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LRRK2 phosphorylates membrane-bound Rabs and is activated by GTP-bound Rab7L1 to promote recruitment to the trans-Golgi network

Liu, Zhiyong, Bryant, Nicole, Kumaran, Ravindran, Beilina, Alexandra, Abeliovich, Asa, Cookson, Mark R, West, Andrew B·2018·Human Molecular Genetics
DOI 10.1093/hmg/ddx410
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Research works printed but not linked: 39

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  11. Tong, 2010, Loss of leucine-rich repeat kinase 2 causes impairment of protein degradation pathways, accumulation of alpha-synuclein, and apoptotic cell death in aged mice, Proc. Natl Acad. Sci. U S A, 107, 9879, 10.1073/pnas.1004676107 · DOI
  12. Beilina, 2014, Unbiased screen for interactors of leucine-rich repeat kinase 2 supports a common pathway for sporadic and familial Parkinson disease, Proc. Natl Acad. Sci. U S A, 111, 2626, 10.1073/pnas.1318306111 · DOI · Paper page
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  17. Ito, 2016, Phos-tag analysis of Rab10 phosphorylation by LRRK2: a powerful assay for assessing kinase function and inhibitors, Biochem. J, 473, 2671, 10.1042/BCJ20160557 · DOI · Paper page
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  34. West, 2005, Parkinson's disease-associated mutations in leucine-rich repeat kinase 2 augment kinase activity, Proc. Natl. Acad. Sci. U S A, 102, 16842, 10.1073/pnas.0507360102 · DOI · Paper page
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Metadata

Authors
Liu, Z., Bryant, N., Kumaran, R., Beilina, A., Abeliovich, A., Cookson, M. R., & West, A. B.
Affiliations
  • Department of Neurology, Center for Neurodegeneration and Experimental Therapeutics, University of Alabama at Birmingham, Birmingham, AL 35233 USA
  • Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA
  • Departments of Pathology, Cell Biology and Neurology, and Taub Institute, Columbia University, New York, NY 10032, USA
Venue
Human Molecular Genetics
Publisher
Oxford University Press (OUP)
Published
2017-11-21
Volume
27
Issue
2
Pages
385-395
ISSN
  • 0964-6906
  • 1460-2083
DOI
10.1093/hmg/ddx410
Cited by
278
References
1
Language
en
Funders
  • National Institutes of Health
  • National Institute of Neurological Disorders and Stroke (R01 NS064934, R21 NS097643)
  • National Institute on Aging (AG000948, AG000937)

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