Absence of microglia promotes diverse pathologies and early lethality in Alzheimer’s disease mice

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Items 101–168 of 168

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2. Targeting TREM2 signaling shows limited impact on cerebrovascular calcification
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3. Fatty acid amide hydrolase gene inactivation induces hetero‐cellular potentiation of microglial function in the 5xFAD mouse model of Alzheimer's disease
   María Andrea Arnanz, María Ferrer, María T. Grande, Samuel Ruiz de Martı́n Esteban, Gonzalo Ruiz‐Pérez, Benjamin F. Cravatt, Ricardo Mostany, Victor Javier Sanchez-Arevalo Lobo, Julián Romero, Ana M. Martínez-Relimpio · 2024 · Glia
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   Sara Pecoraro, Marloes Verkerke, Jacqueline A. Sluijs, Bert van het Hof, Susanne M. A. van der Pol, Miriam E. van Strien, Rik van der Kant, Carlie J.M. de Vries, Helga E. de Vries, Wilma D. J. van de Berg et al. · 2025 · Brain Behavior and Immunity
5. Studying Alzheimer’s Disease Using Drosophila melanogaster as a Powerful Tool
   Jacob Kasanin, Xingjun Wang, Wanting Jiao, Qiuyu Li, Bingwei Lu · 2022 · Advances in Alzheimer s Disease
6. Microglial depletion does not impact alpha-synuclein aggregation or nigrostriatal degeneration in the rat preformed fibril model
   Anna C. Stoll, Christopher J. Kemp, Joseph R. Patterson, Michael Kubik, Nathan C. Kuhn, Matthew J. Benskey, Megan F. Duffy, Kelvin C. Luk, Caryl E. Sortwell · 2023 · Research Square
7. Emerging Techniques for the Study of Microglia: Visualization, Depletion and Fate Mapping
   Bianca Caroline Bobotis, Torin Halvorson, Micaël Carrier, Marie‐Ève Tremblay · 2023 · Preprints.org
8. Isotope Encoded chemical Imaging Identifies Amyloid Plaque Age Dependent Structural Maturation, Synaptic Loss, and Increased Toxicity
   Jack I. Wood, Maciej Dulewicz, Junyue Ge, Katie M. Stringer, Alicja Szadziewska, Sneha Desai, Srinivas Koutarapu, Haady B. Hajar, Kaj Blennow, Henrik Zetterberg et al. · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
9. Intracranial calcifications in congenital viral infections: mechanisms and cellular roles
   Michael Fraczek, Haley A. Breckenridge, Ivonne Melano, Elisabeth Squillacioti, Karin Nielsen‐Saines, Violette Recinos, Weiqiang Chen · 2025 · Current Opinion in Virology
10. A Question of Origins: Non-neuronal Sources of Amyloid-β
    Andrew Octavian Sasmita, Constanze Depp · 2026 · Neuroscience Bulletin
11. RETRACTED: Brain endothelial CD200 signaling protects brain against ischemic damage
    Afzal Ali Misrani, Conelius Ngwa, Abdullah Al Mamun, Romana Sharmeen, Kanaka Valli Manyam, Rodney M. Ritzel, Louise D. McCullough, Fudong Liu · 2023 · Brain Research Bulletin · Retracted
12. The HDL-Mimetic Peptide 4F Mitigates Vascular and Cortical Amyloid Pathology and Associated Neuroinflammation in a Transgenic Mouse Model of Cerebral Amyloid Angiopathy and Alzheimer’s Disease
    Rui Zhong, Dustin Chernick, David A. Hottman, Yejun Tan, Minwoo Kim, Manojkumar Narayanan, Ling Li · 2025 · Molecular Neurobiology
13. Genetic context controls early microglia-synaptic interactions in mouse models of Alzheimer’s disease
    Sarah E. Heuer, Kelly J. Keezer, Amanda A. Hewes, Kristen D. Onos, Kourtney C. Graham, Gareth R. Howell, Erik B. Bloss · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
14. Alzheimer’s disease associated isoforms of human CD33 distinctively modulate microglial cell responses in 5XFAD mice
    Ghazaleh Eskandari‐Sedighi, Madeline C. Crichton, Sameera Zia, Erik Gomez, Chris D. St. Laurent, Leonardo M. Cortez, Zain H. Patel, Gaurav Sidhu, Susmita Sarkar, Vivian Aghanya et al. · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
15. Metabolic syndrome in New Zealand Obese mice promotes microglial-vascular interactions and reduces microglial plasticity
    Michael MacLean, Olivia J. Marola, Travis L. Cossette, Cory A. Diemler, Amanda A. Hewes, Kelly J. Keezer, Kristen D. Onos, Gareth R. Howell · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
16. Glia in Neurodegenerative Disease
    Gerard Crowley, David Attwell, Hemali P. Phatnani, Harald W. Sontheimer, Soyon Youngae Hong · 2024 · Cold Spring Harbor Perspectives in Biology
17. Sex, not estrous cycle stage, drives differences in the microglial transcriptome in the 5xFAD mouse model of amyloidosis
    L. Calcines Rodriguez, Nikita Noyes-Martel, Jennifer D. Becker, Ania Katarzyna Majewska, M. Kerry O’Banion · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
18. A multimodal approach of microglial CSF1R inhibition and GENUS provides therapeutic effects in Alzheimer’s disease mice
    Chinnakkaruppan Adaikkan, Rezaul Islam, P. Lorenzo Bozzelli, Matt Sears, Cameron Parro, Ping‐Chieh Pao, Na Sun, TaeHyun Kim, Karim Abdelaal, Mia Sedgwick et al. · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
19. Particulate matter constituents trigger the formation of extracellular amyloid β and Tau -containing plaques and neurite shortening in vitro
    Aleksandar Sebastijanović, Laura M. A. Camassa, Vilhelm Malmborg, Slavko Kralj, Joakim Pagels, Ulla Birgitte Vogel, Shanbeh Zienolddiny, Iztok Urbančič, Tilen Koklič, Janez Štrancar · 2024 · Nanotoxicology
20. Toxoplasma gondii drives myeloid immune cell recruitment to amyloid plaques in Alzheimer’s model mice
    Katherine J. Olivia Yanes, Christina T. Bui, Julia Tomasello, Heba Morsy, Emilie Kim, T. Lam, Kate Inman Tsourmas, L Angel Ayala, Kim N. Green, Matthew A. Inlay et al. · 2026 · Journal of Neuroinflammation
21. Physical activity-associated extracellular vesicles inhibit inflammagen-induced microglial activation
    Chien-Yu Su, Heng-Juei Hsu, Tzu-Feng Wang, Hong-Lin Chou, Sheng‐Feng Tsai, Chu-Wan Lee, Ching-Li Cheng, Yang-Kao Wang, Yu‐Min Kuo · 2026 · Brain Behavior & Immunity - Health
22. Microglia–astrocyte crosstalk as a key organizing principle of Alzheimer’s disease: from homeostatic cooperation to maladaptive signaling loops
    Mingqiang Gong, Jiao Xia Lan, Jifei Miao · 2026 · Frontiers in Aging Neuroscience
23. Amyloid-induced mineralization: From biological systems to biomimetic materials
    Congdi Zhang, Yangyang Zhang, Mengqi Zhu, Chunyan Zhang, Danyang Lu, Jimin Jiang, Zhiyong Wang, Peng Deng, Yun Hua Qian, Minjuan Shen et al. · 2025 · Bioactive Materials
24. Microglia determine ß-amyloid plaque burden but are non-essential for downstream pathology
    Mosi Li, Kristján Holt, Katherine Ridley, Jing Qiu, Kirsty Haddow, Deepali Vasoya, Xin He, Jane Tulloch, Declan King, David Arthur Hume et al. · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
25. Complement receptor C3ar1 deficiency does not alter brain structure or functional connectivity across early life development
    Hanna Lemmik, Eugene Kim, Eilidh MacNicol, Davide Maselli, Michel Bernanos, Zhuoni Li, Dauda Abdullahi, Esther H. Walters, Maria Elisa Serrano Navacerrada, Wuding Zhou et al. · 2025 · Brain Communications
26. Sex specific effects of a high fat diet on metabolism, cognition, and pathology in the Tg-SwDI mouse model of Alzheimer’s disease
    Shelby Sabourin, Christina A. Thrasher, Rachel M. Smith, Kasey Belanger, Bryce Thibodeau, Charly Abi‐Ghanem, Jennifer J Lafrican, Celine Camon, Richard D. Kelly, Riane Richard et al. · 2026 · Journal of Neuroinflammation
27. Dual roles of complement in cerebral amyloid angiopathy: A two-compartment framework across the blood–brain barrier
    Wu-meng Yin, Liu-Chang He, Hanghang Zhu, Yuan Cao, An-ming Li, Yun-chao Wang, Yu-ming Xu · 2026 · International Immunopharmacology
28. Multiscale Approximations to Understand the Complex Role of Microglia in Alzheimer's Disease
    Patricia Martínez-Tazo, Marina Mejias‐Ortega, Verónica López-López, Aysha María Bhojwani-Cabrera, Emma Saxton, Santiago Canals, Giles E. Hardingham, Antonia Gutiérrez, José P. López‐Atalaya, Silvia De Santis · 2026 · European Journal of Neuroscience
29. Microglial state transitions are constrained by developmental and metabolic checkpoints
    Adil El Mesaoudi, Dong Won Kim · 2026 · Frontiers in Cellular Neuroscience
30. Frequency-Specific Transcranial Photobiomodulation Elicits Complementary Glial Mechanisms for Neurovascular Protection and Amyloid Clearance in Alzheimer Disease
    Bowen Zhang, Zemeng Chen, Weiguang Li, Louzhe Xu, Songqi Yang, Felix Wang, Kai Yan, Xunbin Wei, Ting Li · 2026 · Cyborg and Bionic Systems
31. Disruption of the brain-spleen axis impairs monocyte-microglia communication and accelerates disease progression in a mouse model of amyloidosis
    Tommaso Croese, Miguel Angel Abellanas, Hodaya Polonsky, Michal Arad, Javier María Peralta Ramos, Yuliya Androsova, Serena Riccitelli, Sedi Medina, Francesca Palmas, Romano Strobelt et al. · 2026 · Nature Communications
32. Depletion and replacement of tissue-resident macrophages in mice with germ-line deletion of a conserved enhancer in the Csf1r locus
    Yajun Liu, Sébastien Jacquelin, Isis Taylor, Emma K. Green, Omkar L. Patkar, Sahar Keshvari, Ginell N. Ranpura, Conan J O O’Brien, Eline E. Jessen, Emma L. Maxwell et al. · 2026 · Development
33. Microglia’s pruning function called into question
    RJ Mackenzie · 2024 · The Transmitter
34. FIREproof: Intricacies of microglial biology
    Wei Cao · 2025 · Neural Regeneration Research
35. Mutation in the rat interleukin 34 gene impacts macrophage development, homeostasis and inflammation in the brain and periphery
    Stephen Huang, Omkar L. Patkar, Sarah Schulze, Dylan Carter‐Cusack, Susan Marie Millard, Ginell N. Ranpura, Emma K. Green, Emma L. Maxwell, Jeeva Kanesarajah, Gary Cowin et al. · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
36. Microglia are not required for normal postnatal brain development and cognitive function in the rat
    Emma K. Green, Xinyi Li, Yang Guo, Dylan Carter‐Cusack, Rocío Rojo, Maia Lyall, Annie Bell, Helen Zheng, Oliver Teenan, Sally M. Till et al. · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
37. Human IL-34 Deficiency Primes Microglia Toward Alzheimer’s Disease-Associated States
    Francisco Hernández-Rasco, RM Romero Ruiz, Itziar de Rojas, Raquel Puerta, Clara Garcia-Mayor, Ana M. Espinosa‐Oliva, Juan García‐Revilla, Paula Bayón-Buján, Alberto Rivera-Ramos, Farah Real Oualit et al. · 2026 · medRxiv
38. Astrocytic APOE3-Christchurch expression ameliorates brain amyloid-β pathology in 5xFAD mice
    Raulin, Ana-Caroline, Alnobani, Alla, Rodriguez-Martinez, Paula, Lee, Eunmi, Linares, Cynthia, Yslas, Aria R., Li, Mingjie, Ren, Yingxue, Doss, Sydney V., Roy, Bhaskar et al. · 2026 · Translational Psychiatry
39. Machine Learning Classification of Alzheimer’s Disease Pathology Reveals Diffuse Amyloid as a Major Predictor of Cognitive Impairment in Human Hippocampal Subregions
    Terri‐Leigh Stephen, Laura Korobkova, Bayla M Breningstall, K. Nguyen, S. Mehta, Maricarmen Pachicano, Kymry T. Jones, Debra Hawes, Ryan P. Cabeen, Michael S. Bienkowski · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
40. Alzheimer’s disease associated isoforms of human CD33 distinctively modulate microglial cell responses in 5XFAD mice
    Ghazaleh Eskandari‐Sedighi, Madeline C. Crichton, Sameera Zia, Erik Gomez, Chris D. St. Laurent, Leonardo M. Cortez, Zain H. Patel, Gaurav Sidhu, Susmita Sarkar, Vivian Aghanya et al. · 2023 · Research Square
41. TonEBP Haploinsufficiency Attenuates Microglial Activation and Memory Deficits in Middle-Aged and Amyloid β Oligomer-Treated Mice
    Jong Youl Lee, Eun Ae Jeong, Jae Woong Lee, Hyun Joo Shin, So Jeong Lee, Hyeong Seok An, Kyung Eun Kim, Won–Ho Kim, Yong Chul Bae, Heeyoung Kang et al. · 2023 · Cells
42. Particulate matter constituents trigger the formation of extracellular amyloid β and Tau-containing plaques and neurite shortening in vitro
    Aleksandar Sebastijanović, Laura M. A. Camassa, Vilhelm Malmborg, Slavko Kralj, Joakim Pagels, Ulla Birgitte Vogel, Shan Zienolddiny-Narui, Iztok Urbančič, Tilen Koklič, Janez Štrancar · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
43. Additional file 1 of Cerebrospinal fluid shotgun proteomics identifies distinct proteomic patterns in cerebral amyloid angiopathy rodent models and human patients
    Marc Vervuurt, Joseph M. Schrader, Anna M. de Kort, Iris Kersten, Hans J. C. T. Wessels, Catharina J.M. Klijn, Floris H.B.M. Schreuder, H. Bea Kuiperij, Jolein Gloerich, William E. Van Nostrand et al. · 2024 · Figshare
44. Microglia-Dependent and Independent Modulation of Brain Lipid Metabolism in Alzheimer’s Disease Revealed by Pharmacological and Genetic Microglial Depletion
    Ziying Xu, Sepideh Kiani Shabestari, Savannah Barannikov, Kevin F. Bieniek, Mathew M. Blurton-Jones, Juan Pablo Palavicini, Xianlin Han · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
45. The Role of M1 and M2 in Modulating Ab Accumulation and Function
    Leqi Rao · 2025 · Theoretical and Natural Science
46. A restarted life: Resetting microglia innate immune memory
    Fangyuan Cheng, Bo Yan, Fanglian Chen, Ping Lei · 2025 · Neuroscience & Biobehavioral Reviews
47. Transcranial photobiomodulation induced frequency-specific dual-pathway glial activation for neurovascular protection vs amyloid clearance in Alzheimer’s disease
    Ting Li, Bowen Zhang, Zemeng Chen, Louzhe Xu, Sifu Yang, Hui Shen, Xunbin Wei · 2025 · Research Square
48. Additional file 1 of Astrocytic APOE4 removal confers cerebrovascular protection despite increased cerebral amyloid angiopathy
    Monica Xiong, Wang, Chao, Maud Gratuze, Fareeha Saadi, Bao, Xin, Megan E. Bosch, Choonghee Lee, Hong Jiang, Serrano, Javier Remolina, Ernesto R. Gonzales et al. · 2023 · Figshare
49. Additional file 1 of Alpha-synuclein inclusion responsive microglia are resistant to CSF1R inhibition
    Anna C. Stoll, Kemp, Christopher J., Joseph R. Patterson, Michael Kubik, Nathan C. Kuhn, Matthew J. Benskey, Megan F. Duffy, Kelvin C. Luk, Sortwell, Caryl E. · 2024 · Figshare
50. Additional file 3 of Astrocytic APOE4 removal confers cerebrovascular protection despite increased cerebral amyloid angiopathy
    Monica Xiong, Wang, Chao, Maud Gratuze, Fareeha Saadi, Bao, Xin, Megan E. Bosch, Choonghee Lee, Hong Jiang, Serrano, Javier Remolina, Ernesto R. Gonzales et al. · 2023 · Figshare
51. Additional file 5 of Astrocytic APOE4 removal confers cerebrovascular protection despite increased cerebral amyloid angiopathy
    Monica Xiong, Wang, Chao, Maud Gratuze, Fareeha Saadi, Bao, Xin, Megan E. Bosch, Choonghee Lee, Hong Jiang, Serrano, Javier Remolina, Ernesto R. Gonzales et al. · 2023 · Figshare
52. Additional file 1 of Alzheimer’s disease associated isoforms of human CD33 distinctively modulate microglial cell responses in 5XFAD mice
    Ghazaleh Eskandari‐Sedighi, Madeline C. Crichton, Sameera Zia, Erik Gomez‐Cardona, Leonardo M. Cortez, Zain H. Patel, Kei Takahashi, St. Laurent, Chris D., Gaurav Sidhu, Sarkar, Susmita et al. · 2024 · Figshare
53. Additional file 2 of Cerebrospinal fluid shotgun proteomics identifies distinct proteomic patterns in cerebral amyloid angiopathy rodent models and human patients
    Marc Vervuurt, Joseph M. Schrader, Anna M. de Kort, Iris Kersten, Hans J. C. T. Wessels, Catharina J.M. Klijn, Floris H.B.M. Schreuder, H. Bea Kuiperij, Jolein Gloerich, William E. Van Nostrand et al. · 2024 · Figshare
54. Additional file 4 of Astrocytic APOE4 removal confers cerebrovascular protection despite increased cerebral amyloid angiopathy
    Monica Xiong, Wang, Chao, Maud Gratuze, Fareeha Saadi, Bao, Xin, Megan E. Bosch, Choonghee Lee, Hong Jiang, Serrano, Javier Remolina, Ernesto R. Gonzales et al. · 2023 · Figshare
55. Additional file 2 of Alpha-synuclein inclusion responsive microglia are resistant to CSF1R inhibition
    Anna C. Stoll, Kemp, Christopher J., Joseph R. Patterson, Michael Kubik, Nathan C. Kuhn, Matthew J. Benskey, Megan F. Duffy, Kelvin C. Luk, Sortwell, Caryl E. · 2024 · Figshare
56. Additional file 3 of Alpha-synuclein inclusion responsive microglia are resistant to CSF1R inhibition
    Anna C. Stoll, Christopher J. Kemp, Joseph R. Patterson, Michael Kubik, Nathan C. Kuhn, Matthew J. Benskey, Megan F. Duffy, Kelvin C. Luk, Sortwell, Caryl E. · 2024 · Figshare
57. Additional file 5 of Alpha-synuclein inclusion responsive microglia are resistant to CSF1R inhibition
    Anna C. Stoll, Kemp, Christopher J., Joseph R. Patterson, Michael Kubik, Nathan C. Kuhn, Matthew J. Benskey, Megan F. Duffy, Kelvin C. Luk, Sortwell, Caryl E. · 2024 · Figshare
58. Additional file 6 of Astrocytic APOE4 removal confers cerebrovascular protection despite increased cerebral amyloid angiopathy
    Monica Xiong, Wang, Chao, Maud Gratuze, Fareeha Saadi, Bao, Xin, Megan E. Bosch, Choonghee Lee, Hong Jiang, Serrano, Javier Remolina, Ernesto R. Gonzales et al. · 2023 · Figshare
59. Additional file 2 of Astrocytic APOE4 removal confers cerebrovascular protection despite increased cerebral amyloid angiopathy
    Monica Xiong, Chao Wang, Maud Gratuze, Fareeha Saadi, Bao, Xin, Megan E. Bosch, Choonghee Lee, Hong Jiang, Serrano, Javier Remolina, Ernesto R. Gonzales et al. · 2023 · Figshare
60. Additional file 4 of Alpha-synuclein inclusion responsive microglia are resistant to CSF1R inhibition
    Anna C. Stoll, Kemp, Christopher J., Joseph R. Patterson, Michael Kubik, Nathan C. Kuhn, Matthew J. Benskey, Megan F. Duffy, Kelvin C. Luk, Sortwell, Caryl E. · 2024 · Figshare
61. Disruption of the Brain-Spleen Axis Impairs Monocyte-Microglia Communication and Accelerates Disease Progression in a Model of Amyloidosis
    Tommaso Croese, Miguel Angel Abellanas, Hodaya Polonsky, Michal Arad, Javier María Peralta Ramos, Yuliya Androsova, Serena Riccitelli, Sedi Medina, Francesca Palmas, Romano Strobel et al. · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
62. Mechanisms controlling microglial colonization of the forebrain
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63. From gene correlations to cell clusters: COTAN improved scRNA-seq analysis
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64. A perivascular perspective on the immune impacts in cerebral amyloid angiopathy
    Beth Eyre, Stephanie K. Bonney · 2026 · Journal of Cerebral Blood Flow & Metabolism
65. CSF1R-related leukoencephalopathy: experimental models and potential for treatment
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66. Natural microbial enrichment modulates microglial states and transcriptional programs relevant to Alzheimer’s disease
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67. Older adult APOE4 mice exhibit modest immunometabolic adaptation following microglial APOE2 replacement
    Nolt, Georgia L., MacLean, Steven M., Golden, Lesley R., Thorpe, Shealee P., Stephens, Isaiah O., Funnell, Jessica L., Brock, Chesney R., Lucido, Chloe C., Smith, Lily, Hernandez, Gabriela et al. · 2027 · Neurobiology of Aging
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