Effects of aging on B cell function

Germinal centres: role in B-cell physiology and malignancy

Klein, U., & Dalla‐Favera, R. (2007) · Nature reviews. Immunology · doi:10.1038/nri2217 · Cited by 899 · see citing works

Lifetime of plasma cells in the bone marrow

Manz, R. A., Thiel, A., & Radbruch, A. (1997) · Nature · doi:10.1038/40540 · Cited by 866 · see citing works

The regulation of IgA class switching

Cerutti, A. (2008) · Nature reviews. Immunology · doi:10.1038/nri2322 · Cited by 756 · see citing works

Immunoglobulin Isotype Switching Is Inhibited and Somatic Hypermutation Perturbed in UNG-Deficient Mice

Rada, C. A., Williams, G. T., Nilsen, H. L., Barnes, D. E., Lindahl, T. L., & Neuberger, M. S. (2002) · Current Biology · doi:10.1016/s0960-9822(02)01215-0 · Cited by 712 · see citing works

B-cell responses to vaccination at the extremes of age

Siegrist, C.-A., & Aspinall, R. (2009) · Nature Reviews Immunology · doi:10.1038/nri2508 · Cited by 659 · see citing works

The immunology of exceptional individuals: the lesson of centenarians

Franceschi, C., Monti, D., Sansoni, P., & Cossarizza, A. (1995) · Immunology Today · doi:10.1016/0167-5699(95)80064-6 · Cited by 531 · see citing works

MicroRNA-155 Suppresses Activation-Induced Cytidine Deaminase-Mediated Myc-Igh Translocation

Dorsett, Y., McBride, K. M., Janković, M., Gazumyan, A., Thai, T., Robbiani, D. F., Virgilio, M. D., Reina‐San‐Martin, B., Heidkamp, G. F., Schwickert, T. A., et al. (2008) · Immunity · doi:10.1016/j.immuni.2008.04.002 · Cited by 456 · see citing works

MicroRNA-155 Is a Negative Regulator of Activation-Induced Cytidine Deaminase

Teng, G., Hakimpour, P., Landgraf, P., Rice, A., Tuschl, T., Casellas, R. C., & Papavasiliou, F. N. (2008) · Immunity · doi:10.1016/j.immuni.2008.03.015 · Cited by 446 · see citing works

B‐cell diversity decreases in old age and is correlated with poor health status

Gibson, K. L., Wu, Y., Barnett, Y., Duggan, O., Vaughan, R., Kondeatis, E., Nilsson, B., Wikby, A., Kipling, D., & Dunn‐Walters, D. K. (2009) · Aging Cell · doi:10.1111/j.1474-9726.2008.00443.x · Cited by 433 · see citing works

Immunophenotypic analysis of hematogones (B-lymphocyte precursors) in 662 consecutive bone marrow specimens by 4-color flow cytometry

McKenna, R. W., Washington, L. T., Aquino, D. B., Picker, L. J., & Kroft, S. H. (2001) · Blood · doi:10.1182/blood.v98.8.2498 · Cited by 392 · see citing works

T cells and aging january 2002 update

Pawelec, G. (2002) · Frontiers in bioscience · doi:10.2741/a831 · Cited by 368 · see citing works

T cells and aging

Pawelec, G. (1998) · Frontiers in bioscience · doi:10.2741/a266 · Cited by 357 · see citing works

Aging Down-Regulates the Transcription Factor E2A, Activation-Induced Cytidine Deaminase, and Ig Class Switch in Human B Cells

Frasca, D., Landin, A. M., Lechner, S. C., Ryan, J. G., Schwartz, R., Riley, R. L., & Blomberg, B. B. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.180.8.5283 · Cited by 333 · see citing works

Resting Human Memory B Cells Are Intrinsically Programmed for Enhanced Survival and Responsiveness to Diverse Stimuli Compared to Naive B Cells

Good‐Jacobson, K. L., Avery, D. T., & Tangye, S. G. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.182.2.890 · Cited by 279 · see citing works

Age-related Defects in CD4 T Cell Cognate Helper Function Lead to Reductions in Humoral Responses

Eaton, S. M., Burns, E. M., Kusser, K. L., Randall, T. D., & Haynes, L. (2004) · The Journal of Experimental Medicine · doi:10.1084/jem.20041395 · Cited by 279 · see citing works

The Decline in B Lymphopoiesis in Aged Mice Reflects Loss of Very Early B-Lineage Precursors

Miller, J. P., & Allman, D. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.171.5.2326 · Cited by 255 · see citing works

Interleukin 2, but Not Other Common γ Chain–Binding Cytokines, Can Reverse the Defect in Generation of Cd4 Effector T Cells from Naive T Cells of Aged Mice

Haynes, L., Linton, P., Eaton, S. M., Tonkonogy, S. L., & Swain, S. L. (1999) · The Journal of Experimental Medicine · doi:10.1084/jem.190.7.1013 · Cited by 248 · see citing works

E-proteins directly regulate expression of activation-induced deaminase in mature B cells

Sayegh, C. E., Quong, M. W., Agata, Y., & Murre, C. (2003) · Nature Immunology · doi:10.1038/ni923 · Cited by 246 · see citing works

Immunological studies of aging. II. Loss of IgG and high avidity plaque-forming cells and increased suppressor cell activity in aging mice.

Goidl, E. A., Innes, J. B., & Weksler, M. E. (1976) · The Journal of Experimental Medicine · doi:10.1084/jem.144.4.1037 · Cited by 239 · see citing works

Regulation of Aged Humoral Immune Defense against Pneumococcal Bacteria by IgM Memory B Cell

Shi, Y., Yamazaki, T., Okubo, Y., Uehara, Y., Sugane, K., & Agematsu, K. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.175.5.3262 · Cited by 229 · see citing works

Immunosenescence and germinal center reaction

Zheng, B. Q., Han, S., Takahashi, Y., & Kelsoe, G. H. (1997) · Immunological Reviews · doi:10.1111/j.1600-065x.1997.tb01028.x · Cited by 229 · see citing works

Changes in the B-cell repertoire with age

Weksler, M. E. (2000) · Vaccine · doi:10.1016/s0264-410x(99)00497-1 · Cited by 213 · see citing works

E Protein Function in Lymphocyte Development

Quong, M. W., Romanow, W. J., & Murre, C. (2002) · Annual Review of Immunology · doi:10.1146/annurev.immunol.20.092501.162048 · Cited by 196 · see citing works

Plasma cell differentiation and survival

Tarlinton, D. M., Radbruch, A., Hiepe, F., & Dörner, T. (2008) · Current Opinion in Immunology · doi:10.1016/j.coi.2008.03.016 · Cited by 187 · see citing works

Relative contribution of T and B cells to hypermutation and selection of the antibody repertoire in germinal centers of aged mice.

Yang, X., Štědra, J., & Cerny, J. (1996) · The Journal of Experimental Medicine · doi:10.1084/jem.183.3.959 · Cited by 182 · see citing works

Changes in circuIating B cells and immunoglobulin cIasses and subcIasses in a healthy aged popuIation

Paganelli, R., Quinti, I., Fagiolo, U., Cossarizza, A., ORTOLANI, C., GUERRA, E., Sansoni, P., Pucillo, L. P., Scala, E., Cozzi, E., et al. (1992) · Clinical & Experimental Immunology · doi:10.1111/j.1365-2249.1992.tb07954.x · Cited by 156 · see citing works

Constitutive crosspresentation of tissue antigens by dendritic cells controls CD8+ T cell tolerance in vivo.

Luckashenak, N. A., Schroeder, S., Endt, K., Schmidt, D., Mahnke, K., Bachmann, M., Marconi, P., Deeg, C., & Brocker, T. (2008) · Immunity · doi:10.1016/j.immuni.2008.02.018 · Cited by 151 · see citing works

Reduced Ig class switch in aged mice correlates with decreased E47 and activation-induced cytidine deaminase

Frasca, D., Van der Put, E., Riley, R. L., & Blomberg, B. B. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.172.4.2155 · Cited by 150 · see citing works

Repertoire diversity of antibody response to bacterial antigens in aged mice. III. Phosphorylcholine antibody from young and aged mice differ in structure and protective activity against infection with Streptococcus pneumoniae

Nicoletti, C., Yang, X., & Cerny, J. (1993) · The Journal of Immunology · doi:10.4049/jimmunol.150.2.543 · Cited by 140 · see citing works

B cells in the aged: CD27, CD5, and CD40 expression

Colonna-Romano, G., Bulati, M., Aquino, A., Scialabba, G., Candore, G., Lio, D., Motta, M., Malaguarnera, M., & Caruso, C. (2003) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(03)00013-7 · Cited by 137 · cited 2× · see citing works

Correlation analysis between frequencies of circulating antigen-specific IgG-bearing memory B cells and serum titers of antigen-specific IgG

Leyendeckers, H., Odendahl, M., Löhndorf, A., Irsch, J., Spangfort, M. D., Miltenyi, S., Hunzelmann, N., Assenmacher, M., Radbruch, A., & Schmitz, J. (1999) · European Journal of Immunology · doi:10.1002/(sici)1521-4141(199904)29:04 · Cited by 135 · see citing works

Aging-Dependent Exclusion of Antigen-Inexperienced Cells from the Peripheral B Cell Repertoire

Johnson, S. A., Rozzo, S. J., & Cambier, J. C. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.168.10.5014 · Cited by 134 · see citing works

B lymphopoiesis is active throughout human life, but there are developmental age-related changes

Rossi, M. I. D., Yokota, T., Medina, K. L., Garrett, K. P., Comp, P. C., Schipul, A. H., & Kincade, P. W. (2002) · Blood · doi:10.1182/blood-2002-03-0896 · Cited by 132 · see citing works

Effects of Aging on the Common Lymphoid Progenitor to Pro-B Cell Transition

Min, H., Montecino-Rodriguez, E., & Dorshkind, K. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.176.2.1007 · Cited by 126 · see citing works

B cells as effectors

McHeyzer‐Williams, M. G. (2003) · Current Opinion in Immunology · doi:10.1016/s0952-7915(03)00046-3 · Cited by 126 · see citing works

Ig VH hypermutation is absent in the germinal centers of aged mice

Miller, C., & Kelsoe, G. H. (1995) · The Journal of Immunology · doi:10.4049/jimmunol.155.7.3377 · Cited by 124 · see citing works

Discovery of Activation‐Induced Cytidine Deaminase, the Engraver of Antibody Memory

Muramatsu, M., Nagaoka, H., Shinkura, R., Begum, N. A., & Honjo, T. (2007) · Advances in immunology · doi:10.1016/s0065-2776(06)94001-2 · Cited by 119 · see citing works

T cell priming by dendritic cells: thresholds for proliferation, differentiation and death and intraclonal functional diversification

Langenkamp, A., Casorati, G., Garavaglia, C., Dellabona, P., Lanzavecchia, A., & Sallusto, F. (2002) · European Journal of Immunology · doi:10.1002/1521-4141(200207)32:7 · Cited by 113 · see citing works

Enhanced Differentiation of Splenic Plasma Cells but Diminished Long-Lived High-Affinity Bone Marrow Plasma Cells in Aged Mice

Han, S., Yang, K., Özen, Z., Peng, W., Marinova, E., Kelsoe, G. H., & Zheng, B. Q. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.170.3.1267 · Cited by 111 · see citing works

Acquired hematopoietic stem cell defects determine B-cell repertoire changes associated with aging

Guerrettaz, L., Johnson, S. A., & Cambier, J. C. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0805498105 · Cited by 99 · see citing works

Cytokine production by T lymphocytes from young and aged mice

Engwerda, C. R., Fox, B. S., & Handwerger, B. S. (1996) · The Journal of Immunology · doi:10.4049/jimmunol.156.10.3621 · Cited by 96 · see citing works

Tristetraprolin, a Negative Regulator of mRNA Stability, Is Increased in Old B Cells and Is Involved in the Degradation of E47 mRNA

Frasca, D., Landin, A. M., Alvarez, J. P., Blackshear, P. J., Riley, R. L., & Blomberg, B. B. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.179.2.918 · Cited by 96 · see citing works

Repertoire diversity of antibody response to bacterial antigens in aged mice. II. Phosphorylcholine-antibody in young and aged mice differ in both VH/VL gene repertoire and in specificity

Nicoletti, C., Borghesi-Nicoletti, C., Yang, X., Schulze, D. H., & Cerny, J. (1991) · The Journal of Immunology · doi:10.4049/jimmunol.147.8.2750 · Cited by 95 · see citing works

Posttranscriptional Mechanisms Regulating the Inflammatory Response

Stoecklin, G., & Anderson, P. (2006) · Advances in immunology · doi:10.1016/s0065-2776(05)89001-7 · Cited by 94 · see citing works

Decreased E47 in Senescent B Cell Precursors Is Stage Specific and Regulated Posttranslationally by Protein Turnover

der Put, E. V., Frasca, D., King, A. M., Blomberg, B. B., & Riley, R. L. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.173.2.818 · Cited by 76 · see citing works

B cells and aging: Balancing the homeostatic equation

MILLER, J., & CANCRO, M. (2007) · Experimental Gerontology · doi:10.1016/j.exger.2007.01.010 · Cited by 67 · see citing works

Senescent BALB/c mice exhibit decreased expression of lambda5 surrogate light chains and reduced development within the pre-B cell compartment.

Sherwood, E. M., Blomberg, B. B., Xu, W., Warner, C. A., & Riley, R. L. (1998) · PubMed · Cited by 62 · see citing works

The Effects of Age on the Immune Response to Type III Pneumococcal Polysaccharide (SIII) and Bacterial Lipopolysaccharide (LPS) in BALB/c, SJL/J, and C3H Mice

Smith, A. M. (1976) · The Journal of Immunology · doi:10.4049/jimmunol.116.2.469 · Cited by 60 · see citing works

Cutting Edge: Senescent BALB/c Mice Exhibit Decreased Expression of λ5 Surrogate Light Chains and Reduced Development Within the Pre-B Cell Compartment

Sherwood, E. M., Blomberg, B. B., Xu, W., Warner, C. A., & Riley, R. L. (1998) · The Journal of Immunology · doi:10.4049/jimmunol.161.9.4472 · Cited by 59 · see citing works

Diversity of the Ig Repertoire is Maintained With Age In Spite of Reduced Germinal Centre Cells in Human Tonsil Lymphoid Tissue

Kolar, G. R., Mehta, D., Wilson, P. C., & Capra, J. D. (2006) · Scandinavian Journal of Immunology · doi:10.1111/j.1365-3083.2006.01817.x · Cited by 52 · see citing works

Deviation of the B Cell Pathway in Senescent Mice Is Associated with Reduced Surrogate Light Chain Expression and Altered Immature B Cell Generation, Phenotype, and Light Chain Expression

Alter-Wolf, S., Blomberg, B. B., & Riley, R. L. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.182.1.138 · Cited by 50 · see citing works

Aging murine B cells have decreased class switch induced by anti-CD40 or BAFF

Frasca, D., RILEY, R., & Blomberg, B. B. (2006) · Experimental Gerontology · doi:10.1016/j.exger.2006.09.003 · Cited by 47 · see citing works

Antibody diversity: one enzyme to rule them all

Nussenzweig, M. C., & Alt, F. W. (2004) · Nature Medicine · doi:10.1038/nm1204-1304 · Cited by 46 · see citing works

RNA Stability of the E2A -Encoded Transcription Factor E47 Is Lower in Splenic Activated B Cells from Aged Mice

Frasca, D., der Put, E. V., Landin, A. M., Gong, D., Riley, R. L., & Blomberg, B. B. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.175.10.6633 · Cited by 39 · see citing works

Increased VH 11 and VH Q52 gene use by splenic B cells in old mice associated with oligoclonal expansions of CD5+ B cells

Ben‐Yehuda, A., Szabo, P., LeMaoult, J., Manavalan, J. S., & Weksler, M. E. (1998) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(98)00004-9 · Cited by 33 · see citing works

Repertoire diversity of antibody response to bacterial antigens in aged mice. IV. Study of VH and VL gene utilization in splenic antibody foci by in situ hybridization.

Yang, X., Štědra, J., & Cerny, J. (1994) · The Journal of Immunology · doi:10.4049/jimmunol.152.5.2214 · Cited by 32 · see citing works

Specific immune responses but not basal functions of B and T cells are impaired in aged mice

Speziali, E., Santiago, A. F., Fernandes, R. M., Vaz, N. M., Menezes, J. S., & Faria, A. M. C. (2009) · Cellular Immunology · doi:10.1016/j.cellimm.2009.01.010 · Cited by 27 · see citing works

Germinal center B cells in Peyer's patches of aged mice exhibit a normal activation phenotype and highly mutated IgM genes

Rogerson, B. J. (2003) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(02)00115-x · Cited by 18 · see citing works

Rectification of age-related impairment in Ig gene hypermutation during a memory response

Han, S. (2004) · International Immunology · doi:10.1093/intimm/dxh054 · Cited by 12 · see citing works

Causes, consequences, and reversal of immune system aging

Montecino-Rodriguez, E., Berent-Maoz, B., & Dorshkind, K. (2013) · Journal of Clinical Investigation · doi:10.1172/jci64096 · Cited by 793 · see citing works

A B-cell subset uniquely responsive to innate stimuli accumulates in aged mice

Hao, Y., O'Neill, P., Naradikian, M. S., Scholz, J. L., & Cancro, M. P. (2011) · Blood · doi:10.1182/blood-2011-01-330530 · Cited by 622 · see citing works

The aging lung: Physiology, disease, and immunity

Schneider, J. L., Rowe, J. H., Garcia-de-Alba, C., Kim, C. F., Sharpe, A. H., & Haigis, M. C. (2021) · Cell · doi:10.1016/j.cell.2021.03.005 · Cited by 500 · see citing works

Aging and Immune Function: Molecular Mechanisms to Interventions

Ponnappan, S., & Ponnappan, U. (2011) · Antioxidants & Redox Signaling · doi:10.1089/ars.2010.3228 · Cited by 339 · see citing works

The possible pathophysiology mechanism of cytokine storm in elderly adults with COVID-19 infection: the contribution of “inflame-aging”

Meftahi, G. H., Jangravi, Z., Sahraei, H., & Bahari, Z. (2020) · Inflammation Research · doi:10.1007/s00011-020-01372-8 · Cited by 289 · see citing works

Age effects on B cells and humoral immunity in humans

Frasca, D., Diaz, A., Romero, M., Landin, A. M., & Blomberg, B. B. (2010) · Ageing Research Reviews · doi:10.1016/j.arr.2010.08.004 · Cited by 271 · see citing works

IBD across the age spectrum—is it the same disease?

Ruel, J., Ruane, D., Mehandru, S., Gower‐Rousseau, C., & Colombel, J. (2013) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2013.240 · Cited by 237 · see citing works

Aging of immune system: immune signature from peripheral blood lymphocyte subsets in 1068 healthy adults

Qin, L., Xie, J., Qiu, Z., Cao, W., Jiao, Y., Routy, J., & Li, T. (2016) · Aging · doi:10.18632/aging.100894 · Cited by 218 · see citing works

Effects of Aging, Cytomegalovirus Infection, and EBV Infection on Human B Cell Repertoires

Wang, C., Liu, Y., Xu, L. T., Jackson, K., Roskin, K. M., Pham, T. D., Laserson, J., Marshall, E. L., Seo, K., Lee, J.-Y., et al. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1301384 · Cited by 179 · see citing works

Aging Affects Human B Cell Responses

Frasca, D., & Blomberg, B. B. (2011) · Journal of Clinical Immunology · doi:10.1007/s10875-010-9501-7 · Cited by 172 · see citing works

Activation of immunosuppressive network in the aging process

Salminen, A. (2019) · Ageing Research Reviews · doi:10.1016/j.arr.2019.100998 · Cited by 153 · see citing works

Transcriptional atlas of the human immune response to 13 vaccines reveals a common predictor of vaccine-induced antibody responses

Hagan, T., Gerritsen, B., Tomalin, L. E., Fourati, S., Mulè, M. P., Chawla, D. G., Rychkov, D., Henrich, E., Miller, H. E. R., Diray‐Arce, J., et al. (2022) · Nature Immunology · doi:10.1038/s41590-022-01328-6 · Cited by 148 · see citing works

COVID-19, Virology and Geroscience: A Perspective

Vellas, C., Delobel, P., Barreto, P. D. S., & Izopet, J. (2020) · The journal of nutrition health & aging · doi:10.1007/s12603-020-1416-2 · Cited by 116 · see citing works

B cell repertoire and ageing

Dunn‐Walters, D. K., & Ademokun, A. (2010) · Current Opinion in Immunology · doi:10.1016/j.coi.2010.04.009 · Cited by 103 · see citing works

Signal inhibition by the dual-specific phosphatase 4 impairs T cell-dependent B-cell responses with age

Yu, M., Li, G., Lee, W.-W., Yuan, M., Cui, D., Weyand, C. M., & Goronzy, J. J. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1109797109 · Cited by 102 · see citing works

Inflammatory and immune markers associated with physical frailty syndrome: findings from Singapore longitudinal aging studies

Lu, Y., Tan, C. T. Y., Nyunt, M. S. Z., Mok, E. W. H., Camous, X., Kared, H., Fülöp, T., Feng, L., Ng, T. P., & Larbi, A. (2016) · Oncotarget · doi:10.18632/oncotarget.8939 · Cited by 98 · see citing works

Aging, immune senescence, and immunotherapy: a comprehensive review

Elias, R., Hartshorn, K., Rahma, O., Lin, N., & Snyder-Cappione, J. E. (2018) · Seminars in Oncology · doi:10.1053/j.seminoncol.2018.08.006 · Cited by 96 · see citing works

Age-related impairment of humoral response to influenza is associated with changes in antigen specific T follicular helper cell responses

Lefebvre, J. S., Masters, A. R., Hopkins, J. W., & Haynes, L. (2016) · Scientific Reports · doi:10.1038/srep25051 · Cited by 91 · see citing works

Age Affects Quantity but Not Quality of Antibody Responses after Vaccination with an Inactivated Flavivirus Vaccine against Tick-Borne Encephalitis

Stiasny, K., Aberle, J. H., Keller, M., Grubeck‐Loebenstein, B., & Heinz, F. X. (2012) · PLoS ONE · doi:10.1371/journal.pone.0034145 · Cited by 88 · see citing works

Immunologic mechanisms of fingolimod and the role of immunosenescence in the risk of cryptococcal infection: A case report and review of literature

Grebenciucova, E., Reder, A. T., & Bernard, J. T. (2016) · Multiple Sclerosis and Related Disorders · doi:10.1016/j.msard.2016.07.015 · Cited by 81 · see citing works

Down syndrome, accelerated aging and immunosenescence

Gensous, N., Bacalini, M. G., Franceschi, C., & Garagnani, P. (2020) · Seminars in Immunopathology · doi:10.1007/s00281-020-00804-1 · Cited by 80 · see citing works

A gut‐centric view of aging: Do intestinal epithelial cells contribute to age‐associated microbiota changes, inflammaging, and immunosenescence?

Hohman, L. S., & Osborne, L. C. (2022) · Aging Cell · doi:10.1111/acel.13700 · Cited by 83 · see citing works

The implications of bone marrow adipose tissue on inflammaging

Aaron, N., Costa, S., Rosen, C. J., & Qiang, L. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.853765 · Cited by 74 · see citing works

The aged nonhematopoietic environment impairs natural killer cell maturation and function

Shehata, H. M., Hoebe, K., & Chougnet, C. A. (2015) · Aging Cell · doi:10.1111/acel.12303 · Cited by 69 · see citing works

Brazilian green propolis improves immune function in aged mice

Gao, W., Wu, J., Wei, J., Pu, L., Guo, C., Yang, J., Yang, M., & Luo, H. (2014) · Journal of Clinical Biochemistry and Nutrition · doi:10.3164/jcbn.13-70 · Cited by 67 · see citing works

Ageing and immunity

Boraschi, D., Giudice, G. D., Dutel, C., Ivanoff, B., Rappuoli, R., & Grubeck‐Loebenstein, B. (2010) · Vaccine · doi:10.1016/j.vaccine.2010.03.035 · Cited by 64 · see citing works

T Follicular Helper Cells and B Cell Dysfunction in Aging and HIV-1 Infection

Pallikkuth, S., de Armas, L. R., Rinaldi, S., & Pahwa, S. G. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01380 · Cited by 63 · see citing works

Modulation of gut microbiota and delayed immunosenescence as a result of syringaresinol consumption in middle-aged mice

Cho, S., Kim, J., Lee, J. H., Sim, J. H., Cho, D.-H., Bae, I., Lee, H., Seol, M. A., Shin, H. M., Kim, T.-J., et al. (2016) · Scientific Reports · doi:10.1038/srep39026 · Cited by 63 · see citing works

Kidney transplantation and the ageing immune system

McKay, D. B., & Jameson, J. (2012) · Nature Reviews Nephrology · doi:10.1038/nrneph.2012.242 · Cited by 61 · see citing works

Long-term intake of Lactobacillus paracasei KW3110 prevents age-related chronic inflammation and retinal cell loss in physiologically aged mice

Morita, Y., Jounai, K., Sakamoto, A., Tomita, Y., Sugihara, Y., Suzuki, H., Ohshio, K., Otake, M., Fujiwara, D., Kanauchi, O., et al. (2018) · Aging · doi:10.18632/aging.101583 · Cited by 60 · see citing works

Age-related Autoimmune Changes in Lacrimal Glands

de Souza, R. G., de Paiva, C. S., & Alves, M. R. (2019) · Immune Network · doi:10.4110/in.2019.19.e3 · Cited by 58 · see citing works

Food Allergies and Ageing

Martinis, M. D., Sirufo, M. M., Viscido, A., & Ginaldi, L. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20225580 · Cited by 55 · see citing works

Ageing and respiratory infections: The airway of ageing

Haq, K., & McElhaney, J. E. (2014) · Immunology Letters · doi:10.1016/j.imlet.2014.06.009 · Cited by 52 · see citing works

Adipocyte-Derived Soluble Factor(s) Inhibits Early Stages of B Lymphopoiesis

Bilwani, F., & Knight, K. L. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1201176 · Cited by 53 · see citing works

Reversing the immune ageing clock: lifestyle modifications and pharmacological interventions

Duggal, N. A. (2018) · Biogerontology · doi:10.1007/s10522-018-9771-7 · Cited by 53 · see citing works

Kidney and liver transplantation in the elderly

Sutherland, A., IJzermans, J. N. M., Forsythe, J. L. R., & Dor, F. J. M. F. (2015) · British journal of surgery · doi:10.1002/bjs.10064 · Cited by 52 · see citing works

Adjuvants that stimulate TLR3 or NLPR3 pathways enhance the efficiency of influenza virus-like particle vaccines in aged mice

Schneider-Ohrum, K., Giles, B. M., Weirback, H. K., Williams, B. L., DeAlmeida, D. R., & Ross, T. M. (2011) · Vaccine · doi:10.1016/j.vaccine.2011.09.051 · Cited by 50 · see citing works

Association of B cell profile and receptor repertoire with the progression of Alzheimer’s disease

Park, J.-C., Noh, J., Jang, S., Kim, K. H., Choi, H., Lee, D., Kim, J., Chung, J., Lee, D. Y., Lee, Y., et al. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.111391 · Cited by 48 · see citing works

Aging, cytomegalovirus (CMV) and influenza vaccine responses

Frasca, D., & Blomberg, B. B. (2016) · Human Vaccines & Immunotherapeutics · doi:10.1080/21645515.2015.1105413 · Cited by 46 · see citing works

With Great Age Comes Great Metastatic Ability: Ovarian Cancer and the Appeal of the Aging Peritoneal Microenvironment

Harper, E. I., Sheedy, E. F., & Stack, M. S. (2018) · Cancers · doi:10.3390/cancers10070230 · Cited by 45 · see citing works

Immune senescence in aged nonhuman primates☆

Haberthur, K., Engelmann, F., Barron, A., & Messaoudi, I. (2010) · Experimental Gerontology · doi:10.1016/j.exger.2010.06.001 · Cited by 44 · see citing works

Pentamers Not Found in the Universal Proteome Can Enhance Antigen Specific Immune Responses and Adjuvant Vaccines

Patel, A. R., Dong, J. C., Trost, B., Richardson, J. S., Tohme, S., Babiuk, S., Kusalik, A., Kung, S. K. P., & Kobinger, G. (2012) · PLoS ONE · doi:10.1371/journal.pone.0043802 · Cited by 35 · see citing works

Immune response to influenza vaccination in the elderly is altered by chronic medication use

Agarwal, D., Schmader, K. E., Kossenkov, A. V., Doyle, S. A., Kurupati, R. K., & Ertl, H. C. J. (2018) · Immunity & Ageing · doi:10.1186/s12979-018-0124-9 · Cited by 43 · see citing works

The concentration of total serum IgG and IgM in sera of healthy individuals varies at different age intervals

Jazayeri, M. H., Pourfathollah, A. A., Rasaee, M. J., Porpak, Z., & Jafari, M. E. (2013) · Biomedicine & Aging Pathology · doi:10.1016/j.biomag.2013.09.002 · Cited by 42 · see citing works

Report of the ad-hoc consultation on aging and immunization for a future WHO research agenda on life-course immunization

Thomas-Crusells, J., McElhaney, J. E., & Aguado, M. T. (2012) · Vaccine · doi:10.1016/j.vaccine.2012.07.025 · Cited by 39 · see citing works

Cytokine Response in SARS-CoV-2 Infection in the Elderly

Sherwani, S., & Khan, M. W. A. (2020) · Journal of Inflammation Research · doi:10.2147/jir.s276091 · Cited by 41 · see citing works

Modeling human immune responses to vaccination in vitro

Morrocchi, E., van Haren, S. D., Palma, P., & Levy, O. (2023) · Trends in Immunology · doi:10.1016/j.it.2023.11.002 · Cited by 39 · see citing works

Dementia-associated changes of immune cell composition within the cerebrospinal fluid

Busse, S., Hoffmann, J., Michler, E., Hartig, R., Frodl, T., & Busse, M. (2021) · Brain Behavior & Immunity - Health · doi:10.1016/j.bbih.2021.100218 · Cited by 39 · see citing works

Protein phosphatase 2A (PP2A) is increased in old murine B cells and mediates p38 MAPK/tristetraprolin dephosphorylation and E47 mRNA instability

Frasca, D., Romero, M., Landin, A. M., Diaz, A., Riley, R. L., & Blomberg, B. B. (2010) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2010.02.002 · Cited by 35 · see citing works

Frailty Is Associated With Increased Hemagglutination-Inhibition Titers in a 4-Year Randomized Trial Comparing Standard- and High-Dose Influenza Vaccination

Loeb, N., Andrew, M. K., Loeb, M. B., Kuchel, G. A., Haynes, L., McElhaney, J. E., & Verschoor, C. P. (2020) · Open Forum Infectious Diseases · doi:10.1093/ofid/ofaa148 · Cited by 32 · see citing works

B cell‐intrinsic changes with age do not impact antibody‐secreting cell formation but delay B cell participation in the germinal centre reaction

Lee, J. L., Fra-Bidó, S., Burton, A. R., Innocentin, S., Hill, D. L., & Linterman, M. A. (2022) · Aging Cell · doi:10.1111/acel.13692 · Cited by 34 · see citing works

Frequency and phenotype of B cell subpopulations in young and aged HIV-1 infected patients receiving ART

Amu, S., Lavy-Shahaf, G., Cagigi, A., Hejdeman, B., Nozza, S., Lopalco, L., Mehr, R., & Chiodi, F. (2014) · Retrovirology · doi:10.1186/s12977-014-0076-x · Cited by 32 · see citing works

Vaccines for the Elderly

Giudice, G. D., Weinberger, B., & Grubeck‐Loebenstein, B. (2014) · Gerontology · doi:10.1159/000366162 · Cited by 32 · see citing works

Repeated COVID-19 mRNA vaccination results in IgG4 class switching and decreased NK cell activation by S1-specific antibodies in older adults

Gelderloos, A. T., Verheul, M. K., Middelhof, I., de Zeeuw‐Brouwer, M., van Binnendijk, R. S., Buisman, A., & van Kasteren, P. B. (2024) · Immunity & Ageing · doi:10.1186/s12979-024-00466-9 · Cited by 31 · see citing works

Immunosenescence and age-related viral diseases

Ma, Y. C., & Fang, M. (2013) · Science China Life Sciences · doi:10.1007/s11427-013-4478-0 · Cited by 31 · see citing works

Food Allergy: Only a Pediatric Disease?

Diesner, S. C., Untersmayr, E., Pietschmann, P., & Jensen‐Jarolim, E. (2010) · Gerontology · doi:10.1159/000279756 · Cited by 30 · see citing works

Age-associated changes in the circulating human antibody repertoire are upregulated in autoimmunity

Arvey, A. J., Rowe, M., Legutki, J. B., An, G., Gollapudi, A., Lei, A., Colston, B. W., Putterman, C., Smith, D. S., Stiles, J., et al. (2020) · Immunity & Ageing · doi:10.1186/s12979-020-00193-x · Cited by 29 · see citing works

Augmentation of Primary Influenza A Virus-Specific CD8+ T Cell Responses in Aged Mice through Blockade of an Immunoinhibitory Pathway

DiMenna, L. J., Latimer, B. P., Parzych, E. M., Haut, L. H., Töpfer, K., Abdulla, S., Yu, H. B., Manson, B., Giles‐Davis, W., Zhou, D., et al. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.0903808 · Cited by 28 · see citing works

Improving intestinal inflammaging to delay aging? A new perspective

Zhang, L., Yan, J., Zhang, C., Feng, S., Zhan, Z., Bao, Y., Zhan, Z., & Chao, G. (2023) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2023.111841 · Cited by 27 · see citing works

Management of the Elderly Patients with Inflammatory Bowel Disease

Katz, S., Surawicz, C. M., & Pardi, D. S. (2013) · Inflammatory Bowel Diseases · doi:10.1097/mib.0b013e31828c8536 · Cited by 26 · see citing works

Changes in T and B cell subsets in end stage renal disease patients before and after kidney transplantation

Wang, L., Rondaan, C., de Joode, A. A. E., Raveling‐Eelsing, E., Bos, N. A., & Westra, J. (2021) · Immunity & Ageing · doi:10.1186/s12979-021-00254-9 · Cited by 22 · see citing works

EBNA-1 titer gradient in families with multiple sclerosis indicates a genetic contribution

Mescheriakova, J. Y., van Nierop, G. P., van der Eijk, A. A., Kreft, K. L., & Hintzen, R. Q. (2020) · Neurology Neuroimmunology & Neuroinflammation · doi:10.1212/nxi.0000000000000872 · Cited by 22 · see citing works

Characteristics and Outcome of Patients Diagnosed With HIV at Older Age

Asher, I., Mahlab‐Guri, K., Elbirt, D., Bezalel, S. R., Maldarelli, F. M., Mor, O., Grossman, Z., & Sthoeger, Z. M. (2016) · Medicine · doi:10.1097/md.0000000000002327 · Cited by 22 · see citing works

The potential of non-myeloablative heterochronous autologous hematopoietic stem cell transplantation for extending a healthy life span

Rožman, P. J. (2018) · GeroScience · doi:10.1007/s11357-018-0027-x · Cited by 20 · see citing works

The Immune System, a Marker and Modulator of the Rate of Aging

la Fuente, M. D. (2013) · Springer eBooks · doi:10.1007/978-3-642-39495-9_2 · Cited by 20 · see citing works

The reference ranges and characteristics of lymphocyte parameters and the correlation between lymphocyte parameters and routine health indicators in adults from China

Liu, W., Xu, J., Pu, Q., Lan, M., Zhang, X., Gu, Y., Wang, Y., Fan, Z., Qian, J., Fan, C., et al. (2022) · Immunity & Ageing · doi:10.1186/s12979-022-00298-5 · Cited by 20 · see citing works

Cytomegalovirus Infection Minimally Affects the Frequencies of B-Cell Phenotypes in Peripheral Blood of Younger and Older Adults

Goldeck, D., Oettinger, L., Janssen, N., Demuth, I., Steinhagen‐Thiessen, E., & Pawelec, G. (2016) · Gerontology · doi:10.1159/000382076 · Cited by 18 · see citing works

Clinical Presentation and Management of Histoplasmosis in Older Adults

Ledtke, C., Tomford, J. W., Jain, A., Isada, C. M., & van Duin, D. (2012) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2011.03825.x · Cited by 18 · see citing works

SNPs in DNA repair genes associated to meningitis and host immune response

da Silva, T. A., Fontes-Dantas, F. L., Coutinho, L. G., de Souza, F. R. S., Campos, J. T. A. D. M., de Souto, J. T., Leib, S. L., & Agnez‐Lima, L. F. (2011) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2011.05.012 · Cited by 18 · see citing works

Dysregulated expression of miR-101b and miR-26b lead to age-associated increase in LPS-induced COX-2 expression in murine macrophage

Liu, D., Wang, D., Xu, Z., Gao, J., Liu, M., Liu, Y., Jiang, M., & Zheng, D. (2015) · AGE · doi:10.1007/s11357-015-9836-3 · Cited by 17 · see citing works

IgD + age‐associated B cells are the progenitors of the main T‐independent B cell response to infection that generates protective Ab and can be induced by an inactivated vaccine in the aged

Kugler‐Umana, O., Zhang, W., Kuang, Y., Liang, J., Castonguay, C. H., Tonkonogy, S. L., Marshak‐Rothstein, A., Devarajan, P., & Swain, S. L. (2022) · Aging Cell · doi:10.1111/acel.13705 · Cited by 16 · see citing works

Age has a role in driving host immunopathological response to alphavirus infection

Chan, Y., & Ng, L. F. P. (2017) · Immunology · doi:10.1111/imm.12799 · Cited by 17 · see citing works

Selection and Neutral Mutations Drive Pervasive Mutability Losses in Long-Lived Anti-HIV B-Cell Lineages

Vieira, M. C., Zinder, D., & Cobey, S. E. (2018) · Molecular Biology and Evolution · doi:10.1093/molbev/msy024 · Cited by 17 · see citing works

Infection, Sepsis, and Immune Function in the Older Adult Receiving Critical Care

Lineberry, C., & Stein, D. E. (2014) · Critical Care Nursing Clinics of North America · doi:10.1016/j.ccell.2013.09.009 · Cited by 17 · see citing works

Effects of Cathepsin S Inhibition in the Age-Related Dry Eye Phenotype

Galletti, J. G., Scholand, K. K., Trujillo-Vargas, C. M., Haap, W. J., Santos‐Ferreira, T., Ullmer, C., Yu, Z., & de Paiva, C. S. (2023) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.64.11.7 · Cited by 16 · see citing works

Advanced biological age is associated with improved antibody responses in older high-dose influenza vaccine recipients over four consecutive seasons

Verschoor, C. P., Belsky, D. W., Andrew, M. K., Haynes, L., Loeb, M. B., Pawelec, G., McElhaney, J. E., & Kuchel, G. A. (2022) · Immunity & Ageing · doi:10.1186/s12979-022-00296-7 · Cited by 16 · see citing works

What immunosuppression should be used for old-to-old recipients?

Meur, Y. L. (2015) · Transplantation Reviews · doi:10.1016/j.trre.2015.08.004 · Cited by 16 · see citing works

Age-related changes in the TRB and IGH repertoires in healthy adult males and females

Gong, M., Li, X., Zheng, A., Xu, H., Xie, S., Yan, R., Wu, H., & Wang, Z. (2021) · Immunology Letters · doi:10.1016/j.imlet.2021.10.002 · Cited by 17 · see citing works

The Evaluation of Oxidative Stress in the Young Adults with COVID-19 mRNA Vaccines Induced Acute Pericarditis- Myopericarditis

Dursun, A. D., Sarıçam, E., Sarıyıldız, G. T., İşcanlı, M. D., & Cantekin, Ö. F. (2022) · International Journal of General Medicine · doi:10.2147/ijgm.s347977 · Cited by 15 · see citing works

T cell responses in senior patients with community-acquired pneumonia related to disease severity

Bian, L., Bi, Y., Zhou, S., Chen, Z.-D., Wen, J., Jin, S. K., Mao, L., & Wang, L. (2017) · Experimental Cell Research · doi:10.1016/j.yexcr.2017.09.041 · Cited by 15 · see citing works

Older Human B Cells and Antibodies

Dunn‐Walters, D. K., & O’Hare, J. S. (2017) · Springer eBooks · doi:10.1007/978-3-319-64597-1_21-1 · Cited by 14 · see citing works

Effective inactivated influenza vaccine for the elderly using a single-stranded RNA-based adjuvant

Bang, Y., Hong, S., Park, H., Kwak, H. W., Lee, Y., Kim, J. Y., Park, H.-J., Bae, S., Kim, H. J., Kim, Y.-H., et al. (2021) · Scientific Reports · doi:10.1038/s41598-021-91445-3 · Cited by 14 · see citing works

Myc-Interacting Zinc Finger Protein 1 (Miz-1) Is Essential to Maintain Homeostasis and Immunocompetence of the B Cell Lineage

Piskor, E.-M., Ross, J., Möröy, T., & Kosan, C. (2022) · Biology · doi:10.3390/biology11040504 · Cited by 13 · see citing works

Mechanisms and strategies of immunosenescence effects on non-small cell lung cancer (NSCLC) treatment: A comprehensive analysis and future directions

Zhou, H., Zheng, Z., Fan, C., & Zhou, Z. (2025) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2025.01.001 · Cited by 15 · see citing works

L-Rhamnose Is Often an Important Part of Immunodominant Epitope for Pneumococcal Serotype 23F Polysaccharide Antibodies in Human Sera Immunized with PPV23

Park, S., & Nahm, M. H. (2013) · PLoS ONE · doi:10.1371/journal.pone.0083810 · Cited by 13 · see citing works

Memory B cells from older people express normal levels of cyclooxygenase-2 and produce higher levels of IL-6 and IL-10 upon in vitro activation

Bancos, S., & Phipps, R. P. (2010) · Cellular Immunology · doi:10.1016/j.cellimm.2010.09.002 · Cited by 13 · see citing works

Testing Efficacy of a Conserved Polypeptide from the Bm86 Protein against Rhipicephalus microplus in the Mexican Tropics

Coate-Camacho, R., Alonso-Díaz, M. Á., Martínez‐Velázquez, M., Castro-Saines, E., Hernández-Ortíz, R., & Quintanilla, R. E. L. (2023) · Vaccines · doi:10.3390/vaccines11071267 · Cited by 12 · see citing works

The association between human B-1 cell frequency and aging: From cord blood to the elderly

Jazayeri, M. H., Pourfathollah, A. A., Jafari, M. E., Rasaee, M. J., & Dargahi, Z. V. (2013) · Biomedicine & Aging Pathology · doi:10.1016/j.biomag.2013.01.001 · Cited by 12 · see citing works

Phenotypic Heterogeneity in a Family with a CD40 Ligand Intracellular Domain Mutation

Kiani‐Alikhan, S., Yong, P. F. K., Gilmour, K. C., Grosse‐Kreul, D., Davies, E. G., & Ibrahim, M. A. A. (2011) · Journal of Clinical Immunology · doi:10.1007/s10875-011-9607-6 · Cited by 12 · see citing works

Development of Streptococcus pneumoniae Vaccines Using Live Vectors

Wang, S., & Curtiss, R. (2014) · Vaccines · doi:10.3390/vaccines2010049 · Cited by 12 · see citing works

Serologic Survey of the Pandemic H1N1 2009 Virus in Guangdong Province, China: A Cross Sectional Study

Zhang, X., He, J., Li, L., Zhu, X., Ke, C., Ni, H., Hou, N., Zhong, H., & Wu, J. (2011) · PLoS ONE · doi:10.1371/journal.pone.0023034 · Cited by 11 · see citing works

The impact of TLR2 and aging on the humoral immune response to Staphylococcus aureus bacteremia in mice

Gupta, P., Hu, Z., Kopparapu, P. K., Deshmukh, M. V., Sághy, T., Mohammad, M., Jin, T., & Engdahl, C. (2023) · Scientific Reports · doi:10.1038/s41598-023-35970-3 · Cited by 11 · see citing works

Visualization of Resident Memory CD8 T Cells in the Lungs of Young and Aged Influenza Memory Mice and after Heterosubtypic Challenge

Cookenham, T. S., Lanzer, K. G., Tighe, M., Ward, J. M., Reiley, W. W., & Blackman, M. A. (2021) · ImmunoHorizons · doi:10.4049/immunohorizons.2100032 · Cited by 10 · see citing works

Stress-related Behavioural Responses, Immunity and Ageing in Animal Models

Vida, C., & la Fuente, M. D. (2012) · Springer eBooks · doi:10.1007/978-1-4614-4776-4_8 · Cited by 10 · see citing works

The immunosenescence-related factor DOCK11 is involved in secondary immune responses of B cells

Sugiyama, Y., Fujiwara, M., Sakamoto, A., Tsushima, H., Nishikimi, A., & Maruyama, M. (2022) · Immunity & Ageing · doi:10.1186/s12979-021-00259-4 · Cited by 10 · see citing works

E47 retroviral rescue of intrinsic B‐cell defects in senescent mice

Landin, A. M., Frasca, D., Harrison, P. T., Scallan, M. F., Riley, R. L., & Blomberg, B. B. (2011) · Aging Cell · doi:10.1111/j.1474-9726.2011.00673.x · Cited by 10 · see citing works

Acute systemic DNA damage in youth does not impair immune defense with aging

Pugh, J. L., Foster, S. A., Sukhina, A. S., Petravic, J., Uhrlaub, J. L., Padilla‐Torres, J., Hayashi, T., Nakachi, K., Smithey, M. J., & Nikolich‐Žugich, J. (2016) · Aging Cell · doi:10.1111/acel.12478 · Cited by 10 · see citing works

Aging and lung diseases: Unraveling mechanisms and therapeutic targets

Zhou, Y., Chen, G., Li, X., Li, X., Lin, Z., Liu, L., Pu, D., Chen, J., Chen, Y., Lin, Z., et al. (2025) · Chinese Medical Journal - Pulmonary and Critical Care Medicine · doi:10.1016/j.pccm.2025.11.005 · Cited by 9 · see citing works

The reactivity of human serum natural autoantibodies with certain autoantigens increases along with aging

Jazayeri, M. H., Pourfathollah, A. A., Rasaee, M. J., Farhadi, M. R., Zarei, N., & Jafari, M. E. (2013) · Biomedicine & Aging Pathology · doi:10.1016/j.biomag.2013.06.001 · Cited by 8 · see citing works

Correction: L-Rhamnose Is Often an Important Part of Immunodominant Epitope for Pneumococcal Serotype 23F Polysaccharide Antibodies in Human Sera Immunized with PPV23

Park, S., & Nahm, M. H. (2014) · PLoS ONE · doi:10.1371/annotation/84458b5b-2bae-4d71-b003-7d584c1bfd8c · Cited by 6 · see citing works

Age effects on B cells and humoral immunity in humans

Frasca, D., Diaz, A., Romero, M., Landin, A. M., & Blomberg, B. B. (2010) · Ageing Research Reviews · doi:10.1016/j.arr.2010.08.004 · Cited by 271 · see citing works

Humoral immune response and B-cell functions including immunoglobulin class switch are downregulated in aged mice and humans

Frasca, D., Riley, R. L., & Blomberg, B. B. (2005) · Seminars in Immunology · doi:10.1016/j.smim.2005.05.005 · Cited by 136 · see citing works

Decreases in E2A, AID, and Ig class switch show intrinsic defects in human B cells with age (85.14)

Blomberg, B. B., Landin, A. M., Riley, R. L., Lechner, S. C., Ryan, J., Schwartz, R. J., & Frasca, D. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.supp.85.14 · Cited by 1 · see citing works

Aging Down-Regulates the Transcription Factor E2A, Activation-Induced Cytidine Deaminase, and Ig Class Switch in Human B Cells

Frasca, D., Landin, A. M., Lechner, S. C., Ryan, J. G., Schwartz, R., Riley, R. L., & Blomberg, B. B. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.180.8.5283 · Cited by 333 · see citing works

Effect of Age on the Immunoglobulin Class Switch

Frasca, D., Riley, R. L., & Blomberg, B. B. (2004) · Critical Reviews in Immunology · doi:10.1615/critrevimmunol.v24.i5.10 · Cited by 41 · see citing works