The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
The Neonatal and Adult Human Testis Defined at the Single-Cell Level
Open accessAbstract
Spermatogenesis has been intensely studied in rodents but remains poorly understood in humans. Here, we used single-cell RNA sequencing to analyze human testes. Clustering analysis of neonatal testes reveals several cell subsets, including cell populations with characteristics of primordial germ cells (PGCs) and spermatogonial stem cells (SSCs). In adult testes, we identify four undifferentiated spermatogonia (SPG) clusters, each of which expresses specific marker genes. We identify protein markers for the most primitive SPG state, allowing us to purify this likely SSC-enriched cell subset. We map the timeline of male germ cell development from PGCs through fetal germ cells to differentiating adult SPG stages. We also define somatic cell subsets in both neonatal and adult testes and trace their developmental trajectories. Our data provide a blueprint of the developing human male germline and supporting somatic cells. The PGC-like and SSC markers are candidates to be used for SSC therapy to treat infertility.
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Cites
Integrating single-cell transcriptomic data across different conditions, technologies, and species
Butler, A., Hoffman, P., Smibert, P., Papalexi, E., & Satija, R. (2018) · Nature Biotechnology · doi:10.1038/nbt.4096 · Cited by 13,174
Trapnell, C., Cacchiarelli, D., Grimsby, J., Pokharel, P., Li, S., Morse, M., Lennon, N. J., Livak, K. J., Mikkelsen, T. S., & Rinn, J. L. (2014) · Nature Biotechnology · doi:10.1038/nbt.2859 · Cited by 7,314
Spatial reconstruction of single-cell gene expression data
Satija, R., Farrell, J. A., Gennert, D., Schier, A. F., & Regev, A. (2015) · Nature Biotechnology · doi:10.1038/nbt.3192 · Cited by 7,055
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Zhao, L., Yao, C., Xing, X., Jing, T., Li, P., Zhu, Z., Yang, C., Zhai, J., Tian, R., Chen, H., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-19414-4 · Cited by 298
Huang, Y., Li, L., An, G., Yang, X., Cui, M., Song, X., Lin, J., Zhang, X., Yao, Z., Wan, C., et al. (2023) · Nature Cell Biology · doi:10.1038/s41556-023-01232-7 · Cited by 59
Metadata
- Authors
- Sohni, A., Tan, K., Song, H.-W., Burow, D., de Rooij, D. G., Laurent, L., Hsieh, T.-C., Rabah, R., Hammoud, S. S., Vicini, E., & Wilkinson, M. F.
- Venue
- Cell Reports
- Publisher
- Elsevier BV
- Published
- 2019-02
- Volume
- 26
- Issue
- 6
- Pages
- 1501-1517.e4
- ISSN
- 2211-1247 (ISSN-L)
- OpenAlex
- W2914225474
- Cited by
- 339
- References
- 3
- FWCI
- 32.44
- Type
- journal article
- Language
- en
- Open access
- gold
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