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Transcription Factor NFIB Is a Driver of Small Cell Lung Cancer Progression in Mice and Marks Metastatic Disease in Patients
Open accessAbstract
Small cell lung cancer (SCLC) is an aggressive neuroendocrine tumor, and no effective treatment is available to date. Mouse models of SCLC based on the inactivation of Rb1 and Trp53 show frequent amplifications of the Nfib and Mycl genes. Here, we report that, although overexpression of either transcription factor accelerates tumor growth, NFIB specifically promotes metastatic spread. High NFIB levels are associated with expansive growth of a poorly differentiated and almost exclusively E-cadherin (CDH1)-negative invasive tumor cell population. Consistent with the mouse data, we find that NFIB is overexpressed in almost all tested human metastatic high-grade neuroendocrine lung tumors, warranting further assessment of NFIB as a tumor progression marker in a clinical setting.
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Massive genomic rearrangement acquired in a single catastrophic event during cancer development
Stephens, P. J., Greenman, C. D., Fu, B., Yang, F., Bignell, G. R., Mudie, L. J., Pleasance, E. D., Lau, K. W., Beare, D., Stebbings, L. A., et al. (2011) · Cell · doi:10.1016/j.cell.2010.11.055 · Cited by 2,414
Meuwissen, R., Linn, S. C., Linnoila, R. I., Zevenhoven, J., Mooi, W. J., & Berns, A. (2003) · Cancer Cell · doi:10.1016/s1535-6108(03)00220-4 · Cited by 643
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Cited by
Small-cell lung cancer: what we know, what we need to know and the path forward
Gazdar, A. F., Bunn, P. A., & Minna, J. D. (2017) · Nature Reviews Cancer · doi:10.1038/nrc.2017.87 · Cited by 904
Germline and somatic genetics of osteosarcoma — connecting aetiology, biology and therapy
Gianferante, D. M., Mirabello, L., & Savage, S. A. (2017) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2017.16 · Cited by 477
Lung Cancers: Molecular Characterization, Clonal Heterogeneity and Evolution, and Cancer Stem Cells
Testa, U., Castelli, G., & Pelosi, E. (2018) · Cancers · doi:10.3390/cancers10080248 · Cited by 403
Megyesfalvi, Z., Gay, C. M., Popper, H., Pirker, R., Ostoros, G., Heeke, S., Lang, C., Hoetzenecker, K., Schwendenwein, A., Boettiger, K., et al. (2023) · CA: A Cancer Journal for Clinicians · doi:10.3322/caac.21785 · Cited by 369
miR-1224 inhibits cell proliferation in acute liver failure by targeting the antiapoptotic gene Nfib
Roy, S., Bantel, H., Wandrer, F., Schneider, A. T., Gautheron, J., Vucur, M., Tacke, F., Trautwein, C., Luedde, T., & Roderburg, C. (2017) · Journal of Hepatology · doi:10.1016/j.jhep.2017.06.007 · Cited by 56
Metadata
- Authors
- Semenova, E. A., Kwon, M.-C., Monkhorst, K., Song, J.-Y., Bhaskaran, R., Krijgsman, O., Kuilman, T., Peters, D., Buikhuisen, W. A., Smit, E. F., Pritchard, C., Cozijnsen, M., van der Vliet, J., Zevenhoven, J., Lambooij, J.-P., Proost, N., van Montfort, E., Velds, A., Huijbers, I. J., & Berns, A.
- Venue
- Cell Reports
- Publisher
- Elsevier BV
- Published
- 2016-07
- Volume
- 16
- Issue
- 3
- Pages
- 631-643
- ISSN
- 2211-1247 (ISSN-L)
- OpenAlex
- W2465282683
- Cited by
- 159
- References
- 2
- FWCI
- 7.57
- Type
- journal article
- Language
- en
- Open access
- gold
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