The DOI matches its Crossref record; 113 of the 113 references it cites were found in a registry or an index.
Pan-cancer Alterations of the MYC Oncogene and Its Proximal Network across the Cancer Genome Atlas
Open accessAbstract
Although the MYC oncogene has been implicated in cancer, a systematic assessment of alterations of MYC, related transcription factors, and co-regulatory proteins, forming the proximal MYC network (PMN), across human cancers is lacking. Using computational approaches, we define genomic and proteomic features associated with MYC and the PMN across the 33 cancers of The Cancer Genome Atlas. Pan-cancer, 28% of all samples had at least one of the MYC paralogs amplified. In contrast, the MYC antagonists MGA and MNT were the most frequently mutated or deleted members, proposing a role as tumor suppressors. MYC alterations were mutually exclusive with PIK3CA, PTEN, APC, or BRAF alterations, suggesting that MYC is a distinct oncogenic driver. Expression analysis revealed MYC-associated pathways in tumor subtypes, such as immune response and growth factor signaling; chromatin, translation, and DNA replication/repair were conserved pan-cancer. This analysis reveals insights into MYC biology and is a reference for biomarkers and therapeutics for cancers with alterations of MYC or the PMN.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“The Myc oncogene, including its three subtypes C-Myc, N-Myc, and L-Myc, is believed to act as a transcriptional “amplifier” that can trigger a variety of oncogenic transcriptional programs in different types of cancer.410,411”
From Recent advances in targeting the “undruggable” proteins: from drug discovery to clinical trials (2023) · cites this paper as [411]
In the citing paper
“Overexpression or hyperactivation of Myc is one of the most common occurrences in cancer, making it a key factor in oncogenesis.”
From Recent advances in targeting the “undruggable” proteins: from drug discovery to clinical trials (2023) · cites this paper as [411]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Subramanian, A., Tamayo, P., Mootha, V. K., Mukherjee, S., Ebert, B. L., Gillette, M. A., Paulovich, A., Pomeroy, S. L., Golub, T. R., Lander, E. S., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0506580102 · Cited by 53,625
Bartel (2004) · doi:10.1016/s0092-8674(04)00045-5 · Cited by 34,714
Mootha, V. K., Lindgren, C. M., Eriksson, K.-F., Subramanian, A., Sihag, S., Lehar, J., Puigserver, P., Carlsson, E., Ridderstråle, M., Laurila, E., et al. (2003) · Nature Genetics · doi:10.1038/ng1180 · Cited by 10,197
Comprehensive molecular profiling of lung adenocarcinoma
The Cancer Genome Atlas Research Network (2014) · Nature · doi:10.1038/nature13385 · Cited by 5,732
Distribution Theory for Glass's Estimator of Effect Size and Related Estimators
Hedges, L. V. (1981) · Journal of Educational Statistics · doi:10.2307/1164588 · Cited by 5,695
The landscape of somatic copy-number alteration across human cancers
Beroukhim, R., Mermel, C. H., Porter, D., Wei, G., Raychaudhuri, S., Donovan, J., Barretina, J., Boehm, J. S., Dobson, J., Urashima, M., et al. (2010) · Nature · doi:10.1038/nature08822 · Cited by 4,017 · cited 2×
“More recently, a report broadly analyzing the landscape of focal amplifications in cancers found MYC amplification to be among the most frequent of all such events (Beroukhim et al., 2010).”
Self-citationGregory, P. A., Bert, A. G., Paterson, E. L., Barry, S. C., Tsykin, A., Farshid, G., Vadas, M. A., Khew‐Goodall, Y., & Goodall, G. J. (2008) · Nature Cell Biology · doi:10.1038/ncb1722 · Cited by 3,852 · cited 1×
“…to modulate epithelial-mesenchymal transition (EMT) by forming a negative feedback loop with the master transcription factors ZEB1 and ZEB2 (Burk et al., 2008; Gregory et al., 2008; Korpal et al., 2008; Park (B) The table lists the top four genes most mutually exclusive with respect to MYC .”
Super-enhancers in the control of cell identity and disease
Hnisz, D., Abraham, B. J., Lee, T. I., Lau, A., Saint-André, V., Sigova, A. A., Hoke, H. A., & Young, R. A. (2013) · Cell · doi:10.1016/j.cell.2013.09.053 · Cited by 3,662
A microRNA polycistron as a potential human oncogene
He, L., Thomson, J. M., Hemann, M. T., Hernando, E., Mu, D., Goodson, S. G., Powers, S., Cordon‐Cardo, C., Lowe, S. W., Hannon, G. J., et al. (2005) · Nature · doi:10.1038/nature03552 · Cited by 3,642 · cited 2×
“Studies in mouse models of human cancers have demonstrated that this cluster, also known as Oncomir1, is a bona fide oncogene and a direct MYC transcriptional target (He et al., 2005; O’Donnell et al., 2005).”
Mermel, C. H., Schumacher, S. E., Hill, B., Meyerson, M. M., Beroukhim, R., & Getz, G. A. (2011) · Genome biology · doi:10.1186/gb-2011-12-4-r41 · Cited by 3,520
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
Items 301–400 of 434
LARP1 integrates MYC and mTOR signaling to enable anabolic growth during tumor initiation
Fuentes, P., Iannizzotto, F., Battaglia, E., Balzamo, C., Tola, C., Forcada, B., Bosch-i-Crespo, P., Morón-Duran, F. D., Frank, B. E., Herraez, C. M., et al. (2026) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2523043123 · Cited by 3
Targeting Metabolic Vulnerabilities in Glioblastoma: a Framework for Multi-node Combination Therapy
Gokani, V., Kotta, A., Repaka, V., Rauniyar, S., & Noch, E. (2026) · Current Oncology Reports · doi:10.1007/s11912-026-01746-x · Cited by 4
Leen, E., Yeoh, S., Sahak, E., Mitchell, E., Wildsmith, G., Batchelor, M., Calabrese, A. N., Büchel, G., & Bayliss, R. (2026) · Nucleic Acids Research · doi:10.1093/nar/gkag181 · Cited by 3
“Of 11 000 samples covering 33 cancer types, that were tested from the Pan Cancer Genome Atlas, 28% were found to be copy number amplified for a myc family member [ 5 ].”
I kappa B kinase interacting protein as a promising biomarker in pan-cancer: A multi-omics analysis
Bi, C., Wang, Z., Xiao, Y., Zhao, Y., Guo, R., Xiong, L., Ji, Z., Li, Y., Li, Q., & Qin, C. (2023) · Frontiers in Genetics · doi:10.3389/fgene.2023.1138137 · Cited by 3
“A block in the immune system is removed by immune checkpoint blocking medication, which also prompts a long-lasting anticancer response (Schaub et al., 2018; Deng et al., 2020; Sheng et al., 2020; Xu et al., 2020).”
BackgroundSelf-citationMYC Point Mutations in Cancer: A Reboot and a Sequel
Luca, D. D., Munafò, C., Lorenzi, L., & Cucco, F. (2025) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-25-0940 · Cited by 3
“Indeed, this study showed that MYC and/or its paralogs ( MYCN and MYCL ) were amplified in 28% of all tumor samples (11).”
Zhou, J., Zhang, M., Gao, A., Herman, J. G., & Guo, M. (2024) · Epigenomics · doi:10.1080/17501911.2024.2370590 · Cited by 3
“How ev er, therapeutic targeting some of oncogenes was challenged due to lack of enzymatic activity or proper binding sites for drugs, such as transcription factor MYC [ 14–17 ].”
BackgroundLandi, C., Liberatori, G., Puccini, M., Shaba, E., Vantaggiato, L., Vitolo, S., Corsi, I., & Bini, L. (2023) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2023.164651 · Cited by 3
Li, Z., & Vacanti, N. M. (2023) · Journal of Proteome Research · doi:10.1021/acs.jproteome.3c00290 · Cited by 3
Spt5 interacts genetically with Myc and is limiting for brain tumor growth in Drosophila
Hofstetter, J., Ogunleye, A. O., Kutschke, A., Buchholz, L. M., Wolf, E., Raabe, T., & Gallant, P. (2023) · Life Science Alliance · doi:10.26508/lsa.202302130 · Cited by 3
“Up to 28% of all tumors exhibit gene ampli fi cation of one of the MYC isoforms ( MYCN , MYCL or MYC ), de fi ning MYC genes as the most frequently ampli fi ed oncogene family across human cancers (Schaub et al, 2018).”
BackgroundWu, S., & Wagner, G. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.10.12.336263 · Cited by 3
Identification of MYC synthetic lethal genes and networksPreprint
Martin, T. D., Choi, M. Y., Patel, R. S., Liang, A. C. T., Li, M. Z., & Elledge, S. J. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.04.25.590465 · Cited by 3
Currie, C., Bjerknes, C., Nicol, M., Kumar, S., & Framroze, B. (2025) · Cancer Biology & Therapy · doi:10.1080/15384047.2025.2503417 · Cited by 2
“40 Normally, therefore, its expression is tightly controlled.”
Colchicine Binding Site Tubulin Inhibitors Impair Vincristine-Resistant Neuroblastoma Cell Function
Reed, C. N., Garrison, K. B., Thammathong, J., Cinatl, J. J., Michaelis, M., Banerjee, S., & Weissmiller, A. M. (2025) · Molecules · doi:10.3390/molecules30102186 · Cited by 2
“Further studies that detail the contribution of MYC to CBSI response would be very informative to the ~50% of cancers that overexpress this major oncogene [38].”
Ma, W., Tian, Y., Shen, W., Song, Z., Yang, B. Y., Zhou, D., & Ye, D. (2025) · Scientific Reports · doi:10.1038/s41598-025-96654-8 · Cited by 2
“Pan-cancer analysis could reveal the similarities and difference of various cancers, which provided more data for cancer prevention, target screen and potent therapeutic drug identification 44 .”
Fischer, K. C., Litalien, V., Diepstraten, S. T., Jahja, M., Brown, F. C., Kelly, G. L., Wei, A. H., & Cory, S. (2025) · Blood Neoplasia · doi:10.1016/j.bneo.2025.100149 · Cited by 2
“25,26 The deregulated overexpression of MYC is critical for driving many human cancers 60,61 .”
MYC and Metabolomics: Can We Use What We Know for DLBCL Subtyping and Diagnosis?
Suman, A. F., Luca, D. D., Gaggini, M., & Cucco, F. (2025) · Biomolecules · doi:10.3390/biom15091346 · Cited by 2
“However, in the last 20 years, the routine use of next-generation sequencing approaches allowed for the identification of MYC point mutations in various cancer types, including both solid and non-solid tumors, often in association with poor outcomes [31–33].”
Teitel, J., Farah, M., Dziubinski, M. L., Lee, P. H., White, A. D., Sobeck, A. M., Colina, J. A., Takyi‐Williams, J., Wen, B., Nurmemmedov, E., et al. (2025) · Scientific Reports · doi:10.1038/s41598-025-22011-4 · Cited by 3
Lu, X., Qin, J., Dong, S., Yuan, Y., Zhang, Z., Zhang, B., Chen, X., Gan, X., Liang, H., & Liu, F. (2026) · Biomarker Research · doi:10.1186/s40364-026-00937-9 · Cited by 3
Self-citationA novel role of MNT as a negative regulator of REL and the NF-κB pathway
Liaño-Pons, J., Lafita‐Navarro, M. C., García-Gaipo, L., Colomer, C., Rodríguez, J., von Kriegsheim, A., Hurlin, P. J., Ourique, F., Delgado, M. D., Bigas, A., et al. (2021) · Oncogenesis · doi:10.1038/s41389-020-00298-4 · Cited by 2
Self-citationZhao, Y., Dong, Y., Sun, Y., & Cheng, C. (2021) · Frontiers in Genetics · doi:10.3389/fgene.2021.665065 · Cited by 2
Self-citationKadry, M. O., & Megeed, R. M. A. (2024) · Toxicology Reports · doi:10.1016/j.toxrep.2024.101807 · Cited by 2
Song, X., Pan, Z., Zhang, Y., Yang, W., Zhang, T., Wang, H., Chen, Y., Yu, X., Ding, H., Li, R., et al. (2025) · Advanced Science · doi:10.1002/advs.202403851 · Cited by 2
Shi, S., Li, X., Alderman, C., Wick, L., Huang, W., Foulon, N., Zhang, L., Rossi, J. J., Hu, W., Cui, S., et al. (2025) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2025.110287 · Cited by 2
Self-citationJalbert, A., Sfairy, S.-M., Ekindi‐Ndongo, N., & Pavic, M. (2025) · JU Open Plus · doi:10.1097/ju9.0000000000000344 · Cited by 2
Network analysis of aging acceleration reveals systematic properties of 11 types of cancers
Xia, X., Zhou, M., Yan, H., Li, S., Sha, X., & Wang, Y. (2019) · FEBS Open Bio · doi:10.1002/2211-5463.12679 · Cited by 2
Advances in gastric cancer research will light the way to control this cancer
de Assumpção, P. P., & Burbano, R. M. R. (2022) · Chinese Journal of Cancer Research · doi:10.21147/j.issn.1000-9604.2022.06.04 · Cited by 2
Minasi, S., Gianno, F., Bargiacchi, L., Barresi, V., Miele, E., Antonelli, M., & Buttarelli, F. R. (2023) · Archiv für Pathologische Anatomie und Physiologie und für Klinische Medicin · doi:10.1007/s00428-023-03560-3 · Cited by 2
“Because of the rarity of this findings, we performed 850 k methylation array in order to define the molecular group and CNVs [7, 9, 11].”
InfluentialLiang, H., Lin, C., Hou, Y., Li, F., & Wu, K. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.03.30.015180 · Cited by 2
Self-citationSee, Y. X., Chen, K., & Fullwood, M. J. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.01.04.425344 · Cited by 2
MYC controls metastatic heterogeneity in pancreatic cancerPreprint
Maddipati, R., Norgard, R. J., Baslan, T., Rathi, K. S., Zhang, A. X. W., Raman, P., Pitarresi, J. R., Wengyn, M. D., Yamazoe, T., Li, J., et al. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.01.30.428641 · Cited by 2
Self-citationUnraveling the Complex Interplay between lncRNAs and Myc in Breast CancerPreprint
Mirmazhari, S. P., Abdi, M. J., Mosadeghrad, A. H., Bonab, R. A., Babadi, A. A., Rigi, G., Shahrokhi, S. Z., Chamanara, M., Amodio, N., & Heidari, R. (2023) · Preprints.org · doi:10.20944/preprints202307.1901.v1 · Cited by 2
Liver cancer development driven by the AP-1/c-Jun~Fra-2 dimer through c-Myc (Author copy)Preprint
Bakiri, L. (2024) · doi:10.22541/au.171403693.35484937/v1 · Cited by 1
MYC: Master Regulator of Cell Death and Tumor Progression
Capasso, L., Mele, D., Fayyaz, F., Altucci, L., & Nebbioso, A. (2025) · Biochemistry · doi:10.5772/intechopen.1008763 · Cited by 2
Husted, C. R., Adrianowycz, S., Peterson, C., DeWitt, S. B., Karlsson, E. K., Eward, W. C., Somarelli, J. A., Megquier, K., & Gardner, H. L. (2025) · PLoS ONE · doi:10.1371/journal.pone.0325181 · Cited by 1
“ZFHX3 is a transcription factor and negative regulator of c-Myb [58] that has been previously reported as gained in canine OS [9,59], and has been shown to be altered in a mutually exclusive manner with MYC in human cancers [60].”
Alamholo, M., & Tarinejad, A. (2025) · Discover Applied Sciences · doi:10.1007/s42452-025-07765-w · Cited by 1
“The MYC oncogene (c-MYC) is part of genes with products that are commonly activated in breast cancer and MYC proteins are master regulators of cellular programs [35].”
Khandocar, M. P., Islam, M. R., Dulal, P., Haque, S. M. J., & Islam, M. K. (2025) · Computational and Structural Biotechnology Reports · doi:10.1016/j.csbr.2025.100071 · Cited by 1
Zhao, P., Wang, Q., Wang, X., Tian, L., Liu, Y., Li, H., & Liu, H. (2026) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2026.105295 · Cited by 1
Self-citationKRAS and MYC synergistic inhibition: a powerful strategy targeting KRAS-mutant cancers
Yan, M., Liu, K., Xu, J., Liu, Y., Ji, L., & Zhang, S. (2026) · Molecular Cancer · doi:10.1186/s12943-026-02659-w · Cited by 1
“Whereas KRAS oncogenes are typically activated by mutations, MYC dysregulation is driven by a variety of mechanisms, including gene amplification, chromosomal translocation, retroviral promoter insertion, enhanced cellular signaling, and modified protein degradation [27, 28].”
Self-citationDeshpande, A. A., Lockhart, J. H., Napoli, M., & Flores, E. R. (2026) · Molecular and Cellular Biology · doi:10.1080/10985549.2026.2662223 · Cited by 1
“47,48 Indeed, other frequently mutated genes in cancer, such as RAS 49,50 and MYC , 51,52 also converge on cell-cycle regulation.”
NAT10‐Mediated ac4C Modification of circANKRD12 Reprograms the Tumor Microenvironment
Zhang, J. Y., Shi, H., Wang, C., Liu, Z., Zhou, L., Lv, X., Guo, M., Yang, Y. F., & Gu, C. (2026) · Advanced Science · doi:10.1002/advs.75797 · Cited by 1
Self-citationThe MYC network: Hub of malignancy and blueprint for intervention
Yin, H., Liu, T., & Pan, J. (2026) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2026.189651 · Cited by 1
Saniei, S., & Wagenblast, E. (2026) · Nature Communications · doi:10.1038/s41467-026-75182-7 · Cited by 1
Genetic Diversity Analysis of Different Populations of Lutjanus kasmira Based on SNP Markers
Zhao, F., Guo, L., Zhang, N., Yang, J., Zhu, K.-C., Guo, H., Liu, B.-S., Liu, B., Zhang, D., & Jiang, S. (2022) · Journal of Marine Science and Engineering · doi:10.3390/jmse10101547 · Cited by 1
“The R package poppr [17] was used to calculate a distance matrix and draw a heatmap [18].”
MethodSelf-citationCD112 is an epithelial-to-mesenchymal transition-related and immunological biomarker in pan-cancer
Zhang, H., Lü, J., Dong, Q., Wang, G., & Wang, X. (2024) · Translational Cancer Research · doi:10.21037/tcr-23-2258 · Cited by 1
Self-citationIn Silico Study of the Anti-MYC Potential of Lanostane-Type Triterpenes
de Oliveira, J. A. C., Negreiro, J. M., Nunes, F. M., Barbosa, F. G., Mafezoli, J., de Mattos, M. C., Fernandes, M. E. G. C., Pessoa, C., Furtado, C. L. M., Zanatta, G., et al. (2024) · ACS Omega · doi:10.1021/acsomega.4c10201 · Cited by 1
Liu, F., Zhang, H., Xue, L., Yang, Q., & Yan, W. (2019) · Oncology Letters · doi:10.3892/ol.2019.10523 · Cited by 1
“Among them, two studies focused on TFs in the context of Pan‐Cancer (7,26).”
BackgroundSelf-citationMYC needs MNT to drive B cells over the edge
Janz, S. (2020) · Blood · doi:10.1182/blood.2019004766 · Cited by 1
A Roadmap to Immunotherapy: Lesson from the Hallmarks and Signaling Pathways of CancerPreprint
Derakhshani, A., Rostami, Z., Safarpour, H., Taefehshokr, S., Tabrizi, N. J., Shadbad, M. A., Kooshkaki, O., Astamal, R. V., Argentiero, A., Singh, P. K., et al. (2020) · Preprints.org · doi:10.20944/preprints202011.0034.v1
Yang, R., Wang, W., Dong, M., Roso, K., Greer, P. K., Bao, X., Pirozzi, C. J., Bigner, D. D., Yan, H., Ashley, D. M., et al. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.06.07.447394 · Cited by 1
Self-citationPredicting Individual Cell Division Events from Single-Cell ERK and Akt DynamicsPreprint
Stern, A. D., Smith, G. R., SANTOS, L. V. D. S., Sarmah, D., Zhang, X., Lu, X., Iuricich, F., Pandey, G. S., Iyengar, R., & Birtwistle, M. R. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.09.14.460349 · Cited by 1
Self-citationMNT suppresses T cell apoptosis via BIM and is vital for MYC-driven T lymphomagenesisPreprint
Nguyen, H. V., Vandenberg, C. J., Robati, M., Ng, A. P., & Cory, S. (2022) · Research Square · doi:10.21203/rs.3.rs-1555936/v1 · Cited by 1
Dhanasekaran, R., Hansen, A. S., Park, J., Lai, I. K., Adeniji, N., Kuruvilla, S. P., Suresh, A., Swamy, V., & Felsher, D. W. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.05.13.491873 · Cited by 1
“INTRODUCTION The MYC oncogene is one of the most common drivers of human neoplasia, with more than 70% of human cancers having genetic alterations either in MYC or in one of the members of the proximal MYC network(1).”
BackgroundSelf-citationBoudra, R., Patenall, B. L., King, S. L., Wang, D., Best, S. A., Ko, J. Y., Xu, S., Padilla, M. G., Schmults, C. D., Barthel, S. R., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.03.27.533164 · Cited by 1
Hormone Receptor Expression and Disease Prognosis in High-Grade Serous Ovarian CancerPreprint
Dodds, L. V., Covarrubias, A. P. S., Sowamber, R., Milea, A. L., Pinto, A., Ban, Y. J., Schlumbrecht, M. P., Shaw, P. A., & George, S. H. L. (2023) · medRxiv · doi:10.1101/2023.04.21.23288934 · Cited by 1
MYC amplifies mitotic perturbations elicited by LXY18 to enable synthetic lethalityPreprint
Kalashova, J., Yang, C., Long, Y., Li, H., Zhang, S., Zhang, T., Yu, D., Liu, X., Lv, G., Choudhry, N., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.11.07.565938 · Cited by 1
Self-citationMicrotubule Inhibition Triggers MYC-Mediated Immunogenic Cell Death in Breast CancerPreprint
Liu, R., Aung, J., Peura, A., Hiltunen, A. O., Id, L., Savelius, M., Peltonen, M., Turpin, R., Salmelin, N., Anttila, J. M., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.08.26.671755 · Cited by 1
Richardson, A. B. (2018)
Self-citationAn integrative approach uncovers genes with perturbed interactions in cancersPreprint
Kobren, S. N., Chazelle, B., & Singh, M. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/733485
“properties across cancers further indicates its role as a tumor suppressor [53].”
BackgroundMXD/MIZ1 complexes activate transcription of MYC-repressed genesPreprint
Shostak, A., Schermann, G., Diernfellner, A. C. R., & Brunner, M. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/842799
Prognostic Significance of GRINA in Colorectal CancerPreprint
Cui, Y., Bai, Y., Yang, J., Yao, Y., Li, Q., Lü, X., Wu, F., Qiao, W., & Zhang, Y. (2021) · Research Square · doi:10.21203/rs.3.rs-707758/v1
Self-citationAlves, D. S. R. L. (2021) · Open University of Cape Town (University of Cape Town)
Genomics-based Precision Medicine for Patients with Cancer
van de Haar, J. (2021) · Utrecht University Repository (Utrecht University) · doi:10.33540/946
Thege, F. I., Rupani, D. N., Barathi, B. B., Manning, S. L., Maitra, A., Rhim, A. D., & Wörmann, S. M. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.12.09.471859
See, Y. X. (2021) · DR-NTU (Nanyang Technological University) · doi:10.32657/10356/154939
Tan, S., Liao, X., Wang, W., & Yu, B. (2022) · Research Square · doi:10.21203/rs.3.rs-1288390/v1
Peer Review #2 of "Machine learning analysis of TCGA cancer data (v0.1)"
(2021) · PeerJ Computer Science · doi:10.7287/peerj-cs.584v0.1/reviews/2
“They also catalogued the variants of the 10 pathways that are most frequently altered in most tumours (Sanchez-Vega et al., 2018), in addition to alterations in genes related to the ubiquitin (Ge et al., 2018), DNA damage repair (Knijnenburg et al., 2018) and the MYC pathways (Schaub et al., 2018).”
The role of breast cancer derived-exosomes in the tumour micro-environment
Ham, S. (2021) · Queensland University of Technology · doi:10.5204/thesis.eprints.208432
Peer Review #1 of "Machine learning analysis of TCGA cancer data (v0.1)"
(2021) · PeerJ Computer Science · doi:10.7287/peerj-cs.584v0.1/reviews/1
Peer Review #2 of "Machine learning analysis of TCGA cancer data (v0.2)"
(2021) · PeerJ Computer Science · doi:10.7287/peerj-cs.584v0.2/reviews/2
Jahnke, W. (2019) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.735358489.793558240
SHCBP1: A Novel Potential Molecular Target for Pan- Cancer Therapy
Zhao, X., Wang, W., Li, D., Li, Q., Zhang, Y., & Niu, B. (2022) · Neurological Disorders and Stroke International · doi:10.25107/2641-1407-v4-id1026
Yu, T., Xie, M., Fang, Y., Xu, T., Pan, Y.-T., Shu, Y., & Xu, T. (2022) · SSRN Electronic Journal · doi:10.2139/ssrn.4121723
Genetic diversity analysis of different populations of Lutjanus kasmira based on SNP markersPreprint
Zhao, F., Guo, L., Zhang, N., Yang, J., Zhu, K., Liu, B.-S., Guo, H., Liu, B., Zhang, D., & Jiang, S. (2022) · Research Square · doi:10.21203/rs.3.rs-1699907/v2
Self-citationGenetic diversity analysis of different populations of Lutjanus kasmira based on SNP markersPreprint
Zhao, F., Guo, L., Zhang, N., Yang, J., Zhu, K., Liu, B.-S., Guo, H., Liu, B., Zhang, D., & Jiang, S. (2022) · Research Square · doi:10.21203/rs.3.rs-1699907/v1
Self-citationMolina, E., García-Gutiérrez, L., Junco, V., Pérez‐Olivares, M., de Yébenes, V. G., Blanco, R. E., Quevedo, L., Acosta, J. C., Marín, A. V., Ulgiati, D., et al. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.12.28.522143
Schulz, W. A. (2023) · Springer eBooks · doi:10.1007/978-3-031-16286-2_4
Tsai, J. W., Cejas, P., Wang, D. K., Patel, S. K., Wu, D. W., Arounleut, P., Wei, X., Zhou, N., Syamala, S., Dubois, F. P. B., et al. (2023) · doi:10.1158/0008-5472.c.6514136.v1
Self-citationSharma, P., Abramson, V. G., O’Dea, A. P., Nye, L. E., Mayer, I. A., Pathak, H. B., Hoffmann, M., Stecklein, S. R., Elia, M., Lewis, S., et al. (2023) · doi:10.1158/1078-0432.c.6530748
Self-citationSharma, P., Abramson, V. G., O’Dea, A. P., Nye, L. E., Mayer, I. A., Pathak, H. B., Hoffmann, M., Stecklein, S. R., Elia, M., Lewis, S., et al. (2023) · doi:10.1158/1078-0432.c.6530748.v1
Self-citationThege, F. I., Rupani, D. N., Barathi, B. B., Manning, S. L., Maitra, A., Rhim, A. D., & Wörmann, S. M. (2023) · doi:10.1158/0008-5472.22432145
Schaafsma, E., Zhao, Y., Zhang, L., Li, Y., & Cheng, C. (2023) · doi:10.1158/1541-7786.22526001.v1
Self-citationLi, H., Xu, L., Li, M., & Gao, Z. (2023) · Journal of Biomedical Nanotechnology · doi:10.1166/jbn.2023.3519
Xi, Y., Chen, B., Zeng, Y., Wei, L., Shao, Y.-C., Feng, M., & Zhang, J. (2023) · Research Square · doi:10.21203/rs.3.rs-2970917/v1
Self-citationSriratanasak, N., Chanvorachote, P., & Luanpitpong, S. (2019) · doi:10.58837/chula.the.2019.428
Ma, W., Tian, Y., Shen, W., Song, Z., Yang, B. Y., & Ye, D. (2023) · Research Square · doi:10.21203/rs.3.rs-3282515/v1
Exploring glycolytic adaptations in cancer cells
Matos, B., Howl, J., Jerónimo, C., & Fardilha, M. (2023) · Elsevier eBooks · doi:10.1016/b978-0-323-91704-9.00014-8
Zhang, J., Xiong, X., Li, J., Luo, C., Su, Q., Hao, X., Wu, Q., & Huang, W. (2023) · Research Square · doi:10.21203/rs.3.rs-3769377/v1
Self-citationSchulz, W. A. (2024) · Springer eBooks · doi:10.1007/978-3-031-42806-7_4
CHAN, H., Luo, M.-Y., Wen, N., Chen, Y.-M., Zhang, L., & Cao, Y. (2024) · Research Square · doi:10.21203/rs.3.rs-4022866/v1
Self-citationRen, S., Zhang, Y., Ouyang, Y., Zhang, C., Su, Y., Shi, X., Xiao, Y., & Huang, Y. (2024) · Fortune Journal of Health Sciences · doi:10.26502/fjhs.175
“This network is considered as proximal MYC network (PMN), including MAX, MGA, MXD1, MXD3, MXD4, MXI1, MNT, MLX, MLXIP, and MLXIPL [16, 18].”
InfluentialÜlgen, E., Gerlevik, U., Gerlevik, S., Oktay, Y., Sezerman, O. U., Turcan, Ş., & Özduman, K. (2024) · Acta Neuropathologica Communications · doi:10.1186/s40478-024-01811-1
“Copy number gains of MYC are commonly observed in IDH-mutant gliomas [5].”
BackgroundMethodInfluentialZhang, J., Xiong, X., Li, J., Luo, C., Su, Q., Hao, X., Wu, Q., & Huang, W. (2024) · Journal of Cardiovascular Pharmacology · doi:10.1097/fjc.0000000000001613
Self-citationBMP2 Pan-Cancer Analysis in Multiple Tumor Types of TCGA Datasets *Preprint
Liu, F., Chung, B., Wu, K. C., & Lee, V. (2024) · Research Square · doi:10.21203/rs.3.rs-4787801/v1
Zhu, C.-Y., Yang, Q.-W., Mu, X.-Y., Zhai, Y.-Y., Zhao, W., & Yin, Z. (2024) · Cancer Informatics · doi:10.1177/11769351241300030
Self-citationVo, J. N., Franson, A. T., Waszak, S. M., Wu, Y.-M., Becker, N., Chinnaiyan, A. M., & Robinson, D. R. (2024) · Acta Neuropathologica Communications · doi:10.1186/s40478-024-01896-8
Self-citationBi, Q., Nie, J. H., Wu, Q., Sun, L., Zhu, S., Bai, J., Liu, Y. U., Huang, F., & Chai, K. (2025) · Medical Oncology · doi:10.1007/s12032-025-02604-9
Self-citationiModEst: disentangling -omic impacts on gene expression variation across genes and tissues
Sokolowski, D., Mai, M., Verma, A., Morgenshtern, G., Subasri, V., Naveed, H., Yampolsky, M., Wilson, M. D., Goldenberg, A., & Erdman, L. (2025) · NAR Genomics and Bioinformatics · doi:10.1093/nargab/lqaf011
Pardo, L., Moore, M., Deshmukh, R. S., Powley, I. R., Waldron, J. A., Kruspig, B., McGarry, L., Wood, C. S., Leslie, H., Hughes, M. M., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.03.19.644135
“Mutant KRAS is a well-recognised driver of lung cancer while MYC shows low-level amplification in over a third of all lung cancers [13] and strongly promotes ribosome biogenesis and protein translation [14-16].”
Wang, Y., Guo, J., Huang, M. S., Gao, S., Yuan, J., Jia, L., Wu, Z., Jiang, J., & Li, J. (2025) · Natural Product Research · doi:10.1080/14786419.2025.2543460
“…core targets are highly expressed in oesophageal cancer, with EGFR also associated with reduced recurrence-free survival and overall survival in oesophageal cancer (Chang et al. 2017, Hu et al. 2011, Moasser 2007, Nicholson et al. 2001, Schaub et al. 2018, Shan et al. 2017, Talukdar et al. 2020).”
Self-citationBurchett, J. B., Ambeskovic, A., Ford, M., Naccarato, J. C., Cazarin, J., Hecht, F., Hulver, M., He, X., Munger, J. C., Vertino, P. M., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.08.15.670530
Metadata
- Authors
- Schaub, F. X., Dhankani, V., Berger, A. C., Trivedi, M., Richardson, A. B., Shaw, R., Zhao, W., Zhang, X., Ventura, A., Liu, Y., Ayer, D. E., Hurlin, P. J., Cherniack, A. D., Eisenman, R. N., Bernard, B., Grandori, C., Caesar-Johnson, S. J., Demchok, J. A., Felau, I., Kasapi, M., Ferguson, M. L., Hutter, C. M., Sofia, H. J., Tarnuzzer, R., Wang, Z., Yang, L., Zenklusen, J. C., Zhang, J. (., Chudamani, S., Liu, J., Lolla, L., Naresh, R., Pihl, T., Sun, Q., Wan, Y., Wu, Y., Cho, J., DeFreitas, T., Frazer, S., Gehlenborg, N., Getz, G., Heiman, D. I., Kim, J., Lawrence, M. S., Lin, P., Meier, S., Noble, M. S., Saksena, G., Voet, D., Zhang, H., Bernard, B., Chambwe, N., Dhankani, V., Knijnenburg, T., Kramer, R., Leinonen, K., Liu, Y., Miller, M., Reynolds, S., Shmulevich, I., Thorsson, V., Zhang, W., Akbani, R., Broom, B. M., Hegde, A. M., Ju, Z., Kanchi, R. S., Korkut, A., Li, J., Liang, H., Ling, S., Liu, W., Lu, Y., Mills, G. B., Ng, K.-S., Rao, A., Ryan, M., Wang, J., Weinstein, J. N., Zhang, J., Abeshouse, A., Armenia, J., Chakravarty, D., Chatila, W. K., de Bruijn, I., Gao, J., Gross, B. E., Heins, Z. J., Kundra, R., La, K., Ladanyi, M., Luna, A., Nissan, M. G., Ochoa, A., Phillips, S. M., Reznik, E., Sanchez-Vega, F., Sander, C., Schultz, N., Sheridan, R., Sumer, S. O., Sun, Y., Taylor, B. S., Wang, J., Zhang, H., Anur, P., Peto, M., Spellman, P., Benz, C., Stuart, J. M., Wong, C. K., Yau, C., Hayes, D. N., Parker, J. S., Wilkerson, M. D., Ally, A., Balasundaram, M., Bowlby, R., Brooks, D., Carlsen, R., Chuah, E., Dhalla, N., Holt, R., Jones, S. J. M., Kasaian, K., Lee, D., Ma, Y., Marra, M. A., Mayo, M., Moore, R. A., Mungall, A. J., Mungall, K., Robertson, A. G., Sadeghi, S., Schein, J. E., Sipahimalani, P., Tam, A., Thiessen, N., Tse, K., Wong, T., Berger, A. C., Beroukhim, R., Cherniack, A. D., Cibulskis, C., Gabriel, S. B., Gao, G. F., Ha, G., Meyerson, M., Schumacher, S. E., Shih, J., Kucherlapati, M. H., Kucherlapati, R. S., Baylin, S., Cope, L., Danilova, L., Bootwalla, M. S., Lai, P. H., Maglinte, D. T., Van Den Berg, D. J., Weisenberger, D. J., Auman, J. T., Balu, S., Bodenheimer, T., Fan, C., Hoadley, K. A., Hoyle, A. P., Jefferys, S. R., Jones, C. D., Meng, S., Mieczkowski, P. A., Mose, L. E., Perou, A. H., Perou, C. M., Roach, J., Shi, Y., Simons, J. V., Skelly, T., Soloway, M. G., Tan, D., Veluvolu, U., Fan, H., Hinoue, T., Laird, P. W., Shen, H., Zhou, W., Bellair, M., Chang, K., Covington, K., Creighton, C. J., Dinh, H., Doddapaneni, H., Donehower, L. A., Drummond, J., Gibbs, R. A., Glenn, R., Hale, W., Han, Y., Hu, J., Korchina, V., Lee, S., Lewis, L., Li, W., Liu, X., Morgan, M., Morton, D., Muzny, D., Santibanez, J., Sheth, M., Shinbrot, E., Wang, L., Wang, M., Wheeler, D. A., Xi, L., Zhao, F., Hess, J., Appelbaum, E. L., Bailey, M., Cordes, M. G., Ding, L., Fronick, C. C., Fulton, L. A., Fulton, R. S., Kandoth, C., Mardis, E. R., McLellan, M. D., Miller, C. A., Schmidt, H. K., Wilson, R. K., Crain, D., Curley, E., Gardner, J., Lau, K., Mallery, D., Morris, S., Paulauskis, J., Penny, R., Shelton, C., Shelton, T., Sherman, M., Thompson, E., Yena, P., Bowen, J., Gastier-Foster, J. M., Gerken, M., Leraas, K. M., Lichtenberg, T. M., Ramirez, N. C., Wise, L., Zmuda, E., Corcoran, N., Costello, T., Hovens, C., Carvalho, A. L., de Carvalho, A. C., Fregnani, J. H., Longatto-Filho, A., Reis, R. M., Scapulatempo-Neto, C., Silveira, H. C. S., Vidal, D. O., Burnette, A., Eschbacher, J., Hermes, B., Noss, A., Singh, R., Anderson, M. L., Castro, P. D., Ittmann, M., Huntsman, D., Kohl, B., Le, X., Thorp, R., Andry, C., Duffy, E. R., Lyadov, V., Paklina, O., Setdikova, G., Shabunin, A., Tavobilov, M., McPherson, C., Warnick, R., Berkowitz, R., Cramer, D., Feltmate, C., Horowitz, N., Kibel, A., Muto, M., Raut, C. P., Malykh, A., Barnholtz-Sloan, J. S., Barrett, W., Devine, K., Fulop, J., Ostrom, Q. T., Shimmel, K., Wolinsky, Y., Sloan, A. E., De Rose, A., Giuliante, F., Goodman, M., Karlan, B. Y., Hagedorn, C. H., Eckman, J., Harr, J., Myers, J., Tucker, K., Zach, L. A., Deyarmin, B., Hu, H., Kvecher, L., Larson, C., Mural, R. J., Somiari, S., Vicha, A., Zelinka, T., Bennett, J., Iacocca, M., Rabeno, B., Swanson, P., Latour, M., Lacombe, L., Têtu, B., Bergeron, A., McGraw, M., Staugaitis, S. M., Chabot, J., Hibshoosh, H., Sepulveda, A., Su, T., Wang, T., Potapova, O., Voronina, O., Desjardins, L., Mariani, O., Roman-Roman, S., Sastre, X., Stern, M.-H., Cheng, F., Signoretti, S., Berchuck, A., Bigner, D., Lipp, E., Marks, J., McCall, S., McLendon, R., Secord, A., Sharp, A., Behera, M., Brat, D. J., Chen, A., Delman, K., Force, S., Khuri, F., Magliocca, K., Maithel, S., Olson, J. J., Owonikoko, T., Pickens, A., Ramalingam, S., Shin, D. M., Sica, G., Van Meir, E. G., Zhang, H., Eijckenboom, W., Gillis, A., Korpershoek, E., Looijenga, L., Oosterhuis, W., Stoop, H., van Kessel, K. E., Zwarthoff, E. C., Calatozzolo, C., Cuppini, L., Cuzzubbo, S., DiMeco, F., Finocchiaro, G., Mattei, L., Perin, A., Pollo, B., Chen, C., Houck, J., Lohavanichbutr, P., Hartmann, A., Stoehr, C., Stoehr, R., Taubert, H., Wach, S., Wullich, B., Kycler, W., Murawa, D., Wiznerowicz, M., Chung, K., Edenfield, W. J., Martin, J., Baudin, E., Bubley, G., Bueno, R., De Rienzo, A., Richards, W. G., Kalkanis, S., Mikkelsen, T., Noushmehr, H., Scarpace, L., Girard, N., Aymerich, M., Campo, E., Giné, E., Guillermo, A. L., Van Bang, N., Hanh, P. T., Phu, B. D., Tang, Y., Colman, H., Evason, K., Dottino, P. R., Martignetti, J. A., Gabra, H., Juhl, H., Akeredolu, T., Stepa, S., Hoon, D., Ahn, K., Kang, K. J., Beuschlein, F., Breggia, A., Birrer, M., Bell, D., Borad, M., Bryce, A. H., Castle, E., Chandan, V., Cheville, J., Copland, J. A., Farnell, M., Flotte, T., Giama, N., Ho, T., Kendrick, M., Kocher, J.-P., Kopp, K., Moser, C., Nagorney, D., O’Brien, D., O’Neill, B. P., Patel, T., Petersen, G., Que, F., Rivera, M., Roberts, L., Smallridge, R., Smyrk, T., Stanton, M., Thompson, R. H., Torbenson, M., Yang, J. D., Zhang, L., Brimo, F., Ajani, J. A., Angulo Gonzalez, A. M., Behrens, C., Bondaruk, J., Broaddus, R., Czerniak, B., Esmaeli, B., Fujimoto, J., Gershenwald, J., Guo, C., Lazar, A. J., Logothetis, C., Meric-Bernstam, F., Moran, C., Ramondetta, L., Rice, D., Sood, A., Tamboli, P., Thompson, T., Troncoso, P., Tsao, A., Wistuba, I., Carter, C., Haydu, L., Hersey, P., Jakrot, V., Kakavand, H., Kefford, R., Lee, K., Long, G., Mann, G., Quinn, M., Saw, R., Scolyer, R., Shannon, K., Spillane, A., Stretch, J., Synott, M., Thompson, J., Wilmott, J., Al-Ahmadie, H., Chan, T. A., Ghossein, R., Gopalan, A., Levine, D. A., Reuter, V., Singer, S., Singh, B., Tien, N. V., Broudy, T., Mirsaidi, C., Nair, P., Drwiega, P., Miller, J., Smith, J., Zaren, H., Park, J.-W., Hung, N. P., Kebebew, E., Linehan, W. M., Metwalli, A. R., Pacak, K., Pinto, P. A., Schiffman, M., Schmidt, L. S., Vocke, C. D., Wentzensen, N., Worrell, R., Yang, H., Moncrieff, M., Goparaju, C., Melamed, J., Pass, H., Botnariuc, N., Caraman, I., Cernat, M., Chemencedji, I., Clipca, A., Doruc, S., Gorincioi, G., Mura, S., Pirtac, M., Stancul, I., Tcaciuc, D., Albert, M., Alexopoulou, I., Arnaout, A., Bartlett, J., Engel, J., Gilbert, S., Parfitt, J., Sekhon, H., Thomas, G., Rassl, D. M., Rintoul, R. C., Bifulco, C., Tamakawa, R., Urba, W., Hayward, N., Timmers, H., Antenucci, A., Facciolo, F., Grazi, G., Marino, M., Merola, R., de Krijger, R., Gimenez-Roqueplo, A.-P., Piché, A., Chevalier, S., McKercher, G., Birsoy, K., Barnett, G., Brewer, C., Farver, C., Naska, T., Pennell, N. A., Raymond, D., Schilero, C., Smolenski, K., Williams, F., Morrison, C., Borgia, J. A., Liptay, M. J., Pool, M., Seder, C. W., Junker, K., Omberg, L., Dinkin, M., Manikhas, G., Alvaro, D., Bragazzi, M. C., Cardinale, V., Carpino, G., Gaudio, E., Chesla, D., Cottingham, S., Dubina, M., Moiseenko, F., Dhanasekaran, R., Becker, K.-F., Janssen, K.-P., Slotta-Huspenina, J., Abdel-Rahman, M. H., Aziz, D., Bell, S., Cebulla, C. M., Davis, A., Duell, R., Elder, J. B., Hilty, J., Kumar, B., Lang, J., Lehman, N. L., Mandt, R., Nguyen, P., Pilarski, R., Rai, K., Schoenfield, L., Senecal, K., Wakely, P., Hansen, P., Lechan, R., Powers, J., Tischler, A., Grizzle, W. E., Sexton, K. C., Kastl, A., Henderson, J., Porten, S., Waldmann, J., Fassnacht, M., Asa, S. L., Schadendorf, D., Couce, M., Graefen, M., Huland, H., Sauter, G., Schlomm, T., Simon, R., Tennstedt, P., Olabode, O., Nelson, M., Bathe, O., Carroll, P. R., Chan, J. M., Disaia, P., Glenn, P., Kelley, R. K., Landen, C. N., Phillips, J., Prados, M., Simko, J., Smith-McCune, K., VandenBerg, S., Roggin, K., Fehrenbach, A., Kendler, A., Sifri, S., Steele, R., Jimeno, A., Carey, F., Forgie, I., Mannelli, M., Carney, M., Hernandez, B., Campos, B., Herold-Mende, C., Jungk, C., Unterberg, A., von Deimling, A., Bossler, A., Galbraith, J., Jacobus, L., Knudson, M., Knutson, T., Ma, D., Milhem, M., Sigmund, R., Godwin, A. K., Madan, R., Rosenthal, H. G., Adebamowo, C., Adebamowo, S. N., Boussioutas, A., Beer, D., Giordano, T., Mes-Masson, A.-M., Saad, F., Bocklage, T., Landrum, L., Mannel, R., Moore, K., Moxley, K., Postier, R., Walker, J., Zuna, R., Feldman, M., Valdivieso, F., Dhir, R., Luketich, J., Mora Pinero, E. M., Quintero-Aguilo, M., Carlotti, C. G., Dos Santos, J. S., Kemp, R., Sankarankuty, A., Tirapelli, D., Catto, J., Agnew, K., Swisher, E., Creaney, J., Robinson, B., Shelley, C. S., Godwin, E. M., Kendall, S., Shipman, C., Bradford, C., Carey, T., Haddad, A., Moyer, J., Peterson, L., Prince, M., Rozek, L., Wolf, G., Bowman, R., Fong, K. M., Yang, I., Korst, R., Rathmell, W. K., Fantacone-Campbell, J. L., Hooke, J. A., Kovatich, A. J., Shriver, C. D., DiPersio, J., Drake, B., Govindan, R., Heath, S., Ley, T., Van Tine, B., Westervelt, P., Rubin, M. A., Lee, J. I., Aredes, N. D., & Mariamidze, A.
- Affiliations
- The University of Texas MD Anderson Cancer Center (US)
- Broad Institute (US)
- Memorial Sloan Kettering Cancer Center (US)
- University of Utah (US)
- Oregon Health & Science University (US)
- Fred Hutch Cancer Center (US)
- Corresponding author
- Grandori, Carla
- ORCID
- Schaub, Franz X.
- Richardson, Anne B.
- Shaw, Reid
- Zhao, Wei
- Zhang, Xiaoyang
- Ventura, Andrea
- Ayer, Donald E.
- Hurlin, Peter J.
- Eisenman, Robert N.
- Grandori, Carla
- Felau, Ina
- Kasapi, Melpomeni
- Ferguson, Martin L.
- Sofia, Heidi J.
- Tarnuzzer, Roy
- Yang, Liming
- Zenklusen, Jean C.
- Zhang, Jiashan (Julia)
- Liu, Jia
- Pihl, Todd
- Sun, Qiang
- Wan, Yunhu
- Wu, Ye
- Gehlenborg, Nils
- Getz, Gad
- Heiman, David I.
- Kim, Jaegil
- Lawrence, Michael S.
- Lin, Pei
- Noble, Michael S.
- Saksena, Gordon
- Zhang, Hailei
- Chambwe, Nyasha
- Knijnenburg, Theo
- Miller, Michael
- Zhang, Wei
- Akbani, Rehan
- Broom, Bradley M.
- Hegde, Apurva M.
- Ju, Zhenlin
- Korkut, Anil
- Li, Jun
- Liang, Han
- Liu, Wenbin
- Lu, Yiling
- Mills, Gordon B.
- Rao, Arvind
- Ryan, Michael
- Wang, Jing
- Weinstein, John N.
- Zhang, Jiexin
- Armenia, Joshua
- Chakravarty, Debyani
- Chatila, Walid K.
- Gross, Benjamin E.
- Heins, Zachary J.
- Kundra, Ritika
- Ladanyi, Marc
- Luna, Augustin
- Ochoa, Angelica
- Phillips, Sarah M.
- Reznik, Ed
- Sander, Chris
- Schultz, Nikolaus
- Sun, Yichao
- Taylor, Barry S.
- Zhang, Hongxin
- Spellman, Paul
- Benz, Christopher
- Stuart, Joshua M.
- Wong, Christopher K.
- Yau, Christina
- Hayes, D. Neil
- Parker, Joel S.
- Wilkerson, Matthew D.
- Holt, Robert
- Jones, Steven J.M.
- Marra, Marco A.
- Mayo, Michael
- Mungall, Andrew J.
- Mungall, Karen
- Sadeghi, Sara
- Tam, Angela
- Wong, Tina
- Beroukhim, Rameen
- Cibulskis, Carrie
- Gabriel, Stacey B.
- Ha, Gavin
- Meyerson, Matthew
- Schumacher, Steven E.
- Shih, Juliann
- Kucherlapati, Melanie H.
- Kucherlapati, Raju S.
- Baylin, Stephen
- Cope, Leslie
- Danilova, Ludmila
- Bootwalla, Moiz S.
- Maglinte, Dennis T.
- Weisenberger, Daniel J.
- Auman, J. Todd
- Hoadley, Katherine A.
- Hoyle, Alan P.
- Jones, Corbin D.
- Mieczkowski, Piotr A.
- Perou, Charles M.
- Roach, Jeffrey
- Shi, Yan
- Fan, Huihui
- Hinoue, Toshinori
- Laird, Peter W.
- Shen, Hui
- Zhou, Wanding
- Chang, Kyle
- Covington, Kyle
- Creighton, Chad J.
- Dinh, Huyen
- Doddapaneni, HarshaVardhan
- Drummond, Jennifer
- Gibbs, Richard A.
- Han, Yi
- Korchina, Viktoriya
- Li, Wei
- Morgan, Margaret
- Muzny, Donna
- Sheth, Margi
- Shinbrot, Eve
- Wang, Linghua
- Wheeler, David A.
- Zhao, Fengmei
- Hess, Julian
- Bailey, Matthew
- Ding, Li
- Fronick, Catrina C.
- Fulton, Robert S.
- Kandoth, Cyriac
- Mardis, Elaine R.
- McLellan, Michael D.
- Miller, Christopher A.
- Wilson, Richard K.
- Morris, Scott
- Sherman, Mark
- Bowen, Jay
- Lichtenberg, Tara M.
- Ramirez, Nilsa C.
- Zmuda, Erik
- Corcoran, Niall
- Hovens, Christopher
- Fregnani, José H.
- Reis, Rui M.
- Silveira, Henrique C.S.
- Vidal, Daniel O.
- Anderson, Matthew L.
- Ittmann, Michael
- Huntsman, David
- Kohl, Bernard
- Andry, Chris
- Duffy, Elizabeth R.
- Lyadov, Vladimir
- Paklina, Oxana
- Setdikova, Galiya
- Tavobilov, Mikhail
- Warnick, Ronald
- Berkowitz, Ross
- Feltmate, Colleen
- Horowitz, Neil
- Kibel, Adam
- Raut, Chandrajit P.
- Ostrom, Quinn T.
- Sloan, Andrew E.
- Giuliante, Felice
- Goodman, Marc
- Karlan, Beth Y.
- Somiari, Stella
- Bennett, Joseph
- Iacocca, Mary
- Lacombe, Louis
- Têtu, Bernard
- Bergeron, Alain
- McGraw, Mary
- Hibshoosh, Hanina
- Sepulveda, Antonia
- Wang, Timothy
- Potapova, Olga
- Voronina, Olga
- Desjardins, Laurence
- Mariani, Odette
- Stern, Marc-Henri
- Cheng, Feixiong
- Signoretti, Sabina
- Bigner, Darell
- Lipp, Eric
- Marks, Jeffrey
- McCall, Shannon
- McLendon, Roger
- Secord, Angeles
- Behera, Madhusmita
- Brat, Daniel J.
- Chen, Amy
- Delman, Keith
- Force, Seth
- Khuri, Fadlo
- Magliocca, Kelly
- Maithel, Shishir
- Olson, Jeffrey J.
- Owonikoko, Taofeek
- Ramalingam, Suresh
- Sica, Gabriel
- Zhang, Hongzheng
- Looijenga, Leendert
- Oosterhuis, Wolter
- Zwarthoff, Ellen C.
- Calatozzolo, Chiara
- Cuzzubbo, Stefania
- DiMeco, Francesco
- Finocchiaro, Gaetano
- Mattei, Luca
- Perin, Alessandro
- Pollo, Bianca
- Chen, Chu
- Taubert, Helge
- Wach, Sven
- Wullich, Bernd
- Kycler, Witold
- Murawa, Dawid
- Wiznerowicz, Maciej
- Martin, Julie
- Bubley, Glenn
- Bueno, Raphael
- Richards, William G.
- Kalkanis, Steven
- Mikkelsen, Tom
- Noushmehr, Houtan
- Scarpace, Lisa
- Girard, Nicolas
- Aymerich, Marta
- Giné, Eva
- Tang, Yufang
- Colman, Howard
- Evason, Kimberley
- Gabra, Hani
- Juhl, Hartmut
- Hoon, Dave
- Kang, Koo Jeong
- Beuschlein, Felix
- Breggia, Anne
- Borad, Mitesh
- Bryce, Alan H.
- Chandan, Vishal
- Cheville, John
- Copland, John A.
- Flotte, Thomas
- Ho, Thai
- Kendrick, Michael
- Kocher, Jean-Pierre
- Nagorney, David
- O’Brien, Daniel
- O’Neill, Brian Patrick
- Patel, Tushar
- Petersen, Gloria
- Rivera, Michael
- Roberts, Lewis
- Smyrk, Thomas
- Torbenson, Michael
- Yang, Ju Dong
- Zhang, Lizhi
- Brimo, Fadi
- Ajani, Jaffer A.
- Behrens, Carmen
- Broaddus, Russell
- Czerniak, Bogdan
- Esmaeli, Bita
- Fujimoto, Junya
- Guo, Charles
- Lazar, Alexander J.
- Logothetis, Christopher
- Ramondetta, Lois
- Sood, Anil
- Troncoso, Patricia
- Tsao, Anne
- Wistuba, Ignacio
- Carter, Candace
- Haydu, Lauren
- Jakrot, Valerie
- Kakavand, Hojabr
- Kefford, Richard
- Lee, Kenneth
- Long, Georgina
- Mann, Graham
- Saw, Robyn
- Scolyer, Richard
- Shannon, Kerwin
- Spillane, Andrew
- Stretch, Jonathan
- Thompson, John
- Wilmott, James
- Chan, Timothy A.
- Ghossein, Ronald
- Gopalan, Anuradha
- Levine, Douglas A.
- Singer, Samuel
- Singh, Bhuvanesh
- Broudy, Thomas
- Nair, Praveen
- Smith, Jennifer
- Zaren, Howard
- Park, Joong-Won
- Kebebew, Electron
- Linehan, W. Marston
- Metwalli, Adam R.
- Pinto, Peter A.
- Schiffman, Mark
- Schmidt, Laura S.
- Vocke, Cathy D.
- Wentzensen, Nicolas
- Yang, Hannah
- Moncrieff, Marc
- Goparaju, Chandra
- Melamed, Jonathan
- Pass, Harvey
- Cernat, Mircea
- Arnaout, Angel
- Bartlett, John
- Thomas, George
- Rassl, Doris M.
- Rintoul, Robert C.
- Bifulco, Carlo
- Urba, Walter
- Hayward, Nicholas
- Facciolo, Francesco
- Marino, Mirella
- Piché, Alain
- Chevalier, Simone
- McKercher, Ginette
- Farver, Carol
- Pennell, Nathan A.
- Borgia, Jeffrey A.
- Seder, Christopher W.
- Junker, Kerstin
- Omberg, Larsson
- Manikhas, George
- Alvaro, Domenico
- Bragazzi, Maria Consiglia
- Cardinale, Vincenzo
- Carpino, Guido
- Gaudio, Eugenio
- Dubina, Michael
- Moiseenko, Fedor
- Dhanasekaran, Renumathy
- Becker, Karl-Friedrich
- Janssen, Klaus-Peter
- Cebulla, Colleen M.
- Elder, J. Bradley
- Lehman, Norman L.
- Nguyen, Phuong
- Pilarski, Robert
- Rai, Karan
- Schoenfield, Lynn
- Wakely, Paul
- Lechan, Ronald
- Tischler, Arthur
- Grizzle, William E.
- Henderson, Joel
- Porten, Sima
- Fassnacht, Martin
- Asa, Sylvia L.
- Schadendorf, Dirk
- Couce, Marta
- Graefen, Markus
- Huland, Hartwig
- Sauter, Guido
- Schlomm, Thorsten
- Simon, Ronald
- Tennstedt, Pierre
- Nelson, Mark
- Bathe, Oliver
- Carroll, Peter R.
- Chan, June M.
- Kelley, Robin K.
- Landen, Charles N.
- Phillips, Joanna
- VandenBerg, Scott
- Roggin, Kevin
- Kendler, Ady
- Steele, Ruth
- Jimeno, Antonio
- Forgie, Ian
- Mannelli, Massimo
- Carney, Michael
- Campos, Benito
- Unterberg, Andreas
- Bossler, Aaron
- Ma, Deqin
- Milhem, Mohammed
- Godwin, Andrew K.
- Madan, Rashna
- Adebamowo, Clement
- Adebamowo, Sally N.
- Boussioutas, Alex
- Beer, David
- Giordano, Thomas
- Bocklage, Therese
- Landrum, Lisa
- Moxley, Katherine
- Walker, Joan
- Zuna, Rosemary
- Feldman, Michael
- Dhir, Rajiv
- Luketich, James
- Carlotti, Carlos Gilberto
- Kemp, Rafael
- Tirapelli, Daniela
- Catto, James
- Swisher, Elizabeth
- Creaney, Jenette
- Robinson, Bruce
- Shelley, Carl Simon
- Bradford, Carol
- Carey, Thomas
- Prince, Mark
- Rozek, Laura
- Wolf, Gregory
- Fong, Kwun M.
- Yang, Ian
- Rathmell, W. Kimryn
- Kovatich, Albert J.
- Shriver, Craig D.
- DiPersio, John
- Drake, Bettina
- Govindan, Ramaswamy
- Heath, Sharon
- Ley, Timothy
- Rubin, Mark A.
- Lee, Jung Il
- Aredes, Natália D.
- Mariamidze, Armaz
- Venue
- Cell Systems
- Publisher
- Elsevier BV
- Published
- 2018-03
- Volume
- 6
- Issue
- 3
- Pages
- 282-300.e2
- ISSN
- 2405-4712 (ISSN-L)
- PMC
- PMC5892207
- OpenAlex
- W2795073885
- Cited by
- 431
- References
- 112
- Citations by year
- 2026: 36 · 2025: 56 · 2024: 62 · 2023: 53 · 2022: 58 · 2021: 63 · 2020: 57 · 2019: 33 · 2018: 13
- FWCI
- 12.55
- Type
- journal article
- Language
- en
- Open access
- hybrid
- dx.doi.org
- Licence
- Locations
- Cell Systems (publishedVersion, cc-by)
- UWA Profiles and Research Repository (UWA) (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- IRIS Research product catalog (Sapienza University of Rome) (submittedVersion, other-oa)
- Archivio Istituzionale della Ricerca (Universita Degli Studi Di Milano) (submittedVersion, other-oa)
- Bern Open Repository and Information System (University of Bern) (submittedVersion, cc-by)
- Archivio istituzionale della ricerca (Alma Mater Studiorum Università di Bologna) (submittedVersion)
- Utrecht University Repository (Utrecht University) (submittedVersion, other-oa)
- eScholarship (California Digital Library) (submittedVersion, cc-by)
- Florence Research (University of Florence) (submittedVersion, cc-by-nc-nd)
- mediaTUM – the media and publications repository of the Technical University Munich (Technical University Munich) (submittedVersion, other-oa)
- Institutional Research Information System University of Ferrara (University of Ferrara) (submittedVersion, other-oa)
- Spiral (Imperial College London) (submittedVersion, cc-by-nc-nd)
- Open Access CRIS of the University of Bern
- Funders
- NIH (4U01CA176303-04, U24CA143867, RO1CA57138, 5R01CA149707)
- SEngine Precision Medicine
- Cure First
- Shriners Hospitals for Children and Leukemia and Lymphoma Society
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer Genomics and Diagnostics
- Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Chromatin Remodeling and Cancer
- Keywords
- MYC oncogene, MGA, medical nutrition therapy, tumor suppressor, oncogenic drivers, MYC transcription factors, pan-cancer analysis, PIK3CA, PTEN, APC, BRAF, tumor subtypes, immune response, growth factor signaling, chromatin, translation (biology), DNA replication and repair, biomarkers, cancer therapeutics
- MeSH terms
- Chromatin, Humans, Neoplasms, Oncogenes, Repressor Proteins, Transcription Factors, Biomarkers, Tumor, Signal Transduction, Genes, myc, Proto-Oncogene Proteins c-myc, Computational Biology, Genomics, Proteomics, Basic Helix-Loop-Helix Leucine Zipper Transcription Factors, Basic Helix-Loop-Helix Transcription Factors, Basic Helix-Loop-Helix Proteins, Carcinogenesis
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
