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Cited by 28Liver physiology and pathologyLiver Disease Diagnosis and TreatmentCell Adhesion Molecules Research

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TM4SF5-dependent crosstalk between hepatocytes and macrophages to reprogram the inflammatory environment

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Kim, Eunmi, Um, Hyejin, Park, Jinsoo, Jung, Jae Woo, Kim, Ji Eon, Lee, Haesong, Shin, Eun-Ae, Pinanga, Yangie, Lee, Hyejin, Nam, Seo Hee, Lee, Jung Weon·2021·Cell Reports
DOI 10.1016/j.celrep.2021.110018
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Abstract

Chronic injury to hepatocytes results in inflammation, steatohepatitis, fibrosis, and nonalcoholic fatty liver disease (NAFLD). The tetraspanin TM4SF5 is implicated in fibrosis and cancer. We investigate the role of TM4SF5 in communication between hepatocytes and macrophages (MΦs) and its possible influence on the inflammatory microenvironment that may lead to NAFLD. TM4SF5 induction in differentiated MΦs promotes glucose uptake, glycolysis, and glucose sensitivity, leading to M1-type MΦ activation. Activated M1-type MΦs secrete pro-inflammatory interleukin-6 (IL-6), which induces the secretion of CCL20 and CXCL10 from TM4SF5-positive hepatocytes. Although TM4SF5-dependent secretion of these chemokines enhances glycolysis in M0 MΦs, further chronic exposure reprograms MΦs for an increase in the proportion of M2-type MΦs in the population, which may support diet- and chemical-induced NAFLD progression. We suggest that TM4SF5 expression in MΦs and hepatocytes is critically involved in modulating the inflammatory environment during NAFLD progression.

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Metadata

Authors
Kim, E., Um, H., Park, J., Jung, J. W., Kim, J. E., Lee, H., Shin, E.-A., Pinanga, Y., Lee, H., Nam, S. H., & Lee, J. W.
Affiliations
Seoul National University (KR)
ORCID
Venue
Cell Reports
Publisher
Elsevier BV
Published
2021-11
Volume
37
Issue
7
Pages
110018
ISSN
2211-1247 (ISSN-L)
DOI
10.1016/j.celrep.2021.110018
OpenAlex
W3205110794
Cited by
28
References
3
Citations by year
2026: 3 · 2025: 8 · 2024: 3 · 2023: 7 · 2022: 6
FWCI
2.24
Type
journal article
Language
en
Open access
Licence
Locations
  • Cell Reports (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
  • Seoul National University Open Repository (Seoul National University) (submittedVersion)
Funders
  • National Research Foundation of Korea
  • Ministry of Science, ICT and Future Planning (NRF-2020R1I1A1A01070020, NRF-2018M3A9C8020027, NRF-2021M3A9D3024752, - 2020R1A2C3008993, NRF-2020R1A2C3008993)
Topics
  • Health Sciences › Medicine › Hepatology › Liver physiology and pathology
  • Health Sciences › Medicine › Hepatology › Liver Disease Diagnosis and Treatment
  • Health Sciences › Medicine › Immunology and Allergy › Cell Adhesion Molecules Research
Keywords
TM4SF5, tetraspanins, non-alcoholic fatty liver disease, macrophage polarization, M1 macrophages, M2 macrophages, interleukin-6, CCL20, CXCL10, chemokine secretion, glucose uptake, glycolysis, liver inflammation, liver fibrosis
MeSH terms
Animals, Inflammation, Liver, Macrophages, Male, Membrane Proteins, Mice, Inbred C57BL, Cytokines, Chemokines, Hepatocytes, Mice, Non-alcoholic Fatty Liver Disease

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