Association of B cell profile and receptor repertoire with the progression of Alzheimer’s disease
Open accessAbstract
Alzheimer's disease (AD) is the most prevalent type of dementia. Reports have revealed that the peripheral immune system is linked to neuropathology; however, little is known about the contribution of B lymphocytes in AD. For this longitudinal study, 133 participants are included at baseline and second-year follow-up. Also, we analyze B cell receptor (BCR) repertoire data generated from a public dataset of three normal and 10 AD samples and perform BCR repertoire profiling and pairwise sharing analysis. As a result, longitudinal increase in B lymphocytes is associated with increased cerebral amyloid deposition and hyperactivates induced pluripotent stem cell-derived microglia with loss-of-function for beta-amyloid clearance. Patients with AD share similar class-switched BCR sequences with identical isotypes, despite the high somatic hypermutation rate. Thus, BCR repertoire profiling can lead to the development of individualized immune-based therapeutics and treatment. We provide evidence of both quantitative and qualitative changes in B lymphocytes during AD pathogenesis.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Other reports showed either no correlation or a positive association between peripheral B cell number and AD severity.
“while other reports showed either no correlation [86] or a positive association [90].”
From Is there a role for B cells in Alzheimer's disease? (2026) · cites this paper as [90]
Cites
Reiman, E. M., Chen, K., Liu, X., Bandy, D., Yu, M., Lee, W., Ayutyanont, N., Keppler, J., Reeder, S. A., Langbaum, J. B. S., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0900345106 · Cited by 785 · see citing works
Commonality despite exceptional diversity in the baseline human antibody repertoire
Briney, B., Inderbitzin, A., Joyce, C., & Burton, D. R. (2019) · Nature · doi:10.1038/s41586-019-0879-y · Cited by 544 · see citing works
Altered lymphocyte distribution in Alzheimer’s disease
RICHARTZSALZBURGER, E., BATRA, A., STRANSKY, E., LASKE, C., KOHLER, N., BARTELS, M., BUCHKREMER, G., & SCHOTT, K. (2007) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2006.01.010 · Cited by 167 · see citing works
Effects of aging on B cell function
Frasca, D., & Blomberg, B. B. (2009) · Current Opinion in Immunology · doi:10.1016/j.coi.2009.06.001 · Cited by 161 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Is there a role for B cells in Alzheimer's disease?
Charavner, E.-L., Fillatreau, S., & El Behi, M. (2026) · Cellular Immunology · doi:10.1016/j.cellimm.2026.105154
- Authors
- Park, J.-C., Noh, J., Jang, S., Kim, K. H., Choi, H., Lee, D., Kim, J., Chung, J., Lee, D. Y., Lee, Y., Lee, H., Yoo, D. K., Lee, A. C., Byun, M. S., Yi, D., Han, S.-H., Kwon, S., & Mook-Jung, I.
- Affiliations
- Seoul National University (KR)
- Corresponding author
- Han, Sun-Ho
- Kwon, Sunghoon
- ORCID
- Venue
- Cell Reports
- Publisher
- Elsevier BV
- Published
- 2022-09
- Volume
- 40
- Issue
- 12
- Pages
- 111391
- ISSN
- 2211-1247 (ISSN-L)
- OpenAlex
- W4296478810
- Cited by
- 48
- References
- 4
- Citations by year
- 2026: 9 · 2025: 18 · 2024: 12 · 2023: 9
- FWCI
- 6.50
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Cell Reports (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- Ministry of Health and Welfare (HI19C1132020019, HU20C0187)
- Korea Health Industry Development Institute (HI19C1339)
- National Research Foundation of Korea (NRF-2020M3H1A1073304, NRF2019R1I1A1A01063525)
- Ministry of Science, ICT and Future Planning (2015K1A4A3047345, NRF-2020R1A3B3079653)
- Massachusetts Institute of Technology
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Keywords
- Alzheimer's disease, B cells, B cell receptor repertoire, disease progression, cerebral amyloid deposition, microglia, amyloid-beta clearance, somatic hypermutation, class-switched B cells, peripheral immune system
- MeSH terms
- Alzheimer Disease, B-Lymphocytes, Humans, Longitudinal Studies, Receptors, Antigen, B-Cell, Amyloid beta-Peptides
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
