Pan-cancer Alterations of the MYC Oncogene and Its Proximal Network across the Cancer Genome Atlas

Schaub, Franz X., Dhankani, Varsha, Berger, Ashton C., Trivedi, Mihir, Richardson, Anne B., Shaw, Reid, Zhao, Wei, Zhang, Xiaoyang +733 more·2018·Cell Systems

DOI 10.1016/j.cels.2018.03.003

Cited by (434)

Items 201–300 of 434

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A Drug Repurposing Screen Identifies Fludarabine Phosphate as a Potential Therapeutic Agent for N-MYC Overexpressing Neuroendocrine Prostate Cancers
Hussain Elhasasna, Raymond Khan, Kalpana Kalyanasundaram Bhanumathy, Frederick S. Vizeacoumar, Prachi Walke, Maricris Bautista, Dinesh Kumar Dahiya, Vincent Maranda, Hardikkumar M. Patel, Balagopal Amrutha et al. · 2022 · Cells
Splice‐switch oligonucleotide‐based combinatorial platform prioritizes synthetic lethal targets CHK1 and BRD4 against MYC ‐driven hepatocellular carcinoma
Dexter Kai Hao Thng, Tan Boon Toh, Paolo Pigini, Lissa Hooi, Yock Young Dan, Pierce K. H. Chow, Glenn Kunnath Bonney, Masturah Bte Mohd Abdul Rashid, Ernesto Guccione, Dave Keng Boon Wee et al. · 2022 · Bioengineering & Translational Medicine
Comprehensive analysis of TLX2 in pan cancer as a prognostic and immunologic biomarker and validation in ovarian cancer
Buze Chen, Xiaojuan Ding, Ailing Wan, Xin Qi, Xiaoman Lin, Haihong Wang, Wenyu Mu, Gang Wang, Junnian Zheng · 2023 · Scientific Reports
Directly Suppressing MYC Function with Novel Alkynyl-Substituted Phenylpyrazole Derivatives that Induce Protein Degradation and Perturb MYC/MAX Interaction
Can Zhao, Fang Zhao, Liuqing Yang, Yang Wang, Henian Wang, Fang Fang, Haojie Zuo, Zhi Li, Ge He, Wenhu Zhan et al. · 2024 · Journal of Medicinal Chemistry
RET inhibition in novel patient-derived models of RET fusion- positive lung adenocarcinoma reveals a role for MYC upregulation
Takuo Hayashi, Igor Odintsov, Roger S. Smith, Kota Ishizawa, Allan J. W. Liu, Lukas Delasos, Christopher Kurzatkowski, Huichun Tai, Eric Gladstone, Morana Vojnic et al. · 2020 · Disease Models & Mechanisms
Circular RNA PVT1 Regulates Cell Proliferation, Migration, and Apoptosis by Stabilizing c-Myc and Downstream Target CXCR4 Expression in Acute Myeloid Leukemia
Xianfu Sheng, Li Li Hong, Lei Fan, Yu Zhang, Kaili Chen, Jie Mu, Si Yu Shen, Hai Feng Zhuang · 2023 · Turkish Journal of Hematology
Nuclear factor I X is a recurrent target for HPV16 insertions in anal carcinomas
Emmanuelle Jeannot, Alexandre Harlé, Allyson M. Holmes, Xavier Sastre‐Garau · 2018 · Genes Chromosomes and Cancer
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Weiquan Gu, Na Wang, Weiguang Gu, Yuan Qiu, Hua Zhang, Jianmiao Liang, Tongfei Zhou, Liheng Ma, Weijing Cai, Weineng Feng et al. · 2020 · Translational Lung Cancer Research
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Beaulieu, Marie-Eve, Martínez-Martín, Sandra, Kaur, Jastrinjan, Castillo Cano, Virginia, Massó-Vallés, Daniel, Foradada Felip, Laia, López-Estévez, Sergio, Serrano del Pozo, Erika, Thabussot, Hugo, Soucek, Laura · 2023 · Cancers
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Hani Lee, Sojung Ha, SeokGyeong Choi, Soomin Do, Sukjoon Yoon, Yong Kee Kim, Woo‐Young Kim · 2023 · International Journal of Molecular Sciences
WNT Oncogenic Transcription Requires MYC Suppression of Lysosomal Activity and EPCAM Stabilization in Gastric Tumors
Patrizia Mulé, Daniel Fernández-Pérez, Simona Amato, Daria Manganaro, Paola Oldani, Stefania Brandini, Giuseppe Riccardo Diaferia, Alessandro Cuomo, Camilla Recordati, Chiara Soriani et al. · 2024 · Gastroenterology
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Abhay Hukku, Corbin Quick, Francesca Luca, Roger Piqué-Regi, Xiaoquan Wen · 2019 · Bioinformatics
Decursin inhibits tumor progression in head and neck squamous cell carcinoma by downregulating CXCR7 expressionin vitro
Mina Joo, Jong Beom Heo, Solbi Kim, Nayoung Kim, Heung Jin Jeon, Yueun An, Gyu‐Yong Song, Jin‐Man Kim, Hyo Jin Lee · 2021 · Oncology Reports
Long non-coding RNAs and MYC association in hematological malignancies
Leonidas Benetatos, Agapi Benetatou, George Vartholomatos · 2020 · Annals of Hematology
Rewired Metabolism Caused by the Oncogenic Deregulation of MYC as an Attractive Therapeutic Target in Cancers
Laura Vízkeleti, Sándor Spisák · 2023 · Cells
Multiomic characterization, immunological and prognostic potential of SMAD3 in pan-cancer and validation in LIHC
Tao Zhou, Dan Dan Zhang, Junhao Jin, Jinyang Xie, Jianhua Yu, Chao Zhu, Rong Wan · 2025 · Scientific Reports
Digital PCR for the Analysis of MYC Copy Number Variation in Lung Cancer
Alexander Brik, Daniel Gilbert Weber, Swaantje Casjens, P. Rozynek, Swetlana Meier, Thomas Behrens, Georgios Stamatis, Kaid Darwiche, Dirk Theegarten, Thomas Brüning et al. · 2020 · Disease Markers
MYCN Amplifications and Metabolic Rewiring in Neuroblastoma
Marialena Pouliou, Marianna A. Koutsi, Lydia Champezou, Angeliki-Ioanna Giannopoulou, Giannis Vatsellas, Christina Piperi, Marios Agelopoulos · 2023 · Cancers
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Peifeng Li, Mingyang Li, Kaijing Wang, Yixiong Liu, Yingmei Wang, Danhui Zhao, Jia Chai, Jing Ma, Xia Li, Jie Wei et al. · 2019 · Laboratory Investigation
Growth Signaling Networks Orchestrate Cancer Metabolic Networks
Brendan D. Manning, Christian C. Dibble · 2024 · Cold Spring Harbor Perspectives in Medicine
MYC directly transactivates CR2/CD21, the receptor of the Epstein–Barr virus, enhancing the viral infection of Burkitt lymphoma cells
Ester Molina, Lucia García-Gutiérrez, Vanessa Junco, Mercedes Pérez‐Olivares, Virginia G. de Yébenes, Rosa E. Blanco, Laura Quevedo, Juan Carlos Acosta, Ana V. Marín, Daniela Ulgiati et al. · 2023 · Oncogene
CRL2KLHDC3 and CRL1Fbxw7 cooperatively mediate c-Myc degradation
Saori Motomura, Kanae Yumimoto, Takeshi Tomonaga, Keiichi I. Nakayama · 2024 · Oncogene
YAP promotes global mRNA translation to fuel oncogenic growth despite starvation
Daehee Hwang, Seonguk Baek, Jeeyoon Chang, Taejun Seol, Bomin Ku, Hongseok Ha, Hyeonji Lee, Suhyeon Cho, Tae‐Young Roh, Yoon Ki Kim et al. · 2024 · Experimental & Molecular Medicine
Promoter methylation status of key genes and its implications in the pathogenesis of endometriosis, endometrioid carcinoma of ovary and endometrioid endometrial cancer
Priti Kumari, Indu Sharma, SubhasChandra Saha, Radhika Srinivasan, Anuradha Sharma · 2022 · Journal of Cancer Research and Therapeutics
ATM suppresses c-Myc overexpression in the mammary epithelium in response to estrogen
Rifat Ara Najnin, Md Rasel Al Mahmud, Md Maminur Rahman, Shunichi Takeda, Hiroyuki Sasanuma, Hisashi Tanaka, Yasuhiro Murakawa, Naoto Shimizu, Salma Akter, Masatoshi Takagi et al. · 2022 · Cell Reports
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Ye Hu, Meiling Wang, Kainan Wang, Jiyue Gao, Jiaci Tong, Zuowei Zhao, Man Li · 2021 · Mathematical Biosciences & Engineering
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Yong Joon Kim, Seo Jin Park, Kyung Joo Maeng, Sung Chul Lee, Christopher Seungkyu Lee · 2019 · Scientific Reports
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Comparative transcriptional analyses of preclinical models and patient samples reveal MYC and RELA driven expression patterns that define the molecular landscape of IBC
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Rubén Fernández, Luis Francisco Lorenzo‐Martín, Vı́ctor Quesada, Xosé R. Bustelo · 2025 · Frontiers in Bioinformatics
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PARP and PI3K inhibitor combination therapy eradicates c-MYC-driven murine prostate cancers via cGAS/STING pathway activation within tumor-associated macrophages
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