The DOI matches its Crossref record; 58 of the 58 references it cites were found in a registry or an index.
Toll-like receptor 4 and CD11b expressed on microglia coordinate eradication of Candida albicans cerebral mycosis
Abstract
The fungal pathogen Candida albicans is linked to chronic brain diseases such as Alzheimer's disease (AD), but the molecular basis of brain anti-Candida immunity remains unknown. We show that C. albicans enters the mouse brain from the blood and induces two neuroimmune sensing mechanisms involving secreted aspartic proteinases (Saps) and candidalysin. Saps disrupt tight junction proteins of the blood-brain barrier (BBB) to permit fungal brain invasion. Saps also hydrolyze amyloid precursor protein (APP) into amyloid β (Aβ)-like peptides that bind to Toll-like receptor 4 (TLR4) and promote fungal killing in vitro while candidalysin engages the integrin CD11b (Mac-1) on microglia. Recognition of Aβ-like peptides and candidalysin promotes fungal clearance from the brain, and disruption of candidalysin recognition through CD11b markedly prolongs C. albicans cerebral mycosis. Thus, C. albicans is cleared from the brain through innate immune mechanisms involving Saps, Aβ, candidalysin, and CD11b.
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Metadata
- Authors
- Wu, Y., Du, S., Bimler, L. H., Mauk, K. E., Lortal, L., Kichik, N., Griffiths, J. S., Osicka, R., Song, L., Polsky, K., Kasper, L., Sebo, P., Weatherhead, J., Knight, J. M., Kheradmand, F., Zheng, H., Richardson, J. P., Hube, B., Naglik, J. R., & Corry, D. B.
- Venue
- Cell Reports
- Publisher
- Elsevier BV
- Published
- 2023-10
- Volume
- 42
- Issue
- 10
- Pages
- 113240
- ISSN
- 2211-1247
- Cited by
- 67
- References
- 58
- Language
- en
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- creativecommons.org/licenses/by-nc-nd/4.0/ (vor)
- Funders
- Deutsche Forschungsgemeinschaft (390713860)
- Wellcome Trust (R37-DE022550)
- Office of Research and Development (I01BX004828, CPRIT-RP180672, RR024574)
- DBT/Wellcome Trust India Alliance (214229_Z_18_Z)
- CPRIT
- Department of Veterans Affairs
- National Institutes of Health (CA125123, T32AI053831, R37-DE022550, HL140398, R01AI135803, R01HL117181, T32HL139425, R41AI124997, T32HL007747)
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- The paper
- Wu, Y., Du, S., Bimler, L. H., Mauk, K. E., Lortal, L., Kichik, N., Griffiths, J. S., Osicka, R., Song, L., Polsky, K., Kasper, L., Sebo, P., Weatherhead, J., Knight, J. M., Kheradmand, F., Zheng, H., Richardson, J. P., Hube, B., Naglik, J. R., & Corry, D. B. (2023). Toll-like receptor 4 and CD11b expressed on microglia coordinate eradication of Candida albicans cerebral mycosis. Cell Reports. https://doi.org/10.1016/j.celrep.2023.113240
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
