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PML at Mitochondria-Associated Membranes Is Critical for the Repression of Autophagy and Cancer Development

Missiroli, Sonia, Bonora, Massimo, Patergnani, Simone, Poletti, Federica, Perrone, Mariasole, Gafà, Roberta, Magri, Eros, Raimondi, Andrea, Lanza, Giovanni, Tacchetti, Carlo, Kroemer, Guido, Pandolfi, Pier Paolo, Pinton, Paolo, Giorgi, Carlotta·2016·Cell Reports
DOI 10.1016/j.celrep.2016.07.082PMC PMC5011426
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Crossref · 10.1016/j.celrep.2016.07.082

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  • MAMs play roles in lipid synthesis, calcium transport and homeostasis, mitochondrial dynamics, and regulating autophagosome and inflammasome formation.

    “play a role in lipid synthesis, calcium transport and homeostasis, mitochondria dynamics, and regulating autophagosome and inflammasome formation [1–12]”

    From The Mitochondria-Associated ER Membranes Are Novel Subcellular Locations Enriched for Inflammatory-Responsive MicroRNAs (2020) · cites this paper as [9]

    The Results sections on PML localization at MAMs and the AMPK/mTOR/Ulk1 pathway link ER–mitochondria calcium transfer to autophagy regulation; the Discussion says PML at these sites represses autophagosome formation. Our copy does not establish the other attributed roles—lipid synthesis, mitochondrial dynamics, or inflammasome formation. (LLM, conf=0.87)

    Experimental — accuracy not yet measured

  • MAMs are specific ER domains that tether mitochondria to regions of the ER.

    “The MAMs are specific ER domains that tether the mitochondria to regions of the ER”

    From The Mitochondria-Associated ER Membranes Are Novel Subcellular Locations Enriched for Inflammatory-Responsive MicroRNAs (2020) · cites this paper as [9]

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Research works printed but not linked: 50

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Metadata

Authors
Missiroli, S., Bonora, M., Patergnani, S., Poletti, F., Perrone, M., Gafà, R., Magri, E., Raimondi, A., Lanza, G., Tacchetti, C., Kroemer, G., Pandolfi, P. P., Pinton, P., & Giorgi, C.
Venue
Cell Reports
Publisher
Elsevier BV
Published
2016-08
Volume
16
Issue
9
Pages
2415-2427
ISSN
2211-1247
DOI
10.1016/j.celrep.2016.07.082
PMC
PMC5011426
Cited by
154
References
7
Language
en
Licence
Funders
  • Associazione Italiana per la Ricerca sul Cancro (MFAG-13521)
  • Università degli Studi di Ferrara
  • Fondazione per la Ricerca sulla Fibrosi Cistica (19/2014)
  • Fondazione Telethon (IG-14442)
  • Ministero dell’Istruzione, dell’Università e della Ricerca (20129JLHSY_002, RBAP11FXBC_002)
  • Ministero della Salute

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