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Apocryphal FADS2 activity promotes fatty acid diversification in cancer

Young, Reuben S.E., Bowman, Andrew P., Williams, Elizabeth D., Tousignant, Kaylyn D., Bidgood, Charles L., Narreddula, Venkateswara R., Gupta, Rajesh, Marshall, David L., Poad, Berwyck L.J., Nelson, Colleen C., Ellis, Shane R., Heeren, Ron M.A., Sadowski, Martin C., Blanksby, Stephen J.·2021·Cell Reports
DOI 10.1016/j.celrep.2021.108738
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CC-BY-NC-ND · From the PDF
Figure 1 Lipid composition and targeted transcripts of normal prostate (BPH-1 and RWPE-1) and cancer (PC-3, LNCaP, DU145, and VCaP) cell lines
Figure 1 Lipid composition and targeted transcripts of normal prostate (BPH-1 and RWPE-1) and cancer (PC-3, LNCaP, DU145, and VCaP) cell linesCC-BY-NC-ND · From the PDF
Figure 2 Variation of DBs across the hydrolyzed fatty acyl pool (GCMS) and PC, PI, and PG (OzID) complex lipids for normal prostate BPH-1 cells and PC-3 and LNCaP cancer cells
Figure 2 Variation of DBs across the hydrolyzed fatty acyl pool (GCMS) and PC, PI, and PG (OzID) complex lipids for normal prostate BPH-1 cells and PC-3 and LNCaP cancer cellsCC-BY-NC-ND · From the PDF
Image 4
CC-BY-NC-ND · From the PDF
Figure 3 Enzyme/metabolite correlations and increased enzyme plasticity
Figure 3 Enzyme/metabolite correlations and increased enzyme plasticityCC-BY-NC-ND · From the PDF
Image 6
CC-BY-NC-ND · From the PDF
Figure 5 Fatty acyl desaturase and elongase pathways rationalizing the fatty acyl species observed within this study
Figure 5 Fatty acyl desaturase and elongase pathways rationalizing the fatty acyl species observed within this studyCC-BY-NC-ND · From the PDF
Image 8
CC-BY-NC-ND · From the PDF
Figure 6 Metabolic differentiation of tumor in human prostate tissue
Figure 6 Metabolic differentiation of tumor in human prostate tissueCC-BY-NC-ND · From the PDF

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Citations

Cites

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Metadata

Authors
Young, R. S. E., Bowman, A. P., Williams, E. D., Tousignant, K. D., Bidgood, C. L., Narreddula, V. R., Gupta, R., Marshall, D. L., Poad, B. L. J., Nelson, C. C., Ellis, S. R., Heeren, R. M. A., Sadowski, M. C., & Blanksby, S. J.
ORCID
Venue
Cell Reports
Publisher
Elsevier BV
Published
2021-02
Volume
34
Issue
6
Pages
108738
ISSN
2211-1247
DOI
10.1016/j.celrep.2021.108738
Cited by
109
References
3
Language
en
Licence
Funders
  • Department of Health, Australian Government
  • Australian Government
  • Science and Engineering Faculty, Queensland University of Technology
  • Australian Research Council (DP150101715, DP190101486, LP180100238)
  • Prostate Cancer Foundation of Australia
  • Queensland University of Technology
  • Ministerie van Economische Zaken (EMR23)
  • Interreg
  • Movember Foundation

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