The DOI matches its Crossref record; 45 of the 45 references it cites were found in a registry or an index.
Modulation of circRNA Metabolism by m6A Modification
Open accessAbstract
N 6 -methyladenosine (m 6 A) is an RNA modification well-known for its contribution to different processes controlling RNA metabolism, including splicing, stability, and translation of mRNA. Conversely, the role of m 6 A on the biogenesis and function of circular RNAs (circRNAs) has yet to be addressed. circRNAs belong to a class of covalently closed transcripts produced via a back-splicing reaction whereby a downstream 5′ splice donor site fuses to an upstream 3′ splice acceptor site. Starting from circ-ZNF609 as a study case, we discover that specific m 6 As control its accumulation and that METTL3 and YTHDC1 are required to direct the back-splicing reaction. This feature is shared with other circRNAs because we find a significant direct correlation among METTL3 requirement, YTHDC1 binding, and the ability of m 6 A exons to undergo back-splicing. Finally, because circ-ZNF609 displays the ability to be translated, we show that m 6 A modifications, through recognition by YTHDF3 and eIF4G2, modulate its translation.
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Cites
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Aligning sequence reads, clone sequences and assembly contigs with BWA-MEM
Li, H. (2013) · DROPS (Schloss Dagstuhl – Leibniz Center for Informatics) · doi:10.48550/arxiv.1303.3997 · Cited by 5,159
Aligning sequence reads, clone sequences and assembly con*gs with BWA-MEM
Li, H. (2014) · arXiv (Cornell University) · doi:10.6084/m9.figshare.963153.v1 · Cited by 4,932
circRNA biogenesis competes with pre-mRNA splicing
Ashwal-Fluss, R., Meyer, M., Pamudurti, N. R., Ivanov, A., Bartok, O., Hanan, M., Evantal, N., Memczak, S., Rajewsky, N., & Kadener, S. (2014) · Molecular Cell · doi:10.1016/j.molcel.2014.08.019 · Cited by 3,083
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Cited by
Functions of Circular RNA in Human Diseases and Illnesses
Gu, A., Jaijyan, D. K., Yang, S., Zeng, M., Pei, S., & Zhu, H. (2023) · Non-Coding RNA · doi:10.3390/ncrna9040038 · Cited by 65
SUPREM: an engineered non-site-specific m6A RNA methyltransferase with highly improved efficiency
Ochiai, Y., Clifton, B. E., Le Coz, M., Terenzio, M., & Laurino, P. (2024) · Nucleic Acids Research · doi:10.1093/nar/gkae887 · Cited by 9
m6A-dependent circular RNA formation mediates tau-induced neurotoxicity
Atrian, F., Ramirez, P., De Mange, J., Marquez, M., Gonzalez, E. M., Minaya, M., Karch, C. M., & Frost, B. (2024) · doi:10.1101/2024.01.25.577211 · Cited by 7
Metadata
- Authors
- Di Timoteo, G., Dattilo, D., Centrón-Broco, A., Colantoni, A., Guarnacci, M., Rossi, F., Incarnato, D., Oliviero, S., Fatica, A., Morlando, M., & Bozzoni, I.
- Venue
- Cell Reports
- Publisher
- Elsevier BV
- Published
- 2020-05
- Volume
- 31
- Issue
- 6
- Pages
- 107641
- ISSN
- 2211-1247 (ISSN-L)
- OpenAlex
- W3025043200
- Cited by
- 365
- References
- 45
- FWCI
- 17.43
- Type
- journal article
- Language
- en
- Open access
- gold
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- Di Timoteo, G., Dattilo, D., Centrón-Broco, A., Colantoni, A., Guarnacci, M., Rossi, F., Incarnato, D., Oliviero, S., Fatica, A., Morlando, M., & Bozzoni, I. (2020). Modulation of circRNA Metabolism by m6A Modification. Cell Reports. https://doi.org/10.1016/j.celrep.2020.107641
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