TP63-Mediated Enhancer Reprogramming Drives the Squamous Subtype of Pancreatic Ductal Adenocarcinoma

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5. Interactive enhancer hubs (iHUBs) mediate transcriptional reprogramming and adaptive resistance in pancreatic cancer
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6. Combination immunohistochemistry for CK5/6, p63, GATA6, and HNF4a predicts clinical outcome in treatment-naïve pancreatic ductal adenocarcinoma
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8. Epigenetic silencing of AATK in acinar to ductal metaplasia in murine model of pancreatic cancer
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10. Glucocorticoid receptor suppresses GATA6-mediated RNA polymerase II pause release to modulate classical subtype identity in pancreatic cancer
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12. Interleukin-1 signaling in solid organ malignancies
    Austin R. Dosch, Samara P. Singh, Nagaraj S. Nagathihalli, Jashodeep Datta, Nipun B. Merchant · 2021 · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer
13. Integrated analysis revealed hypoxia signatures and LDHA related to tumor cell dedifferentiation and unfavorable prognosis in pancreatic adenocarcinoma
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15. MUC16 and TP53 family co-regulate tumor-stromal heterogeneity in pancreatic adenocarcinoma
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16. Molecular, metabolic, and histological subtypes of pancreatic ductal adenocarcinoma and its tumor microenvironment: Insights into tumor heterogeneity and clinical implications
    Yuuki Ohara, Huaitian Liu, Paloma Moreno, Seiya Suzuki, S. Perwez Hussain · 2025 · Pharmacology & Therapeutics
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18. Two rare cancers of the exocrine pancreas: to treat or not to treat like ductal adenocarcinoma?
    Nebojša Skorupan, Shadin Ghabra, Jose Alberto Maldonado, Yang Zhang, Christine Alewine · 2023 · Journal of Cancer Metastasis and Treatment
19. Epigenetic priming targets tumor heterogeneity to shift transcriptomic phenotype of pancreatic ductal adenocarcinoma towards a Vitamin D susceptible state
    Bo He, Lauren A. Stoffel, Clifford Jiajun He, Kumsun Cho, Albert Mao Li, Haowen Jiang, Brittany M. Flowers, Kha The Nguyen, K. Wang, Audrey Yixin Zhao et al. · 2024 · Cell Death and Disease
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    David J. Easty, Christine J. Farr, Bryan T. Hennessy · 2021 · Frontiers in Endocrinology
21. The tumor microenvironment drives transcriptional phenotypes and their plasticity in metastatic pancreatic cancer
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22. Identification of a ΔNp63-Dependent Basal-Like A Subtype-Specific Transcribed Enhancer Program (B-STEP) in Aggressive Pancreatic Ductal Adenocarcinoma
    Xin Wang, Ana P. Kutschat, Joana E. Aggrey-Fynn, Feda H. Hamdan, Rondell Patrell Graham, Alexander Q. Wixom, Yara Souto, Swetlana Ladigan‐Badura, Jennifer A. Yonkus, Amro M. Abdelrahman et al. · 2023 · Molecular Cancer Research
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    Paul Manoukian, Leo C Kuhnen, Hanneke W.M. van Laarhoven, Maarten F. Bijlsma · 2024 · Critical Reviews in Oncology/Hematology
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    Samuel Ogden, Kashmala Carys, Ibrahim Ahmed, Jason I.E. Bruce, Andrew D Sharrocks · 2022 · Oncogene
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    Zejiao Li, Fengwei Gao, Xuesha Liu, Shijie Fan, Yucheng Qi, Mingzhu He, Xiushuang Luo, Xinwen Nie, Jia Wang, Yajun Wang et al. · 2025 · Science Signaling
30. Pan-p63 but not ΔNp63 (p40) expression in undifferentiated carcinoma of the pancreas
    Łukasz Liszka · 2020 · Polish Journal of Pathology
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    Oleg A. Kuchur, Daria O. Kuzmina, Marina Dukhinova, Alexandr A. Shtil · 2021 · Acta Naturae
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    Arnaldo Franco, Jeffrey Duryea, Oliver Gene McDonald · 2023 · Cancer and Metastasis Reviews
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    E. Sıla Özdemir, Michelle M. Gomes, Jared M. Fischer · 2022 · Molecular Cancer Therapeutics
39. An integrated genomic approach identifies follistatin as a target of the p63-epidermal growth factor receptor oncogenic network in head and neck squamous cell carcinoma
    Akinsola Oyelakin, Jennifer Sosa, Kasturi Bala Nayak, Alexandra Ruth Glathar, Christian B. Gluck, Isha Sethi, Maria Tsompana, Norma J. Nowak, Michael Joseph Buck, Rose‐Anne Romano et al. · 2023 · NAR Cancer
40. ΔNp63 bookmarks and creates an accessible epigenetic environment for TGFβ-induced cancer cell stemness and invasiveness
    Eleftheria Vasilaki, Yu Bai, Mohamad Moustafa Ali, Anders Sundqvist, Aristidis Moustakas, Carl‐Henrik Heldin · 2024 · Cell Communication and Signaling
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42. HNF1B‐driven three‐dimensional chromatin structure for molecular classification in pancreatic cancers
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    Bradley Balk, David W. Goodrich · 2024 · Cancer Heterogeneity and Plasticity
44. UPF1 deficiency enhances mitochondrial ROS which promotes an immunosuppressive microenvironment in pancreatic ductal adenocarcinoma
    Wenjuan Su, Juan Andres Kochen Rossi, Cristina Nuevo‐Tapioles, Ting Chen, Emily A. Kawaler, Cristina M. Branco, Kwok‐Kin Wong, Diane M. Simeone, Lawrence B. Gardner, Mark R. Philips · 2024 · Proceedings of the National Academy of Sciences
45. KLF5 enables dichotomous lineage programs in pancreatic cancer via the AAA+ ATPase coactivators RUVBL1 and RUVBL2
    Patrick J. Cunniff, N. Sivetz, D. Skopelitis, Olaf Klingbeil, Daniel Toobian, Diogo Maia-Silva, M. Egeblad, Christopher R. Vakoc · 2025 · Nature Communications
46. Epigenetic therapeutic strategies in pancreatic cancer
    Arturo Orlacchio, Stephen Muzyka, Tamas A. Gonda · 2024 · International review of cytology
47. SPDEF promotes the classical subtype of pancreatic ductal adenocarcinoma
    Claudia Tonelli, Georgi N. Yordanov, Hao Yuan, Astrid Deschênes, Olaf Klingbeil, Hsiu-Chi Ting, Erin Brosnan, Abishek Doshi, Youngkyu Park, Christopher R. Vakoc et al. · 2022 · bioRxiv (Cold Spring Harbor Laboratory)
48. The epipliancy journey: Tumor initiation at the mercy of identity crisis and epigenetic drift
    Rahma Benhassoun, Anne‐Pierre Morel, Victoria Jacquot, Alain Puisieux, Maria Ouzounova · 2025 · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer
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    Min Jae Yang, Seokhwi Kim, Jae Chul Hwang, Woohyun Jung, So Hyun Park, So Mi Heo, Jae‐Il Choi, Byung Moo Yoo, You‐Sun Kim, Dakeun Lee · 2025 · Journal of Gastroenterology and Hepatology
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    Yong‐Qiang Ning, Jie Wang, Yihui Zhang, Hongrui Li, Zenan Jiang, Xinyu Su, Yang Xiao, Xiaoxuan Wu, Bing Wei, Jianmin Ying et al. · 2025 · Advanced Science
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    Nana Chen, Mouxiang Fang, Leqi Zhong, Xiaolong Li, Yijia Zhou, Jianhua Zhan, Manli Wang, Zhaoyuan Fang, Hua Wang, Shijie Tang et al. · 2026 · Cell Death and Differentiation
52. Epigenetic and transcriptional control of classical and basal-like cell states in pancreatic ductal adenocarcinoma
    Christina Parassiadis, Steven A. Johnsen · 2026 · Gastroenterology report
53. A Systemic and Integrated Analysis of p63-Driven Regulatory Networks in Mouse Oral Squamous Cell Carcinoma
    Alexandra Ruth Glathar, Akinsola Oyelakin, Kasturi Bala Nayak, Jennifer Sosa, Rose‐Anne Romano, Satrajit Sinha · 2023 · Cancers
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    Beate Haugk, David Horton, Kofi W. Oppong, John Samuel Leeds, Antony Darné, Philip Sloan, Thomas Ness, Claire Jones, Paul Bassett, Manu K. Nayar · 2021 · Scientific Reports
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    Joep Sprangers, Jeroen M. Bugter, Despina Xanthakis, Michiel Boekhout, Rutger N.U. Kok, Veerle Geurts, Hans C. Clevers, Lodewijk A.A. Brosens, Frederike Dijk, Maria J. Rodríguez Colman et al. · 2026 · iScience
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    Samuel Ogden, Kashmala Carys, Jason I.E. Bruce, Andrew D Sharrocks · 2021 · bioRxiv (Cold Spring Harbor Laboratory)
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    Dennis H. Gong, Jimmy A. Guo, Jennifer Su, Sueda Cetinkaya, Connor J. Hennessey, Patrick Z. Yu, Ananya D. Jambhale, Peter L. Wang, Nicholas J Caldwell, Ashley Lam et al. · 2026 · Cell Reports
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    June-Ha Shin, Hwa-Ryeon Kim, Jae‐Seok Roe · 2025 · Cellular and Molecular Life Sciences
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    Anna Wolters, Maarten F. Bijlsma, Jai Prakash · 2026 · Trends in cancer
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    Charles J. David · 2022 · Journal of Cancer Metastasis and Treatment
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    Evangelina López de Maturana, Sladjana Zagorac, Núria Malats, Francisco X. Real · 2023 · Elsevier eBooks
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    Charles J. David · 2019 · Journal of Pancreatology
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    Holly Brunton, Giuseppina Caligiuri, Gareth J. Inman, Peter J. Bailey · 2020 · Molecular and translational medicine
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    Turan Tufan, Jiekun Yang, Krishna Seshu Tummala, Harun Cingoz, Cem Kuscu, Sara J. Adair, Gamze Cömertpay, Sarbajeet Nagdas, Bernadette J. Goudreau, Husnu Umit Luleyap et al. · 2020 · bioRxiv (Cold Spring Harbor Laboratory)
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    Stella K. Hur, Tim D.D. Somerville, Xiaoli Wu, Diogo Maia-Silva, Osama E. Demerdash, David Arthur Tuveson, Faiyaz Notta, Christopher R. Vakoc · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
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    Grace Oh, Surajit Dhara, Diane M. Simeone · 2023 · Wiley eBooks
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    Jan-Lars Van den Bossche, Marijke van der Vliet, Ellis Michiels, Oier Azurmendi Senar, Silke Van Lint, Z Madran, K Coolens, J Brons, Montserrat Nacher, T Arsenijevic et al. · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
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    Adam S. Bryce, Silvia Martinelli, Leonor Schubert Santana, Leah Officer-Jones, Rachel L. Baird, Fiona Ballantyne, Kai Rakovic, Ian R. Powley, Dina Tataran, David J. Meltzer et al. · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
80. The USP28-ΔNp63 axis is a vulnerability of squamous tumours
    Cristian Prieto‐Garcia, Oliver Hartmann, Michaela Reissland, Fabian Braun, Thomas Fischer, Susanne Walz, Annalena Fischer, Marco A. Calzado, Amir Orian, Mathias Tillmann Rosenfeldt et al. · 2019 · bioRxiv (Cold Spring Harbor Laboratory)
81. Identificação e anotação funcional de RNAs longos não codificadores associados à subtipos moleculares em tumores pancreáticos
    Diogo de Oliveira Pessôa · 2019 · Digital Library of Theses and Dissertations (Universidade de São Paulo)
82. Discovery of the pancreatic basal cell: a new candidate for an adult stem cell emerges
    Simone Benitz, Howard C. Crawford · 2021 · Gut
83. Epithelial-mesenchymal transition status is the main driver of intrinsic metabolism in cancer cell lines
    Nicola Zamboni, Sarah Cherkaoui · 2021 · bioRxiv (Cold Spring Harbor Laboratory)
84. Overcoming Cisplatin Resistance in Pancreatic Cancer
    Katharina M. Ewers · 2021
85. TP53-status dependent oncogenic EZH2 Activity in Pancreatic Cancer
    Lennart Versemann · 2022 · eDiss (Georg-August-Universität Göttingen)
86. Adenocarcinoma Variants
    2023 · American Registry of PathologyArlington, Virginia eBooks
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    Lukas Krauß, Bettina C. Urban, Sieglinde Hastreiter, Carolin Schneider, Patrick Wenzel, Zonera Hassan, Matthias Wirth, Katharina Lankes, Andrea Terrasi, Christine Klement et al. · 2023
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    Jihao Xu, Jae‐Seok Roe, Eunjung Lee, Claudia Tonelli, Tim D.D. Somerville, Melissa A. Yao, Joseph P. Milazzo, Hervé Tiriac, Ania M. Kolarzyk, Esak Lee et al. · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
89. Super-enhancer-driven ITGA6 enhances stemness features of squamous cell carcinoma through stabilizing c-myc protein
    Bo Xiang, Ying Liu, Hu Meng, Jing Cai, Quanzhu Chen, Pan Chen, Zhaoyang Zeng, Guiyuan Li, Wei Xiong, Songqing Fan et al. · 2023 · Research Square
90. A ΔNp63–MED12 axis drives basal-like identity in pancreatic cancer
    Maia-Silva, Diogo, Christopher R. Vakoc · 2024 · Nature Genetics
91. GNA15 signaling facilitates the initial phases of pancreas cell transformation and is associated with the basal-like/squamous subtype
    Yalda Zolghadri, Thomas Martin Wilkie, Elisa Venturini, Giorgio Malpeli, Marco Zanotto, Farnoosh Mirzaei, Maria Teresa Valenti, Shreoshi Pal Choudhuri, Roberto Salvia, Salvatore Paiella et al. · 2024 · Research Square
92. Heritable non-genetic phenotypes are enriched for stress responses as a form of bet hedging
    Spencer Grissom, Zachary Dixon, Abhyudai Singh, Mark Blenner · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
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94. TRANSCRIPTOMIC ANALYSIS OF THE RELATIONSHIP BETWEEN PANCREATIC DUCTAL ADENOCARCINOMA STROMAL SUBTYPES AND NEURAL INVASION
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    Yao Wang, Hara Apostolopoulou, Im‐Hong Sun, Arjan Bains, David L. Gibbs, Sui Huang, Tamara N. Alliston, Ajay V. Maker, Thea Dorothy Tlsty, Vasilis Ntranos et al. · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
96. Hypoxia-induced metastatic heterogeneity in pancreatic cancer
    Pradeep Moon Gunasekaran, Qianqian Wang, Polina Guseva, Yoke‐Chen Chang, Rajika Chauhan, Alexander Kley, Mengdie Xu, Gene Lee, Gregory Marshall, Siddharth Ghosh Roy et al. · 2026 · Nature Communications
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98. Blocking Osteoprotegerin Reprograms Cancer Associated Fibroblast to Promotes Immune Infiltration into the Tumor Microenvironment
    Yao Wang, Hara Apostolopoulou, Im‐Hong Sun, Arjan Bains, David L. Gibbs, Sui Huang, Tamara N. Alliston, Ajay V. Maker, Thea Dorothy Tlsty, Vasilis Ntranos et al. · 2025 · eLife
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    Akihisa Ohno, Nao Fujimori, Kazuhide Matsumoto, Shojiro Haji, Osamu Sugahara, Ayumu Takeno, Takeo Yamamoto, Akihiko Suenaga, Shotaro Kakehashi, Takahiro Ueda et al. · 2025 · Oncogene
100. Additional file 1 of Integrative analysis of spatial and single-cell transcriptome data from human pancreatic cancer reveals an intermediate cancer cell population associated with poor prognosis
     Kim, Seongryong, Galam Leem, Junjeong Choi, Yongjun Koh, Lee, Suho, Nam, Sang-Hee, Jin Su Kim, Chan Hee Park, Hwang, Ho Kyoung, Min, Kyoung Il et al. · 2024 · Figshare