Transgenic tools targeting the basal ganglia reveal both evolutionary conservation and specialization of neural circuits in zebrafish
Open accessAbstract
The cortico-basal ganglia circuit mediates decision making. Here, we generated transgenic tools for adult zebrafish targeting specific subpopulations of the components of this circuit and utilized them to identify evolutionary homologs of the mammalian direct- and indirect-pathway striatal neurons, which respectively project to the homologs of the internal and external segment of the globus pallidus (dorsal entopeduncular nucleus [dEN] and lateral nucleus of the ventral telencephalic area [Vl]) as in mammals. Unlike in mammals, the Vl mainly projects to the dEN directly, not by way of the subthalamic nucleus. Further single-cell RNA sequencing analysis reveals two pallidal output pathways: a major shortcut pathway directly connecting the dEN with the pallium and the evolutionarily conserved closed loop by way of the thalamus. Our resources and circuit map provide the common basis for the functional study of the basal ganglia in a small and optically tractable zebrafish brain for the comprehensive mechanistic understanding of the cortico-basal ganglia circuit.
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The telencephalon contains putative analogues to components of the mammalian limbic system (for example, hippocampus).
“a brain region that contains putative analogues to components of the mammalian limbic system (for example, hippocampus)2–4”
From A population code for spatial representation in the zebrafish telencephalon (2024) · cites this paper as [4]
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A population code for spatial representation in the zebrafish telencephalon
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“Spatial learning in teleost fish requires an intact telencephalon 1 , a brain region that contains putative analogues to components of the mammalian limbic system (for example, hippocampus) 2–4 .”
Hierarchical sensory processing in zebrafish thalamocortical-like circuits
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- Authors
- Tanimoto, Y., Kakinuma, H., Aoki, R., Shiraki, T., Higashijima, S.-I., & Okamoto, H.
- Affiliations
- RIKEN Center for Brain Science (JP)
- National Institute for Basic Biology (JP)
- Corresponding author
- Okamoto, Hitoshi
- Venue
- Cell Reports
- Publisher
- Elsevier BV
- Published
- 2024-03
- Volume
- 43
- Issue
- 3
- Pages
- 113916
- ISSN
- 2211-1247 (ISSN-L)
- OpenAlex
- W4392740371
- Cited by
- 16
- References
- 8
- Citations by year
- 2026: 8 · 2025: 6 · 2024: 2
- FWCI
- 3.61
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Cell Reports (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- Japan Society for the Promotion of Science
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Zebrafish Biomedical Research Applications
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Health Sciences › Medicine › Neurology › Neurological disorders and treatments
- Keywords
- cortico-basal ganglia circuits, basal ganglia, zebrafish, globus pallidus, thalamus, evolutionary conservation, neural circuit mapping, decision-making
- MeSH terms
- Animals, Basal Ganglia, Corpus Striatum, Globus Pallidus, Mammals, Neural Pathways, Zebrafish, Animals, Genetically Modified
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