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Cited by 67

The DOI matches its Crossref record; 58 of the 58 references it cites were found in a registry or an index.

Toll-like receptor 4 and CD11b expressed on microglia coordinate eradication of Candida albicans cerebral mycosis

Wu, Yifan, Du, Shuqi, Bimler, Lynn H., Mauk, Kelsey E., Lortal, Léa, Kichik, Nessim, Griffiths, James S., Osicka, Radim, Song, Lizhen, Polsky, Katherine, Kasper, Lydia, Sebo, Peter, Weatherhead, Jill, Knight, J. Morgan, Kheradmand, Farrah, Zheng, Hui, Richardson, Jonathan P., Hube, Bernhard, Naglik, Julian R., Corry, David B.·2023·Cell Reports
DOI 10.1016/j.celrep.2023.113240
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Abstract

The fungal pathogen Candida albicans is linked to chronic brain diseases such as Alzheimer's disease (AD), but the molecular basis of brain anti-Candida immunity remains unknown. We show that C. albicans enters the mouse brain from the blood and induces two neuroimmune sensing mechanisms involving secreted aspartic proteinases (Saps) and candidalysin. Saps disrupt tight junction proteins of the blood-brain barrier (BBB) to permit fungal brain invasion. Saps also hydrolyze amyloid precursor protein (APP) into amyloid β (Aβ)-like peptides that bind to Toll-like receptor 4 (TLR4) and promote fungal killing in vitro while candidalysin engages the integrin CD11b (Mac-1) on microglia. Recognition of Aβ-like peptides and candidalysin promotes fungal clearance from the brain, and disruption of candidalysin recognition through CD11b markedly prolongs C. albicans cerebral mycosis. Thus, C. albicans is cleared from the brain through innate immune mechanisms involving Saps, Aβ, candidalysin, and CD11b.

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Cites

Research works printed but not linked: 4

  1. Moyes, 2016, Candidalysin is a fungal peptide toxin critical for mucosal infection, Nature, 532, 64, 10.1038/nature17625 · DOI · Paper page
  2. Wu, 2019, Microglia and amyloid precursor protein coordinate control of transient Candida cerebritis with memory deficits, Nat. Commun., 10, 58, 10.1038/s41467-018-07991-4 · DOI · Paper page
  3. Wu, 2021, Candida albicans elicits protective allergic responses via platelet mediated T helper 2 and T helper 17 cell polarization, Immunity, 54, 2595, 10.1016/j.immuni.2021.08.009 · DOI
  4. Landers, 2019, Selective cleavage of fibrinogen by diverse proteinases initiates innate allergic and antifungal immunity through CD11b, J. Biol. Chem., 294, 8834, 10.1074/jbc.RA118.006724 · DOI

Metadata

Authors
Wu, Y., Du, S., Bimler, L. H., Mauk, K. E., Lortal, L., Kichik, N., Griffiths, J. S., Osicka, R., Song, L., Polsky, K., Kasper, L., Sebo, P., Weatherhead, J., Knight, J. M., Kheradmand, F., Zheng, H., Richardson, J. P., Hube, B., Naglik, J. R., & Corry, D. B.
Venue
Cell Reports
Publisher
Elsevier BV
Published
2023-10
Volume
42
Issue
10
Pages
113240
ISSN
2211-1247
DOI
10.1016/j.celrep.2023.113240
Cited by
67
References
58
Language
en
Licence
Funders
  • Deutsche Forschungsgemeinschaft (390713860)
  • Wellcome Trust (R37-DE022550)
  • Office of Research and Development (I01BX004828, CPRIT-RP180672, RR024574)
  • DBT/Wellcome Trust India Alliance (214229_Z_18_Z)
  • CPRIT
  • Department of Veterans Affairs
  • National Institutes of Health (CA125123, T32AI053831, R37-DE022550, HL140398, R01AI135803, R01HL117181, T32HL139425, R41AI124997, T32HL007747)

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Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.