Molecular subtypes of diffuse large B cell lymphoma are associated with distinct pathogenic mechanisms and outcomes

Chapuy, Bjoern; Stewart, Chip; Dunford, Andrew J.; Kim, Jaegil; Kamburov, Atanas; Redd, Robert A.; Lawrence, Mike S.; Roemer, Margaretha G. M.; Li, Amy J.; Ziepert, Marita; Staiger, Annette M.; Wala, Jeremiah A.; Ducar, Matthew D.; Leshchiner, Ignaty; Rheinbay, Ester; Taylor-Weiner, Amaro; Coughlin, Caroline A.; Hess, Julian M.; Pedamallu, Chandra S.; Livitz, Dimitri; Rosebrock, Daniel; Rosenberg, Mara; Tracy, Adam A.; Horn, Heike; van Hummelen, Paul; Feldman, Andrew L.; Link, Brian K.; Novak, Anne J.; Cerhan, James R.; Habermann, Thomas M.; Siebert, Reiner; Rosenwald, Andreas; Thorner, Aaron R.; Meyerson, Matthew L.; Golub, Todd R.; Beroukhim, Rameen; Wulf, Gerald G.; Ott, German; Rodig, Scott J.; Monti, Stefano; Neuberg, Donna S.; Loeffler, Markus; Pfreundschuh, Michael; Trümper, Lorenz; Getz, Gad; Shipp, Margaret A.

doi:10.1038/s41591-018-0016-8

Molecular subtypes of diffuse large B cell lymphoma are associated with distinct pathogenic mechanisms and outcomes

Diffuse large B cell lymphoma (DLBCL), the most common lymphoid malignancy in adults, is a clinically and genetically heterogeneous disease that is further classified into transcriptionally defined activated B cell (ABC) and germinal center B cell (GCB) subtypes. We carried out a comprehensive ge…