A Dominant Mutation That Predisposes to Multiple Intestinal Neoplasia in the Mouse
Abstract
In a pedigree derived from a mouse treated with the mutagen ethylnitrosourea, a mutation has been identified that predisposes to spontaneous intestinal cancer. The mutant gene was found to be dominantly expressed and fully penetrant. Affected mice developed multiple adenomas throughout the entire intestinal tract at an early age.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
ApcMin/+ mice carry a mutation predisposing them to intestinal adenomas and are used as a colon cancer model.
“ApcMin/+ mice have a nonsense mutation at codon 850 in the Apc (Adenomatous polyposis coli) gene that predisposes them to both small and large intestinal adenomas, thus these mice have been used as a model of colon cancer (359).”
From Lack of Exercise Is a Major Cause of Chronic Diseases (2012) · cites this paper as [359]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cited by
Sorted by citations
Lack of Exercise Is a Major Cause of Chronic Diseases
Booth, F. W., Roberts, C. K., & Laye, M. J. (2012) · Comprehensive Physiology · doi:10.1002/cphy.c110025 · Cited by 2,575 · see citing works
Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts
Sato, T., van Es, J. H., Snippert, H. J., Stange, D. E., Vries, R. G., van den Born, M., Barker, N., Shroyer, N. F., van de Wetering, M., & Clevers, H. (2011) · Nature · doi:10.1038/nature09637 · Cited by 2,510 · see citing works
Fusobacterium nucleatum — symbiont, opportunist and oncobacterium
Brennan, C. A., & Garrett, W. S. (2019) · Nature Reviews Microbiology · doi:10.1038/s41579-018-0129-6 · Cited by 1,205 · see citing works
Somatic activation of the K-ras oncogene causes early onset lung cancer in mice
Johnson, L., Mercer, K., Greenbaum, D., Bronson, R. T., Crowley, D., Tuveson, D. A., & Jacks, T. (2001) · Nature · doi:10.1038/35074129 · Cited by 1,179 · see citing works
Canonical Wnt signals are essential for homeostasis of the intestinal epithelium
Pinto, D., Gregorieff, A., Begthel, H., & Clevers, H. (2003) · Genes & Development · doi:10.1101/gad.267103 · Cited by 1,026 · see citing works
The histone deacetylase SIRT6 is a tumor suppressor that controls cancer metabolism
Sebastián, C., Zwaans, B. M. M., Silberman, D. M., Gymrek, M., Goren, A., Zhong, L., Ram, O., Truelove, J., Guimaraes, A. R., Toiber, D., et al. (2012) · Cell · doi:10.1016/j.cell.2012.10.047 · Cited by 660 · see citing works
Modulating the therapeutic response of tumours to dietary serine and glycine starvation
Maddocks, O. D. K., Athineos, D., Cheung, E. C., Lee, P., Zhang, T., van den Broek, N. J. F., Mackay, G. M., Labuschagne, C. F., Gay, D., Kruiswijk, F., et al. (2017) · Nature · doi:10.1038/nature22056 · Cited by 603 · see citing works
Goodwin, A. C., Shields, C. E. D., Wu, S., Huso, D. L., Wu, X., Murray-Stewart, T. R., Hacker-Prietz, A., Rabizadeh, S., Woster, P. M., Sears, C. L., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1010203108 · Cited by 612 · see citing works
A targeted chain-termination mutation in the mouse Apc gene results in multiple intestinal tumors.
Fodde, R., Edelmann, W., Yang, K., van Leeuwen, C., Carlson, C., Renault, B., Breukel, C., Alt, E., Lipkin, M., & Khan, P. M. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.19.8969 · Cited by 531 · see citing works
Telomere dysfunction and evolution of intestinal carcinoma in mice and humans
Rudolph, K. L., Millard, M., Bosenberg, M. W., & DePinho, R. A. (2001) · Nature Genetics · doi:10.1038/88871 · Cited by 527 · see citing works
Mutations and mechanisms of WNT pathway tumour suppressors in cancer
Bugter, J. M., Fenderico, N., & Maurice, M. M. (2021) · Nature Reviews Cancer · doi:10.1038/s41568-020-00307-z · Cited by 466 · see citing works
Gut microbial metabolism drives transformation of MSH2-deficient colon epithelial cells
Belcheva, A., Irrazabal, T., Robertson, S. J., Streutker, C., Maughan, H., Rubino, S., Moriyama, E. H., Copeland, J. K., Surendra, A., Kumar, S., et al. (2014) · Cell · doi:10.1016/j.cell.2014.04.051 · Cited by 473 · see citing works
Role of Folate in Colon Cancer Development and Progression
Kim, Y.-I. (2003) · The Journal of Nutrition · doi:10.1093/jn/133.11.3731s · Cited by 386 · see citing works
The gut microbiome switches mutant p53 from tumour-suppressive to oncogenic
Kadosh, E., Snir-Alkalay, I., Venkatachalam, A., May, S., Lasry, A., Elyada, E., Zinger, A., Shaham, M., Vaalani, G., Mernberger, M., et al. (2020) · Nature · doi:10.1038/s41586-020-2541-0 · Cited by 378 · see citing works
NOTUM from Apc-mutant cells biases clonal competition to initiate cancer
Flanagan, D. J., Pentinmikko, N., Luopajärvi, K., Willis, N. J., Gilroy, K., Raven, A. P., Mcgarry, L., Englund, J. I., Webb, A. T., Scharaw, S., et al. (2021) · Nature · doi:10.1038/s41586-021-03525-z · Cited by 255 · see citing works
Locoregional Effects of Microbiota in a Preclinical Model of Colon Carcinogenesis
Tomkovich, S., Yang, Y., Winglee, K., Gauthier, J., Mühlbauer, M., Sun, X., Mohamadzadeh, M., Liu, X., Martin, P., Wang, G. P., et al. (2017) · Cancer Research · doi:10.1158/0008-5472.can-16-3472 · Cited by 252 · see citing works
Tumor-associated fibroblasts predominantly come from local and not circulating precursors
Arina, A., Idel, C., Hyjek, E. M., Alegre, M.-L., Wang, Y., Bindokas, V. P., Weichselbaum, R. R., & Schreiber, H. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1600363113 · Cited by 238 · see citing works
Langenbach, R., Loftin, C., Lee, C., & Tiano, H. (1999) · Biochemical Pharmacology · doi:10.1016/s0006-2952(99)00158-6 · Cited by 230 · see citing works
Tumor suppression and normal aging in mice with constitutively high p53 activity
Mendrysa, S. M., O'Leary, K. A., McElwee, M. K., Michalowski, J., Eisenman, R. N., Powell, D. A., & Perry, M. E. (2006) · Genes & Development · doi:10.1101/gad.1378506 · Cited by 210 · see citing works
HOXA5 Counteracts Stem Cell Traits by Inhibiting Wnt Signaling in Colorectal Cancer
Ordóñez-Morán, P., Dafflon, C., Imajo, M., Nishida, E., & Huelsken, J. (2015) · Cancer Cell · doi:10.1016/j.ccell.2015.11.001 · Cited by 209 · see citing works
Targeting LGR5 <sup>+</sup> cells with an antibody-drug conjugate for the treatment of colon cancer
Junttila, M. R., Mao, W., Wang, X., Wang, B.-E., Pham, T., Flygare, J., Yu, S.-F., Yee, S., Goldenberg, D., Fields, C., et al. (2015) · Science Translational Medicine · doi:10.1126/scitranslmed.aac7433 · Cited by 182 · see citing works
Metformin suppresses intestinal polyp growth in <i>Apc</i> <sup>Min/+</sup> mice
Tomimoto, A., Endo, H., Sugiyama, M., Fujisawa, T., Hosono, K., Takahashi, H., Nakajima, N., Nagashima, Y., Wada, K., Nakagama, H., et al. (2008) · Cancer Science · doi:10.1111/j.1349-7006.2008.00933.x · Cited by 185 · see citing works
Physical Activity and Cancer Prevention: Pathways and Targets for Intervention
Rogers, C. J., Colbert, L. H., Greiner, J. W., Perkins, S. N., & Hursting, S. D. (2008) · Sports Medicine · doi:10.2165/00007256-200838040-00002 · Cited by 170 · see citing works
LANGENBACH, R., LOFTIN, C. D., LEE, C., & TIANO, H. (1999) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1999.tb08723.x · Cited by 170 · see citing works
Beneficial bacteria inhibit cachexia
Varian, B. J., Goureshetti, S., Poutahidis, T., Lakritz, J. R., Levkovich, T., Kwok, C., Teliousis, K., Ibrahim, Y. M., Mirabal, S., & Erdman, S. E. (2016) · Oncotarget · doi:10.18632/oncotarget.7730 · Cited by 146 · see citing works
Mehl, K. A., Davis, J. M., Clements, J. M., Berger, F. G., Pena, M. M., & Carson, J. A. (2005) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00975.2004 · Cited by 99 · see citing works
RasGRP1 opposes proliferative EGFR–SOS1–Ras signals and restricts intestinal epithelial cell growth
Depeille, P., Henricks, L. M., van de Ven, R. A. H., Lemmens, E., Wang, C.-Y., Matli, M., Werb, Z., Haigis, K. M., Donner, D., Warren, R., et al. (2015) · Nature Cell Biology · doi:10.1038/ncb3175 · Cited by 80 · see citing works
Patient-derived tumor models: a more suitable tool for pre-clinical studies in colorectal cancer
Rizzo, G., Bertotti, A., Leto, S. M., & Vetrano, S. (2021) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-021-01970-2 · Cited by 51 · see citing works
Flavonoids: Nutraceutical Potential for Counteracting Muscle Atrophy
Kim, C., & Hwang, J.-K. (2020) · Food Science and Biotechnology · doi:10.1007/s10068-020-00816-5 · Cited by 45 · see citing works
Backshall, A., Alferez, D., Teichert, F., Wilson, I. D., Wilkinson, R. W., Goodlad, R. A., & Keun, H. C. (2009) · Journal of Proteome Research · doi:10.1021/pr800793w · Cited by 42 · see citing works
Ni, Y., Wong, V. H. Y., Tai, W. C. S., Li, J., Wong, W. Y., Lee, M. M. L., Fong, F. L. Y., El-Nezami, H., & Panagiotou, G. (2017) · Journal of Applied Microbiology · doi:10.1111/jam.13386 · Cited by 29 · see citing works
Nakai, K., Lin, H., Yamano, S., Tanaka, S., Kitamoto, S., Saitoh, H., Sakuma, K., Kurauchi, J., Akter, E., Konno, M., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-42774-6 · Cited by 14 · see citing works
- Authors
- Moser, A. R., Pitot, H. C., & Dove, W. F.
- Affiliations
- University of Wisconsin–Madison (US)
- ORCID
- Dove, William F.
- Venue
- Science
- Published
- 1990-01-19
- Volume
- 247
- Issue
- 4940
- Pages
- 322-324
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1990606472
- Cited by
- 1,591
- References
- 0
- Citations by year
- 2026: 15 · 2025: 35 · 2024: 36 · 2023: 53 · 2022: 33 · 2021: 52 · 2020: 56 · 2019: 46 · 2018: 50 · 2017: 59 · 2016: 60 · 2015: 61 · 2014: 67 · 2013: 70 · 2012: 62
- FWCI
- 7.90
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r01ca050585-08, 5p30ca007175-36)
- National Cancer Institute (CA-50585, CA-07175)
- Topics
- Health Sciences › Medicine › Pathology and Forensic Medicine › Genetic factors in colorectal cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Carcinogens and Genotoxicity Assessment
- Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
- Keywords
- multiple intestinal neoplasia, dominant mutations, intestinal adenoma, ethylnitrosourea mutagenesis, penetrance, hereditary cancer predisposition
- MeSH terms
- Adenoma, Alleles, Anemia, Animals, Ethylnitrosourea, Female, Intestinal Neoplasms, Male, Mice, Inbred AKR, Mice, Inbred C57BL, Mice, Mutant Strains, Mutation, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
