Hume, David A.

Interferon-γ: an overview of signals, mechanisms and functions

Schroder, K., Hertzog, P. J., Ravasi, T., & Hume, D. A. (2004) · Journal of Leukocyte Biology

Cytokine Signaling Pathways and Interactionsinterferon and immune responses

Cited by 4,120

Fate Mapping Reveals Origins and Dynamics of Monocytes and Tissue Macrophages under Homeostasis

Yona, S., Kim, K.-W., Wolf, Y., Mildner, A., Varol, D., Breker, M., Strauss-Ayali, D., Viukov, S., Guilliams, M., Misharin, A., et al. (2013) · Immunity

Immune cells in cancerPhagocytosis and Immune Regulation

Cited by 3,245

An atlas of active enhancers across human cell types and tissues

The FANTOM Consortium, Andersson, R., Gebhard, C., Miguel-Escalada, I., Hoof, I., Bornholdt, J., Boyd, M., Chen, Y., Zhao, X., Schmidl, C., et al. (2014) · Nature

Genomics and Chromatin DynamicsCancer-related molecular mechanisms research

Cited by 2,550

Microglia states and nomenclature: A field at its crossroads

Paolicelli, R. C., Sierra, A., Stevens, B., Tremblay, M.-E., Aguzzi, A., Ajami, B., Amit, I., Audinat, E., Bechmann, I., Bennett, M., et al. (2022) · Neuron

Neuroinflammation and Neurodegeneration MechanismsNeurogenesis and neuroplasticity mechanisms

Cited by 1,973

Genome-wide analysis of mammalian promoter architecture and evolution

Carninci, P., Sandelin, A., Lenhard, B., Katayama, S., Shimokawa, K., Ponjavic, J., Semple, C. A. M., Taylor, M. S., Engström, P. G., Frith, M. C., et al. (2006) · Nature Genetics

Genomics and Chromatin DynamicsGenomics and Phylogenetic Studies

Cited by 1,350

Immunohistochemical localization of macrophages and microglia in the adult and developing mouse brain

Perry, V. H., Hume, D. A., & Gordon, S. (1985) · Neuroscience

Neuroinflammation and Neurodegeneration MechanismsPhagocytosis and Immune Regulation

Cited by 902

An atlas of combinatorial transcriptional regulation in mouse and man

Ravasi, T., Suzuki, H., Cannistraci, C. V., Katayama, S., Bajic, V. B., Tan, K., Akalin, A., Schmeier, S., Kanamori-Katayama, M., Bertin, N., et al. (2010) · Cell

Genomics and Chromatin DynamicsGene Regulatory Network Analysis

Cited by 715

Somatic retrotransposition alters the genetic landscape of the human brain

Baillie, J. K., Barnett, M. W., Upton, K. R., Gerhardt, D. J., Richmond, T. A., De Sapio, F., Brennan, P. M., Rizzu, P., Smith, S., Fell, M., et al. (2011) · Nature

Chromosomal and Genetic VariationsGenomic variations and chromosomal abnormalities

Cited by 684

A macrophage colony-stimulating factor receptor–green fluorescent protein transgene is expressed throughout the mononuclear phagocyte system of the mouse

Sasmono, R. T., Oceandy, D., Pollard, J. W., Tong, W., Pavli, P., Wainwright, B. J., Ostrowski, M. C., Himes, S. R., & Hume, D. A. (2003) · Blood

Genomics and Chromatin DynamicsImmune cells in cancer

Cited by 662

Osteal macrophages promote in vivo intramembranous bone healing in a mouse tibial injury model

Alexander, K. A., Chang, M. K., Maylin, E. R., Kohler, T., Müller, R., Wu, A. C., Van Rooijen, N., Sweet, M. J., Hume, D. A., Raggatt, L. J., et al. (2011) · Journal of Bone and Mineral Research

Bone Metabolism and DiseasesBone fractures and treatments

Cited by 485

CX3CR1+ CD115+ CD135+ common macrophage/DC precursors and the role of CX3CR1 in their response to inflammation

Auffray, C., Fogg, D. K., Narni-Mancinelli, E., Senechal, B., Trouillet, C., Saederup, N., Leemput, J., Bigot, K., Campisi, L., Abitbol, M., et al. (2009) · Journal of Experimental Medicine

Chemokine receptors and signalingImmune cells in cancer

Cited by 422

Macrophage therapy for murine liver fibrosis recruits host effector cells improving fibrosis, regeneration, and function

Thomas, J. A., Pope, C., Wojtacha, D., Robson, A. J., Gordon-Walker, T. T., Hartland, S., Ramachandran, P., Van Deemter, M., Hume, D. A., Iredale, J. P., et al. (2011) · Hepatology

Liver physiology and pathologyMesenchymal stem cell research

Cited by 346

Ras-Mediated Phosphorylation of a Conserved Threonine Residue Enhances the Transactivation Activities of c-Ets1 and c-Ets2

Yang, B.-S., Hauser, C. A., Henkel, G., Colman, M. S., Beveren, C. V., Stacey, K. J., Hume, D. A., Maki, R. A., & Ostrowski, M. C. (1996) · Molecular and Cellular Biology

Protein Kinase Regulation and GTPase SignalingProtein Tyrosine Phosphatases

Cited by 333

FANTOM5 CAGE profiles of human and mouse samples

Noguchi, S., Arakawa, T., Fukuda, S., Furuno, M., Hasegawa, A., Hori, F., Ishikawa-Kato, S., Kaida, K., Kaiho, A., Kanamori-Katayama, M., et al. (2017) · Scientific Data

Genomics and Chromatin DynamicsGenomics and Phylogenetic Studies

Cited by 310

Signal integration between IFNγ and TLR signalling pathways in macrophages

Schroder, K., Sweet, M. J., & Hume, D. A. (2006) · Immunobiology

Immune Response and InflammationImmune responses and vaccinations

Cited by 288

Differential effects of selective HDAC inhibitors on macrophage inflammatory responses to the Toll-like receptor 4 agonist LPS

Halili, M. A., Andrews, M. R., Labzin, L. I., Schroder, K., Matthias, G., Cao, C., Lovelace, E., Reid, R. C., Le, G. T., Hume, D. A., et al. (2010) · Journal of Leukocyte Biology

Histone Deacetylase Inhibitors ResearchImmune Response and Inflammation

Cited by 186

Absence of microglia promotes diverse pathologies and early lethality in Alzheimer’s disease mice

Kiani Shabestari, S., Morabito, S., Danhash, E. P., McQuade, A., Sanchez, J. R., Miyoshi, E., Chadarevian, J. P., Claes, C., Coburn, M. A., Hasselmann, J., et al. (2022) · Cell Reports

Neuroinflammation and Neurodegeneration MechanismsAlzheimer's disease research and treatments

Cited by 167

Syntaxin 6 and Vti1b Form a Novel SNARE Complex, Which Is Up-regulated in Activated Macrophages to Facilitate Exocytosis of Tumor Necrosis Factor-α

Murray, R. Z., Wylie, F. G., Khromykh, T., Hume, D. A., & Stow, J. L. (2005) · Journal of Biological Chemistry

Cellular transport and secretionExtracellular vesicles in disease

Cited by 157

Opposing actions of c-ets/PU.1 and c-myb protooncogene products in regulating the macrophage-specific promoters of the human and mouse colony-stimulating factor-1 receptor (c-fms) genes.

Reddy, M. A., Yang, B. S., Yue, X., Barnett, C. J., Ross, I. L., Sweet, M. J., Hume, D. A., & Ostrowski, M. C. (1994) · The Journal of Experimental Medicine

Genomics and Chromatin DynamicsCytokine Signaling Pathways and Interactions

Cited by 123

The JNK Are Important for Development and Survival of Macrophages

Himes, S. R., Sester, D. P., Ravasi, T., Cronau, S. L., Sasmono, T., & Hume, D. A. (2006) · The Journal of Immunology

Cytokine Signaling Pathways and InteractionsImmune cells in cancer

Cited by 117

TFEC is a macrophage-restricted member of the microphthalmia-TFE subfamily of basic helix-loop-helix leucine zipper transcription factors

Rehli, M., Lichanska, A., Cassady, A. I., Ostrowski, M. C., & Hume, D. A. (1999) · The Journal of Immunology

Genomics and Chromatin DynamicsDevelopmental Biology and Gene Regulation

Cited by 116

A Transgenic Line That Reports CSF1R Protein Expression Provides a Definitive Marker for the Mouse Mononuclear Phagocyte System

Grabert, K., Sehgal, A., Irvine, K. M., Wollscheid-Lengeling, E., Ozdemir, D. D., Stables, J., Luke, G. A., Ryan, M. D., Adamson, A., Humphreys, N. E., et al. (2020) · The Journal of Immunology

Immune cells in cancerPhagocytosis and Immune Regulation

Cited by 114

Pleiotropic effects of extended blockade of CSF1R signaling in adult mice

Sauter, K. A., Pridans, C., Sehgal, A., Tsai, Y. T., Bradford, B. M., Raza, S., Moffat, L., Gow, D. J., Beard, P. M., Mabbott, N. A., et al. (2014) · Journal of Leukocyte Biology

Phagocytosis and Immune RegulationBone Metabolism and Diseases

Cited by 100

Cellular Plasticity of Inflammatory Myeloid Cells in the Peritoneal Foreign Body Response

Mooney, J. E., Rolfe, B. E., Osborne, G. W., Sester, D. P., van Rooijen, N., Campbell, G. R., Hume, D. A., & Campbell, J. H. (2010) · The American Journal of Pathology

Immune cells in cancerPhagocytosis and Immune Regulation

Cited by 87