Vakoc, Christopher R.

Selective Inhibition of Tumor Oncogenes by Disruption of Super-Enhancers

Lovén, J., Hoke, H. A., Lin, C. Y., Lau, A., Orlando, D. A., Vakoc, C. R., Bradner, J. E., Lee, T. I., & Young, R. A. (2013) · Cell

Protein Degradation and InhibitorsChromatin Remodeling and Cancer

Cited by 2,961

RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia

Zuber, J., Shi, J., Wang, E., Rappaport, A. R., Herrmann, H., Sison, E. A., Magoon, D., Qi, J., Blatt, K., Wunderlich, M., et al. (2011) · Nature

Protein Degradation and InhibitorsAcute Myeloid Leukemia Research

Cited by 1,870

Organoid Profiling Identifies Common Responders to Chemotherapy in Pancreatic Cancer

Tiriac, H., Belleau, P., Engle, D. D., Plenker, D., Deschênes, A., Somerville, T. D. D., Froeling, F. E. M., Burkhart, R. A., Denroche, R. E., Jang, G.-H., et al. (2018) · Cancer Discovery

Pancreatic and Hepatic Oncology ResearchCancer Genomics and Diagnostics

Cited by 1,092

Proximity among Distant Regulatory Elements at the β-Globin Locus Requires GATA-1 and FOG-1

Vakoc, C. R., Letting, D. L., Gheldof, N., Sawado, T., Bender, M. A., Groudine, M., Weiss, M. J., Dekker, J., & Blobel, G. A. (2005) · Molecular Cell

Genomics and Chromatin DynamicsHemoglobinopathies and Related Disorders

Cited by 490

Role of SWI/SNF in acute leukemia maintenance and enhancer-mediated Myc regulation

Shi, J., Whyte, W. A., Zepeda-Mendoza, C. J., Milazzo, J. P., Shen, C., Roe, J.-S., Minder, J. L., Mercan, F., Wang, E., Eckersley-Maslin, M. A., et al. (2013) · Genes & Development

Chromatin Remodeling and CancerGenomics and Chromatin Dynamics

Cited by 463

BRD4 Connects Enhancer Remodeling to Senescence Immune Surveillance

Tasdemir, N., Banito, A., Roe, J.-S., Alonso-Curbelo, D., Camiolo, M., Tschaharganeh, D. F., Huang, C.-H., Aksoy, O., Bolden, J. E., Chen, C.-C., et al. (2016) · Cancer Discovery

Telomeres, Telomerase, and SenescenceGenomics and Chromatin Dynamics

Cited by 415

Optimized base editors enable efficient editing in cells, organoids and mice

Zafra, M. P., Schatoff, E. M., Katti, A., Foronda, M., Breinig, M., Schweitzer, A. Y., Simon, A., Han, T., Goswami, S., Montgomery, E., et al. (2018) · Nature Biotechnology

CRISPR and Genetic EngineeringRNA regulation and disease

Cited by 347

Targeting Transcription Factors in Cancer

Bhagwat, A. S., & Vakoc, C. R. (2015) · Trends in Cancer

Protein Degradation and InhibitorsChromatin Remodeling and Cancer

Cited by 276

TP63-mediated enhancer reprogramming drives the squamous subtype of pancreatic ductal adenocarcinoma

Somerville, T. D. D., Xu, Y., Miyabayashi, K., Tiriac, H., Cleary, C. R., Maia-Silva, D., Milazzo, J. P., Tuveson, D. A., & Vakoc, C. R. (2018) · Cell Reports

Pancreatic and Hepatic Oncology ResearchGenomics and Chromatin Dynamics

Cited by 225

WRAD: enabler of the SET1-family of H3K4 methyltransferases

Ernst, P., & Vakoc, C. R. (2012) · Briefings in Functional Genomics

Genomics and Chromatin DynamicsEpigenetics and DNA Methylation

Cited by 140

Histone H2B ubiquitin ligase RNF20 is required for MLL -rearranged leukemia

Wang, E., Kawaoka, S., Yu, M., Shi, J., Ni, T., Yang, W., Zhu, J., Roeder, R. G., & Vakoc, C. R. (2013) · Proceedings of the National Academy of Sciences

Acute Myeloid Leukemia ResearchChromatin Remodeling and Cancer

Cited by 121

TGF-β/Smad signaling through DOCK4 facilitates lung adenocarcinoma metastasis

Yu, J.-R., Tai, Y., Jin, Y., Hammell, M. C., Wilkinson, J. E., Roe, J.-S., Vakoc, C. R., & Van Aelst, L. (2015) · Genes & Development

TGF-β signaling in diseasesMechanisms of cancer metastasis

Cited by 66

The transcriptional cofactor TRIM33 prevents apoptosis in B lymphoblastic leukemia by deactivating a single enhancer

Wang, E., Kawaoka, S., Roe, J.-S., Shi, J., Hohmann, A. F., Xu, Y., Bhagwat, A. S., Suzuki, Y., Kinney, J. B., & Vakoc, C. R. (2015) · eLife

Genomics and Chromatin DynamicsAcute Lymphoblastic Leukemia research

Cited by 54