References
- 10
- FWCI
- 47.13
- Type
- journal article
- Language
- en
- Open access
- gold
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
