The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Periostin Promotes Colorectal Tumorigenesis through Integrin-FAK-Src Pathway-Mediated YAP/TAZ Activation
Open accessAbstract
Periostin is a multifunctional extracellular matrix protein involved in various inflammatory diseases and tumor metastasis; however, evidence regarding whether and how periostin actively contributes to inflammation-associated tumorigenesis remains elusive. Here, we demonstrate that periostin deficiency significantly inhibits the occurrence of colorectal cancer in azoxymethane/dextran sulfate sodium-treated mice and in Apc Min/+ mice. Moreover, periostin deficiency attenuates the severity of colitis and reduces the proliferation of tumor cells. Mechanistically, stromal fibroblast-derived periostin activates FAK-Src kinases through integrin-mediated outside-in signaling, which results in the activation of YAP/TAZ and, subsequently, IL-6 expression in tumor cells. Conversely, IL-6 induces periostin expression in fibroblasts by activating STAT3, which ultimately facilitates colorectal tumor development. These findings provide the evidence that periostin promotes colorectal tumorigenesis, and identify periostin- and IL-6-mediated tumor-stroma interaction as a promising target for treating colitis-associated colorectal cancer.
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Cited by
Yuan, Z., Li, Y., Zhang, S., Wang, X., Dou, H., Yu, X., Zhang, Z., Yang, S., & Xiao, M. (2023) · Molecular Cancer · doi:10.1186/s12943-023-01744-8 · Cited by 977
Signaling pathways in cancer‐associated fibroblasts: recent advances and future perspectives
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Determinants and functions of CAFs secretome during cancer progression and therapy
Linares, J., Marín-Jiménez, J. A., Badia-Ramentol, J., & Calon, A. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.621070 · Cited by 110
Linares, J., Sallent-Aragay, A., Badia-Ramentol, J., Recort-Bascuas, A., Méndez, A., Manero-Rupérez, N., Re, D. L., Rivas, E. I., Guiu, M., Zwick, M., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-36334-1 · Cited by 109
Zheng, Y., Zhou, R., Cai, J., Yang, N., Wen, Z., Zhang, Z., Sun, H., Huang, G., Guan, Y., Huang, N., et al. (2023) · Cancer Research · doi:10.1158/0008-5472.can-23-0025 · Cited by 105
Metadata
- Authors
- Ma, H., Wang, J., Zhao, X., Wu, T., Huang, Z., Chen, D., Liu, Y., & Ouyang, G.
- Venue
- Cell Reports
- Publisher
- Elsevier BV
- Published
- 2020-01
- Volume
- 30
- Issue
- 3
- Pages
- 793-806.e6
- ISSN
- 2211-1247 (ISSN-L)
- OpenAlex
- W3002782139
- Cited by
- 196
- References
- 6
- FWCI
- 10.22
- Type
- journal article
- Language
- en
- Open access
- gold
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- Ma, H., Wang, J., Zhao, X., Wu, T., Huang, Z., Chen, D., Liu, Y., & Ouyang, G. (2020). Periostin Promotes Colorectal Tumorigenesis through Integrin-FAK-Src Pathway-Mediated YAP/TAZ Activation. Cell Reports. https://doi.org/10.1016/j.celrep.2019.12.075
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