The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.
Rational identification of potent and broad sarbecovirus-neutralizing antibody cocktails from SARS convalescents
Open accessAbstract
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron sublineages have escaped most receptor-binding domain (RBD)-targeting therapeutic neutralizing antibodies (NAbs), which proves that previous NAb drug screening strategies are deficient against the fast-evolving SARS-CoV-2. Better broad NAb drug candidate selection methods are needed. Here, we describe a rational approach for identifying RBD-targeting broad SARS-CoV-2 NAb cocktails. Based on high-throughput epitope determination, we propose that broad NAb drugs should target non-immunodominant RBD epitopes to avoid herd-immunity-directed escape mutations. Also, their interacting antigen residues should focus on sarbecovirus conserved sites and associate with critical viral functions, making the antibody-escaping mutations less likely to appear. Following these criteria, a featured non-competing antibody cocktail, SA55+SA58, is identified from a large collection of broad sarbecovirus NAbs isolated from SARS-CoV-2-vaccinated SARS convalescents. SA55+SA58 potently neutralizes ACE2-utilizing sarbecoviruses, including circulating Omicron variants, and could serve as broad SARS-CoV-2 prophylactics to offer long-term protection, especially for individuals who are immunocompromised or with high-risk comorbidities.
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Citations
Cites
Graph-based genome alignment and genotyping with HISAT2 and HISAT-genotype
Kim, D., Paggi, J. M., Park, C., Bennett, C., & Salzberg, S. L. (2019) · Nature Biotechnology · doi:10.1038/s41587-019-0201-4 · Cited by 15,022
Omicron escapes the majority of existing SARS-CoV-2 neutralizing antibodies
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Self-citationConvergent Antibody Responses to SARS-CoV-2 in Convalescent Individuals
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Self-citationStriking antibody evasion manifested by the Omicron variant of SARS-CoV-2
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Self-citation
Cited by
ACE2 binding and antibody evasion in enhanced transmissibility of XBB.1.5
Yue, C., Song, W., Wang, L., Jian, F., Chen, X., Gao, F., Shen, Z., Wang, Y., Wang, X., & Cao, Y. (2023) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(23)00010-5 · Cited by 328
Self-citationRepeated Omicron exposures override ancestral SARS-CoV-2 immune imprinting
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Self-citationSARS-CoV-2 antibodies recognize 23 distinct epitopic sites on the receptor binding domain
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A broadly generalizable stabilization strategy for sarbecovirus fusion machinery vaccines
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Metadata
- Authors
- Cao, Y., Jian, F., Zhang, Z., Yisimayi, A., Hao, X., Bao, L., Yuan, F., Yu, Y., Du, S., Wang, J., Xiao, T., Song, W., Zhang, Y., Liu, P., An, R., Wang, P., Wang, Y., Yang, S., Niu, X., Zhang, Y., Gu, Q., Shao, F., Hu, Y., Yin, W., Zheng, A., Wang, Y., Qin, C., Jin, R., Xiao, J., & Xie, X. S.
- Venue
- Cell Reports
- Publisher
- Elsevier BV
- Published
- 2022-12
- Volume
- 41
- Issue
- 12
- Pages
- 111845
- ISSN
- 2211-1247 (ISSN-L)
- OpenAlex
- W4312210144
- Cited by
- 161
- References
- 11
- FWCI
- 14.40
- Type
- journal article
- Language
- en
- Open access
- gold
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- Cao, Y., Jian, F., Zhang, Z., Yisimayi, A., Hao, X., Bao, L., Yuan, F., Yu, Y., Du, S., Wang, J., Xiao, T., Song, W., Zhang, Y., Liu, P., An, R., Wang, P., Wang, Y., Yang, S., Niu, X., . . . Xie, X. S. (2022). Rational identification of potent and broad sarbecovirus-neutralizing antibody cocktails from SARS convalescents. Cell Reports. https://doi.org/10.1016/j.celrep.2022.111845
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