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The Parkinson’s Disease Protein LRRK2 Interacts with the GARP Complex to Promote Retrograde Transport to the trans-Golgi Network

Beilina, Alexandra, Bonet-Ponce, Luis, Kumaran, Ravindran, Kordich, Jennifer J., Ishida, Morié, Mamais, Adamantios, Kaganovich, Alice, Saez-Atienzar, Sara, Gershlick, David C., Roosen, Dorien A., Pellegrini, Laura, Malkov, Vlad, Fell, Matthew J., Harvey, Kirsten, Bonifacino, Juan S., Moore, Darren J., Cookson, Mark R.·2020·Cell Reports
DOI 10.1016/j.celrep.2020.107614PMC PMC7315779
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  • Knockdown or knockout of RAB29 causes deficits in retrograde sorting events between the late endosome and the Golgi complex, which is crucial for the correct trafficking of lysosomal enzymes and associated with defects in lysosomal homeostasis.

    “However, knockdown or knockout of RAB29 causes deficits in retrograde sorting events between the late endosome and the Golgi complex, which is crucial for the correct trafficking of lysosomal enzymes and associated with defects in lysosomal homeostasis [22,27,74].”

    From Distinct Roles for RAB10 and RAB29 in Pathogenic LRRK2-Mediated Endolysosomal Trafficking Alterations (2020) · cites this paper as [27]

  • Deficits in the trafficking/degradation of the EGFR may not have been evident owing to the incomplete and/or transient nature of the RAB29 knockdown, because alterations in the correct processing of lysosomal hydrolases have only been described in RAB29 knockout contexts, and may thus only arise as a consequence of the prolonged missorting of cargo.

    “Deficits in the trafficking/degradation of the EGFR may not have been evident owing to the incomplete and/or transient nature of the RAB29 knockdown, because alterations in the correct processing of lysosomal hydrolases have only been described in RAB29 knockout contexts, and may thus only arise as a consequence of the prolonged missorting of cargo [27,74].”

    From Distinct Roles for RAB10 and RAB29 in Pathogenic LRRK2-Mediated Endolysosomal Trafficking Alterations (2020) · cites this paper as [27]

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Research works printed but not linked: 65

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Metadata

Authors
Beilina, A., Bonet-Ponce, L., Kumaran, R., Kordich, J. J., Ishida, M., Mamais, A., Kaganovich, A., Saez-Atienzar, S., Gershlick, D. C., Roosen, D. A., Pellegrini, L., Malkov, V., Fell, M. J., Harvey, K., Bonifacino, J. S., Moore, D. J., & Cookson, M. R.
ORCID
Venue
Cell Reports
Publisher
Elsevier BV
Published
2020-05
Volume
31
Issue
5
Pages
107614
ISSN
2211-1247
DOI
10.1016/j.celrep.2020.107614
PMC
PMC7315779
Cited by
82
References
3
Language
en
Licence
Funders
  • National Institute of Child Health and Human Development
  • National Institutes of Health
  • National Institute on Aging
  • Medical Research Council

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