Influential role of 7-Ketocholesterol in the progression of Alzheimer’s disease

Neuropathological stageing of Alzheimer-related changes.

Braak, H., & Braak, E. (1991) · Acta Neuropathologica · doi:10.1007/bf00308809 · Cited by 16,123 · see citing works

Alzheimer’s disease

Querfurth, H. W., & LaFerla, F. M. (2010) · New England Journal of Medicine · doi:10.1056/nejmra0909142 · Cited by 4,569 · see citing works

Loss of autophagy in the central nervous system causes neurodegeneration in mice

Komatsu, M., Waguri, S., Chiba, T., Murata, S., Iwata, J.-I., Tanida, I., Ueno, T., Koike, M., Uchiyama, Y., Kominami, E., et al. (2006) · Nature · doi:10.1038/nature04723 · Cited by 3,500 · see citing works

Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1.

Urano, F., Wang, X.-Z., Bertolotti, A., Zhang, Y.-H., Chung, P., Harding, H., & Ron, D. (2000) · Science · doi:10.1126/science.287.5453.664 · Cited by 3,081 · see citing works

Neuronal Calcium Signaling

Berridge, M. J. (1998) · Neuron · doi:10.1016/s0896-6273(00)80510-3 · Cited by 2,189 · see citing works

Twenty years of the Alzheimer's disease amyloid hypothesis: a genetic perspective

Tanzi, R. E., & Bertram, L. (2005) · Cell · doi:10.1016/j.cell.2005.02.008 · Cited by 1,849 · see citing works

ASK1 is essential for endoplasmic reticulum stress-induced neuronal cell death triggered by expanded polyglutamine repeatsPreprint

Nishitoh, H., Matsuzawa, A., Tobiume, K., Saegusa, K., Takeda, K., Inoue, K., Hori, S., Kakizuka, A., & Ichijo, H. (2002) · Genes & Development · doi:10.1101/gad.992302 · Cited by 1,331 · see citing works

The presence of malfolded proteins in the endoplasmic reticulum signals the induction of glucose-regulated proteins

Kozutsumi, Y., Segal, M. S., Normington, K., Gething, M.-J. H., & Sambrook, J. (1988) · Nature · doi:10.1038/332462a0 · Cited by 1,322 · see citing works

Mitochondria in neuroplasticity and neurological disorders

Mattson, M. P., Gleichmann, M., & Cheng, A. (2008) · Neuron · doi:10.1016/j.neuron.2008.10.010 · Cited by 1,081 · see citing works

Role of oxidative stress in Alzheimer’s disease

HUANG, W.-J., ZHANG, X., & CHEN, W.-W. (2016) · Biomedical Reports · doi:10.3892/br.2016.630 · Cited by 1,023 · see citing works

A Receptor for the Selective Uptake and Degradation of Proteins by Lysosomes

Cuervo, A. M., & Dice, J. F. (1996) · Science · doi:10.1126/science.273.5274.501 · Cited by 979 · see citing works

ER stress and neurodegenerative diseases

Lindholm, D., Wootz, H., & Korhonen, L. (2006) · Cell Death & Differentiation · doi:10.1038/sj.cdd.4401778 · Cited by 882 · see citing works

Cell biology of protein misfolding: the examples of Alzheimer's and Parkinson's diseases

Selkoe, D. J. (2004) · Nature Cell Biology · doi:10.1038/ncb1104-1054 · Cited by 863 · see citing works

Alzheimer's disease

Burns, A., & Iliffe, S. (2009) · BMJ · doi:10.1136/bmj.b158 · Cited by 859 · see citing works

Oxidative stress in Alzheimer’s disease

Chen, Z., & Zhong, C. (2014) · Neuroscience Bulletin · doi:10.1007/s12264-013-1423-y · Cited by 797 · see citing works

Mammalian Autophagy: How Does It Work?

Bento, C. F., Renna, M., Ghislat, G., Puri, C., Ashkenazi, A., Vicinanza, M., Menzies, F. M., & Rubinsztein, D. C. (2016) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-060815-014556 · Cited by 692 · see citing works

Membrane lipid saturation activates endoplasmic reticulum unfolded protein response transducers through their transmembrane domains

Volmer, R., van der Ploeg, K., & Ron, D. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1217611110 · Cited by 655 · see citing works

IRE1α Cleaves Select microRNAs During ER Stress to Derepress Translation of Proapoptotic Caspase-2

Upton, J.-P., Wang, L., Han, D., Wang, E. S., Huskey, N. E., Lim, L., Truitt, M., McManus, M. T., Ruggero, D., Goga, A., et al. (2012) · Science · doi:10.1126/science.1226191 · Cited by 640 · see citing works

THE ESCRT COMPLEXES: Structure and Mechanism of a Membrane-Trafficking Network

Hurley, J. H., & Emr, S. D. (2006) · Annual Review of Biophysics and Biomolecular Structure · doi:10.1146/annurev.biophys.35.040405.102126 · Cited by 546 · see citing works

Microglial Phagocytosis Induced by Fibrillar β-Amyloid and IgGs Are Differentially Regulated by Proinflammatory Cytokines

Koenigsknecht-Talboo, J., & Landreth, G. E. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.1808-05.2005 · Cited by 477 · see citing works

Alzheimer Disease and Oxidative Stress

Perry, G., Cash, A. D., & Smith, M. A. (2002) · BioMed Research International · doi:10.1155/s1110724302203010 · Cited by 455 · see citing works

Trehalose induces autophagy via lysosomal-mediated TFEB activation in models of motoneuron degeneration

Rusmini, P., Cortese, K., Crippa, V., Cristofani, R., Cicardi, M. E., Ferrari, V., Vezzoli, G., Tedesco, B., Meroni, M., Messi, E., et al. (2019) · Autophagy · doi:10.1080/15548627.2018.1535292 · Cited by 436 · see citing works

NAD(P)H Oxidase Nox-4 Mediates 7-Ketocholesterol-Induced Endoplasmic Reticulum Stress and Apoptosis in Human Aortic Smooth Muscle Cells

Pédruzzi, E., Guichard, C., Ollivier, V., Driss, F., Fay, M., Prunet, C., Marie, J., Pouzet, C., Samadi, M. H., Elbim, C., et al. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.24.10703-10717.2004 · Cited by 435 · see citing works

Survival in dementia and predictors of mortality: a review

Todd, S., Barr, S., Roberts, M., & Passmore, A. P. (2013) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.3946 · Cited by 417 · see citing works

Increased Endoplasmic Reticulum Stress in Atherosclerotic Plaques Associated With Acute Coronary Syndrome

Myoishi, M., Hao, H., Minamino, T., Watanabe, K., Nishihira, K., Hatakeyama, K., Asada, Y., Okada, K.-I., Ishibashi‐Ueda, H., Gabbiani, G., et al. (2007) · Circulation · doi:10.1161/circulationaha.106.682054 · Cited by 371 · see citing works

Proteolytic Degradation of Amyloid -Protein

Saido, T., & Leissring, M. A. (2012) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a006379 · Cited by 368 · see citing works

Functional and therapeutic potential of inulin: A comprehensive review

Ahmed, W., & Rashid, S. (2017) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2017.1355775 · Cited by 338 · see citing works

Oxysterols: From cholesterol metabolites to key mediators

Mutemberezi, V., Guillemot‐Legris, O., & Muccioli, G. G. (2016) · Progress in Lipid Research · doi:10.1016/j.plipres.2016.09.002 · Cited by 336 · see citing works

Protein kinase R-like ER kinase and its role in endoplasmic reticulum stress-decided cell fate

Liu, Z.-L., Lv, Y., Zhao, N., Guan, G., & Wang, J. (2015) · Cell Death and Disease · doi:10.1038/cddis.2015.183 · Cited by 314 · see citing works

Clinical aspects of Alzheimer's disease

Zvěřová, M. (2019) · Clinical Biochemistry · doi:10.1016/j.clinbiochem.2019.04.015 · Cited by 308 · see citing works

Changes in brain oxysterols at different stages of Alzheimer's disease: Their involvement in neuroinflammation

Testa, G., Staurenghi, E., Zerbinati, C., Gargiulo, S., Iuliano, L., Giaccone, G., Fantò, F., Poli, G., Leonarduzzi, G., & Gamba, P. (2016) · Redox Biology · doi:10.1016/j.redox.2016.09.001 · Cited by 293 · see citing works

Inhibition and disaggregation of α-synuclein oligomers by natural polyphenolic compounds

Caruana, M., Högen, T., Levin, J., Hillmer, A. S., Giese, A., & Vassallo, N. (2011) · FEBS Letters · doi:10.1016/j.febslet.2011.03.046 · Cited by 274 · see citing works

Cellular prion protein regulates β-secretase cleavage of the Alzheimer's amyloid precursor protein

Parkin, E. T., Watt, N. T., Hussain, I., Eckman, E. A., Eckman, C. B., Manson, J. C., Baybutt, H. N., Turner, A. J., & Hooper, N. M. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0609621104 · Cited by 274 · see citing works

Activation of Microglia Acidifies Lysosomes and Leads to Degradation of Alzheimer Amyloid Fibrils

Majumdar, A., Cruz, D., Asamoah, N., Buxbaum, A., Sohar, I., Lobel, P., & Maxfield, F. R. (2007) · Molecular Biology of the Cell · doi:10.1091/mbc.e06-10-0975 · Cited by 271 · see citing works

Differential Expression of Cholesterol Hydroxylases in Alzheimer's Disease

Brown, J. A., Theisler, C. M., Silberman, S., Magnuson, D. J., Gottardi-Littell, N. R., Lee, J. M., Yager, D., Crowley, J., Sambamurti, K., Rahman, M. M., et al. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m402324200 · Cited by 268 · see citing works

Ceramide function in the brain: when a slight tilt is enough

Mencarelli, C., & Martínez‐Martínez, P. (2012) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-012-1038-x · Cited by 261 · see citing works

Mitochondrial Dysfunction and Chronic Disease: Treatment With Natural Supplements.

Nicolson, G. L. (2014) · PubMed Central · Cited by 235 · see citing works

Downregulation of PI3K/Akt/mTOR signaling pathway in curcumin-induced autophagy in APP/PS1 double transgenic mice

Wang, C., Zhang, X., Teng, Z., Zhang, T., & Li, Y. (2014) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2014.06.051 · Cited by 233 · see citing works

Peroxisomal alterations in Alzheimer’s disease

Kou, J., Kovacs, G. G., Höftberger, R., Kulik, W., Brodde, A., Forss-Petter, S., Hönigschnabl, S., Gleiss, A., Brügger, B., Wanders, R., et al. (2011) · Acta Neuropathologica · doi:10.1007/s00401-011-0836-9 · Cited by 227 · see citing works

Peroxisomes Are Oxidative Organelles

Antonenkov, V. D., Grunau, S., Ohlmeier, S., & Hiltunen, J. K. (2009) · Antioxidants and Redox Signaling · doi:10.1089/ars.2009.2996 · Cited by 223 · see citing works

Endo-lysosomal dysregulations and late-onset Alzheimer’s disease: impact of genetic risk factors

Van Acker, Z. P., Bretou, M., & Annaert, W. (2019) · Molecular Neurodegeneration · doi:10.1186/s13024-019-0323-7 · Cited by 222 · see citing works

Lipid Rafts: Linking Alzheimer′s Amyloid‐βProduction, Aggregation, and Toxicity at Neuronal Membranes

Rushworth, J. V., & Hooper, N. M. (2010) · International Journal of Alzheimer s Disease · doi:10.4061/2011/603052 · Cited by 218 · see citing works

Involvement of oxysterols in age-related diseases and ageing processes

Zarrouk, A., Véjux, A., Mackrill, J. J., O’Callaghan, Y. C., Hammami, M., O’Brien, N. M., & Lizard, G. (2014) · Ageing Research Reviews · doi:10.1016/j.arr.2014.09.006 · Cited by 217 · see citing works

Correction: Corrigendum: H+-type and OH−-type biological protonic semiconductors and complementary devices

Deng, Y., Josberger, E. E., Jin, J., Roudsari, A. F., Helms, B. A., Zhong, C., Anantram, M. P., & Rolandi, M. (2015) · Scientific Reports · doi:10.1038/srep12118 · Cited by 217 · see citing works

NADPH oxidase- and mitochondria-derived reactive oxygen species in proinflammatory microglial activation: A bipartisan affair?

Bordt, E. A., & Polster, B. M. (2014) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2014.07.033 · Cited by 202 · see citing works

Autophagic/lysosomal dysfunction in Alzheimer’s disease

Orr, M. E., & Oddo, S. (2013) · Alzheimer's Research & Therapy · doi:10.1186/alzrt217 · Cited by 199 · see citing works

Multivesicular bodies in neurons: Distribution, protein content, and trafficking functions

von Bartheld, C. S., & Altick, A. L. (2011) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2011.01.003 · Cited by 197 · see citing works

7-Ketocholesterol in disease and aging

Anderson, A., Campo, A., Fulton, E. C., Corwin, A., Jerome, W. G., & O’Connor, M. S. (2019) · Redox Biology · doi:10.1016/j.redox.2019.101380 · Cited by 194 · see citing works

Role of mitochondria in neuronal cell death induced by oxidative stress; neuroprotection by Coenzyme Q10

Somayajulu, M., McCarthy, S., Hung, M.-Y., Sikorska, M., Borowy‐Borowski, H., & Pandey, S. (2005) · Neurobiology of Disease · doi:10.1016/j.nbd.2004.10.021 · Cited by 183 · see citing works

Lipid and Lipid Raft Alteration in Aging and Neurodegenerative Diseases: A Window for the Development of New Biomarkers

Mesa-Herrera, F., Taoro‐González, L., Valdés‐Baizabal, C., Díaz, M. L., & Marín, R. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20153810 · Cited by 182 · see citing works

Lipid Biomarkers in Alzheimer's Disease

Zarrouk, A., Debbabi, M., Bezine, M., Karym, E. M., Badreddine, A., Rouaud, O., Moreau, T., Cherkaoui-Malki, M., El Ayeb, M., Nasser, B., et al. (2018) · Current Alzheimer Research · doi:10.2174/1567205014666170505101426 · Cited by 170 · see citing works

Mitochondria in Neuroprotection by Phytochemicals: Bioactive Polyphenols Modulate Mitochondrial Apoptosis System, Function and Structure

Naoi, M., Wu, Y., Shamoto‐Nagai, M., & Maruyama, W. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20102451 · Cited by 170 · see citing works

The roles of amyloid precursor protein (APP) in neurogenesis

Zhou, Z., Chan, C. H.-S., Ma, Q., Xu, X., Xiao, Z., & Tan, E. (2011) · Cell Adhesion & Migration · doi:10.4161/cam.5.4.16986 · Cited by 169 · see citing works

Mitochondria-Associated Membranes Response to Nutrient Availability and Role in Metabolic Diseases

Theurey, P., & Rieusset, J. (2016) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2016.09.002 · Cited by 159 · see citing works

Imbalanced cholesterol metabolism in Alzheimer's disease

Xue-shan, Z., Peng, J., Wu, Q., Zhong, R., Li-hong, P., Tang, Z., Jiang, Z., Wang, G., & Liu, L. (2016) · Clinica Chimica Acta · doi:10.1016/j.cca.2016.02.024 · Cited by 155 · see citing works

Activation of Microglial Poly(ADP-Ribose)-Polymerase-1 by Cholesterol Breakdown Products during Neuroinflammation

Diestel, A., Aktas, O., Hackel, D., Häke, I., Meier, S., Raine, C. S., Nitsch, R., Zipp, F., & Ullrich, O. (2003) · The Journal of Experimental Medicine · doi:10.1084/jem.20030975 · Cited by 155 · see citing works

The Role of the Antioxidant Response in Mitochondrial Dysfunction in Degenerative Diseases: Cross-Talk between Antioxidant Defense, Autophagy, and Apoptosis

Huang, M., Chiang, S., Kalinowski, D. S., Bae, D.-H., Sahni, S., & Richardson, D. R. (2019) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2019/6392763 · Cited by 154 · see citing works

PML at Mitochondria-Associated Membranes Is Critical for the Repression of Autophagy and Cancer Development

Missiroli, S., Bonora, M., Patergnani, S., Poletti, F., Perrone, M., Gafà, R., Magri, E., Raimondi, A., Lanza, G., Tacchetti, C., et al. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.07.082 · Cited by 150 · see citing works

Roles of sigma-1 receptors on mitochondrial functions relevant to neurodegenerative diseases

Weng, T.-Y., Tsai, S., & Su, T. (2017) · Journal of Biomedical Science · doi:10.1186/s12929-017-0380-6 · Cited by 139 · see citing works

Sterol Efflux Is Impaired from Macrophage Foam Cells Selectively Enriched with 7-Ketocholesterol

Gelissen, I. C., Brown, A. J., Mander, E. L., Kritharides, L., Dean, R. T., & Jessup, W. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.30.17852 · Cited by 131 · see citing works

Black Tea Theaflavins Inhibit Formation of Toxic Amyloid-β and α-Synuclein Fibrils

Grelle, G., Otto, A., Lorenz, M., Frank, R. F., Wanker, E. E., & Bieschke, J. (2011) · Biochemistry · doi:10.1021/bi2012383 · Cited by 130 · see citing works

Critical review: involvement of endoplasmic reticulum stress in the aetiology of Alzheimer's disease

Hashimoto, S., & Saido, T. C. (2018) · Open Biology · doi:10.1098/rsob.180024 · Cited by 129 · see citing works

Evidence of oxidative stress in very long chain fatty acid – Treated oligodendrocytes and potentialization of ROS production using RNA interference-directed knockdown of ABCD1 and ACOX1 peroxisomal proteins

Baarine, M., Andreoletti, P., Athias, A., Nury, T., Zarrouk, A., Ragot, K., Véjux, A., Riedinger, J., Kattan, Z., Bessède, G., et al. (2012) · Neuroscience · doi:10.1016/j.neuroscience.2012.03.058 · Cited by 119 · see citing works

Resveratrol Regulates Mitochondrial Biogenesis and Fission/Fusion to Attenuate Rotenone‐Induced Neurotoxicity

Peng, K., Tao, Y., Zhang, J., Wang, J., Feng, Y., Dan, G., Zhao, Y., Cai, Y., Zhao, J., Wu, Q., et al. (2015) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2016/6705621 · Cited by 118 · see citing works

Mitochondria-associated ER membranes (MAMs) and lysosomal storage diseases

Annunziata, I., Sano, R., & d’Azzo, A. (2018) · Cell Death and Disease · doi:10.1038/s41419-017-0025-4 · Cited by 118 · see citing works

Arachidonate metabolism and the signaling pathway of induction of apoptosis by oxidized LDL/oxysterol

Panini, S. R., Yang, L., Rusiñol, A. E., Sinensky, M. S., Bonventre, J. V., & Leslie, C. C. (2001) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)32223-9 · Cited by 109 · see citing works

Lysosomal dysfunction in proteinopathic neurodegenerative disorders: possible therapeutic roles of cAMP and zinc

Koh, J., Kim, H., Hwang, J. J., Kim, Y. H., & Park, S. E. (2019) · Molecular Brain · doi:10.1186/s13041-019-0439-2 · Cited by 109 · see citing works

Mechanisms of Disease: new therapeutic strategies for Alzheimer's disease—targeting APP processing in lipid rafts

Cheng, H., Vetrivel, K. S., Gong, P., Meckler, X., Parent, A., & Thinakaran, G. (2007) · Nature Clinical Practice Neurology · doi:10.1038/ncpneuro0549 · Cited by 107 · see citing works

7-Ketocholesterol increases retinal microglial migration, activation, and angiogenicity: a potential pathogenic mechanism underlying age-related macular degeneration.

Indaram, M., Ma, W., Zhao, L., Fariss, R. N., Rodriguez, I. R., & Wong, W. T. (2015) · Scientific Reports · doi:10.1038/srep09144 · Cited by 101 · see citing works

Neuronal lysosomes

Ferguson, S. M. (2018) · Neuroscience Letters · doi:10.1016/j.neulet.2018.04.005 · Cited by 101 · see citing works

Evidence for altered cholesterol metabolism in <scp>H</scp>untington's disease <i>post mortem</i> brain tissue

Kreilaus, F., Spiro, A. S., McLean, C. A., Garner, B., & Jenner, A. M. (2016) · Neuropathology and Applied Neurobiology · doi:10.1111/nan.12286 · Cited by 92 · see citing works

7-Ketocholesterol and 7β-hydroxycholesterol: In vitro and animal models used to characterize their activities and to identify molecules preventing their toxicity

Véjux, A., Abed-Vieillard, D., Hajji, K., Zarrouk, A., Mackrill, J. J., Ghosh, S., Nury, T., Yammine, A., Zaibi, M. S., Mihoubi, W., et al. (2019) · Biochemical Pharmacology · doi:10.1016/j.bcp.2019.113648 · Cited by 92 · see citing works

7-Ketocholesterol Incorporation into Sphingolipid/Cholesterol-enriched (Lipid Raft) Domains Is Impaired by Vitamin E

Royer, M.-C., Lemaire‐Ewing, S., Desrumaux, C. M., Monier, S., de Barros, J.-P. P., Athias, A., Néel, D., & Lagrost, L. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m808641200 · Cited by 86 · see citing works

7-Ketocholesterol is increased in the plasma of X-ALD patients and induces peroxisomal modifications in microglial cells: Potential roles of 7-ketocholesterol in the pathophysiology of X-ALD

Nury, T., Zarrouk, A., Ragot, K., Debbabi, M., Riedinger, J., Véjux, A., Aubourg, P. R., & Lizard, G. (2016) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2016.03.037 · Cited by 84 · see citing works

Comparison of the effects of major fatty acids present in the Mediterranean diet (oleic acid, docosahexaenoic acid) and in hydrogenated oils (elaidic acid) on 7-ketocholesterol-induced oxiapoptophagy in microglial BV-2 cells

Debbabi, M., Zarrouk, A., Bezine, M., Meddeb, W., Nury, T., Badreddine, A., Karym, E. M., Sghaier, R., Brétillon, L., Guyot, S., et al. (2017) · Chemistry and Physics of Lipids · doi:10.1016/j.chemphyslip.2017.04.002 · Cited by 82 · see citing works

Biochemical Identification of a Linear Cholesterol-Binding Domain within Alzheimer’s β Amyloid Peptide

Scala, C. D., Yahi, N., Lelièvre, C., Garmy, N., Chahinian, H., & Fantini, J. (2012) · ACS Chemical Neuroscience · doi:10.1021/cn300203a · Cited by 82 · see citing works

Absence of correlation between oxysterol accumulation in lipid raft microdomains, calcium increase, and apoptosis induction on 158N murine oligodendrocytes

Ragot, K., Mackrill, J. J., Zarrouk, A., Nury, T., Aires, V., Jacquin, A., Athias, A., de Barros, J.-P. P., Véjux, A., Riedinger, J., et al. (2013) · Biochemical Pharmacology · doi:10.1016/j.bcp.2013.02.028 · Cited by 80 · see citing works

Protective Effects of α-Tocopherol, γ-Tocopherol and Oleic Acid, Three Compounds of Olive Oils, and No Effect of Trolox, on 7-Ketocholesterol-Induced Mitochondrial and Peroxisomal Dysfunction in Microglial BV-2 Cells

Debbabi, M., Nury, T., Zarrouk, A., Mekahli, N., Bezine, M., Sghaier, R., Gregoire, S., Martine, L., Durand, P., Prost-Camus, E., et al. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17121973 · Cited by 80 · see citing works

Prevention by Dietary Polyphenols (Resveratrol, Quercetin, Apigenin) Against 7-Ketocholesterol-Induced Oxiapoptophagy in Neuronal N2a Cells: Potential Interest for the Treatment of Neurodegenerative and Age-Related Diseases

Yammine, A., Zarrouk, A., Nury, T., Vejux, A., Latruffe, N., Vervandier-Fasseur, D., Samadi, M., Mackrill, J. J., Greige-Gerges, H., Auezova, L., et al. (2020) · Cells · doi:10.3390/cells9112346 · Cited by 79 · see citing works

Sphingolipids and Mitochondrial Dynamic

Fugio, L. B., Coeli‐Lacchini, F. B., & Leopoldino, A. M. (2020) · Cells · doi:10.3390/cells9030581 · Cited by 74 · see citing works

The Polar Nature of 7-Ketocholesterol Determines Its Location within Membrane Domains and the Kinetics of Membrane Microsolubilization by Apolipoprotein A-I

Massey, J. B., & Pownall, H. J. (2005) · Biochemistry · doi:10.1021/bi0506425 · Cited by 72 · see citing works

Ceramide generation occurring during 7β-hydroxycholesterol- and 7-ketocholesterol-induced apoptosis is caspase independent and is not required to trigger cell death

Miguet‐Alfonsi, C., Monier, S., Bettaı̈eb, A., Athias, A., Bessède, G., Laubriet, A., Barrère‐Lemaire, S., Néel, D., Gambert, P., & Lizard, G. (2001) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4400792 · Cited by 72 · see citing works

Effect of Ergothioneine on 7-Ketocholesterol-Induced Endothelial Injury

Koh, S. S., Ooi, S. C.-Y., Lui, N. M.-Y., Cao, Q., Ho, L. T.-Y., Cheah, I. K.-M., Halliwell, B. B., Herr, D. R., & Ong, W.-Y. (2020) · NeuroMolecular Medicine · doi:10.1007/s12017-020-08620-4 · Cited by 70 · see citing works

Early Biochemical and Morphological Modifications in the Brain of a Transgenic Mouse Model of Alzheimer's Disease: A Role for Peroxisomes

Cimini, A., Moreno, S., D’Amelio, M., Cristiano, L., D’Angelo, B., Falone, S., Benedetti, E., Carrara, P., Fanelli, F., Cecconi, F., et al. (2009) · Journal of Alzheimer s Disease · doi:10.3233/jad-2009-1199 · Cited by 68 · see citing works

Mitochondrial dysfunctions in 7-ketocholesterol-treated 158N oligodendrocytes without or with α-tocopherol: Impacts on the cellular profil of tricarboxylic cycle-associated organic acids, long chain saturated and unsaturated fatty acids, oxysterols, cholesterol and cholesterol precursors

Leoni, V., Nury, T., Véjux, A., Zarrouk, A., Caccia, C., Debbabi, M., Fromont, A., Sghaier, R., Moreau, T., & Lizard, G. (2016) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2016.03.029 · Cited by 68 · see citing works

Determination of 7-ketocholesterol in plasma by LC-MS for rapid diagnosis of acid SMase-deficient Niemann-Pick disease

Lin, N., Zhang, H., Qiu, W., Ye, J., Han, L., Wang, Y., & Gu, X. (2013) · Journal of Lipid Research · doi:10.1194/jlr.d044024 · Cited by 67 · see citing works

Biomarkers of Amyotrophic Lateral Sclerosis: Current Status and Interest of Oxysterols and Phytosterols

Véjux, A., Namsi, A., Nury, T., Moreau, T., & Lizard, G. (2018) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2018.00012 · Cited by 65 · see citing works

Prevention of 7-ketocholesterol-induced side effects by natural compounds

Brahmi, F., Véjux, A., Sghaier, R., Zarrouk, A., Nury, T., Meddeb, W., Rezig, L., Namsi, A., Sassi, K., Yammine, A., et al. (2018) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2018.1491828 · Cited by 65 · see citing works

7-Ketocholesterol induces apoptosis in differentiated PC12 cells via reactive oxygen species-dependent activation of NF-κB and Akt pathways

Jang, E.-R., & Lee, C. S. (2010) · Neurochemistry International · doi:10.1016/j.neuint.2010.10.012 · Cited by 65 · see citing works

PPAR-δ and erucic acid in multiple sclerosis and Alzheimer's Disease. Likely benefits in terms of immunity and metabolism

Altinoz, M. A., & Özpınar, A. (2019) · International Immunopharmacology · doi:10.1016/j.intimp.2019.01.057 · Cited by 64 · see citing works

Phytochemical indicaxanthin suppresses 7-ketocholesterol-induced THP-1 cell apoptosis by preventing cytosolic Ca2+increase and oxidative stress

Tesoriere, L., Attanzio, A., Allegra, M., Gentile, C., & Livrea, M. A. (2012) · British Journal Of Nutrition · doi:10.1017/s000711451200493x · Cited by 63 · see citing works

Argan Oil-Mediated Attenuation of Organelle Dysfunction, Oxidative Stress and Cell Death Induced by 7-Ketocholesterol in Murine Oligodendrocytes 158N

Badreddine, A., Zarrouk, A., Karym, E. M., Debbabi, M., Nury, T., Meddeb, W., Sghaier, R., Bezine, M., Véjux, A., Martine, L., et al. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18102220 · Cited by 62 · see citing works

Oxidized LDL lipids increase β-amyloid production by SH-SY5Y cells through glutathione depletion and lipid raft formation

Dias, I. H. K., Mistry, J. J., Fell, S., Reis, A., Spickett, C. M., Polidori, M. C., Lip, G. Y. H., & Griffiths, H. R. (2014) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2014.07.012 · Cited by 60 · see citing works

Cholesterol in the Pathogenesis of Alzheimer’s, Parkinson’s Diseases and Autism: Link to Synaptic Dysfunction

Petrov, A. M., Kasimov, M. R., & Zefirov, A. L. (2017) · Acta Naturae · doi:10.32607/20758251-2017-9-1-26-37 · Cited by 56 · see citing works

Prevention of 7-Ketocholesterol-Induced Overproduction of Reactive Oxygen Species, Mitochondrial Dysfunction and Cell Death with Major Nutrients (Polyphenols, ω3 and ω9 Unsaturated Fatty Acids) of the Mediterranean Diet on N2a Neuronal Cells

Yammine, A., Nury, T., Véjux, A., Latruffe, N., Fasseur, D., Samadi, M. H., Greige‐Gerges, H., Auezova, L., & Lizard, G. (2020) · Molecules · doi:10.3390/molecules25102296 · Cited by 54 · see citing works

7‐Ketocholesterol‐induced lysosomal dysfunction exacerbates vascular smooth muscle cell calcification via oxidative stress

Sudo, R., Sato, F., Azechi, T., & Wachi, H. (2015) · Genes to Cells · doi:10.1111/gtc.12301 · Cited by 52 · see citing works

Lrp, a global regulator, regulates the virulence of Vibrio vulnificus

Ho, Y.-C., Hung, F.-R., Weng, C.-H., Li, W.-T., Chuang, T.-H., Liu, T.-L., Lin, C.-Y., Lo, C., Chen, C., Chen, J.-W., et al. (2017) · Journal of Biomedical Science · doi:10.1186/s12929-017-0361-9 · Cited by 52 · see citing works

Alzheimer's disease and blood-based biomarkers – potential contexts of use

Zvěřová, M. (2018) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s172285 · Cited by 52 · see citing works

Oxidative stress related changes in the brain of hypercholesterolemic rabbits

Aytan, N., Tamtürk, F., Özer, N. K., Jung, T., & Grune, T. (2008) · BioFactors · doi:10.1002/biof.5520330308 · Cited by 49 · see citing works

Lipid accumulation and lysosomal pathways contribute to dysfunction and apoptosis of human endothelial cells caused by 7-oxysterols

Li, W., Ghosh, M., Eftekhari, S., & Yuan, X. (2011) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2011.05.071 · Cited by 48 · see citing works

Effects of cholesterol oxides on cell death induction and calcium increase in human neuronal cells (SK-N-BE) and evaluation of the protective effects of docosahexaenoic acid (DHA; C22:6 n-3)

Zarrouk, A., Nury, T., Samadi, M. H., O’Callaghan, Y. C., Hammami, M., O’Brien, N. M., Lizard, G., & Mackrill, J. J. (2015) · Steroids · doi:10.1016/j.steroids.2015.01.018 · Cited by 46 · see citing works

Cross-Talk Among Integrin, Cadherin, and Growth Factor Receptor: Roles of Nectin and Nectin-Like Molecule

Ogita, H., & Takai, Y. (2008) · International review of cytology · doi:10.1016/s0074-7696(07)65001-3 · Cited by 45 · see citing works

7-Ketocholesterol activates caspases-3/7, -8, and -12 in human microvascular endothelial cells in vitro

Luthra, S., Dong, J., Gramajo, A. L., Chwa, M., Kim, D., Neekhra, A., Kuppermann, B. D., & Kenney, M. C. (2007) · Microvascular Research · doi:10.1016/j.mvr.2007.10.003 · Cited by 44 · see citing works

In vitrofolate supplementation alleviates oxidative stress, mitochondria-associated death signalling and apoptosis induced by 7-ketocholesterol

Huang, R.-F. S., Yaong, H.-C., Chen, S.-C., & Lu, Y. (2004) · British Journal Of Nutrition · doi:10.1079/bjn20041259 · Cited by 44 · see citing works

Inhibition of cholesterol autoxidation by the nonsaponifiable fraction in rice bran in an aqueous model system

Kim, J., Godber, J. S., King, J. M., & Prinyawiwatkul, W. (2001) · Journal of the American Oil Chemists Society · doi:10.1007/s11746-001-0326-8 · Cited by 41 · see citing works

Prevention of 7-ketocholesterol-induced mitochondrial damage and cell death by calmodulin inhibition

Han, J. H., Kim, Y. J., Han, E. S., & Lee, C. S. (2006) · Brain Research · doi:10.1016/j.brainres.2006.12.041 · Cited by 37 · see citing works

Protective effect of catechin rich extract of Rhizophora mucronata against β-amyloid-induced toxicity in PC12 cells

Suganthy, N., & Devi, K. P. (2015) · Journal of Applied Biomedicine · doi:10.1016/j.jab.2015.10.003 · Cited by 36 · see citing works

Endolysosome and Autolysosome Dysfunction in Alzheimer’s Disease: Where Intracellular and Extracellular Meet

van Weering, J. R. T., & Scheper, W. (2019) · CNS Drugs · doi:10.1007/s40263-019-00643-1 · Cited by 36 · see citing works

Emotion Recognition in the Dementias: Brain Correlates and Patient Implications

Kumfor, F., & Piguet, O. (2013) · Neurodegenerative Disease Management · doi:10.2217/nmt.13.16 · Cited by 33 · see citing works

Differential Modulation of 7-Ketocholesterol Toxicity Against PC12 Cells by Calmodulin Antagonists and Ca2+ Channel Blockers

Lee, C. S., Park, W. J., Han, E. S., & Bang, H. (2006) · Neurochemical Research · doi:10.1007/s11064-006-9230-8 · Cited by 30 · see citing works

Autophagy Induction Protects against 7-Oxysterol-induced Cell Death via Lysosomal Pathway and Oxidative Stress

Yuan, X., Sultana, N., Siraj, N., Ward, L. J., Ghafouri, B., & Li, W. (2016) · Journal of Cell Death · doi:10.4137/jcd.s37841 · Cited by 29 · see citing works

Lipid raft-based membrane order is important for antigen-specific clonal expansion of CD4+ T lymphocytes

Schieffer, D., Naware, S., Bakun, W., & Bamezai, A. K. (2014) · BMC Immunology · doi:10.1186/s12865-014-0058-8 · Cited by 27 · see citing works

Oxidized LDL‐Exposed Human Macrophages Display Increased MMP‐9 Expression and Secretion Mediated by Endoplasmic Reticulum Stress

Sanda, G. M., Deleanu, M., Toma, L., Stancu, C. S., Simionescu, M., & Sima, A. V. (2016) · Journal of Cellular Biochemistry · doi:10.1002/jcb.25637 · Cited by 26 · see citing works

Nicotinamide phosphoribosyltransferase delays cellular senescence by upregulating SIRT 1 activity and antioxidant gene expression in mouse cells

Khaidizar, F. D., Nakahata, Y., Kume, A., Sumizawa, K., Kohno, K., Matsui, T., & Bessho, Y. (2017) · Genes to Cells · doi:10.1111/gtc.12542 · Cited by 26 · see citing works

Role of emerging neuroimaging modalities in patients with cognitive impairment: a review from the Canadian Consensus Conference on the Diagnosis and Treatment of Dementia 2012

Burhan, A. M., Bartha, R., Bocti, C., BORRIE, M. J., Laforce, R. J., Rosa‐Neto, P., & Soucy, J. (2013) · Alzheimer s Research & Therapy · doi:10.1186/alzrt200 · Cited by 24 · see citing works

Attenuation of Aβ toxicity by promotion of mitochondrial fusion in neuroblastoma cells by liquiritigenin

Jo, D. S., Shin, D. W., Park, S. J., Bae, J., Kim, J. B., Park, N. Y., Kim, J., Oh, J. S., Shin, J.-W., & Cho, D. (2016) · Archives of Pharmacal Research · doi:10.1007/s12272-016-0780-2 · Cited by 21 · see citing works

Tyrosine Kinase Inhibitor AG126 Reduces 7-Ketocholesterol-Induced Cell Death by Suppressing Mitochondria-Mediated Apoptotic Process

Kim, Y. J., & Lee, C. S. (2009) · Neurochemical Research · doi:10.1007/s11064-009-0105-7 · Cited by 19 · see citing works

7‐Ketocholesterol is Not Cytotoxic to U937 Cells When Incorporated into Acetylated Low Density Lipoprotein

Rutherford, L. D., & Gieseg, S. P. (2011) · Lipids · doi:10.1007/s11745-011-3634-1 · Cited by 18 · see citing works

Effects of 7-ketocholesterol on the activity of endothelial poly(ADP-ribose) polymerase and on endothelium-dependent relaxant function

Kiss, L., Chen, M., Gerő, D., Módis, K., Lacza, Z., & Szabó, C. (2006) · International Journal of Molecular Medicine · doi:10.3892/ijmm.18.6.1113 · Cited by 18 · see citing works

Glycyrrhizin Prevents 7-Ketocholesterol Toxicity Against Differentiated PC12 Cells by Suppressing Mitochondrial Membrane Permeability Change

Kim, D. E., Youn, Y. C., Kim, Y. K., Hong, K. M., & Lee, C. S. (2009) · Neurochemical Research · doi:10.1007/s11064-009-9930-y · Cited by 16 · see citing works

Localization of amyloid beta (Aβ1‐42) protofibrils in membrane lateral compartments: Effect of cholesterol and 7‐Ketocholesterol

Phan, H. T. T., Vestergaard, M. C. M., Baek, K., Shimokawa, N., & Takagi, M. (2014) · FEBS Letters · doi:10.1016/j.febslet.2014.08.007 · Cited by 10 · see citing works

A survey of cell biology

Jeon, K. W. (2016) · Cited by 2 · see citing works

Lipid metabolism, remodelling and intercellular transfer in the CNS

Vanherle, S., Loix, M., Miron, V. E., Hendriks, J. J. A., & Bogie, J. F. J. (2025) · Nature reviews. Neuroscience · doi:10.1038/s41583-025-00908-3 · Cited by 90 · see citing works

Natural Bioactive Molecules as Neuromedicines for the Treatment/Prevention of Neurodegenerative Diseases

Babazadeh, A., Vahed, F. M., Liu, Q., Siddiqui, S. A., Kharazmi, M. S., & Jafari, S. M. (2023) · ACS Omega · doi:10.1021/acsomega.2c06098 · Cited by 58 · see citing works

Sources of 7-ketocholesterol, metabolism and inactivation strategies: food and biomedical applications

Ghzaiel, I., Sassi, K., Zarrouk, A., Ghosh, S., Dias, I. H. K., Nury, T., Ksila, M., Essadek, S., Tahri-Joutey, M., Brahmi, F., et al. (2022) · Redox Experimental Medicine · doi:10.1530/rem-22-0005 · Cited by 54 · see citing works

Oxysterols are potential physiological regulators of ageing

de Médina, P., Silvente‐Poirot, S., & Poirot, M. (2022) · Ageing Research Reviews · doi:10.1016/j.arr.2022.101615 · Cited by 51 · see citing works

7β-Hydroxycholesterol and 7-ketocholesterol: New oxidative stress biomarkers of sarcopenia inducing cytotoxic effects on myoblasts and myotubes

Ghzaiel, I., Zarrouk, A., Pires, V., de Barros, J.-P. P., Hammami, S. O., Ksila, M., Hammami, M., Ghrairi, T., Jouanny, P., Véjux, A., et al. (2023) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2023.106345 · Cited by 31 · see citing works

White matter injury, cholesterol dysmetabolism, and APP/Abeta dysmetabolism interact to produce Alzheimer’s disease (AD) neuropathology: A hypothesis and review

Sharp, F. R., DeCarli, C. S., Jin, L., & Zhan, X. (2023) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2023.1096206 · Cited by 30 · see citing works

The Role of Dietary Lipids in Cognitive Health: Implications for Neurodegenerative Disease

Hans, S., Karadimou, A., Mulvihill, J. J., Grabrucker, A. M., & Zabetakis, I. (2022) · Biomedicines · doi:10.3390/biomedicines10123250 · Cited by 23 · see citing works

Which neuroimaging and fluid biomarkers method is better in theranostic of Alzheimer’s disease? An umbrella review

Mohammadi, H., Ariaei, A., Ghobadi, Z., Gorgich, E. A. C., & Rustamzadeh, A. (2024) · IBRO Neuroscience Reports · doi:10.1016/j.ibneur.2024.02.007 · Cited by 18 · see citing works

Impact of Oxysterols in Age-Related Disorders and Strategies to Alleviate Adverse Effects

Ghosh, S., Ghzaiel, I., Véjux, A., Meaney, S., Nag, S., Lizard, G., Tripathi, G., Naez, F., & Paul, S. (2023) · Advances in experimental medicine and biology · doi:10.1007/978-3-031-43883-7_9 · Cited by 16 · see citing works

Crosstalk between Lipid Rafts and Aging: New Frontiers for Delaying Aging

Zhang, S., Zhu, N., Gu, J., Li, H., Qiu, Y., Liao, D.-F., & Li, Q. (2022) · Aging and Disease · doi:10.14336/ad.2022.0116 · Cited by 16 · see citing works

Influence of the Gut Microbiota on the Development of Neurodegenerative Diseases

Singh, M. P., Chakrabarty, R., Shabir, S., Yousuf, S., Obaid, A. A., Moustafa, M., Al-Shehri, M., Al‐Emam, A., Alamri, A. S., Alsanie, W. F., et al. (2022) · Mediators of Inflammation · doi:10.1155/2022/3300903 · Cited by 15 · see citing works

Cholesterol Oxidation Products: Potential Adverse Effect and Prevention of Their Production in Foods

Deng, C., Li, M., Liu, Y. D., Yan, C., He, Z., Chen, Z., & Zhu, H. (2023) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.3c05158 · Cited by 14 · see citing works

Sitosterol-rich Digera muricata against 7-ketocholesterol and lipopolysaccharide-mediated atherogenic responses by modulating NF-ΚB/iNOS signalling pathway in macrophages

Ravi, S., Duraisamy, P., Krishnan, M., Martin, L. C., Manikandan, B., & Ramar, M. (2023) · 3 Biotech · doi:10.1007/s13205-023-03741-6 · Cited by 13 · see citing works

Cytoprotective effects of α-linolenic acid, eicosapentaenoic acid, docosahexaenoic acid, oleic acid and α-tocopherol on 7-ketocholesterol – Induced oxiapoptophagy: Major roles of PI3-K / PDK-1 / Akt signaling pathway and glutathione peroxidase activity in cell rescue

Yammine, A., Ghzaiel, I., Pires, V., Zarrouk, A., Kharoubı, O., Greige‐Gerges, H., Auezova, L., Lizard, G., & Véjux, A. (2024) · Current Research in Toxicology · doi:10.1016/j.crtox.2024.100153 · Cited by 10 · see citing works

Network pharmacology-guided systems biology reveals β-Sitosterol’s multi-target role in reversing 7-ketocholesterol-induced oxidative and inflammatory stress

Ganamurali, N., & Sabarathinam, S. (2025) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2025.106863 · Cited by 9 · see citing works

Circulating oxysterols in Alzheimer’s disease: a systematic review and meta-analysis

Ademowo, O. S., & Dias, I. H. K. (2022) · Redox Experimental Medicine · doi:10.1530/rem-22-0009 · Cited by 9 · see citing works

7-ketocholesterol as a critical oxysterol: Impact on human health and safety in food systems

Kumar, S. S., Prakash, A., Keerthana, P. V., & John, M. (2025) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2025.106856 · Cited by 7 · see citing works

Lipid droplets dependent or independent cytoprotective activities of unsaturated fatty acids, Lorenzo’s oil and sulfo-N-succinimidyl oleate on 7-ketocholesterol-induced oxidative stress, organelle dysfunction and cell death on 158N and ARPE-19 cells: Cell targets and benefits of sulfo-N-succinimidyl oleate

Nury, T., Ghzaiel, I., Hichami, A., Caccia, C., Leoni, V., Pires, V., Atanasov, A. G., Zarrouk, A., Lizard, G., & Véjux, A. (2024) · Current Research in Biotechnology · doi:10.1016/j.crbiot.2024.100195 · Cited by 7 · see citing works

Effects of thiram exposure on liver metabolism of chickens

Wang, M., Wang, L., Shabbir, S., Zhou, D., Shahid, M. A., Luo, H., Li, H., Li, Z., Sun, X., Wu, C., et al. (2023) · Frontiers in Veterinary Science · doi:10.3389/fvets.2023.1139815 · Cited by 7 · see citing works

7-Ketocholesterol: occurrence, biological activities, and plausible remediation

Ghosh, S. (2025) · Redox Experimental Medicine · doi:10.1530/rem-25-0009 · Cited by 6 · see citing works

Oxysterol signaling in the central nervous system: cellular mechanisms and implications for neurodegeneration

Ricci, R., Foo, C. X., Ronacher, K., & Cullen, C. L. (2026) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2026.1709065 · Cited by 5 · see citing works

Emerging role of 7-Ketocholesterol and hydroxylated 7-Ketocholesterol in the pathophysiology of disease

Dias, I. H. K., Petler, N., Harihararajah, K., Kremenska, Y., Anderson, A., & O’Connor, M. S. (2026) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2026.106981 · Cited by 5 · see citing works

Scoparia dulcis and Indigofera tinctoria as potential herbal remedies against 7-ketocholesterol-induced pro-inflammatory mediators of macrophage polarization

Duraisamy, P., Ravi, S., Krishnan, M., Martin, L. C., Manikandan, B., Raman, T., Arumugam, M., & Manikandan, R. (2023) · Journal of Herbal Medicine · doi:10.1016/j.hermed.2023.100652 · Cited by 5 · see citing works

Neurotoxicity induced by lipid metabolism–associated endogenous toxicants

Mahalakshmi, K., Duraisamy, P., Sangeetha, R., Martin, L. C., Manikandan, B., & Manikandan, R. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-23763-8.00079-8 · Cited by 4 · see citing works

Therapeutic potential of monoterpene molecules acts against 7KCh-mediated oxidative stress and neuroinflammatory amyloidogenic signalling pathways

Krishnan, M., Kumaresan, M., Ravi, S., Martin, L. C., Duraisamy, P., Manikandan, B., Arumugam, M., & Ramar, M. (2024) · Prostaglandins & Other Lipid Mediators · doi:10.1016/j.prostaglandins.2024.106910 · Cited by 4 · see citing works

Targeting 7-ketocholesterol–driven metabolic dysfunction in obesity: Therapeutic potential of Bifidobacterium and dietary antioxidants

Natania, S. A. (2026) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2026.106998 · Cited by 4 · see citing works

7-ketocholesterol contributes to microglia-driven increases in astrocyte reactive oxygen species in a mouse model of Alzheimer’s disease

Radhakrishnan, K., Zhang, Y., Mustapha, O., Weigel, T. K., Upchurch, C. M., Tian, X., Herbert, F. J., Huang, W., Leitinger, N., Eyo, U. B., et al. (2026) · Scientific Reports · doi:10.1038/s41598-026-61753-7 · Cited by 3 · see citing works

Neuroprotective effects of Persea americana and Tabebuia rosea ethanolic extracts against aluminum chloride-induced Alzheimer’s disease in rat model

Onifade, O. F., Abodunrin, O. P., Oyeneye, E. O., Chigozie, E. G., Arafa, A. G., & Okunlola, B. O. (2025) · Medicine in Omics · doi:10.1016/j.meomic.2025.100044 · Cited by 2 · see citing works

Hormetic Effects of 7‐Ketocholesterol in Preventing Ferroptosis in Hepatocytes

Anavi, S., Giltman, N., Zeigerman, H., Madar, Z., & Tirosh, O. (2026) · Oxidative Medicine and Cellular Longevity · doi:10.1155/omcl/7958511 · Cited by 2 · see citing works

7-ketocholesterol enhances BACE1-amyloid precursor protein cleavage and amyloidogenic peptide generation targeted by natural moleculesPreprint

Krishnan, M., Kumaresan, M., Ravi, S., Martin, L. C., Duraisamy, P., Arumugam, M., & Ramar, M. (2024) · Research Square · doi:10.21203/rs.3.rs-3955730/v1 · Cited by 2 · see citing works

Reversal of foam cell formation by removal of 7-ketocholesterol with the cyclodextrin dimer UDP-003: a new potential drug candidate to promote atherosclerotic plaque regression

Lizard, G. (2025) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2025.120419 · Cited by 1 · see citing works

APOE2 attenuates APOE4-associated amyloid pathology and related toxicity in a mouse model of Alzheimer’s disease

Chen, K., Chen, Y., Ren, Y., Wang, Z., Huang, Y., Pan, M., Li, Z., Casey, M. C., Qiao, W., Shi, J., et al. (2026) · Nature Communications · doi:10.1038/s41467-026-78407-x

7-ketocholesterol as a theranostic target: Potential applications and future perspectives

Lizard, G., Sassi, K., Mackrill, J. J., Ghzaiel, I., Meziane, S., Hassen, E., Abdelkarim, M., Masmoudi‐Kouki, O., Ghrairi, T., Brahmi, F., et al. (2026) · Chemistry and Physics of Lipids · doi:10.1016/j.chemphyslip.2026.105588

Prévention de la neurodégénérescence induite par le 7-cétocholestérol pardes polyphénols et des acides gras présents dans le régime méditerranéen

Yammine, A. (2022) · theses.fr (ABES) · doi:10.70675/de185fe4z64e5z41d5zaad3zfec2b8dd184b

7‐Keto Cholesterol as a Mediator in Alzheimer's Disease Pathogenesis

Dias, I. H. K., Sanchez, L. D., Angelini, T., & Marinozzi, M. (2025) · Alzheimer s & Dementia · doi:10.1002/alz70856_105279

Oxidized cholesterol as the driving force behind the development of Alzheimer’s disease

Gamba, P., Testa, G., Gargiulo, S., Staurenghi, E., Poli, G., & Leonarduzzi, G. (2015) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2015.00119 · Cited by 202 · see citing works

Free radicals and disruption of neuronal ion homeostasis in AD: A role for amyloid β-peptide?

Mattson, M. P. (1995) · Neurobiology of Aging · doi:10.1016/0197-4580(95)00063-k · Cited by 45 · see citing works

Evidence of K+ homeostasis disruption in cellular dysfunction triggered by 7-ketocholesterol, 24S-hydroxycholesterol, and tetracosanoic acid (C24:0) in 158N murine oligodendrocytes

Bezine, M., Debbabi, M., Nury, T., Khalifa, R. B., Samadi, M. H., Cherkaoui‐Malki, M., Véjux, A., Raas, Q., Seze, J. D., Moreau, T., et al. (2017) · Chemistry and Physics of Lipids · doi:10.1016/j.chemphyslip.2017.03.006 · Cited by 26 · see citing works

Strikingly different effects of cholesterol and 7-ketocholesterol on lipid bilayer-mediated aggregation of amyloid beta (1-42)

Phan, H. T. T., Shimokawa, N., Sharma, N., Takagi, M., & Vestergaard, M. C. M. (2018) · Biochemistry and Biophysics Reports · doi:10.1016/j.bbrep.2018.04.007 · Cited by 15 · see citing works